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Molecular Pathogenesis and Prognostic Markers in Monoclonal Gammopathies

Contact/Address

PD Dr. Christian Langer

Department of Internal Medicine III

University Hospital of Ulm

Albert-Einstein-Allee 23

89081 Ulm

Germany

 

E-Mail: christian.langer[at]uniklinik-ulm.de

Phone (direct):
Phone (laboratory):
Fax:

+49-(0)731-500-45743
+49-(0)731-500-45814
+49-(0)731-500-45925

Project Leader

PD Dr. Christian Langer

 

Technicians

Sonja Kolmus

 

Viktoria Werner

 

Students

Meike Kirschenlohr

Nadine Kurb

Christine Tetzner

Kathrin Tschajka

Research Fields

(A)
Incidence of genomic aberrations Multiple Myeloma (MM) and Monoclonal Gammopathy of Undetermined Significance (MGUS). Analysis by fluorescence in-situ hybridization (FISH) with comprehensive probe sets for detection of genetic imbalances involving chromosome bands 1p22, 1q21, 6q21, 8p11, 9q34, 11q25, 13q14, 17p13 and 22q11 as well as for detection of myeloma-specific translocations.

(B)
Development of automated high-resolution genotyping through microarray based matrix-CGH.

(C)
Evaluation of genomic aberrations as prognostic markers within multicenter treatment trials of the German Multiple Myeloma Study Group (DSMM)

(D)
Development of plasma cell tissue arrays for protein analyzes using immunohisto-chemistry

Techniques

  • Isolation of tumor cells by ficoll gradient and immunomagnetic cell sorting
  • Fluorescence in-situ hybridization (FISH), also in combination with immunostaining
  • DNA and RNA preparation of cells and tissues
  • DNA sequencing, sequence analysis cloning and preparation of various vector systems (plasmids, cosmids, BAC, PAC, YAC)
  • Metaphase-based and array-based comparative genomic hybridization (CGH)

Grants/Funding

  • Medizinische Fakultät Universität Ulm
  • Deutsche Krebshilfe
  • Wilhelm Sander-Stiftung
  • Deutsche José Carreras Leukämie-Stiftung

Representative Publications

Liebisch P, Viardot A, Bassermann N, Wendl C, Roth K, Goldschmidt H, Einsele H, Straka C, Stilgenbauer S, Döhner H, Bentz M (2003) Value of Comparative Genomic Hybridization (CGH) and Fluorescence in-situ Hybridization (FISH) for molecular diagnostics in multiple myeloma.
Br J Haematol; 122:193-201.
 
Liebisch P, Wendl C, Wellmann A, Kröber A, Schilling G, Goldschmidt H, Einsele H, Straka C, Bentz M, Stilgenbauer S, Döhner H (2003) High incidence of trisomies 1q, 9q, and 11q in multiple myeloma: results from a comprehensive molecular cytogenetic analysis.
Leukemia; 17:2535-2537.
 

Liebisch P, Scheck D, Erné SA, Wellmann A, Wendl C, Janczik S, Kolmus S, Kröber A, Einsele H, Straka C, Goldschmidt H, Benner A, Stilgenbauer S, Döhner H (2005) Duplication of chromosome arms 9q and 11q: Evidence for a novel, 14q32 translocation-independent pathogenetic pathway in multiple myeloma.
Genes Chromosomes Cancer; 42: 78-81.


Liebisch P, Eppinger S, Schöpflin C, Stehle G, Munzert G, Döhner H, Schmid M (2005) CD44v6, a target for novel antibody treatment approaches, is frequently expressed in multiple myeloma and associated with deletion of chromosome arm 13q.
Haematologica; 90: 489-493.

 
Liebisch P, Döhner H (2006) Cytogenetics and molecular cytogenetics in multiple myeloma.
Eur J
Cancer; 42: 1520-1529.

Collaborations

Dipl. Stat. A. Benner, DKFZ, Heidelberg, Germany

Prof. Dr. rer. nat. P. Lichter, DKFZ, Heidelberg, Germany

Prof. Dr. S. Dirnhofer, Basel, Switzerland

German Multiple Myeloma Study Group (DSMM)

Forschungsbereiche

Molecular Genetics of Myeloid Leukemia
Prof. Dr. Konstanze Döhner / Prof. Dr. Lars Bullinger

Molecular Genetics of Myeloproliferative Disorders
Dr. Frank Stegelmann / Prof. Dr. Konstanze Döhner

Molecular Pathogenesis and Progression of Lymphoproliferative Disorders
Prof. Dr. Stephan Stilgenbauer

Mechanisms of Leukemogenesis
PD Dr. Daniel Mertens

Molecular Pathogenesis and Prognostic Markers in Monoclonal Gammopathies
PD Dr. Christian Langer

Tumor Immunology Group (TIG)
Prof. Dr. Jochen Greiner

Haemostaseology
PD Dr. Christian Langer
 

Molecular Hematopoiesis
PD Dr. Dr. Florian Kuchenbauer

 

Emmy Noether Research Group

Dr. Jan Krönke

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