• Neuromuskuläre Erkrankungen
• Motorische Systemdegenerationen
  (Oberärztin der Spezialsprechstunde für Motoneuronerkrankungen der Hochschulambulanz der Universität Ulm)

Promotion

Universität Ulm

20.11.1997

• Neuromuskuläre Erkrankungen
  (seit 2004 Leitung des Muskellabors der Klinik für Neurologie der Universität Ulm im RKU)
• Atypische Motoneuronerkrankungen
  (Spinale Muskelatrophien, Spinobulbäre Muskelatrophie Typ Kennedy)
• Amyotrophe Lateralsklerose

3. Preis

Deutsche Gesellschaft für Muskelkranke

2003

Originalarbeiten

 

Habedank D, Reindl I, Viezke G, Bauer U, Sperfeld AD, Gläser S, Wernecke KD, Kleber FX. Ventilatory efficiency and exercise tolerance in 101 healthy volunteers. Eur J Appl Physiol 77: 421 - 426, 1998.

 

Sperfeld AD, Vietzke G, Kleber FX, Ludolph AC. Die Spiroergometrie in der Diagnostik mitochondrialer Erkrankungen. Nervenarzt 70: 155 - 161, 1999.

 

Sperfeld AD, Collatz BM, Baier H, Palmbach M, Storch A, Schwarz J, MD, Tatsch K, Reske S, Joosse M, Heutink P, Ludolph AC . FTDP-17: An early-onset phenotype with parkinsonism and epileptic seizures caused by a novel mutation. Ann Neurol 46: 708-715. 1999.

 

Karitzky J, Block W, Mellies JK, Träber F, Sperfeld AD, Schild HH, Haller P, Ludolph AC. Proton magnetic resonance spectroscopy in Kennedy syndrome. Arch Neurol 56: 1465 - 1471, 1999.

 

Kleber FX, Vietzke G, Wernecke KD, Bauer U, Opitz C, Wensel R, Sperfeld A, Glaser S. Impairment of ventilatory efficiency in heart failure: prognostic impact. Circulation 101: 2803-9; 2000.

 

Huber R, Buchner M, Li H, Schlieter M, Sperfeld AD, Riepe MW. Protein binding of NADH on chemical preconditioning. J Neurochem75: 329-35, 2000.

 

Lund A, Udd B, Juvonen V, Andersen PM, Cederquist K, Davis M, Gellera C, Kolmel C, Ronnevi LO, Sperfeld AD, Sorensen SA, Tranebjaerg L, Van Maldergem L, Watanabe M, Weber M, Yeung L, Savontaus ML. Multiple founder effects in spinal and bulbar muscular atrophy (SBMA, Kennedy disease) around the world. Eur J Hum Genet 9: 431-6, 2001.

 

Ludolph AC, Sperfeld A, Collatz BM, Storch A. [Tauopathies -a new class of neurodegenerative diseases. Nervenarzt, 72: 78-85; 2001.

 

Sperfeld AD, Hein C, Schröder JM, Ludolph AC, Hanemann CO. Occurrence and characterization of peripheral nerve involvement in neurofibromatosis type 2. Brain; 125: 996 – 1004, 2002.

 

Mader I, Karitzky J, Klose U, Seeger U, Sperfeld A, Naegele T, Schick F, Ludolph A, Grodd W. Proton MRS in Kennedy disease: Absolute metabolite and macromolecular concentrations. J Magn Reson Imaging 16:160-7, 2002.

 

AD Sperfeld, J Karitzky, D Brummer, Schreiber H, Häußler J, Ludolph AC, Hanemann CO. X-linked Bulbospinal Neuronopathy Kennedy: Clinical, Electrophysiological and Muscle Biopsy Findings in 34 cases. Arch Neurol 59: 1921-6, 2002.

 

J Kassubek, AD Sperfeld, P Satrapi, J Fischer, C Schönfeldt-Lecuona, BJ Connemann. Klinik und aktuelle Therapie des Gilles-de-la-Tourette-Syndroms. Nervenheilkunde 21: 149-55, 2002.

 

J Kassubek, FD Jüngling, AD Sperfeld, A. Wunderlich, G. Grön. Klinische Anwendung bildgebender Diagnostik bei fortgeschrittener frontotemporaler Lobaratrophie. Nervenheilkunde 21: 214-8, 2002.

 

CO Hanemann, C Bergmann, J Senderek, K Zerres, AD Sperfeld. Transient, recurrent white matter lesion in CMTX with novel Cx32 mutation. Arch Neurol 60: 605-9, 2003.

 

S Züchner, AD Sperfeld, J Senderek, B Sellhaus,CO Hanemann, JM Schröder. A novel nonsense mutation in the ABC1 gene causes a severe syringomyelia-like phenotype of Tangier disease. Brain 126: 920-7, 2003.

 

Butz M, Wollinsky KH, Wiedemuth-Catrinescu U, Sperfeld A, Winter S, Mehrkens HH, Ludolph AC, Schreiber H. Longitudinal effects of noninvasive positive-pressure ventilation in patients with amyotrophic lateral sclerosis. Am J Phys Med Rehabil 82: 597-604, 2003.

 

Sperfeld AD, Kassubek J, Crosby AH, Winner B, Ludolph AC, Uttner I, Hanemann CO. Complicated hereditary spastic paraplegia with thin corpus callosum: variation of phenotypic expression over time. J Neurol.; 251: 1285-7, 2004.

 

A.-D. Sperfeld, C. O. Hanemann, A. C. Ludolph, J. Kassubek. Laryngospasm: an underdiagnosed symptom of X-linked spinobulbar muscular atrophy. Neurology; 64: 753-4, 2005.

 

Kaufmann E, Boehm BO, Sussmuth SD, Kientsch-Engel R, Sperfeld A, Ludolph AC, Tumani H. The advanced glycation end-product N(varepsilon)-(carboxymethyl)lysine level is elevated in cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Neurosci Lett.; 371: 226-9, 2004.

 

Sperfeld AD, Kassubek J, Ludolph. Aktuelle Aspekte in der Diagnostik und Therapie der Amyotrophen Lateralsklerose. Akt Neurol 31: 1 – 7, 2004.

 

Baba Y, Tsuboi Y, Baker MC, Uitti RJ, Hutton ML, Dickson DW, Farrer M, Putzke JD, Woodruff BK, Ghetti B, Murrell JR, Boeve BF, Petersen RC, Verpillat P, Brice A, Delisle MB, Rascol O, Arima K, Dysken MW, Yasuda M, Kobayashi T, Sunohara N, Komure O, Kuno S, Sperfeld AD, Stoppe G, Kohlhase J, Pickering-Brown S, Neary D, Bugiani O, Wszolek ZK. The Effect of tau genotype on clinical features in FTDP-17. Parkinsonism Relat Disord.; 11: 205-8, 2005.

 

Kassubek J, Bretschneider V, Sperfeld AD.             Corticospinal tract MRI hyperintensity in X-linked Charcot-Marie-Tooth Disease.J Clin Neurosci. 2005;12(5):588-9.

 

AD Sperfeld, V Bretschneider, L Flaith, A Unrath, CO Hanemann, AC Ludolph, J Kassubek. MR-Pathologic Comparison of Upper Spinal Cord in Different Motor Neuron Diseases. Eur Neurol; 53: 74-77, 2005.

 

Alber B, Pernauer M, Schwan A, Rothmund G, Hoffmann KT, Brummer D, Sperfeld AD, Uttner I, Binder H, Epplen JT, Dullinger J, Ludolph AC, Meyer T. Spastin related hereditary spastic paraplegia with dysplastic corpus callosum. J Neurol Sci; 236: 9-12, 2005.

 

J. Kassubek, A. Unrath, H.-J. Huppertz, D. Lulé, T. Ethofer, A.-D. Sperfeld, A. C. Ludolph. "Global brain atrophy and corticospinal tract alterations in ALS, as investigated by voxel-based morphometry of 3-D MRI " Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 2005; in press.

 

J.A. Kress, P. Kühnlein, P. Winter, A.C. Ludolph, J. Kassubek , U. Müller , A.D. Sperfeld. Novel mutation in the ALS2 gene in juvenile amyotrophic lateral sclerosis. Ann Neurol 2005, in press.

 

J. Kassubek, AD Sperfeld, A. Baumgartner, HJ Huppertz, A Riecker, F.D. Juengling. Brain Atrophy in Pure and Complicated Hereditary Spastic Paraparesis: A Quantitative 3-D MRI Study. Eur J Neurol 2005, in press.

 

Buchartikel

Anne-Dorte Sperfeld und Albert Christian Ludolph Kap. 21. Motoneuronerkrankungen. In Praktische Neurogeriatrie,. Hrsg. Günnewig und F. Erbguth, Kohlhammer:Stuttgart - Berlin - Köln, erscheint 2005.

 

Links

Muskelzentrum Universität Ulm