Experimental Cardiovascular Imaging (ExCaVI)
| rapid imaging of the coronary vasculature
Example shows 3D whole-heart coronary angiograms acquired with two-dimensional accelerated parallel imaging | |
General
The group was found in 2007 for the assessement of the value of non-invasive imaging tools in the realm of cardiovascular imaging. The main focus is to establish comprehensive non-invasive diagnostic imaging procedures for risk stratification, staging, diagnosis and therapy selection for the major cardiovascular diseases. Current research is focussed on:
- Assessment of the clincal role of magnetic resonance imaging (MRI) for diagnosis of cardiovascular diseases
- Development of non-invasive image based individual risk stratification for atherosclerotic diseases of the vascular system
- Assessment of the clinical role of MRI for cardiac electrophysiology including ablation treatment and device implantation
- Assessment of the value of MRI for cardiovascular intervention planning and guidance
Collaborations
- Prof. Dr. Reza Razavi, King's College, London, GB
- Prof. Dr. Tobias Schaeffter, King's College, London GB
- PD Dr. Martin Hoffmann, Clinic for Radiology, University of Ulm
- Prof. Dr. Katharina Landfester, MPI for Polymer Research, Mainz, D
- Dr. Michael Grass, Philips Research Labs, Hamburg, Germany
- Prof. Dr. Klaus Dietmayer, Institute für Mess-, Regel- und Mikrotechnik, University of Ulm
- Prof. Dr. G. Ulrich Nienhaus, Institute of Biophysics, University of Ulm
Industrial collaborations
- Philips Medical Systems, Best, The Netherlands
- Pie Medical Imaging, Maastricht, The Netherlands
- TomTec, Unterschleissheim, Germany
- Schering, Berlin, Germany
- Sirona Dental, Bensheim, Germany
Funding
- Reborne (European Community - FP7; 2010-2014) - Regenerating Bone defects using New biomedical Engineering approaches. Biomaterial development
- Else Kröner-Fresenius Stiftung, Germany
- Takeda Pharma
- Philips Medical Systems, Best, The Netherlands
- Sirona Dental, Bensheim, Germany
Publications
2010
Journal Contributions
- Sharma S, Boujraf S, Bornstedt A, Hombach V, Ignatius A, Oberhuber A, Rasche V. Quantification of Calcifications in Endarterectomy Samples by Means of High – Resolution Ultra-Short Echo Time (UTE) Imaging. Inv Radiol, 2010;45:109-113
- Sharma S, Paiphansiri U, Hombach V, Mailänder V, Landfester K, Rasche V, Characterization of MRI contrast agent loaded polymeric nanocapsules as versatile vehicle for targeted imaging, Contrast Media Mol Imaging. 2010;5:59-69
- Gottschalk A, Schmitz B, Mauer UM, Bornstedt A, Steinhoff S, Danz B, Rasche V. Dynamic visualization of arachnoid adhesions in patients with idiopathic syringomyelia using high-resolution cine magnetic resonance imaging at 3T. J Magn Reson Imaging. 2010; 32:218-222
- Manzke R, Binner L, Bornstedt A, Merkle N, Lutz A, Gradinger R, Rasche V. Assessment of the coronary venous system in heart failure patients by blood pool agent enhanced whole-heart MRI. Eur Radiol, 2010, accepted
Conference Contributions
- Schenderlein, M., Rasche, V. & Dietmayer, K. Image-based catheter tip tracking during cardiac ablation therapy, in " Proceedings of Medical Image Understanding and Analysis (MIUA) 2010, Warwick", 65-69
- Schenderlein, M., Stierlin, S., Manzke, R., Rasche, V. & Dietmayer, K. Catheter tracking in asynchronous biplane fluoroscopy images by 3D B-snakes. in "Proceedings of SPIE Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling, San Diego" 76251U
- Schmidtke-Schrezenmeier, G, Rasche V, Urban M. Fekete, N, Rojewski M, Henschler R, Rohde, E, Landfester K, Schrezenmeier H. IRON-PLLA PARTICLES FOR IMAGING OF IN VIVO TRAFFICKING AND HOMING OF HUMAN MESENCHYMAL STEM/STROMAL CELLS VIA MRI. ISBT - International Congress, Berlin (2010), oral presentation (3D-S11-03)
- Schmidtke-Schrezenmeier, G, Rasche V, Urban M. Fekete, N, Deak E, Rohde, E, Landfester K, Schrezenmeier H. Imaging von MSC mit Eisen/Fluoreszenpartikeln. IGLD - Bad Soden Germany (2010) oral presentation
- G. Schmidtke-Schrezenmeier, M. Urban, S. Sharma, K. Landfester, H. Schrezenmeier, V. Rasche. Poly-L-Lactic Acid (PLLA) Iron Loaded Nanoparticles for MRI Cell Labelling. In “Procceding Annual Meeting ISMRM, Stockholm” (2010)
- J. Zhu, A. Bornstedt, V. Hombach, A. Oberhuber, G. Ma, N. Liu, V. Rasche. T2-Prepared Segmented 3D-Gradient-Echo as Alternative to T2-Weighted TSE for Fast High-Resolution Three-Dimensional Imaging. In “Procceding Annual Meeting ISMRM, Stockholm” (2010)
- Manzke R, Lutz A, Schenderlein M, Bornstedt A, Chan RC, Dietmeyer K, Rasche V. A New PVA-Based Dynamic Cardiac Phantom for Evaluation of Functional MR Imaging Methods at 3T. In “Procceding Annual Meeting ISMRM, Stockholm” (2010)
- A. Gottschalk, A. Bornstedt, U. Maurer, S. Steinhoff, B. Schmitz, V. Rasche. High-Resolution CINE MRI for the Visualization of Arachnoid Adhesions. In “Procceding Annual Meeting ISMRM, Stockholm” (2010)
- A. Lutz, A. Bornstedt, R. Manzke, G. U. Nienhaus, V. Rasche. Combination of Through-Plane Tissue Phase Mapping and SPAMM for 3D Cardiac Motion Assessment. In “Procceding Annual Meeting ISMRM, Stockholm” (2010) . In “Procceding Annual Meeting ISMRM, Stockholm” (2010)
- Bracher AK, Hoffmann C, Boujraf S, Bornstedt A, Hell E, Ulrici J, Spahr A, Rasche V. Ultrashort Echo-Time (UTE) Imaging for Early Diagnosis of
Dental Demineralization. In “Procceding Annual Meeting ISMRM, Stockholm” (2010) - Merkle M, Manzke R, Bornstedt A, Gradinger R, Hombach V, Lutz A, Rasche V. Pre-interventional assessment of the course of the coronary veins in CRT patients. Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P45
- Lutz A, Bornstedt A, Bernhardt P, Hombach V, Merkle M, Manzke R, Rasche V. Assessment of the myocardial twisting motion by through-plane velocity-mapping in long axis geometry. Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P83
- Lutz A, Bornstedt A, Bernhardt P, Hombach V, Merkle M, Manzke R, Rasche V. Black blood TPM imaging at 3 T: comparison of two SAR reducing black blood methods. Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P89
- Manzke R, Bornstedt A, Lutz A, Schenderlein M, Hombach V, Binner L, Rasche V. Respiratory motion compensated overlay of surface models from cardiac MR on interventional X-ray fluoroscopy for guidance of cardiac resynchronization therapy procedures. in "Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling", edited by Kenneth H. Wong, Michael I. Miga, Proc. of SPIE Vol. 7625, 762508






