Publikationsliste der Zentralen Einrichtung für Klinische Chemie seit 2001

Interaction of Stellate Cells with Pancreatic Carcinoma Cells.
Habisch,-H; Zhou,-S; Siech,-M; Bachem M-G
Cancers 2010; 2:1661-1682

Up-regulation of L1CAM in Pancreatic Duct Cells Is Transforming Growth Factor ß1- and Slug-Dependent: Role in Malignant Transformation of Pancreatic Cancer.
Geismann,-C; Morscheck,-M; Koch,-D; Bergmann,-F; Ungefroren,-H; Arlt,-A; Tsao,-M-S; Bachem,-M-G; Altevogt,-P; Sipos,-B; Fölsch,-U-R; Schäfer,-H; Müerköster,-S-S;
Cancer-Res. 2009; 69: 4517–26

EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction.
Seizer,-P; Borst,-O; Langer,-H-F; Bültmann,-A; Münch,-G; Herouy,-Y; Stellos,-K; Krämer,-B; Bigalke,-B; Büchele,-B; Bachem,-M-G; Vestweber,-D; Simmet,-T; Gawaz,-M; May,-A-E
Thromb-Haemost. 2009;101: 682-6

Pancreatitis-associated protein inhibits human pancreatic stellate cell MMP-1 and -2, TIMP-1 and -2 secretion and RECK expression.
Li,-L; Bachem,-M-G; Zhou,-S; Sun,-Z; Chen,-J; Siech,-M; Bimmler,-D; Graf R

ancreatology. 2009; 9: 99-110

Identification of a novel switch in the dominant forms of cell adhesion-mediated drug resistance in glioblastoma cells.
Westhoff,-M-A; Zhou,-S; Bachem,-M-G; Debatin,-K-M; Fulda,-S
Oncogene. 2008; 27: 5169-81

Pulmonary contusion induces alveolar type 2 epithelial cell apoptosis: role of alveolar macrophages and neutrophils.
Seitz,-D-H; Perl,-M; Mangold,-S; Neddermann,-A; Braumüller,-S-T; Zhou,-S; Bachem,-M-G; Huber-Lang,-M-S; Knöferl,-M-W
Shock. 2008; 30: 537-44

Low intensity pulsed ultrasound accelerates macrophage phagocytosis by a pathway that requires actin polymerization, Rho, and Src/MAPKs activity.
Zhou,-S; Bachem,-M-G; Seufferlein,-T; Li,-Y; Gross,-H-J; Schmelz,-A
Cell-Signal. 2008; 20: 695-704

Pancreatic stellate cells--role in pancreas cancer.
Bachem,-M-G; Zhou,-S; Buck,-K; Schneiderhan,-W; Siech,-M;
Langenbecks-Arch-Surg. 2008; 393: 891-900

Human fibroblast growth factor receptor 1-IIIb is a functional fibroblast growth factor receptor expressed in the pancreas and involved in proliferation and movement of pancreatic ductal cells.
Liu,-Z; Ishiwata,-T; Zhou,-S; Maier,-S; Henne-Bruns,-D; Korc,-M; Bachem,-M; Kornmann,-M
Pancreas. 2007; 35: 147-57

Infiltration of blood outgrowth endothelial cells into tumor spheroids: role of matrix metalloproteinases and irradiation.
Wei,-J; Zhou,-S; Bachem,-M-G; Debatin,-K-M; Beltinger,-C;
Anticancer Res. 2007; 27: 1415-21

Identification of a fibroblast growth factor receptor 1 splice variant that inhibits pancreatic cancer cell growth.
Liu,-Z; Neiss,-N; Zhou,-S; Henne-Bruns,-D; Korc,-M; Bachem,-M; Kornmann,-M Cancer-Res. 2007; 67: 2712-9

Bile synthesis in rat models of inflammatory bowel diseases.
Dikopoulos,-N; Schmid,-R-M; Bachem,-M; Buttenschoen,-K; Adler,-G; Chiang,-J-Y; Weidenbach,-H
Eur-J-Clin-Invest. 2007; 37: 222-30

Pancreatic stellate cells are an important source of MMP-2 in human pancreatic cancer and accelerate tumor progression in a murine xenograft model and CAM assay.
Schneiderhan,-W; Diaz,-F; Fundel,-M; Zhou,-S; Siech,-M; Hasel,-C; Möller,-P; Gschwend,-J-E; Seufferlein,-T; Gress,-T; Adler,-G; Bachem,-M-G
J-Cell-Sci. 2007; 120: 512-9

Human cytomegalovirus-induced reduction of extracellular matrix proteins in vascular smooth muscle cell cultures: a pathomechanism in vasculopathies?
Reinhardt,-B; Winkler,-M; Schaarschmidt,-P; Pretsch,-R; Zhou,-S; Vaida,-B; Schmid-Kotsas,-A; Michel,-D; Walther,-P; Bachem,-M; Mertens,-T
 J-Gen-Virol. 2006; 87: 2849-58

Role of stellate cells in pancreatic fibrogenesis associated with acute and chronic pancreatitis.
Bachem,-M-G; Zhou,-Z; Zhou,-S; Siech,-M
J-Gastroenterol-Hepatol. 2006; 21 Suppl 3: S92-6

Effect of rosiglitazone treatment on plaque inflammation and collagen content in nondiabetic patients: data from a randomized placebo-controlled trial.
Meisner,-F; Walcher,-D; Gizard,-F; Kapfer,-X; Huber,-R; Noak,-A; Sunder-Plassmann,-L; Bach,-H; Haug,-C; Bachem,-M; Stojakovic,-T; Marz,-W; Hombach,-V; Koenig,-W; Staels,-B; Marx,-N
Arterioscler-Thromb-Vasc-Biol. 2006 Apr; 26(4): 845-50

Transcriptome analysis of human hepatic and pancreatic stellate cells: organ-specific variations of a common transcriptional phenotype.
Buchholz,-M; Kestler,-H-A; Holzmann,-K; Ellenrieder,-V; Schneiderhan,-W; Siech,-M; Adler,-G; Bachem,-M-G; Gress,-T-M
J-Mol-Med. 2005 Oct; 83(10): 795-805

Different effects of growth factors on proliferation and matrix production of normal and fibrotic human lung fibroblasts.
Hetzel,-M; Bachem,-M; Anders,-D; Trischler,-G; Faehling,-M
Lung. 2005 Jul-Aug; 183(4): 225-37

Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells.
Bachem,-M-G; Schunemann,-M; Ramadani,-M; Siech,-M; Beger,-H; Buck,-A; Zhou,-S; Schmid-Kotsas,-A; Adler,-G
Gastroenterology. 2005 Apr; 128(4): 907-21

Oxidized LDL inhibit hepatocyte growth factor synthesis in coronary smooth muscle cells.
Haug,-C; Lenz,-C; Bachem,-M-G
Int-J-Cardiol. 2005 Sep 1; 103(3): 298-306

Fibrogenesis in the pancreas.
Ellenrieder,-V; Schneiderhan,-W; Bachem,-M; Adler,-G
Rocz-Akad-Med-Bialymst. 2004; 49: 40-6

Molecular mechanisms of low intensity pulsed ultrasound in human skin fibroblasts.
Zhou,-S; Schmelz,-A; Seufferlein,-T; Li,-Y; Zhao,-J; Bachem,-M-G
J-Biol-Chem. 2004 Dec 24; 279(52): 54463-9

Oxidized low-density lipoproteins stimulate extracellular matrix metalloproteinase Inducer (EMMPRIN) release by coronary smooth muscle cells.
Haug,-C; Lenz,-C; Diaz,-F; Bachem,-M-G
Arterioscler-Thromb-Vasc-Biol. 2004 Oct; 24(10): 1823-9

Pancreatic tumor cells influence the composition of the extracellular matrix.
Koninger,-J; Giese,-T; di-Mola,-F-F; Wente,-M-N; Esposito,-I; Bachem,-M-G; Giese,-N-A; Buchler,-M-W; Friess,-H
Biochem-Biophys-Res-Commun. 2004 Sep 24; 322(3): 943-9

Overexpressed decorin in pancreatic cancer: potential tumor growth inhibition and attenuation of chemotherapeutic action.
Koninger,-J; Giese,-N-A; di-Mola,-F-F; Berberat,-P; Giese,-T; Esposito,-I; Bachem,-M-G; Buchler,-M-W; Friess,-H
Clin-Cancer-Res. 2004 Jul 15; 10(14): 4776-83

Sensitivity and specificity of different staining methods to monitor apoptosis induced by oxidative stress in adherent cells.
Zhao,-J; Schmid-Kotsas,-A; Gross,-H-J; Gruenert,-A; Bachem,-M-G
Chin-Med-J-(Engl). 2003 Dec; 116(12): 1923-9

In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas.
Hasel,-C; Durr,-S; Rau,-B; Strater,-J; Schmid,-R-M; Walczak,-H; Bachem,-M-G; Moller,-P
Lab-Invest. 2003 Jun; 83(6): 825-36

Biological markers in nasal secretions.
Riechelmann,-H; Deutschle,-T; Friemel,-E; Gross,-H-J; Bachem,-M
Eur-Respir-J. 2003 Apr; 21(4): 600-5

Triplex-forming oligodeoxynucleotides targeting survivin inhibit proliferation and induce apoptosis of human lung carcinoma cells.
Shen,-C; Buck,-A; Polat,-B; Schmid-Kotsas,-A; Matuschek,-C; Gross,-H-J; Bachem,-M; Reske,-S-N
Oxygen radical production precedes alcohol-induced acute pancreatitis in rats.
Wittel,-U-A; Bachem,-M; Siech,-M
Pancreas. 2003 May; 26(4): e74-80

The pattern of preformed cytokines in tissues frequently affected by blunt trauma.
Perl,-M; Gebhard,-F; Knoferl,-M-W; Bachem,-M; Gross,-H-J; Kinzl,-L; Strecker,-W
Shock. 2003 Apr; 19(4): 299-304

Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells.
Maulen,-N-P; Henriquez,-E-A; Kempe,-S; Carcamo,-J-G; Schmid-Kotsas,-A; Bachem,-M; Grunert,-A; Bustamante,-M-E; Nualart,-F; Vera,-J-C
J-Biol-Chem. 2003 Mar 14; 278(11): 9035-41

Isolation and functional characterization of a stolon specific promoter from potato (Solanum tuberosum L.).
Trindade,-L-M; Horvath,-B; Bachem,-C; Jacobsen,-E; Visser,-R-G
Gene. 2003 Jan 16; 303: 77-87

Evaluation of two modified cardiac troponin I enzyme immunoassays.
Haug,-C; Bachem,-M-G; Woehrle,-H; Hetzel,-M; Gruenert,-A
Clin-Chem-Lab-Med. 2002 Aug; 40(8): 837-9

The immunosuppressive drug mycophenolic acid reduces endothelin-1 synthesis in endothelial cells and renal epithelial cells.
Haug,-C; Schmid-Kotsas,-A; Linder,-T; Jehle,-P-M; Bachem,-M-G; Gruenert,-A; Rozdzinski,-E
Clin-Sci-(Lond). 2002 Aug; 103 Suppl 48: 76S-80S

Liposomal delivery of antisense oligonucleotides for efficient downregulation of Bcl-2 and induction of apoptosis.
Buck,-A-C; Shen,-C; Schirrmeister,-H; Schmid-Kotsas,-A; Munzert,-G; Guhlmann,-A; Mehrke,-G; Klug,-N; Gross,-H-J; Bachem,-M; Reske,-S-N
Cancer-Biother-Radiopharm. 2002 Jun; 17(3): 281-9

IL-10 receptor and coreceptor expression in quiescent and activated hepatic stellate cells.
Mathurin,-P; Xiong,-S; Kharbanda,-K-K; Veal,-N; Miyahara,-T; Motomura,-K; Rippe,-R-A; Bachem,-M-G; Tsukamoto,-H
Am-J-Physiol-Gastrointest-Liver-Physiol. 2002 Jun; 282(6): G981-90

Influence of hepatocyte growth factor, epidermal growth factor, and mycophenolic acid on endothelin-1 synthesis in human endothelial cells.
Haug,-C; Schmid-Kotsas,-A; Linder,-T; Bachem,-M-G; Gruenert,-A; Rozdzinski,-E
Nephrol-Dial-Transplant. 2001 Dec; 16(12): 2310-6

Oxidized low-density lipoproteins bind to the scavenger receptor, CD36, of hepatic stellate cells and stimulate extracellular matrix synthesis.
Schneiderhan,-W; Schmid-Kotsas,-A; Zhao,-J; Grunert,-A; Nussler,-A; Weidenbach,-H; Menke,-A; Schmid,-R-M; Adler,-G; Bachem,-M-G
Hepatology. 2001 Oct; 34(4 Pt 1): 729-37

Endothelin-1 synthesis and endothelin B receptor expression in human coronary artery smooth muscle cells and monocyte-derived macrophages is up-regulated by low density lipoproteins.
Haug,-C; Schmid-Kotsas,-A; Zorn,-U; Schuett,-S; Gross,-H-J; Gruenert,-A; Bachem,-M-G
J-Mol-Cell-Cardiol. 2001 Sep; 33(9): 1701-12

Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cells.
Schneider,-E; Schmid-Kotsas,-A; Zhao,-J; Weidenbach,-H; Schmid,-R-M; Menke,-A; Adler,-G; Waltenberger,-J; Grunert,-A; Bachem,-M-G
Am-J-Physiol-Cell-Physiol. 2001 Aug; 281(2): C532-43

Characterization of modified low density lipoprotein subfractions by capillary isotachophoresis.
Zorn,-U; Haug,-C; Celik,-E; Wennauer,-R; Schmid-Kotsas,-A; Bachem,-M-G; Grunert,-A
Electrophoresis. 2001 Apr; 22(6): 1143-9

Inhibition of nitric oxide synthesis by aminoguanidine increases intestinal damage in the acute phase of rat TNB-colitis.
Dikopoulos,-N; Nussler,-A-K; Liptay,-S; Bachem,-M; Reinshagen,-M; Stiegler,-M; Schmid,-R-M; Adler,-G; Weidenbach,-H
Eur-J-Clin-Invest. 2001 Mar; 31(3): 234-9

Triplex forming oligonucleotide targeted to 3'UTR downregulates the expression of the bcl-2 proto-oncogene in HeLa cells.
Shen,-C; Buck,-A; Mehrke,-G; Polat,-B; Gross,-H; Bachem,-M; Reske,-S
Nucleic-Acids-Res. 2001 Feb 1; 29(3): 622-8

Prevalence of the metabolic syndrome in southwest Germany.
Boehm,-B-O; Claudi-Boehm,-S; Yildirim,-S; Haenle,-M-M; Hay,-B; Mason,-R-A; Steinbach,-G; Koenig,-W; Kern,-P; Marz,-W; Kratzer,-W
Scand-J-Clin-Lab-Invest-Suppl. 2005; 240: 122-8

Procalcitonin in patients with acute and chronic renal insufficiency.
Steinbach,-G; Bolke,-E; Grunert,-A; Storck,-M; Orth,-K
Wien-Klin-Wochenschr. 2004 Dec 30; 116(24): 849-53

Whole blood interleukin 8 and plasma interleukin 8 levels in newborn infants with suspected bacterial infection.
Franz,-A-R; Sieber,-S; Pohlandt,-F; Kron,-M; Steinbach,-G
Acta-Paediatr. 2004 May; 93(5): 648-53

Multicenter evaluation of a new immunoassay for procalcitonin measurement on the Kryptor System.
Steinbach,-G; Rau,-B; Debard,-A-L; Javourez,-J-F; Bienvenu,-J; Ponzio,-A; Bonfa,-A; Hubl,-W; Demant,-T; Kulpmann,-W-R; Buchholz,-J; Schumann,-G
Clin-Chem-Lab-Med. 2004 Apr; 42(4): 440-9

Clinical value of lipopolysaccharide-binding protein (LBP) determinations in acute pancreatitis.
Rau,-B; Steinbach,-G; Kruger,-C-M; Baumgart,-K; Schilling,-M; Beger,-H-G
Langenbecks-Arch-Surg. 2003 Jul; 388(3): 181-8

IL-6 and PGE2 release by human osteoblasts on implant materials.
Schmidt,-C; Steinbach,-G; Decking,-R; Claes,-L-E; Ignatius,-A-A
Biomaterials. 2003 Oct; 24(23): 4191-6

Replacing the pyrophosphate group of HMB-PP by a diphosphonate function abrogates Its potential to activate human gammadelta T cells but does not lead to competitive antagonism.
Reichenberg,-A; Hintz,-M; Kletschek,-Y; Kuhl,-T; Haug,-C; Engel,-R; Moll,-J; Ostrovsky,-D-N; Jomaa,-H; Eberl,-M
Bioorg-Med-Chem-Lett. 2003 Apr 7; 13(7): 1257-60

Therapie der diffusen eitrigen Peritonitis mit kontinuierlicher Peritoneallavage.
[Therapy of diffuse suppurative peritonitis with continuous peritoneal lavage]
Bolke,-E; Jehle,-P-M; Schwarz,-A; Bruckner,-U; Nothnagel,-B; Kelbel,-I; Suger-Wideck,-H; Storck,-M; Steinbach,-G; Trautmann,-M; Orth,-K
Wien-Klin-Wochenschr. 2002 Aug 30; 114(15-16): 709-16

Circulating procalcitonin and cleavage products in septicaemia compared with medullary thyroid carcinoma.
Ittner,-L; Born,-W; Rau,-B; Steinbach,-G; Fischer,-J-A
Eur-J-Endocrinol. 2002 Dec; 147(6): 727-31

Whole blood interleukin-8 concentrations in capillary and cord blood of neonates for the diagnosis of systemic inflammatory states.
Kohse,-K-P; Carl,-A; Steinbach,-G
Clin-Lab. 2002; 48(9-10): 497-503

Chemokine activation within 24 hours after blunt accident trauma.
Liener,-U-C; Bruckner,-U-B; Knoferl,-M-W; Steinbach,-G; Kinzl,-L; Gebhard,-F
Shock. 2002 Mar; 17(3): 169-72

Different acute-phase response in newborns and infants undergoing surgery.
Bolke,-E; Jehle,-P-M; Trautmann,-M; Gotz,-I; Krebs,-B; Steinbach,-G; Orth,-K
Pediatr-Res. 2002 Mar; 51(3): 333-8

Preoperative oral application of immunoglobulin-enriched colostrum milk and mediator response during abdominal surgery.
Bolke,-E; Jehle,-P-M; Hausmann,-F; Daubler,-A; Wiedeck,-H; Steinbach,-G; Storck,-M; Orth,-K

Endovascular stent-graft placement versus conventional open surgery in infrarenal aortic aneurysm: a prospective study on acute phase response and clinical outcome.
Bolke,-E; Jehle,-P-M; Storck,-M; Braun,-C; Schams,-S; Steinbach,-G; Orth,-K; Gorich,-J; Scharrer-Pamler,-R; Sunder-Plassmann,-L
Clin-Chim-Acta. 2001 Dec; 314(1-2): 203-7

Inflammatory response during abdominal and thyroid surgery: a prospective clinical trial on mediator release.
Bolke,-E; Jehle,-P-M; Graf,-M; Baier,-A; Wiedeck,-H; Steinbach,-G; Storck,-M; Orth,-K
Shock. 2001 Nov; 16(5): 334-9
Interleukin-8: a valuable tool to restrict antibiotic therapy in newborn infants.
Franz,-A-R; Steinbach,-G; Kron,-M; Pohlandt,-F
Acta-Paediatr. 2001 Sep; 90(9): 1025-32

Changes of gut barrier function during anesthesia and cardiac surgery.
Bolke,-E; Jehle,-P-M; Orth,-K; Steinbach,-G; Hannekum,-A; Storck,-M
Angiology. 2001 Jul; 52(7): 477-82

Hypertension as a risk factor for cerebral injury during cardiopulmonary bypass. Protein S100B and transcranial Doppler findings.
Schmidt,-M; Scheunert,-T; Steinbach,-G; Schirmer,-U; Marx,-T; Freitag,-N; Reinelt,-H
Anaesthesia. 2001 Aug; 56(8): 733-8

A novel method for continuous online glucose monitoring in humans: the comparative microdialysis technique.
Hoss,-U; Kalatz,-B; Gessler,-R; Pfleiderer,-H-J; Andreis,-E; Rutschmann,-M; Rinne,-H; Schoemaker,-M; Haug,-C; Fussgaenger,-R-D
Diabetes-Technol-Ther. 2001 Summer; 3(2): 237-43

Recent advances in continuous glucose monitoring.
Freckmann,-G; Kalatz,-B; Pfeiffer,-B; Hoss,-U; Haug,-C
Exp-Clin-Endocrinol-Diabetes. 2001; 109 Suppl 2: S347-57

A comparison of the endotracheal tube and the laryngeal mask airway as a route for endobronchial lidocaine administration.
Prengel,-A-W; Rembecki,-M; Wenzel,-V; Steinbach,-G
Anesth-Analg. 2001 Jun; 92(6): 1505-9

Trauma severity-dependent changes in AT III activity.
Liener,-U-C; Bruckner,-U-B; Strecker,-W; Steinbach,-G; Kinzl,-L; Gebhard,-F
Shock. 2001 May; 15(5): 344-7

Prediction of gram-negative bacteremia in patients with cancer and febrile neutropenia by means of interleukin-8 levels in serum: targeting empirical monotherapy versus combination therapy.
Kern,-W-V; Heiss,-M; Steinbach,-G
Clin-Infect-Dis. 2001 Mar 1; 32(5): 832-5

Electrocardiographic exercise stress testing for cardiac risk assessment in patients undergoing noncardiac surgery.
Gauss,-A; Rohm,-H-J; Schauffelen,-A; Vogel,-T; Mohl,-U; Straehle,-A; Meierhenrich,-R; Georgieff,-M; Steinbach,-G; Schutz,-W
Anesthesiology. 2001 Jan; 94(1): 38-46


StellaTUM: current consensus and discussion on pancreatic stellate cell research.

Erkan M, Adler G, Apte MV, Bachem MG, Buchholz M, Detlefsen S, Esposito I, Friess H, Gress TM, Habisch HJ, Hwang RF, Jaster R, Kleeff J, Klöppel G, Kordes C, Logsdon CD, Masamune A, Michalski CW, Oh J, Phillips PA, Pinzani M, Reiser-Erkan C, Tsukamoto H, Wilson J. Gut. 2012;61(2):172-8.


Myofibroblast-induced tumorigenicity of pancreatic ductal epithelial cells is L1CAM dependent. Schäfer H, Geismann C, Heneweer C, Egberts JH, Korniienko O, Kiefel H, Moldenhauer G, Bachem MG, Kalthoff H, Altevogt P, Sebens S.

Carcinogenesis. 2012;33(1):84-93.


Divergent effects of activated neutrophils on inflammation, kupffer cell/splenocyte activation, and lung injury following blunt chest trauma.

Perl M, Kieninger M, Huber-Lang MS, Gross HJ, Bachem MG, Braumüller S, Gebhard F, Ayala A, Knöferl MW.

Shock. 2012;37(2):210-8.


Inflammation, regeneration, and transformation in the pancreas: results of the Collaborative Research Center 518 (SFB 518) at the University of Ulm.

Giehl K, Bachem M, Beil M, Böhm BO, Ellenrieder V, Fulda S, Gress TM, Holzmann K, Kestler HA, Kornmann M, Menke A, Möller P, Oswald F, Schmid RM, Schmidt V, Schirmbeck R, Seufferlein T, von Wichert G, Wagner M, Walther P, Wirth T, Adler G.

Pancreas. 201;40(4):489-502. Review.


TRAIL-induced apoptosis is preferentially mediated via TRAIL receptor 1 in pancreatic carcinoma cells and profoundly enhanced by XIAP inhibitors.

Stadel D, Mohr A, Ref C, MacFarlane M, Zhou S, Humphreys R, Bachem M, Cohen G, Möller P, Zwacka RM, Debatin KM, Fulda S.

Clin Cancer Res. 2010;16(23):5734-49.


Identification of c-FLIP(L) and c-FLIP(S) as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells.

Haag C, Stadel D, Zhou S, Bachem MG, Möller P, Debatin KM, Fulda S.

Gut. 2011;60(2):225-37.


PSP/reg inhibits cultured pancreatic stellate cell and regulates MMP/ TIMP ratio.

Li L, Bimmler D, Graf R, Zhou S, Sun Z, Chen J, Siech M, Bachem MG.

Eur J Clin Invest. 2011;41(2):151-8.


Inhibition of endogenous SPARC enhances pancreatic cancer cell growth: modulation by FGFR1-III isoform expression.

Chen G, Tian X, Liu Z, Zhou S, Schmidt B, Henne-Bruns D, Bachem M, Kornmann M.

Br J Cancer. 2010;102(1):188-95.


Interaction of Stellate Cells with Pancreatic Carcinoma Cells.
Habisch,-H; Zhou,-S; Siech,-M; Bachem M-G
Cancers 2010; 2:1661-1682


Stimulation of stellate cells by injured acinar cells: a model of acute pancreatitis induced by alcohol and fat (VLDL).

Siech M, Zhou Z, Zhou S, Bair B, Alt A, Hamm S, Gross H, Mayer J, Beger HG, Tian X, Kornmann M, Bachem MG.

Am J Physiol Gastrointest Liver Physiol. 2009;297(6):G1163-71. 


Up-regulation of L1CAM in pancreatic duct cells is transforming growth factor beta1- and slug-dependent: role in malignant transformation of pancreatic cancer.

Geismann C, Morscheck M, Koch D, Bergmann F, Ungefroren H, Arlt A, Tsao MS, Bachem MG, Altevogt P, Sipos B, Fölsch UR, Schäfer H, Müerköster SS.

Cancer Res. 2009;69(10):4517-26.


EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction.

Seizer P, Borst O, Langer HF, Bültmann A, Münch G, Herouy Y, Stellos K, Krämer B, Bigalke B, Büchele B, Bachem MG, Vestweber D, Simmet T, Gawaz M, May AE.

Thromb Haemost. 2009;101(4):682-6.


Pancreatitis-associated protein inhibits human pancreatic stellate cell MMP-1 and -2, TIMP-1 and -2 secretion and RECK expression.

Li L, Bachem MG, Zhou S, Sun Z, Chen J, Siech M, Bimmler D, Graf R.

Pancreatology. 2009;9(1-2):99-110.

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