2017

Guidi, N., Sacma, M., Ständker, L., Soller, K., Marka, G., Eiwen, K., Weiss, J.M., Kirchhoff, F., Weil, T., Cancelas, J.A., Florian, M.C., and Geiger, H. (2017). Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells. Embo j. 36, 840-853.

Heusinger, E., and Kirchhoff, F. (2017). Primate Lentiviruses Modulate NF-kappaB Activity by Multiple Mechanisms to Fine-Tune Viral and Cellular Gene Expression. Front. Microbiol. 8, 198.

Hotter, D., Sauter, D., and Kirchhoff, F. (2017). Guanylate binding protein 5: Impairing virion infectivity by targeting retroviral envelope glycoproteins. Small GTPases 8, 31-37.

Jonsson, K.L., Laustsen, A., Krapp, C., Skipper, K.A., Thavachelvam, K., Hotter, D., Egedal, J.H., Kjolby, M., Mohammadi, P., Prabakaran, T., et al. (2017). IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. Nat. Commun. 8, 14391.

Körner, C., Simoneau, C.R., Schommers, P., Granoff, M., Ziegler, M., Hölzemer, A., Lunemann, S., Chukwukelu, J., Corleis, B., and Naranbhai, V. (2017). HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells. Cell Host & Microbe 22, 111-119. e4.

Langer, S., and Sauter, D. (2017). Unusual Fusion Proteins of HIV-1. Front. Microbiol. 7, 2152.

Mack, K., Starz, K., Sauter, D., Langer, S., Bibollet-Ruche, F., Learn, G.H., Sturzel, C.M., Leoz, M., Plantier, J.C., Geyer, M., Hahn, B.H., and Kirchhoff, F. (2017). Efficient Vpu-Mediated Tetherin Antagonism by an HIV-1 Group O Strain. J. Virol. 91, 10.1128/JVI.02177-16. Print 2017 Mar 15.

Müller, J.A., Harms, M., Schubert, A., Mayer, B., Jansen, S., Herbeuval, J.P., Michel, D., Mertens, T., Vapalahti, O., Schmidt-Chanasit, J., and Munch, J. (2017). Development of a high-throughput colorimetric Zika virus infection assay. Med. Microbiol. Immunol. 206, 175-185.

Neidleman, J.A., Chen, J.C., Kohgadai, N., Müller, J.A., Laustsen, A., Thavachelvam, K., Jang, K.S., Sturzel, C.M., Jones, J.J., Ochsenbauer, C., et al. (2017). Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells. PLoS Pathog. 13, e1006163.

Richard, J., Prevost, J., von Bredow, B., Ding, S., Brassard, N., Medjahed, H., Coutu, M., Melillo, B., Bibollet-Ruche, F., Hahn, B.H., et al. (2017). BST-2 Expression Modulates Small CD4-Mimetic Sensitization of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity. J. Virol. 91, 10.1128/JVI.00219-17. Print 2017 Jun 1.

Riegger, A., Chen, C., Zirafi, O., Daiss, N., Mukherji, D., Walter, K., Tokura, Y., Stöckle, B., Kremer, K., and Kirchhoff, F. (2017). Synthesis of Peptide-Functionalized Poly (bis-sulfone) Copolymers Regulating HIV-1 Entry and Cancer Stem Cell Migration. ACS Macro Letters 6, 241-246.

Roan, N.R., Sandi-Monroy, N., Kohgadai, N., Usmani, S.M., Hamil, K.G., Neidleman, J., Montano, M., Ständker, L., Röcker, A., Cavrois, M., et al. (2017). Semen amyloids participate in spermatozoa selection and clearance. Elife 6, 10.7554/eLife.24888.

Rode, S., Hayn, M., Röcker, A., Sieste, S., Lamla, M., Markx, D., Meier, C., Kirchhoff, F., Walther, P., and Fändrich, M. (2017). Generation and Characterization of Virus-Enhancing Peptide Nanofibrils Functionalized with Fluorescent Labels. Bioconjug. Chem. 28, 1260-1270.

Smith, N., Pietrancosta, N., Davidson, S., Dutrieux, J., Chauveau, L., Cutolo, P., Dy, M., Scott-Algara, D., Manoury, B., Zirafi, O., et al. (2017). Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement. Nat. Commun. 8, 14253.

2016

Bego, M.G., Cong, L., Mack, K., Kirchhoff, F., and Cohen, É.A. (2016). Differential Control of BST2 Restriction and Plasmacytoid Dendritic Cell Antiviral Response by Antagonists Encoded by HIV-1 Group M and O Strains. J Virol. 90, 10236-10246.

Bergman, P., Roan, N.R., Römling, U., Bevins, C.L., and Münch, J. (2016). Amyloid formation: functional friend or fearful foe? J Intern Med. 280, 139-152.

Camus, C., Matusali, G., Bourry, O., Mahe, D., Aubry, F., Bujan, L., Pasquier, C., Massip, P., Ravel, C., and Zirafi, O., et al. (2016). Comparison of the effect of semen from HIV-infected and uninfected men on CD4+ T-cell infection. AIDS. 30, 1197-1208.

Guidi, N., Sacma, M., Standker, L., Soller, K., Marka, G., Weiss, J., Kirchhoff, F., Weil, T., Cancelas, J., and Florian, M.C., et al. (2016). OSTEOPONTIN REGULATES AND ATTENUATES AGING-ASSOCIATED PHENOTYPES OF HSCS. Exp Hematol. 44 1, S51-S51.

Heigele, A., Kmiec, D., Regensburger, K., Langer, S., Peiffer, L., Stürzel, C.M., Sauter, D., Peeters, M., Pizzato, M., and Learn, G.H., et al. (2016). The Potency of Nef-Mediated SERINC5 Antagonism Correlates with the Prevalence of Primate Lentiviruses in the Wild. Cell Host Microbe. 20, 381-391.

Hotter, D., Sauter, D., and Kirchhoff, F. (2016). Guanylate binding protein 5: Impairing virion infectivity by targeting retroviral envelope glycoproteins. Small GTPases., 1-7.

Klippert, A., Bleyer, M., Sauermann, U., Neumann, B., Kaul, A., Daskalaki, M., Stolte-Leeb, N., Kirchhoff, F., and Stahl-Hennig, C. (2016). Lymphocryptovirus-dependent occurrence of lymphoma in SIV-infected rhesus macaques with particular consideration to two uncommon cases of non-Hodgkin's lymphoma. Primate Biol . 3, 65-75.

Kmiec, D., Iyer, S.S., Stürzel, C.M., Sauter, D., Hahn, B.H., and Kirchhoff, F. (2016). Vpu-Mediated Counteraction of Tetherin Is a Major Determinant of HIV-1 Interferon Resistance. MBio. 7.

Krapp, C., Hotter, D., Gawanbacht, A., McLaren, P.J., Kluge, S.F., Stürzel, C.M., Mack, K., Reith, E., Engelhart, S., and Ciuffi, A., et al. (2016). Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity. Cell Host Microbe. 19, 504-514.

Lavender, K.J., Gibbert, K., Peterson, K.E., van Dis, E., Francois, S., Woods, T., Messer, R.J., Gawanbacht, A., Müller, J.A., and Münch, J., et al. (2016). Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo. J Virol. 90, 6001-6013.

Müller, J.A., Harms, M., Schubert, A., Jansen, S., Michel, D., Mertens, T., Schmidt-Chanasit, J., and Münch, J. (2016). Inactivation and Environmental Stability of Zika Virus. Emerg Infect Dis. 22, 1685-1687.

Müller, J.A., Zirafi, O., Roan, N.R., Lee, S.J., and Münch, J. (2016). Evaluation of EPI-X4 as a urinary peptide biomarker for diagnosis and prognosis of late acute GvHD. Bone Marrow Transplant. 51, 1137-1139.

Palesch, D., Boldt, F., Müller, J.A., Eisele, K., Stürzel, C.M., Wu, Y., Münch, J., and Weil, T. (2016). PEGylated Cationic Serum Albumin for Boosting Retroviral Gene Transfer. Chembiochem. 17, 1504-1508.

Palesch, D., Wagner, J., Meid, A., Molenda, N., Sienczyk, M., Burkhardt, J., Münch, J., Prokop, L., Stevanovic, S., and Westhoff, M.A., et al. (2016). Cathepsin G-mediated proteolytic degradation of MHC class I molecules to facilitate immune detection of human glioblastoma cells. Cancer Immunol Immunother. 65, 283-291.

Portilho, D.M., Fernandez, J., Ringeard, M., Machado, A.K., Boulay, A., Mayer, M., Müller-Trutwin, M., Beignon, A.S., Kirchhoff, F., and Nisole, S., et al. (2016). Endogenous TRIM5? Function Is Regulated by SUMOylation and Nuclear Sequestration for Efficient Innate Sensing in Dendritic Cells. Cell Rep. 14, 355-369.

Röcker, A., Kirchhoff, F., and Munch, J. (2016). Combating HIV: what the human peptidome offers. Future Virol. 11, 167-170.

Sauter, D., and Kirchhoff, F. (2016). HIV replication: a game of hide and sense. Curr Opin HIV AIDS. 11, 173-181.

Sauter, D., and Kirchhoff, F. (2016). IFITMs: Important Factors In Trans-Mission of HIV-1. Cell Host Microbe. 20, 407-408.

Vermeire, J., Roesch, F., Sauter, D., Rua, R., Hotter, D., van Nuffel, A., Vanderstraeten, H., Naessens, E., Iannucci, V., and Landi, A., et al. (2016). HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4(+) T Cells. Cell Rep. 17, 413-424.

Zirafi, O., Hermann, P.C., and Münch, J. (2016). Proteolytic processing of human serum albumin generates EPI-X4, an endogenous antagonist of CXCR4. J Leukoc Biol. 99, 863-868.

2015

Bächle, S.M., Sauter, D., Sibitz, S., Sandberg, J.K., Kirchhoff, F., and Moll, M. (2015). Involvement of a C-terminal motif in the interference of primate lentiviral Vpu proteins with CD1d-mediated antigen presentation. Sci Rep. 5, 9675.

Buske, C., Kirchhoff, F., and Münch, J. (2015). EPI-X4, a novel endogenous antagonist of CXCR4. Oncotarget. 6, 35137-35138.

Chen, J., Tibroni, N., Sauter, D., Galaski, J., Miura, T., Alter, G., Mueller, B., Haller, C., Walker, B.D., and Kirchhoff, F., et al. (2015). Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma. PLoS ONE. 10, e0120434.

Ding, S., Veillette, M., Coutu, M., Prévost, J., Scharf, L., Bjorkman, P.J., Ferrari, G., Robinson, J.E., Stürzel, C., and Hahn, B.H., et al. (2015). A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies. J Virol. 90, 2127-2134.

Groß, A., Rödel, K., Kneidl, B., Donhauser, N., Mössl, M., Lump, E., Münch, J., Schmidt, B., and Eichler, J. (2015). Enhancement and induction of HIV-1 infection through an assembled peptide derived from the CD4 binding site of gp120. Chembiochem. 16, 446-454.

Heigele, A., Joas, S., Regensburger, K., and Kirchhoff, F. (2015). Increased susceptibility of CD4+ T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels. Retrovirology. 12, 86.

Heusinger, E., Kluge, S.F., Kirchhoff, F., and Sauter, D. (2015). Early Vertebrate Evolution of the Host Restriction Factor Tetherin. J Virol. 89, 12154-12165.

Kaltenmeier, C., Gawanbacht, A., Beyer, T., Lindner, S., Trzaska, T., van der Merwe, J.A., Härter, G., Grüner, B., Fabricius, D., and Lotfi, R., et al. (2015). CD4+ T cell-derived IL-21 and deprivation of CD40 signaling favor the in vivo development of granzyme B-expressing regulatory B cells in HIV patients. J Immunol. 194, 3768-3777.

Klippert, A., Stolte-Leeb, N., Neumann, B., Sauermann, U., Daskalaki, M., Gawanbacht, A., Kirchhoff, F., and Stahl-Hennig, C. (2015). Frequencies of lymphoid T-follicular helper cells obtained longitudinally by lymph node fine-needle aspiration correlate significantly with viral load in SIV-infected rhesus monkeys. J Med Primatol. 44, 253-262.

Kluge, S.F., Sauter, D., and Kirchhoff, F. (2015). SnapShot: Antiviral Restriction Factors. Cell. 163, 774-774.e1.

Langer, S.M., Hopfensperger, K., Iyer, S.S., Kreider, E.F., Learn, G.H., Lee, L.H., Hahn, B.H., and Sauter, D. (2015). A Naturally Occurring rev1-vpu Fusion Gene Does Not Confer a Fitness Advantage to HIV-1. PLoS ONE. 10, e0142118.

Lump, E., Castellano, L.M., Meier, C., Seeliger, J., Erwin, N., Sperlich, B., Stürzel, C.M., Usmani, S., Hammond, R.M., and Einem, J. von, et al. (2015). A molecular tweezer antagonizes seminal amyloids and HIV infection. eLife. 4.

McLaren, P.J., Gawanbacht, A., Pyndiah, N., Krapp, C., Hotter, D., Kluge, S.F., Götz, N., Heilmann, J., Mack, K., and Sauter, D., et al. (2015). Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses. Retrovirology. 12, 41.

Mlcochova, P., Apolonia, L., Kluge, S.F., Sridharan, A., Kirchhoff, F., Malim, M.H., Sauter, D., and Gupta, R.K. (2015). Immune evasion activities of accessory proteins Vpu, Nef and Vif are conserved in acute and chronic HIV-1 infection. Virology. 482, 72-78.

Mohr, K.B., Zirafi, O., Hennies, M., Wiese, S., Kirchhoff, F., and Münch, J. (2015). Sandwich enzyme-linked immunosorbent assay for the quantification of human serum albumin fragment 408-423 in bodily fluids. Anal Biochem. 476, 29-35.

Roan, N.R., and Münch, J. (2015). Improving preclinical models of HIV microbicide efficacy. Trends Microbiol. 23, 445-447.

Sauter, D., Hotter, D., van Driessche, B., Stürzel, C.M., Kluge, S.F., Wildum, S., Yu, H., Baumann, B., Wirth, T., and Plantier, J.C., et al. (2015). Differential Regulation of NF-κB-Mediated Proviral and Antiviral Host Gene Expression by Primate Lentiviral Nef and Vpu Proteins. Cell Rep. 10, 586-599.

Yu, H., Khalid, M., Heigele, A., Schmökel, J., M Usmani, S., van der Merwe, J., Münch, J., Silvestri, G., and Kirchhoff, F. (2015). Lentiviral nef proteins manipulate T cells in a subset-specific manner. J Virol. 89, 1986-2001.

Zirafi, O., Kim, K.A., Ständker, L., Mohr, K.B., Sauter, D., Heigele, A., Kluge, S.F., Wiercinska, E., Chudziak, D., and Richter, R., et al. (2015). Discovery and characterization of an endogenous CXCR4 antagonist. Cell Rep. 11, 737-747.

Contact

Ms. Ingrid Wirth (am)

Tel +49731 50065151

Fax +49731 50065153

Ms. Kristina Wohllaib (pm)

Tel +49731 50065152

Fax +49731 50065153

________________________

Institute of Molecular Virology

Ulm University Hospital

Meyerhofstr. 1

89081, Ulm

Germany

 

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