Publikationen- Universitätsklinikum Ulm

Publikationen

2011

Protein Kinase D2 Controls Cardiac Valve Formation in Zebrafish by Regulating Histone Deacetylase 5 Activity.

Just S, Berger IM, Meder B, Backs J, Keller A, Marquart S, Frese K, Patzel E, Rauch GJ; Tübingen 2000 Screen Consortium, Katus HA, Rottbauer W.

Circulation. 2011 Jul 5.

PINCH proteins regulate cardiac contractility by modulating ILK-PKB signaling.

Meder B, Huttner IG, Sedaghat-Hamedani F, Just S, Dahme T, Frese KS, Vogel B, Köhler D, Kloos W, Rudloff J, Marquart S, Katus HA, Rottbauer W.

Mol Cell Biol. 2011 Jun 13.

Reconstitution of defective protein trafficking rescues Long-QT syndrome in zebrafish.

Meder B, Scholz EP, Hassel D, Wolff C, Just S, Berger IM, Patzel E, Karle C, Katus HA, Rottbauer W.

Biochem Biophys Res Commun. 2011 May 6;408(2):218-24. Epub 2011 Mar 31.

Targeted next-generation sequencing for the molecular genetic diagnostics of cardiomyopathies.

Meder B, Haas J, Keller A, Heid C, Just S, Borries A, Boisguerin V, Scharfenberger-Schmeer M, Stähler P, Beier M, Weichenhan D, Strom TM, Pfeufer A, Korn B, Katus HA, Rottbauer W.

Circ Cardiovasc Genet. 2011 Apr 1;4(2):110-22. Epub 2011 Jan 20.

Nucleoside diphosphate kinase B is required for the formation of heterotrimeric G protein containing caveolae.

Hippe HJ, Wolf NM, Abu-Taha HI, Lutz S, Le Lay S, Just S, Rottbauer W, Katus HA, Wieland T.

Naunyn Schmiedebergs Arch Pharmacol. 2011 Mar 16. [Epub ahead of print]

MicroRNA signatures in total peripheral blood as novel biomarkers for acute myocardial infarction.

Meder B, Keller A, Vogel B, Haas J, Sedaghat-Hamedani F, Kayvanpour E, Just S, Borries A, Rudloff J, Leidinger P, Meese E, Katus HA, Rottbauer W.

Basic Res Cardiol. 2011 Jan;106(1):13-23. Epub 2010 Oct 1.

2010

Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component of the sarcomeric M-band and is involved in stretch sensing.

Will RD, Eden M, Just S, Hansen A, Eder A, Frank D, Kuhn C, Seeger TS, Oehl U, Wiemann S, Korn B, Koegl M, Rottbauer W, Eschenhagen T, Katus HA, Frey N.

Circ Res. 2010 Nov 12;107(10):1253-64. Epub 2010 Sep 16.

Strumpellin is a novel valosin-containing protein binding partner linking hereditary spastic paraplegia to protein aggregation diseases.

Clemen CS, Tangavelou K, Strucksberg KH, Just S, Gaertner L, Regus-Leidig H, Stumpf M, Reimann J, Coras R, Morgan RO, Fernandez MP, Hofmann A, Müller S, Schoser B, Hanisch FG, Rottbauer W, Blümcke I, von Hörsten S, Eichinger L, Schröder R.

Brain. 2010 Oct;133(10):2920-41. Epub 2010 Sep 9.

JunB-CBFbeta signaling is essential to maintain sarcomeric Z-disc structure and when defective leads to heart failure.

Meder B, Just S, Vogel B, Rudloff J, Gärtner L, Dahme T, Huttner I, Zankl A, Katus HA, Rottbauer W.

J Cell Sci. 2010 Aug 1;123(Pt 15):2613-20. Epub 2010 Jul 6.

Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo.

Seeger TS, Frank D, Rohr C, Will R, Just S, Grund C, Lyon R, Luedde M, Koegl M, Sheikh F, Rottbauer W, Franke WW, Katus HA, Olson EN, Frey N.

Circ Res. 2010 Mar 19;106(5):880-90. Epub 2010 Jan 21.

2009

In-vivo characterization of human dilated cardiomyopathy genes in zebrafish.

Vogel B, Meder B, Just S, Laufer C, Berger I, Weber S, Katus HA, Rottbauer W.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):516-22. Epub 2009 Oct 2.

Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy.

Hassel D, Dahme T, Erdmann J, Meder B, Huge A, Stoll M, Just S, Hess A, Ehlermann P, Weichenhan D, Grimmler M, Liptau H, Hetzer R, Regitz-Zagrosek V, Fischer C, Nürnberg P, Schunkert H, Katus HA, Rottbauer W.

Nat Med. 2009 Nov;15(11):1281-8. Epub 2009 Nov 1.

The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function.

Hippe HJ, Wolf NM, Abu-Taha I, Mehringer R, Just S, Lutz S, Niroomand F, Postel EH, Katus HA, Rottbauer W, Wieland T.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16269-74. Epub 2009 Sep 4.

A single serine in the carboxyl terminus of cardiac essential myosin light chain-1 controls cardiomyocyte contractility in vivo.

Meder B, Laufer C, Hassel D, Just S, Marquart S, Vogel B, Hess A, Fishman MC, Katus HA, Rottbauer W.

Circ Res. 2009 Mar 13;104(5):650-9. Epub 2009 Jan 22.

2008

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.

Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M, Galuppo P, Just S, Rottbauer W, Frantz S, Castoldi M, Soutschek J, Koteliansky V, Rosenwald A, Basson MA, Licht JD, Pena JT, Rouhanifard SH, Muckenthaler MU, Tuschl T, Martin GR, Bauersachs J, Engelhardt S.

Nature. 2008 Dec 18;456(7224):980-4. Epub 2008 Nov 30.

Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.

Lange M, Kaynak B, Forster UB, Tönjes M, Fischer JJ, Grimm C, Schlesinger J, Just S, Dunkel I, Krueger T, Mebus S, Lehrach H, Lurz R, Gobom J, Rottbauer W, Abdelilah-Seyfried S, Sperling S.

Genes Dev. 2008 Sep 1;22(17):2370-84.

Deficient zebrafish ether-à-go-go-related gene channel gating causes short-QT syndrome in zebrafish reggae mutants.

Hassel D, Scholz EP, Trano N, Friedrich O, Just S, Meder B, Weiss DL, Zitron E, Marquart S, Vogel B, Karle CA, Seemann G, Fishman MC, Katus HA, Rottbauer W.

Circulation. 2008 Feb 19;117(7):866-75. Epub 2008 Feb 4.

2007

Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development.

Blaschke RJ, Hahurij ND, Kuijper S, Just S, Wisse LJ, Deissler K, Maxelon T, Anastassiadis K, Spitzer J, Hardt SE, Schöler H, Feitsma H, Rottbauer W, Blum M, Meijlink F, Rappold G, Gittenberger-de Groot AC.

Circulation. 2007 Apr 10;115(14):1830-8. Epub 2007 Mar 19.

2006

Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart.

Bendig G, Grimmler M, Huttner IG, Wessels G, Dahme T, Just S, Trano N, Katus HA, Fishman MC, Rottbauer W.

Genes Dev. 2006 Sep 1;20(17):2361-72. Epub 2006 Aug 18.

Cardiac myosin light chain-2: a novel essential component of thick-myofilament assembly and contractility of the heart.

Rottbauer W, Wessels G, Dahme T, Just S, Trano N, Hassel D, Burns CG, Katus HA, Fishman MC.

Circ Res. 2006 Aug 4;99(3):323-31. Epub 2006 Jun 29.

2005

VEGF-PLCgamma1 pathway controls cardiac contractility in the embryonic heart.

Rottbauer W, Just S, Wessels G, Trano N, Most P, Katus HA, Fishman MC.

Genes Dev. 2005 Jul 1;19(13):1624-34.