Publikationen

W. Deppert, M. Kurth, M. Graessmann, A. Graessmann, and U. Knippschild. Altered phosphorylation at specific sites confers a mutant phenotype to SV40 wild-type large T antigen in a flat revertant of SV40-transformed cells. Oncogene, 1991. 6(10): p. 1931-1938. view this abstract

U. Knippschild, J. Kiefer, T. Patschinsky, and W. Deppert. Phenotype-specific phosphorylation of simian virus 40 tsA mutant large T antigens in tsA N-type and A-type transformants. J Virol, 1991. 65(8): p. 4414-4423. view this abstract

T. Patschinsky, U. Knippschild, and W. Deppert. Species-specific phosphorylation of mouse and rat p53 in simian virus 40-transformed cells. J Virol, 1992. 66(6): p. 3846-3859. view this abstract

J. Zerrahn, U. Knippschild, T. Winkler, and W. Deppert. Independent expression of the transforming amino-terminal domain of SV40 large I antigen from an alternatively spliced third SV40 early mRNA. Embo J, 1993. 12(12): p. 4739-4746. view this abstract

U. Knippschild, T. Kolzau, and W. Deppert. Cell-specific transcriptional activation of the mdm2-gene by ectopically expressed wild-type form of a temperature-sensitive mutant p53. Oncogene, 1995. 11(4): p. 683-690. view this abstract

U. Knippschild, D. Milne, L. Campbell, and D. Meek. p53 N-terminus-targeted protein kinase activity is stimulated in response to wild type p53 and DNA damage. Oncogene, 1996. 13(7): p. 1387-1393. view this abstract

U. Knippschild, M. Oren, and W. Deppert. Abrogation of wild-type p53 mediated growth-inhibition by nuclear exclusion. Oncogene, 1996. 12(8): p. 1755-1765. view this abstract

H.W. Sturzbecher, B. Donzelmann, W. Henning, U. Knippschild, and S. Buchhop. p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction. Embo J, 1996. 15(8): p. 1992-2002. view this abstract

W. Henning, G. Rohaly, T. Kolzau, U. Knippschild, H. Maacke, and W. Deppert. MDM2 is a target of simian virus 40 in cellular transformation and during lytic infection. J Virol, 1997. 71(10): p. 7609-7618. view this abstract

U. Knippschild, D.M. Milne, L.E. Campbell, A.J. DeMaggio, E. Christenson, M.F. Hoekstra, and D.W. Meek. p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs. Oncogene, 1997. 15(14): p. 1727-1736. view this abstract

D.W. Meek, L.E. Campbell, L.J. Jardine, U. Knippschild, L. McKendrick, and D.M. Milne. Multi-site phosphorylation of p53 by protein kinases inducible by p53 and DNA damage. Biochem Soc Trans, 1997. 25(2): p. 416-419. no abstract available yet

F. Janus, N. Albrechtsen, U. Knippschild, L. Wiesmuller, F. Grosse, and W. Deppert. Different regulation of the p53 core domain activities 3'-to-5' exonuclease and sequence-specific DNA binding. Mol Cell Biol, 1999. 19(3): p. 2155-2168.
no abstract available yet

L. Behrend, D.M. Milne, M. Stoter, W. Deppert, L.E. Campbell, D.W. Meek, and U. Knippschild. IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. Oncogene, 2000. 19(47): p. 5303-5313. view this abstract

L. Behrend, M. Stoter, M. Kurth, G. Rutter, J. Heukeshoven, W. Deppert, and U. Knippschild. Interaction of casein kinase 1 delta (CK1delta) with post-Golgi structures, microtubules and the spindle apparatus. Eur J Cell Biol, 2000. 79(4): p. 240-251. view this abstract

T. Maritzen, J. Lohler, W. Deppert, and U. Knippschild. Casein kinase I delta (CKIdelta) is involved in lymphocyte physiology. Eur J Cell Biol, 2003. 82(7): p. 369-378. view this abstract

J.I. Martin-Subero, U. Knippschild, L. Harder, T.F. Barth, J. Riemke, S. Grohmann, S. Gesk, J. Hoppner, P. Moller, R.M. Parwaresch, and R. Siebert. Segmental chromosomal aberrations and centrosome amplifications: pathogenetic mechanisms in Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma? Leukemia, 2003. 17(11): p. 2214-2219.
view this abstract

D.W. Meek and U. Knippschild. Posttranslational modification of MDM2. Mol Cancer Res, 2003. 1(14): p. 1017-1026.
view this abstract

R.A. Ventura, J.I. Martin-Subero, U. Knippschild, R.D. Gascoyne, G. Delsol, D.Y. Mason, and R. Siebert. Centrosome abnormalities in ALK-positive anaplastic large-cell lymphoma. Leukemia, 2004. 18(11): p. 1910-1911.
no abstract available yet

M. Winter, D. Milne, S. Dias, R. Kulikov, U. Knippschild, C. Blattner, and D. Meek. Protein kinase CK1delta phosphorylates key sites in the acidic domain of murine double-minute clone 2 protein (MDM2) that regulate p53 turnover. Biochemistry, 2004. 43(51): p. 16356-16364. view this abstract

U. Knippschild, A. Gocht, S. Wolff, N. Huber, J. Lohler, and M. Stoter. The casein kinase 1 family: participation in multiple cellular processes in eukaryotes. Cell Signal, 2005. 17(6): p. 675-689. view this abstract

U. Knippschild, S. Wolff, G. Giamas, C. Brockschmidt, M. Wittau, P.U. Wurl, T. Eismann, and M. Stoter. The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development. Onkologie, 2005. 28(10): p. 508-514. view this abstract

M. Stoter, A.M. Bamberger, B. Aslan, M. Kurth, D. Speidel, T. Loning, H.G. Frank, P. Kaufmann, J. Lohler, D. Henne-Bruns, W. Deppert, and U. Knippschild. Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells. Oncogene, 2005. 24(54): p. 7964-7975. view this abstract

S. Wolff, Z. Xiao, M. Wittau, N. Sussner, M. Stoter, and U. Knippschild. Interaction of casein kinase 1 delta (CK1delta) with the light chain LC2 of microtubule associated protein 1A (MAP1A). Biochim Biophys Acta, 2005. 1745(2): p. 196-206.
view this abstract

S. Wolff, M. Stoter, G. Giamas, M. Piesche, D. Henne-Bruns, G. Banting, and U. Knippschild. Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin. FEBS Lett, 2006. 580(27): p. 6477-6484.
view this abstract

G. Giamas, H. Hirner, L. Shoshiashvili, A. Grothey, S. Gessert, M. Kuhl, D. Henne-Bruns, C.E. Vorgias, and U. Knippschild. Phosphorylation of CK1delta: identification of Ser370 as the major phosphorylation site targeted by PKA in vitro and in vivo. Biochem J, 2007. 406(3): p. 389-398. view this abstract

G. Giamas, J. Stebbing, C.E. Vorgias, and U. Knippschild. Protein kinases as targets for cancer treatment. Pharmacogenomics, 2007. 8(8): p. 1005-1016. view this abstract

J. von Blume, U. Knippschild, F. Dequiedt, G. Giamas, A. Beck, A. Auer, J. Van Lint, G. Adler, and T. Seufferlein. Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2. EMBO J, 2007. 26(22): p. 4619-4633. view this abstract

C. Brockschmidt, H. Hirner, N. Huber, T. Eismann, A. Hillenbrand, G. Giamas, B. Radunsky, O. Ammerpohl, B. Bohm, D. Henne-Bruns, H. Kalthoff, F. Leithauser, A. Trauzold, and U. Knippschild. Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo. Gut, 2008. 57(6): p. 799-806. view this abstract

U. Kintscher, M. Hartge, K. Hess, A. Foryst-Ludwig, M. Clemenz, M. Wabitsch, P. Fischer-Posovszky, T.F. Barth, D. Dragun, T. Skurk, H. Hauner, M. Bluher, T. Unger, A.M. Wolf, U. Knippschild, V. Hombach, and N. Marx. T-lymphocyte Infiltration in Visceral Adipose Tissue. A Primary Event in Adipose Tissue Inflammation and the Development of Obesity-Mediated Insulin Resistance. Arterioscler Thromb Vasc Biol, 2008. view this abstract

Grochola, L.F., Greither, T., Taubert, H., Moller, P., Knippschild, U., Udelnow, A., Henne-Bruns, D. and Wurl, P. (2008). The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related death. Br J Cancer view this abstract

Grochola, L.F., Greither, T., Taubert, H.W., Moller, P., Knippschild, U., Udelnow, A., Henne-Bruns, D. and Wurl, P. (2008). Prognostic relevance of hTERT mRNA expression in ductal adenocarcinoma of the pancreas. Neoplasia 10, 973-6. view this abstract

Michael Schmieder, Sebastian Wolf, Bettina Danner, Susanne Stöhr, Markus S Juchems, Peter Wuerl, Doris Henne-Bruns, Uwe Knippschild, Cornelia Hasel and Klaus Kramer. 2008, p16 expression differentiates high-risk GIST and predicts poor outcome. Neoplasia, Volume 10, 1154-62 view this abstract

Immunohistochemical Characterisation of Cell-Type Specific Expression of  CK1δ in Various Tissues of Young Adult BALB / c Mice view this abstract 

G. Giamas, L. Castellano, Q. Feng, U. Knippschild, J. Jacob, R. S. Thomas, R. C. Coombes, C. L. Smith, L. R. Jiao and J. Stebbing (2009): CK1δ modulates the transcriptional activity
of ERα via AIB1 in an estrogen-dependent manner and regulates ERα–AIB1 interactions. Nucleic Acids Research, 1–14 view this abstract