PhD (Molecular Biology)

Wissenschaftliche Mitarbeiterin (Forschung und Lehre)

Molekulares Muskellabor

  • EINSTEIN Studie
  • ELSA Studie
  • EIEIM European Initiative for Exercise in Medicine
Profilbild von PhD Martina Zügel

PhD Martina Zügel


  • 2011 Doctoral thesis (PhD Molecular Biology), ‘summa cum laude’, German Sports University Cologne (Germany)
  • 2007 Master of Science with first class honours, University of Auckland (New Zealand)
  • 2005 University of Auckland (New Zealand), Bachelor of Science (double major in Sport and Exercise Science and Biology 

Gender-specific Mechanisms of Skeletal Muscle Regeneration and Adaptation

  • Qiu S, Cai X, Yin H, Zügel M, Sun Z Steinacker JM, Schumann U. Association between circulating irisin and insulin resistance in non-diabetic adults: A meta-analysis. Metabolism. 2016 Jun;65(6):825-34. doi: 10.1016/j.metabol.2016.02.006
  • Schild M, Eichner G, Beiter T, Zügel M, Krumholz-Wagner I, Hudemann J, Pilat C, Krüger K, Nieß A, Steinacker JM, Mooren FC. Effects of acute endurance exercise on plasma protein profiles of endurance-trained and untrained individuals over time. Mediators Inflamm. 2016;2016:4851935. doi: 10.1155/2016/4851935
  • Zügel M, Qiu S, Laszlo R, Bosnyák E, Weigt C, Müller D, Diel P, Steinacker JM, Schumann U.. The role of sex, adiposity and gonadectomy in the regulation of irisin secretion.  Endocrine. 2016 Oct;54(1):101-110. DOI: 10.1007/s12020-016-0913-x
  • Sareban M, Zügel D, Koehler K, Hartveg P, Zügel M, Schumann U, Steinacker JM, Treff G. Carbohydrate intake in form of Gel is associated with increased gastrointestinal distress but not with performance differences compared with liquid carbohydrate ingestion during simulated long-distance triathlon. Int J Sport Nutr Exerc Metab. 2016 Apr;26(2):114-22. doi: 10.1123/ijsnem.2015-0060.
  • Cai X, Qiu S, Yin H, Sun Z, Ju C, Zügel M, Steinacker JM, Schumann U. Pedometer intervention and weight loss in overweight and obese adults with type 2 diabetes: a meta-analysis. Diabet Med. 2016 Aug;33(8):1035-44. doi: 10.1111/dme.13104
  • Zügel M & Weydt P. Sports and physical activity in patients suffering from rare neurodegenerative diseases: how much is too much, how much is too little? German Journal of Sports Medicine. 2015; 66 (11): 300-307. DOI: 10.5960/dzsm.2015.206
  • Zügel M, Klingler W, Sareban M, Schumann U, Steinacker JM. Muskuläre Sportverletzungen: Mechanismen, Diagnostik und Therapie. Aktuelle Schmerzmedizin. 2015; 24; 9/15.
  • Qiu S, Cai X, Sun Z,  Schumann U, Zügel M, Steinacker JM. Chronic exercise training and circulating irisin in adults: a meta-analysis. Sports Med. 2015 Nov;45(11):1577-88. doi: 10.1007/s40279-014-0293-4
  • Qiu S, Cai X, Ju C, Sun Z, Yin H, Zügel M, Otto S,  Steinacker JM, Schumann U. Step Counter Use and Sedentary Time in Adults: A Meta-Analysis. Medicine (Baltimore). 2015 Sep;94(35):e1412. doi: 10.1097/MD.0000000000001412
  • Schild M, Ruhs A, Beiter T, Zügel M, Hudemann J, Reimer A, Kumholz-Wagner I, Wagner C, Keller J, Eder K, Krüger K, Braun T, Nieß A, Steinacker JM, Mooren FC. Basal and exercise induced label-free quantitative protein profiling of m. vastus lateralis in trained and untrained individuals. J Proteomics. 2015 Jun 3;122:119-32. doi: 10.1016/j.jprot.2015.03.028
  • Qiu S, Cai X, Schumann U, Velders M, Sun Z, Steinacker JM. Impact of walking on glycemic control and other cardiovascular risk factors in type 2 diabetes: a meta-analysis. PLoS One. 2014 Oct 17;9(10):e109767. doi: 10.1371/journal.pone.0109767
  • Velders M*, Klingler W*, Hoppe K, Pedro M, Schleip R. Clinical relevance of fascial tissue and dysfunctions. Curr Pain Headache Rep. 2014;18(8):439. doi: 10.1007/s11916-014-0439-y
  • Velders M, Treff G, Machus K, Bosnyak E, Steinacker J, Schumann U. Exercise is a potent stimulus for enhancing circulating DNase activity. Clin Biochem. 2014 Apr;47(6):471-4. doi: 10.1016/j.clinbiochem.2013.12.017
  • Velders M, Diel P. How sex hormones promote skeletal muscle regeneration. Sports Med. 2013 Nov;43(11):1089-100. doi: 10.1007/s40279-013-0081-6
  • Beiter T & Velders M. Pimp my genes – gene doping between facts and fiction. German Journal of Sports Medicine. 2012; 63 (5): 121-131. DOI: 10.5960/dzsm.2012.019
  • Velders M, Schleipen B, Laudenbach U, Fritzemeier KH, Diel P. Selective estrogen receptor-β activation stimulates skeletal muscle growth and regeneration. FASEB J. 26(5):1909-20. FASEB J. 2012 May;26(5):1909-20. doi: 10.1096/fj.11-194779
  • Schleipen B, Velders M, Molzberger A, Kluxen F, Lorenz A, Fritzemeier KH, Diel P. ERβ-specific agonists and genistein inhibit proliferation and induce apoptosis in the large and small intestine. Carcinogenesis. 2011 Nov;32(11):1675-83. doi: 10.1093/carcin/bgr188
  • Frese S*, Velders M*, Schleipen B, Laudenbach U, Fritzemeier KH, Diel P. Myosin heavy chain expression pattern as a marker for anabolic potency - desoxymethyltestosterone (Madol), norandrostenedione and testosterone repress MHC-IIb expression and stimulate MHC-IId/x expression in rat gastrocnemius muscle. Arch Toxicol. 2011 Jun;85(6):635-43. doi: 10.1007/s00204-010-0607-8
  • Velders M, Solzbacher M, Laudenbach U, Fritzemeier KH, Diel P. Estradiol and genistein antagonize the ovariectomy effects on skeletal muscle myosin heavy chain expression via ER-beta mediated pathways. J Steroid Biochem Mol Biol. 2010 May;120(1):53-9. doi: 10.1016/j.jsbmb.2010.03.059
  • Hertrampf T, Schleipen B, Offermanns C, Velders M, Laudenbach U, Diel P. Comparison of the bone protective effects of an isoflavone-rich diet with dietary and subcutaneous administrations of genistein in ovariectomized rats. J Steroid Biochem Mol Biol. 2010 May;120(1):53-9. doi: 10.1016/j.jsbmb.2010.03.059
  • Diel P, Baadners D, Schlüpmann K, Velders M, Schwarz JP. C2C12 myoblastoma cell differentiation and proliferation is stimulated by androgens and associated with a moduation of myostatin and Pax-7 expression. J Mol Endocrinol. 2008 May;40(5):231-41. doi: 10.1677/JME-07-0175
  • Hertrampf T, Schleipen B, Velders M, Laudenbach U, Fritzemeier KH, Diel P. Estrogen receptor subtype-specific effects on markers of bone homeostasis. Mol Cell Endocrinol. 2008 Sep 10;291(1-2):104-8. doi: 10.1016/j.mce.2008.03.003
  • Velders M, Legerlotz K, Falconer SJ, Stott NS, McMahon CD, Smith HK. Effect of botulinum toxin A-induced paralysis and exercise training on mechanosensing and signaling gene expression in juvenile rat gastrocnemius muscle.  Exp Physiol. 2008 Dec;93(12):1273-83. doi: 10.1113/expphysiol.2008.043174
  • Buck E, Zügel M, Schumann U, Merz T, Gumpp AM, Witting A, Steinacker JM, Landwehrmeyer GB, Weydt P, Calzia E, Lindenberg KS. High-resolution respirometry of fine-needle muscle biopsies in pre-manifest Huntington's disease expansion mutation carriers shows normal mitochondrial respiratory function. PLoS One. 2017, 13;12(4):e0175248. doi: 10.1371/journal.pone.0175248.

  • Zügel M, Maganaris CN, Wilke J, Jurkat-Rott K, Klingler W, Wearing SC, Findley T, Barbe MF, Steinacker JM, Vleeming A, Bloch W, Schleip R, Hodges PW. Fascial tissue research in sports medicine: from molecules to tissue adaptation, injury and diagnostics. Br J Sports Med. 2018 Aug 2. pii: bjsports-2018-099308. doi: 10.1136/bjsports-2018-099308. [Epub ahead of print]