Publikationen

2010

Impact of ETIF deletion on safety and immunogenicity of equine herpesvirus type 1-vectored vaccines.

2010

Equine herpesvirus type 1 (EHV-1) utilizes microtubules, dynein, and ROCK1 to productively infect cells.

2010

A new tool linking human cytomegalovirus drug resistance mutations to resistance phenotypes.

2010

Human cytomegaloviruses expressing yellow fluorescent fusion proteins--characterization and use in antiviral screening.

2010

Intravenous zanamivir for patients with pneumonitis due to pandemic (H1N1) 2009 influenza virus.

2010

Polyomavirus BK-specific CD8+ T cell responses in patients after allogeneic stem cell transplant.

2010

Differentiation between polymorphisms and resistance-associated mutations in human cytomegalovirus DNA polymerase.

2010

Improved detection of mutated human cytomegalovirus UL97 by pyrosequencing.

2009

Genome-wide innate immune responses in HIV-1-infected macrophages are preserved despite attenuation of the NF-kappa B activation pathway.

Noursadeghi M, Tsang J, Miller RF, Straschewski S, Kellam P, Chain BM, Katz DR.

2009

Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts.

Sodora DL, Allan JS, Apetrei C, Brenchley JM, Douek DC, Else JG, Estes JD, Hahn BH, Hirsch VM, Kaur A, Kirchhoff F, Muller-Trutwin M, Pandrea I, Schmitz JE, Silvestri G.

2009

Is the high virulence of HIV-1 an unfortunate coincidence of primate lentiviral evolution?

Kirchhoff F.

2009

Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains.

Sauter D, Schindler M, Specht A, Landford WN, Münch J, Kim KA, Votteler J, Schubert U, Bibollet-Ruche F, Keele BF, Takehisa J, Ogando Y, Ochsenbauer C, Kappes JC, Ayouba A, Peeters M, Learn GH, Shaw G, Sharp PM, Bieniasz P, Hahn BH, Hatziioannou T, Kirchhoff F.

2009

The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses.

Arhel N, Lehmann M, Clauss K, Nienhaus GU, Piguet V, Kirchhoff F.

2009

Nef proteins from simian immunodeficiency viruses are tetherin antagonists.

Zhang F, Wilson SJ, Landford WC, Virgen B, Gregory D, Johnson MC, Munch J, Kirchhoff F, Bieniasz PD, Hatziioannou T.

2009

Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer.

Hong S, Klein EA, Das Gupta J, Hanke K, Weight CJ, Nguyen C, Gaughan C, Kim KA, Bannert N, Kirchhoff F, Munch J, Silverman RH.

2009

Conservation of Nef function across highly diverse lineages of SIVsmm.

Schmökel J, Li H, Bailes E, Schindler M, Silvestri G, Hahn BH, Apetrei C, Kirchhoff F.

2009

CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling.

Strauss G, Lindquist JA, Arhel N, Felder E, Karl S, Haas TL, Fulda S, Walczak H, Kirchhoff F, Debatin KM.

2009

The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection.

Roan NR, Münch J, Arhel N, Mothes W, Neidleman J, Kobayashi A, Smith-McCune K, Kirchhoff F, Greene WC.

2009

Antiviral treatment of cytomegalovirus infection and resistant strains.

Schreiber A, Härter G, Schubert A, Bunjes D, Mertens T, Michel D.

2009

The human cytomegalovirus-encoded chemokine receptor US28 promotes angiogenesis and tumor formation via cyclooxygenase-2.

Maussang D, Langemeijer E, Fitzsimons CP, Stigter-van Walsum M, Dijkman R, Borg MK, Slinger E, Schreiber A, Michel D, Tensen CP, van Dongen GA, Leurs R, Smit MJ.

2009

Pharmacological and biochemical characterization of human cytomegalovirus-encoded G protein-coupled receptors.

Maussang D, Vischer HF, Schreiber A, Michel D, Smit MJ.

2009

Fluorescence-based assay for phenotypic characterization of human cytomegalovirus polymerase mutations regarding drug susceptibility and viral replicative fitness.

Chevillotte M, Schubert A, Mertens T, von Einem J.

2009

Human cytomegalovirus paralyzes macrophage motility through down-regulation of chemokine receptors, reorganization of the cytoskeleton, and release of macrophage migration inhibitory factor.

Frascaroli G, Varani S, Blankenhorn N, Pretsch R, Bacher M, Leng L, Bucala R, Landini MP, Mertens T.

2009

Major tegument protein pp65 of human cytomegalovirus is required for the incorporation of pUL69 and pUL97 into the virus particle and for viral growth in macrophages.

Chevillotte M, Landwehr S, Linta L, Frascaroli G, Lüske A, Buser C, Mertens T, von Einem J.

2009

Human cytomegalovirus targets different subsets of antigen-presenting cells with pathological consequences for host immunity: implications for immunosuppression, chronic inflammation and autoimmunity.

Varani S, Frascaroli G, Landini MP, Söderberg-Nauclér C.

2009

Generalized Wegener's granulomatosis in an immunocompetent adult after cytomegalovirus mononucleosis and bacterial urinary tract infection.

Varani S, Mastroianni A, Frascaroli G, Tammik C, Rahbar A, Christensson M, Rossini G, Landini MP, Söderberg-Nauclér C.

2008

Hantavirus outbreak, Germany, 2007.

Hofmann J, Meisel H, Klempa B, Vesenbeckh SM, Beck R, Michel D, Schmidt-Chanasit J, Ulrich RG, Grund S, Enders G, Kruger DH.

2008

Protein kinase inhibitors of the quinazoline class exert anti-cytomegaloviral activity in vitro and in vivo.

Schleiss M, Eickhoff J, Auerochs S, Leis M, Abele S, Rechter S, Choi Y, Anderson J, Scott G, Rawlinson W, Michel D, Ensminger S, Klebl B, Stamminger T, Marschall M.

2008

Ganciclovir/valganciclovir prophylaxis decreases cytomegalovirus-related events and bronchiolitis obliterans syndrome after lung transplantation

Chmiel C, Speich R, Hofer M, Michel D, Mertens T, Weder W, Boehler A.

2008

Human cytomegalovirus infection and antiviral immunity in septic patients without canonical immunosuppression

von Müller L, Mertens T.

2008

Multimer staining of cytomegalovirus phosphoprotein 65-specific T cells for diagnosis and therapeutic purposes: a comparative study

Yao J, Bechter C, Wiesneth M, Härter G, Götz M, Germeroth L, Guillaume P, Hasan F, von Harsdorf S, Mertens T, Michel D, Döhner H, Bunjes D, Schmitt M, Schmitt A.

2008

Silencing HIV-1 In Vivo

Kirchhoff F.

2008

Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection

Schindler M, Schmökel J, Specht A, Li H, Münch J, Khalid M, Sodora DL, Hahn BH, Silvestri G, Kirchhoff F.

2008

Human immunodeficiency virus type 1 nef expression prevents AP-2-mediated internalization of the major histocompatibility complex class II-associated invariant chain

Toussaint H, Gobert FX, Schindler M, Banning C, Kozik P, Jouve M, Kirchhoff F, Benaroch P.

2008

CD4 binding affinity determines human immunodeficiency virus type 1-induced alpha interferon production in plasmacytoid dendritic cells

Haupt S, Donhauser N, Chaipan C, Schuster P, Puffer B, Daniels RS, Greenough TC, Kirchhoff F, Schmidt B.

2008

Is Nef the elusive cause of HIV-associated hematopoietic dysfunction?

Kirchhoff F, Silvestri G.

2008

Selective downregulation of rhesus macaque and sooty mangabey major histocompatibility complex class I molecules by Nef alleles of simian immunodeficiency virus and human immunodeficiency virus type 2

DeGottardi MQ, Specht A, Metcalf B, Kaur A, Kirchhoff F, Evans DT.

2008

Selective downmodulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses

Specht A, DeGottardi MQ, Schindler M, Hahn B, Evans DT, Kirchhoff F.

2008

Role of Nef in primate lentiviral immunopathogenesis

Kirchhoff F, Schindler M, Specht A, Arhel N, Münch J.

2007

Pharmacokinetics and pharmacodynamics of mycophenolic acid after enteric-coated
mycophenolate versus mycophenolate mofetil in patients with progressive IgA
nephritis.

Czock D, Rasche FM, Carius A, Glander P, Budde K, Bauer S, Keller F, von Müller L.

2007

Human cytomegalovirus differentially controls B cell and T cell responses through
effects on plasmacytoid dendritic cells.
J Immunol. 2007 Dec 1;179(11):7767-76.

Varani S, Cederarv M, Feld S, Tammik C, Frascaroli G, Landini MP, Söderberg-Nauclér C.

2007

Sequential immunosuppressive therapy in progressive IgA nephropathy.
Contrib Nephrol. 2007;157:109-13.

Rasche FM, Keller F, von Müller L, Czock D, Lepper PM.

2007

Cytomegalovirus primary envelopment occurs at large infoldings of the inner
nuclear membrane.
J Virol. 2007 Mar;81(6):3042-8. Epub 2006 Dec 27.

Buser C, Walther P, Mertens T, Michel D.

2007

CMV monitoring using blood cells and plasma: a comparison of apples with oranges?
Bone Marrow Transplant. 2007 Mar;39(6):353-7. Epub 2007 Feb 5.

von Müller L, Hinz J, Bommer M, Hampl W, Kluwick S, Wiedmann M, Bunjes D, Mertens T.

2007

HCMV-infection in a human arterial organ culture model: effects on cell
proliferation and neointimal hyperplasia.
BMC Microbiol. 2007 Jul 20;7:68.

Voisard R, Krügers T, Reinhardt B, Vaida B, Baur R, Herter T, Lüske A, Weckermann D, Weingärtner K, Rössler W, Hombach V, Mertens T.

2007

Targeted release of oncolytic measles virus by blood outgrowth endothelial cells
in situ inhibits orthotopic gliomas.
Gene Ther. 2007 Nov;14(22):1573-86. Epub 2007 Sep 27.

Wei J, Wahl J, Nakamura T, Stiller D, Mertens T, Debatin KM, Beltinger C.

2007

Quantitative investigation of murine cytomegalovirus nucleocapsid interaction.
J Microsc. 2007 Oct;228(Pt 1):78-87.

Buser C, Fleischer F, Mertens T, Michel D, Schmidt V, Walther P.

2007

Cellular immunity and active human cytomegalovirus infection in patients with
septic shock.
J Infect Dis. 2007 Nov 1;196(9):1288-95. Epub 2007 Oct 1.

von Muller L, Klemm A, Durmus N, Weiss M, Suger-Wiedeck H, Schneider M, Hampl W, Mertens T.

2007

Primary human immunodeficiency virus type 1 nef alleles show major differences in
pathogenicity in transgenic mice.
J Virol. 2007 May;81(9):4677-93. Epub 2007 Feb 21.

Priceputu E, Hanna Z, Hu C, Simard MC, Vincent P, Wildum S, Schindler M, Kirchhoff F, Jolicoeur P.

2007

Human immunodeficiency virus type 1 variants resistant to first- and
second-version fusion inhibitors and cytopathic in ex vivo human lymphoid tissue.
J Virol. 2007 Jun;81(12):6563-72. Epub 2007 Apr 11.

Chinnadurai R, Rajan D, Münch J, Kirchhoff F.

2007

Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41
fusion peptide.
Cell. 2007 Apr 20;129(2):263-75.

Münch J, Ständker L, Adermann K, Schulz A, Schindler M, Chinnadurai R, Pöhlmann S, Chaipan C, Biet T, Peters T, Meyer B, Wilhelm D, Lu H, Jing W, Jiang S, Forssmann WG, Kirchhoff F.

2007

Nef alleles from children with non-progressive HIV-1 infection modulate MHC-II
expression more efficiently than those from rapid progressors.
AIDS. 2007 May 31;21(9):1103-7.

Schindler M, Wildum S, Casartelli N, Doria M, Kirchhoff F.

2007

Proline 35 of human immunodeficiency virus type 1 (HIV-1) Vpr regulates the
integrity of the N-terminal helix and the incorporation of Vpr into virus
particles and supports the replication of R5-tropic HIV-1 in human lymphoid
tissue ex vivo.
J Virol. 2007 Sep;81(17):9572-6. Epub 2007 Jun 6.

Votteler J, Studtrucker N, Sörgel S, Münch J, Rücker E, Kirchhoff F, Schick B, Henklein P, Fossen T, Bruns K, Sharma A, Wray V, Schubert U.

2007

Conserved residue Lys574 in the cavity of HIV-1 Gp41 coiled-coil domain is
critical for six-helix bundle stability and virus entry.
J Biol Chem. 2007 Aug 31;282(35):25631-9. Epub 2007 Jul 6.

He Y, Liu S, Jing W, Lu H, Cai D, Chin DJ, Debnath AK, Kirchhoff F, Jiang S.

2007

Association of Nef with p21-activated kinase 2 is dispensable for efficient human
immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected
human lymphoid tissue.
J Virol. 2007 Dec;81(23):13005-14. Epub 2007 Sep 19.

Schindler M, Rajan D, Specht A, Ritter C, Pulkkinen K, Saksela K, Kirchhoff F.

2007

HIV infection in a patient with alpha-1 antitrypsin deficiency: a detrimental
combination?
AIDS. 2007 Oct 1;21(15):2115-6

Potthoff AV, Münch J, Kirchhoff F, Brockmeyer NH.

2007

Nef-mediated enhancement of virion infectivity and stimulation of viral
replication are fundamental properties of primate lentiviruses.
J Virol. 2007 Dec;81(24):13852-64. Epub 2007 Oct 10.

Münch J, Rajan D, Schindler M, Specht A, Rücker E, Novembre FJ, Nerrienet E, Müller-Trutwin MC, Peeters M, Hahn BH, Kirchhoff F.

2007

Semen-Derived Amyloid Fibrils Drastically Enhance HIV Infection.
Cell. 2007 Dec 14;131(6):1059-71.

Münch J, Rücker E, Ständker L, Adermann K, Goffinet C, Schindler M, Wildum S, Chinnadurai R, Rajan D, Specht A, Giménez-Gallego G, Sánchez PC, Fowler DM, Koulov A, Kelly JW, Mothes W, Grivel JC, Margolis L, Keppler OT, Forssmann WG, Kirchhoff F.

2007

A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5
or common alternative coreceptors is moderately attenuated in vivo.
Virology. 2007 Apr 10;360(2):275-85. Epub 2006 Nov 28.

Pöhlmann S, Münch J, Aziz S, Reeves JD, Otto C, Leslie GJ, Hofmann H, Puffer BA, Baribaud F, Marzi A, Gramberg T, Chen Z, Stolte N, Haaft PT, Heeney JL, Stahl-Hennig C, Mätz-Rensing K, Schneider T, Doms RW, Kirchhoff F.

2006

Contribution of Vpu, Env, and Nef to CD4 down-modulation and resistance of human immunodeficiency virus type 1-infected T cells to superinfection.
J Virol. 2006 Aug;80(16):8047-59.

Wildum S, Schindler M, Munch J, Kirchhoff F.

2006

Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1.
Cell. 2006 Jun 16;125(6):1055-67.

Schindler M, Munch J, Kutsch O, Li H, Santiago ML, Bibollet-Ruche F, Muller-Trutwin MC, Novembre FJ, Peeters M, Courgnaud V, Bailes E, Roques P, Sodora DL, Silvestri G, Sharp PM, Hahn BH, Kirchhoff F.

2006

Importance of the N-distal AP-2 binding element in Nef for simian immunodeficiency virus replication and pathogenicity in rhesus macaques.
J Virol. 2006 May;80(9):4469-81.

Brenner M, Munch J, Schindler M, Wildum S, Stolte N, Stahl-Hennig C, Fuchs D, Matz-Rensing K, Franz M, Heeney J, Ten Haaft P, Swigut T, Hrecka K, Skowronski J, Kirchhoff F.

2006

Effect of R77Q, R77A and R80A changes in Vpr on HIV-1 replication and CD4 T cell depletion in human lymphoid tissue ex vivo.
AIDS. 2006 Apr 4;20(6):831-6.

Rajan D, Wildum S, Rucker E, Schindler M, Kirchhoff F.

2006

Active cytomegalovirus infection in patients with septic shock.
Emerg Infect Dis. 2006 Oct;12(10):1517-22.

von Muller L, Klemm A, Weiss M, Schneider M, Suger-Wiedeck H, Durmus N, Hampl W, Mertens T.

2006

Human cytomegalovirus-induced reduction of extracellular matrix proteins in vascular smooth muscle cell cultures: a pathomechanism in vasculopathies?
J Gen Virol. 2006 Oct;87(Pt 10):2849-58.

Reinhardt B, Winkler M, Schaarschmidt P, Pretsch R, Zhou S, Vaida B, Schmid-Kotsas A, Michel D, Walther P, Bachem M, Mertens T.

2006

Human cytomegalovirus subverts the functions of monocytes, impairing chemokine-mediated migration and leukocyte recruitment.
J Virol. 2006 Aug;80(15):7578-89.

Frascaroli G, Varani S, Moepps B, Sinzger C, Landini MP, Mertens T.

2006

Severe graft rejection, increased immunosuppression, and active CMV infection in renal transplantation.
J Med Virol. 2006 Mar;78(3):394-9.

von Muller L, Schliep C, Storck M, Hampl W, Schmid T, Abendroth D, Mertens T.

2006

Mycophenolic acid therapy after cyclophosphamide pulses in progressive IgA nephropathy.
J Nephrol. 2006 Jul-Aug;19(4):465-72.

Rasche FM, Keller F, von Muller L, Sailer LK, Karges W, Czock D.

2006

Human cytomegalovirus-encoded chemokine receptor US28 promotes tumorigenesis.
Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13068-73. Epub 2006 Aug 21.

Maussang D, Verzijl D, van Walsum M, Leurs R, Holl J, Pleskoff O, Michel D, van Dongen GA, Smit MJ.

2006

Dendritic cell function in cytomegalovirus-infected patients with mononucleosis.
J Leukoc Biol. 2006 May;79(5):932-40. Epub 2006 Feb 24.

Frascaroli G, Varani S, Mastroianni A, Britton S, Gibellini D, Rossini G, Landini MP, Soderberg-Naucler C.

2006

Two-step red-mediated recombination for versatile high-efficiency markerless DNA manipulation in Escherichia coli.
Biotechniques. 2006 Feb;40(2):191-7.

Tischer BK, von Einem J, Kaufer B, Osterrieder N.

2006

The alpha-TIF (VP16) homologue (ETIF) of equine herpesvirus 1 is essential for secondary envelopment and virus egress.
J Virol. 2006 Mar;80(6):2609-20.

von Einem J, Schumacher D, O'Callaghan DJ, Osterrieder N.

2005

RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes.

Oswald F, Winkler M, Cao Y, Astrahantseff K, Bourteele S, Knochel W, Borggrefe T

2005

Inhibition of HIV-1 group M and O isolates by fusion inhibitors.

Chinnadurai R, Munch J,
Dittmar MT, Kirchhoff F 

2005

The role of upstream U3 sequences in HIV-1 replication and CD4+ T cell depletion in human lymphoid tissue ex vivo.

Munch J, Rajan D, Rucker E, Wildum S, Adam N, Kirchhoff F

2005

Effect of naturally-occurring gp41 HR1 variations on susceptibility of HIV-1 to fusion inhibitors.

Chinnadurai R, Munch J, Kirchhoff F

2005

LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus.

Gramberg T, Hofmann H, Moller P, Lalor PF, Marzi A,
Geier M, Krumbiegel M, Winkler T, Kirchhoff F, Adams DH, Becker S, Munch J, Pohlmann S

2005

Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells.

van 't Wout AB, Swain JV, Schindler M, Rao U, Pathmajeyan MS, Mullins JI, Kirchhoff F

2005

Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication.

Munch J, Schindler M, Wildum S, Rucker E, Bailer N, Knoop V, Novembre FJ,
Kirchhoff F

2005

Nef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1.

Hrecka K, Swigut T, Schindler M, Kirchhoff F, Skowronski J

2005

HCMV infection of human vascular smooth muscle cells leads to enhanced expression of functionally intact PDGF beta-receptor.

Reinhardt B, Mertens T, Mayr-Beyrle U, Frank H, Luske A, Schierling K, Waltenberger J

2005

Fatal reactivation of postnatal cytomegalovirus infection with rapid emergence of ganciclovir resistance in an infant after allogeneic stem cell transplantation.

Michel D, Voigt S, Kershaw O, Kuhl JS, Mertens T, Ebell W, Meisel H

2005

Human immunodeficiency virus type 1 inhibits DNA damage-triggered apoptosis by a Nef-independent

Schindler M, Münch J,  Kirchhoff F

2005

Early selection of a new UL97 mutant with a severe defect of ganciclovir phosphorylation after valaciclovir prophylaxis and short-term ganciclovir therapy in a renal transplant recipient.

Hantz S, Michel D, Fillet AM,
Guigonis V, Champier G, Mazeron MC, Bensman A, Denis F, Mertens T, Dehee A, Alain S

2005

Human cytomegalovirus tegument protein ppUL35 is important for viral replication and particle formation.

Schierling K, Buser C, Mertens T, Winkler M

2005

Human cytomegalovirus inhibits the migration of immature dendritic cells by down-regulating cell-surface CCR1 and CCR5.

Varani S, Frascaroli G, Homman-Loudiyi M, Feld S, Landini MP, Soderberg-Naucler C

2005

The human cytomegalovirus UL78 gene is highly conserved among clinical isolates, but is dispensable for replication in fibroblasts and a renal artery organ-culture system.

Michel D, Milotic I, Wagner M, Vaida B, Holl J, Ansorge R, Mertens T

2005

Upregulation of functionally active vascular endothelial growth factor by human cytomegalovirus.

Reinhardt B, Schaarschmidt P, Bossert A, Luske A, Finkenzeller G, Michel D, Mertens T

2005

Impaired dendritic cell immunophenotype and function in heart transplant patients undergoing active cytomegalovirus infection.

Frascaroli G, Varani S,
Gibellini D, Potena L, Lazzarotto T, Lemoli RM, Magelli C, Soderberg-Naucler C, Landini MP

2004

Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts.

Pulkkinen K, Renkema GH, Kirchhoff F, Saksela K.

2004

Cytomegalovirus retinitis in a patient treated with anti-tumor necrosis factor alpha antibody therapy for rheumatoid arthritis.

Haerter G, Manfras BJ, de Jong-Hesse Y, Wilts H, Mertens T, Kern P, Schmitt M.

2004

Vpr and Vpu are important for efficient human immunodeficiency virus type 1 replication and CD4+ T-cell depletion in human lymphoid tissue ex vivo.

Rucker E, Grivel JC, Munch J, Kirchhoff F, Margolis L.

2004

Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques.

Schindler M, Munch J, Brenner M, Stahl-Hennig C, Skowronski J, Kirchhoff F.

2004

Human cytomegalovirus tegument proteins ppUL82 (pp71) and ppUL35 interact and cooperatively activate the major immediate-early enhancer.

Schierling K, Stamminger T, Mertens T, Winkler M.

2004

A naturally occurring variation in the proline-rich region does not attenuate human immunodeficiency virus type 1 nef function.

Rucker E, Munch J, Wildum S, Brenner M, Eisemann J, Margolis L, Kirchhoff F.

2004

CD34 cell selection of peripheral blood progenitor cells using the CliniMACS device for allogeneic transplantation: clinical results in 102 patients.

Ringhoffer M, Wiesneth M, Harsdorf S, Schlenk RF, Schmitt A, Reinhardt PP, Moessner M, Grimminger W, Mertens T, Reske SN, Dohner H, Bunjes D.

2004

Thrombocytopenia and acute renal failure in Puumala hantavirus infections.

Rasche FM, Uhel B, Kruger DH, Karges W, Czock D, Hampl W, Keller F, Meisel H, von Muller L.

2004

Bacteremia in an immunocompromised patient caused by a commensal Neisseria meningitidis strain harboring the capsule null locus (cnl).

Vogel U, Claus H, von Muller L, Bunjes D, Elias J, Frosch M.

2004

Differential regulation of human immunodeficiency virus type 2 and simian immunodeficiency virus promoter activity.

Hiebenthal-Millow K, Pohlmann S, Munch J, Kirchhoff F.

2004

Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors.

Kirchhoff F, Schindler M, Bailer N, Renkema GH, Saksela K, Knoop V, Muller-Trutwin MC, Santiago ML, Bibollet-Ruche F, Dittmar MT, Heeney JL, Hahn BH, Munch J.

2004

Oligoclonal CD8+ T-cell expansion in patients with chronic hepatitis C is associated with liver pathology and poor response to interferon-alpha therapy.

Manfras BJ, Weidenbach H, Beckh KH, Kern P, Moller P, Adler G, Mertens T, Boehm BO.

2004

Amino acid 324 in the simian immunodeficiency virus SIVmac V3 loop can confer CD4 independence and modulate the interaction with CCR5 and
alternative coreceptors.

Pohlmann S, Davis C, Meister S, Leslie GJ, Otto C, Reeves JD, Puffer BA, Papkalla A, Krumbiegel M, Marzi A, Lorenz S, Munch J, Doms RW, Kirchhoff F.

2004

The UL97 protein kinase of human cytomegalovirus and homologues in other herpesviruses: impact on virus and host.

Michel D, Mertens T.

2004

Hydroxymethyl-glutaryl coenzyme a reductase inhibition limits cytomegalovirus infection in human endothelial cells.

Potena L, Frascaroli G, Grigioni F, Lazzarotto T, Magnani G, Tomasi L, Coccolo F, Gabrielli L, Magelli C, Landini MP, Branzi A.

2003

Constitutive signaling of the human cytomegalovirus-encoded receptor UL33 differs from that of its rat cytomegalovirus homolog R33 by promiscuous activation of G proteins of the Gq, Gi, and Gs classes.

Casarosa P, Gruijthuijsen YK, Michel D, Beisser PS, Holl J, Fitzsimons CP, Verzijl D, Bruggeman CA, Mertens T, Leurs R, Vink C, Smit MJ.

2003

Alterations in HIV-1 LTR promoter activity during AIDS progression.

Hiebenthal-Millow K, Greenough TC, Bretttler DB, Schindler M, Wildum S, Sullivan JL, Kirchhoff F.

2003

Polyoma virus-associated interstitial nephritis in a patient with acute myeloic leukaemia and peripheral blood stem cell transplantation.

Stracke S, Helmchen U, von Muller L, Bunjes D, Keller F.

2003

Treatment of chronic hepatitis B with high-dose intravenous N-acetyl-L-cysteine.

Weidenbach H, Orth M, Adler G, Mertens T, Schmid RM.

2003

Mutations in the C3 region of human and simian immunodeficiency virus envelope have differential effects on viral infectivity, replication, and CD4-dependency.

Otto C, Puffer BA, Pohlmann S, Doms RW, Kirchhoff F.

2003

Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles.

Schindler M, Wurfl S, Benaroch P, Greenough TC, Daniels R, Easterbrook P, Brenner M, Munch J, Kirchhoff F.

2003

Relationship between infectious burden, systemic inflammatory response, and risk of stable coronary artery disease: role of confounding and reference group.

Rothenbacher D, Brenner H, Hoffmeister A, Mertens T, Persson K, Koenig W.

2003

Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication.

Arganaraz ER, Schindler M, Kirchhoff F, Cortes MJ, Lama J.

2003

Constitutive inositol phosphate formation in cytomegalovirus-infected human fibroblasts is due to expression of the chemokine receptor homologue pUS28.

Minisini R, Tulone C, Luske A, Michel D, Mertens T, Gierschik P, Moepps B.

2003

Human cytomegalovirus infection in human renal arteries in vitro.

Reinhardt B, Vaida B, Voisard R, Keller L, Breul J, Metzger H, Herter T, Baur R, Luske A, Mertens T.

2003

Gene silencing by adenovirus-delivered siRNA.

Shen C, Buck AK, Liu X, Winkler M, Reske SN.

2003

A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway.

Lischka P, Sorg G, Kann M, Winkler M, Stamminger T.

2003

Viral escape and T-cell immunity during ganciclovir treatment of cytomegalovirus infection: case report of a pancreatico-renal transplant recipient.

Benz C, Holz G, Michel D, Awerkiew S, Dries V, Stippel D, Goeser T, Busch DH.

2003

Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G protein-coupled receptor.

Casarosa P, Menge WM, Minisini R, Otto C, van Heteren J, Jongejan A, Timmerman H, Moepps B, Kirchhoff F, Mertens T, Smit MJ, Leurs R.

2002

Identification of the First Nonpeptidergic Inverse Agonist for a Constitutively Active Viral-encoded G Protein-coupled Receptor*

Paola Casarosa, Wiro M. Menge, Rosalba Minisini, Claas Otto, Jane van Heteren,Aldo Jongejan, Henk Timmerman, Barbara Moepps, Frank Kirchhoff, Thomas Mertens, Martine J. Smit, and Rob Leurs

2002

Role of the Human Herpesvirus 6 U69-Encoded Kinase in the Phosphorylation of Ganciclovir

Leen de Bolle, Detlef Michel, Thomas Mertens, Chaysavanh Manichanh, Henri Agut, Erik de Clercq, and Lieve Naesens

2002

High Variability between Results of Different In-House Tests for Cytomegalovirus (CMV) Monitoring and a Standardized Quantitative Plasma CMV PCR Assay

Lutz von Müller, Walter Hampl, Joachim Hinz, Helga Meisel, Angela Reip, Elisabeth Engelmann, Regine Heilbronn, Barbara Gärtner, Oliver Krämer, Hermann Einsele, Holger Hebart, Tatjana Ljubicic, Jürgen Löffler and Thomas Mertens

2001

Opinion Article: Cytomegalovirus is a Risk Factor in Atherogenesis

Barbara Reinhardt, Rosalba Minisini and Thomas Mertens

2001

Case report:Fatal outcome in a patient developing Epstein–Barr virus-associated lymphoproliferative disorder (EBV-LPD) without measurable disease

M Ringhoffer, K Döhner, S Schei, H Wilts, T Mertens, W Grimminger, H Döhner and D Bunjes

2000

Aciclovir Selects for Ganciclovir-Cross- Resistance of Human Cytomegalovirus In Vitro That is Only in Part Explained by Known Mutations in the UL97 Protein

Detlef Michel, Simone Höhn, Tobias Haller, Dou Jun and Thomas Mertens

2000

Comparison between Human Cytomegalovirus pUL97 and Murine Cytomegalovirus (MCMV) pM97 Expressed by MCMV and Vaccinia Virus: pM97 Does Not Confer Ganciclovir Sensitivity

Markus Wagner, Detlef Michel, Peter Schaarschmidt, Bianca Vaida, Stipan Jonjic, Martin Messerle, Thomas Mertens and Ulrich Koszinowski

1999

Amino Acids of Conserved Kinase Motifs of Cytomegalovirus Protein UL97 Are Essential for Autophosphorylation

Detlef Michel, Silke Kramer, Simone Höhn, Peter Schaarschmidt, Kirsten Wunderlich, and Thomas Mertens

1998

Functional regions of the human cytomegalovirus protein pUL97 involved in nuclear localization and phosphorylation of ganciclovir and pUL97 itself

Detlef Michel, Peter Schaarschmidt, Kirsten Wunderlich, Maria Heuschmid, Lavinia Simoncini,Dita Mühlberger, Albert Zimmermann, Ivica Pavic and Thomas Mertens

1998

Higher detection rate of hepatitis G and C virus RNA in liver tissue than in serum of deceased injection drug users

S. Seidl, B. Koenig, G. Reinhardt, W. Hampl, T. Mertens, D. Michel

1997

Flow Cytometric Analysis of Herpes Simplex Virus Type Susceptibility to Acyclovir, Ganciclovir, and Foscarnet

Ivica Pavic, Anke Hartmann, Albert Zimmermann, Detlef Michel, Walter Hampl, Ingrid Schleyer, Thomas Mertens

1997

Intracellular Metabolism of the N7-Substituted Acyclic Nucleoside Analog 2-Amino-7- (1,3-dihydroxy-2-propoxymethyl)purine, a Potent Inhibitor of Herpesvirus Replication

Johan Neyts, Jan Balzarini, Graciela Abdreil, Zhu Chaoyong, Robert Snoeck, Albert Zimmermann, Thomas Mertens, Anna Karlsson and Erik de Clercq

1996

The UL97 Gene Product of Human Cytomegalovirus Is an Early-Late Protein with a Nuclear Localization but Is Not a Nucleoside Kinase

Detlef Michel, Ivica Pavic, Albert Zimmermann, Edith Haupt, Kirsten Wunderlich, Maria Heuschmid, Thomas Mertens