Recent Publications

2010

• Asztalos, B.F., Mujawar, Z., Morrow, M.P., Grant, A., Pushkarsky, T., Wanke, C., Shannon, R., Geyer, M., Kirchhoff, F., Sviridov, D., Fitzgerald, M.L., Bukrinsky, M., and Mansfield, K.G. (2010). Nef-Mediated Suppression of Cholesterol Efflux May Contribute to Primary Dyslipidemia in SIV-Infected Macaques. J. Inf. Dis. (in press).
• Kim, K.-A., Yolamanova, M., Zirafi, O., Roan, N.R., Staendker, L., Forssmann, W.-G., Burgener, A., Dejucq-Rainsford, N., Hahn, B.H., Shaw, G.M., Greene, W.C., Kirchhoff, F. and Münch, J. (2010). Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI. Retrovirology, 7:55
• Specht, A., Telenti, A., Martinez, R., Fellay, J., Bailes, E., Evans, D.T., Carrington, M., Hahn, B.H., Goldstein, D.B. and Kirchhoff, F. (2010). Counteraction of HLA-C-mediated immune control of HIV-1 by Nef. J. Virol 84:7300-711
• Banning, C., Düsedau, A., Warmer, M., Kirchhoff, F., Hohenberg, H. and Schindler, M. (2010). A FACS based assay to measure protein interactions in living cells by FRET. PLOS one 5(2) e9344
• Schindler, M., Rajan, D., Banning, C., Wimmer, P., Koppensteiner, H., Iwanski, A., Specht, A., Sauter,  D., Dobner, T. and Kirchhoff, F. (2010). Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue. Retrovirology 7:1
• Kühl, A., Münch, J., Sauter, D., Bertram, S., Glowacka, I., Steffen, I., Specht, A., Hofmann, H., Schneider, H., Behrens, G., Pöhlmann, S. (2010). No evidence for a restriction of retrovirus release by calcium modulating cyclophilin ligand. Nature Medicine 16:155-6
• Chaipan C, Steffen I, Solomon Tsegaye T, Bertram S, Glowacka I, Kato Y, Schmökel J, Munch J, Simmons G, Gerardy-Schahn R, Pohlmann S. (2010). Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2. Retrovirology 7:47

2009

• Roan, N.R., Sowinski, S., Münch, J., Kirchhoff, F., and Greene, W.C. (2009). Semen-Mediated Enhancement of HIV-1 Infection Is Inhibited by Surfen, an Antagonist of Heparan Sulfate Proteoglycans. J. Biol. Chem. 285(3) 1861-1869
• Sauter, D., Schindler, M., Specht, A., Landford, W.N. Münch, J., Kim, K.-J., Votteler, J., Schubert, U., Bibollet-Ruche, F., Keele, B.F., Takehisa, J. Ogando, Y., Ochsenbauer, C., Kappes, J.C. Ayouba, A.,  Peeters, M., Learn, G. Shaw, G., Sharp, P.M., Bieniasz, P., Hahn, B.H., Hatziioannou, T., and Kirchhoff, F. (2009). Tetherin-driven adaptation of Vpu and Nef function during the evolution of  pandemic  and non-pandemic HIV-1 strains. Cell Host and Microbe 6, 409-421.
• Arhel, N., Clauss, K., Nienhaus, G.U. and Kirchhoff, F. (2009) The Inability to Disrupt the Immunological Synapse distinguishes HIV-1 from most other Primate Lentiviruses. J. Clin. Invest. 119, 2965-2975. Zhang, F., Wilson, S.J., Langford, W.,  Virgen, B., Gregory, D., Johnson, M., Munch, J., Kirchhoff,  F., Bieniasz, P.D. and Hatziioannou, T. (2009) Nef proteins from simian immunodeficiency viruses are tetherin antagonists. Cell Host & Microbes 6:54-67.
• Hong, S., Klein, E.A., Das Gupta, J., Hanke, K., Weight, C.J., Nguyen, C., Gaughan, C., Kim, K.A., Bannert, N., Kirchhoff, F., Munch, J. and Silverman, R.H. (2009).  Fibrils of Prostatic Acid  Phosphatase Fragments Boost Infection by XMRV, a Human Retrovirus Associated with Prostate Cancer. J. Virol. 83:6995-7003.
• Schmökel J, Li H, Bailes E, Schindler M, Silvestri G, Hahn BH, Apetrei C, and Kirchhoff F. (2009). Conservation of Nef function across highly diverse lineages of SIVsmm. Retrovirology 6:36.
• Strauss, G., Lindquist, J.A., Arhel, N., Felder, E., Karl, S., Haas, T.L., Fulda, S., Walczak, H., Kirchhoff, F., and Debatin, K.-M. (2009). CD95 costimulation blocks activation of naïve T cells by inhibiting T cell receptor signalling. J. Exp. Med. 206:1379-1393.
• Roan, N.R., Münch, J., Arhel, N., Mothes, W., Kobayashi, A., Smith-McCune K., Kirchhoff, F. and  Greene, W.C. (2009). The Cationic Properties of SEVI Underlie Its Ability To Enhance HIV Infection. J. Virol. 83:73-80.
• Richter, R., Casarosa, P., Ständker, L., Münch, J., Springael, J.Y., Nijmeijer, S., Forssmann, W.G., Vischer, H.F., Vakili, J., Detheux, M., Parmentier, M., Leurs, R., Smit, M.J. (2009). Significance of N-terminal proteolysis of CCL14a to activity on the chemokine receptors CCR1 and CCR5 and the human cytomegalovirus-encoded chemokine receptor US28. J Immunol. 183:1229-37

2008

• Schindler, M., Schmökel, J., Specht, A., Li, H., Münch,J., Khalid, M., Sodora, D.L. Hahn, B.H., Silvestri, G., and Kirchhoff, F. (2008). Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+ T cells in natural SIV infection. PLOS Pathogens 4(7) e1000107.
• Toussaint, H., Gobert, F.-X., Schindler, M., Jouve, J., Kozik, P., Kirchhoff, F. and Benaroch, P. (2008). HIV-1 Nef expression prevents AP-2-mediated internalization of the MHC II-associated invariant chain. J. Virol. 82:8373-8382
• Haupt, S., Donhauser, N., Chaipan, C., Schuster, P., Puffer, B., Daniels, R.S., Greenough, T.C., Kirchhoff, F. and Schmidt, B. (2008). CD4 Binding Affinity Determines HIV-1 Induced Plasmacytoid Dendritic Cell Interferon Alpha Production. J. Virol. 82:8900-8905
• DeGottardi, Q.M., Specht, A., Kaur, A., Kirchhoff, F. and Evans D.T. (2008). Selective Downregulation of Rhesus Macaque and Sooty Mangabey MHC Class I Molecules by Nef Alleles of the SIVsmm/mac and HIV-2 lineage. J. Virol. 82:3139-3146.
• Specht, A., DeGottardi, Q.M., Schindler, M., Hahn, B.H., Evans, D.T. and Kirchhoff, F.  (2008). Selective Downmodulation of HLA-A and –B by Nef Alleles from Different Groups of Primate Lentiviruses. Virology 373:229-237.  

Reviews, Commentaries and contributions to books

• Kirchhoff, F. (2010). Immune evasion and counteraction of restriction factors  by HIV-1 and other primate lentiviruses. Cell Host & Microbe (in press)
• Sauter, D., Specht, A., and Kirchhoff, F. (2010). Sticking together and letting go: tetherin and its viral antagonists. Cell 141:392-398.
• Arhel, N., and Kirchhoff, F. (2010). Host proteins involved in HIV infection: New therapeutic targets. Biochimica et Biophysica Acta 1802:313-321
• Arhel, N., and Kirchhoff, F. (2010). Implications of Nef - Host cell Interactions in Progression to AIDS. In: HIV Interactions with Host Cell Proteins." Eds. Spearman and Freed. Current Topics in Microbiology. 339:147-75
• Sodora, D.L., Allan, J.S., Apetrei, C., Brenchley, J.M. Douek, D.C. Else, J.G., Estes, J.D., Hahn, B.H., Hirsch, V.M. Kaur, S., Kirchhoff, F., Muller-Trutwin, M., Pandrea, I.V., Schmitz, J.E., and Silvestri, G. (2009). Towards an AIDS vaccine: Lessons from natural SIV infections of African nonhuman primate hosts. Nat. Med. 15, 861-865. (Note: all coauthors contributed equally to this manuscript).
• Kirchhoff, F. (2009). The high virulence of HIV-1: an accident of primate lentiviral evolution? Nat. Rev. Microbiol. 7:467-76.
• Kirchhoff, F. (2008). Silencing HIV-1 In Vivo. Cell 134: 566-568.
• Kirchhoff, F., Schindler, M., Specht, A., Arhel, N. and Münch J. (2008). Role of Nef in Primate Lentiviral Pathogenesis. Cellular and Molecular Life Sciences 65:2621-2636.
• Kirchhoff, F., and Silvestri, G. (2008). Is Nef the elusive cause of the HIV-associated hematopoietic dysfunction? J. Clin. Invest. 118:1622-1625