Forschungsschwerpunkt

Molecular Genetic and Epigenetic of Neurodegeneration

Our group studies the molecular mechanisms of amyotrophic lateral sclerosis (ALS) and Parkinson’s disease with specific emphasis on molecular genetics and epigenetics of ALS. Amyotrophic lateral sclerosis (ALS) is a one of the classical neurodegenerative diseases characterized primarily by the progressive loss of cortical and spinal motor neurons.

Our work comprises research on the functional role and mechanisms of RNA "dysmetabolism" in ALS, specifically of microRNA dysregulation in ALS patients and pre-symptomatic mutation carriers. In addition, we are employing whole exome sequence data from our familial ALS patients to identify novel mutations and thereby principles of ALS pathogenesis, that are then cell biologically validated in in vitro and in vivo models. A third focus of our group is the implication of the innate immune system in ALS.

Various in vitro ALS models as well as state-of-the art biochemical and molecular biological techniques are routinely used in our laboratory. Our in vivo models comprise both established genetic ALS animal models and novel transgenic animals that are currently being generated, including also genetically modified zebrafish models (cooperation with Jun.-Prof. Stefan Just, Department of Cardiology). Other active collaborative projects within Ulm University include STED and spinning disc imaging of ALS-relevant proteins and their way of cell-to-cell transmission at the nanometer scale (Prof. Jens Michaelis) or the use of protein complementation techniques to study ALS protein oligomerization in vitro and in vivo (Jun.-Prof. Karin Danzer).

Based on the generous contribution of ALS patients visiting our specialized ALS outpatient clinic within the Neurology Department in Ulm, our research substantially benefits from the large Ulm ALS Biobank, which comprises a large collection of DNA, cerebrospinal fluid and blood samples as well as post-mortem tissue from sporadic and familial ALS patients. This gives us the chance to validate experimental in vitro and in vivo data in human biomaterial and helps defining novel therapeutic targets.

Funding:

Charcot-Stiftung, BMBF, Latran Foundation

Mitarbeiter der AG Weishaupt
Profilbild von Prof. Dr. med. Jochen Weishaupt

Prof. Dr. med. Jochen Weishaupt

Oberarzt

Dr. med. Wolfgang Ruf

Tel: +49 731-500 63060
Fax: +49 731-500 63050
Email: wolfgang.ruf@uni-ulm.de

 

Dr. rer. nat Axel Freischmidt

Tel: +49 731-500 63051
Fax: +49 0731-500 63050
Email: axel.freischmidt@uni-ulm.de

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Dr. biol. hum. Kathrin Müller

Tel: +49 731-500 63060
Fax: +49 731-500 63050
Email: kathrin.mueller@uni-ulm.de

Sarah Brockmann
M.Sc. Biochem.
 
Tel: +49 731-500 63060
Fax: +49 731-500 63050
Email: sarah.brockmann@uni-ulm.de

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Anika M. Helferich (geb. Bronnhuber)
M.Sc. Molecular Medicine

Tel: +49 731-500 63060
Fax: +49 731-500 63050
Email: anika.bronnhuber@uni-ulm.de

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Marisa Feiler
M.Sc. Pharmaceutical Biotechnology

Tel: +49 731-500 63051
Fax: +49 731-500 63050
Email: marisa.feiler@uni-ulm.de

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Nicolai Marroquin
M.Sc. Molecular Medicine

Tel: +49 731-500 63060
Fax: +49 731-500 63050
Email: nicolai.marroquin@uni-ulm.de

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Lisa Zondler
M.Sc. Molecular Medicine

Tel: +49 731-500 63051
Fax: +49 731-500 63050
Email: lisa.zondler@uni-ulm.de

Nadine Todt
Medizinisch-technische Assistentin

Tel: +49 731-500 63060
Fax: +49 731-500 63050
Email: nadine.todt@uni-ulm.de

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Elena Jasovskaja
Technische Assistentin

Tel: +49 731-500 63060
Fax: +49 731-500 63050
Email: elena.jasovskaja@uni-ulm.de

 

 
Publikationen

Ausgewählte Publikationen / selected publications

  • Zondler L, Müller K, Khalaji S, Bliederhauser C, Ruf WP, Grozdanov V, Thiemann M, Fundel-Clemes K, Freischmidt A, Holzmann K, Strobel B, Weydt P, Witting A, Thal DR, Helferich AM, Hengerer B, Gottschalk KE, Hill O, Kluge M, Ludolph AC, Danzer KM, and Weishaupt JH: Peripheral monocytes are functionally altered and invade the CNS in ALS patients. Acta Neuropathol, 2016. Feb 24. [Epub ahead of print]
  • Linkus B, Wiesner D, Messner M, Karabatsiakis A, Scheffold A, Rudolph KL, Thal DR, Weishaupt JH, Ludolph AC, and Danzer KM: Telomere shortening leads to earlier age of onset in ALS mice. Aging (Albany NY), 2016. 8(2): p. 382-93.
  • El Oussini H, Bayer H, Scekic-Zahirovic J, Vercruysse P, Sinniger J, Dirrig-Grosch S, Dieterle S, Echaniz-Laguna A, Larmet Y, Müller K, Weishaupt JH, Thal DR, van Rheenen W, van Eijk K, Lawson R, Monassier L, Maroteaux L, Roumier A, Wong PC, van den Berg LH, Ludolph AC, Veldink JH, Witting A, and Dupuis L: Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis. Acta Neuropathol, 2016. 131(3): p. 465-80.
  • Brenner D, Müller K, Wieland T, Weydt P, Bohm S, Lule D, Hübers A, Neuwirth C, Weber M, Borck G, Wahlqvist M, Danzer KM, Volk AE, Meitinger T, Strom TM, Otto M, Kassubek J, Ludolph AC, Andersen PM, and Weishaupt JH: NEK1 mutations in familial amyotrophic lateral sclerosis. Brain, 2016, March 5, Epub ahead of print
  • Feneberg E, Steinacker P, Volk AE, Weishaupt JH, Wollmer MA, Boxer A, Tumani H, Ludolph AC, and Otto M: Progranulin as a candidate biomarker for therapeutic trial in patients with ALS and FTLD. J Neural Transm (Vienna), 2016. 123(3): p. 289-96.
  • Bliederhaeuser C, Grozdanov V, Speidel A, Zondler L, Ruf WP, Bayer H, Kiechle M, Feiler MS, Freischmidt A, Brenner D, Witting A, Hengerer B, Fandrich M, Ludolph AC, Weishaupt JH, Gillardon F, and Danzer KM: Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes. Acta Neuropathol, 2016. 131(3): p. 379-91.
  • Weydt P, Oeckl P, Huss A, Müller K, Volk AE, Kuhle J, Knehr A, Andersen PM, Prudlo J, Steinacker P, Weishaupt JH, Ludolph AC, and Otto M: Neurofilament levels as biomarkers in asymptomatic and symptomatic familial amyotrophic lateral sclerosis. Ann Neurol, 2016. 79(1): p. 152-8.
  • Feiler, M., B. Strobel, A. Freischmidt, A.M. Helferich, J. Kappel, B.M. Brewer, D. Li, D.R. Thal, P. Walther, A.C. Ludolph, K.M. Danzer*, and J.H. Weishaupt*, Cell-to-cell transmission of TDP-43 across axon terminals, J Cell Biol, in press. *Equal contribution.
  • Weydt, P., P. Oeckl, A. Huss, K. Müller, A.E. Volk, J. Kuhle, A. Knehr, P.M. Andersen, J. Prudlo, P. Steinacker, J.H. Weishaupt, A.C. Ludolph, and M. Otto, Neurofilaments levels as biomarkers in asymptomatic and symptomatic familial ALS. Ann Neurol, 2015, in press
  • Freischmidt A., M. Schöpflin, M.S Feiler, A.-K. Fleck, A.C. Ludolph, and J.H. Weishaupt, Profilin 1 with the amyotrophic lateral sclerosis associated mutation T109M displays unaltered actin binding and does not affect the actin cytoskeleton. BMC Neurosci, in press.
  • Maier, A., N. Deigendesch, K. Müller, J.H. Weishaupt, A. Krannich, R. Rohle, F. Meissner, K. Molawi, C. Munch, T. Holm, R. Meyer, T. Meyer, and A. Zychlinsky, Interleukin-1 Antagonist Anakinra in Amyotrophic Lateral Sclerosis-A Pilot Study. PLoS One, 2015. 10(10): p. e0139684.
  • Wagner, J., S. Krauss, S. Shi, S. Ryazanov, J. Steffen, C. Miklitz, A. Leonov, A. Kleinknecht, B. Goricke, J.H. Weishaupt, D. Weckbecker, A.M. Reiner, W. Zinth, J. Levin, D. Ehninger, S. Remy, H.A. Kretzschmar, C. Griesinger, A. Giese, and M. Fuhrmann, Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies. Acta Neuropathol, 2015. 130(5): p. 619-31.
  • Hübers, A., W. Just, A. Rosenbohm, K. Müller, N. Marroquin, I. Goebel, J. Hogel, H. Thiele, J. Altmuller, P. Nurnberg, J.H. Weishaupt, C. Kubisch, A.C. Ludolph, and A.E. Volk, De novo FUS mutations are the most frequent genetic cause in early-onset German ALS patients. Neurobiol Aging, 2015. 36(11): p. 3117 e1-6.
  • Marroquin, N., S. Stranz, K. Müller, T. Wieland, W.P. Ruf, S.J. Brockmann, K.M. Danzer, G. Borck, A. Hübers, P. Weydt, T. Meitinger, T.M. Strom, A. Rosenbohm, A.C. Ludolph, and J.H. Weishaupt, Screening for CHCHD10 mutations in a large cohort of sporadic ALS patients: no evidence for pathogenicity of the p.P34S variant. Brain, 2015.
  • Steinacker, P., E. Feneberg, J. Weishaupt, J. Brettschneider, H. Tumani, P.M. Andersen, C.A. von Arnim, S. Bohm, J. Kassubek, C. Kubisch, D. Lule, H.P. Muller, R. Muche, E. Pinkhardt, P. Oeckl, A. Rosenbohm, S. Anderl-Straub, A.E. Volk, P. Weydt, A.C. Ludolph, and M. Otto, Neurofilaments in the diagnosis of motoneuron diseases: a prospective study on 455 patients. J Neurol Neurosurg Psychiatry, 2015.
  • Freischmidt, A., K. Müller, L. Zondler, P. Weydt, B. Mayer, C.A. von Arnim, A. Hübers, J. Dorst, M. Otto, K. Holzmann, A.C. Ludolph, K.M. Danzer, and J.H. Weishaupt, Serum microRNAs in sporadic amyotrophic lateral sclerosis. Neurobiol Aging, 2015. 36(9): p. 2660 e15-20.
  • Freischmidt, A., T. Wieland, B. Richter, W. Ruf, V. Schaeffer, K. Müller, N. Marroquin, F. Nordin, A. Hübers, P. Weydt, S. Pinto, R. Press, S. Millecamps, N. Molko, E. Bernard, C. Desnuelle, M.H. Soriani, J. Dorst, E. Graf, U. Nordstrom, M.S. Feiler, S. Putz, T.M. Boeckers, T. Meyer, A.S. Winkler, J. Winkelman, M. de Carvalho, D.R. Thal, M. Otto, T. Brannstrom, A.E. Volk, P. Kursula, K.M. Danzer, P. Lichtner, I. Dikic, T. Meitinger, A.C. Ludolph, T.M. Strom, P.M. Andersen, and J.H. Weishaupt, Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia. Nat Neurosci, 2015. 18(5): p. 631-6.
  • Gao, L., D. Brenner, E. Llorens-Bobadilla, G. Saiz-Castro, T. Frank, P. Wieghofer, O. Hill, M. Thiemann, S. Karray, M. Prinz, J.H. Weishaupt, and A. Martin-Villalba, Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. J Exp Med, 2015. 212(4): p. 469-80.
  • Kunadt, M., K. Eckermann, A. Stuendl, J. Gong, B. Russo, K. Strauss, S. Rai, S. Kugler, L. Falomir Lockhart, M. Schwalbe, P. Krumova, L.M. Oliveira, M. Bahr, W. Mobius, J. Levin, A. Giese, N. Kruse, B. Mollenhauer, R. Geiss-Friedlander, A.C. Ludolph, A. Freischmidt, M.S. Feiler, K.M. Danzer, M. Zweckstetter, T.M. Jovin, M. Simons, J.H. Weishaupt, and A. Schneider, Extracellular vesicle sorting of alpha-Synuclein is regulated by sumoylation. Acta Neuropathol, 2015. 129(5): p. 695-713.
  • Mühling, T., J. Duda, J.H. Weishaupt, A.C. Ludolph, and B. Liss, Elevated mRNA-levels of distinct mitochondrial and plasma membrane Ca(2+) transporters in individual hypoglossal motor neurons of endstage SOD1 transgenic mice. Front Cell Neurosci, 2014. 8: p. 353.
  • Büchner, A., P. Krumova, S. Ganesan, M. Bahr, K. Eckermann, and J.H. Weishaupt, Sumoylation of p35 Modulates p35/Cyclin-Dependent Kinase (Cdk) 5 Complex Activity. Neuromolecular Med, 2014.
  • Eschbach, J., B. von Einem, K. Muller, H. Bayer, A. Scheffold, B.E. Morrison, K.L. Rudolph, D.R. Thal, A. Witting, P. Weydt, M. Otto, M. Fauler, B. Liss, P.J. McLean, A.R. Spada, A.C. Ludolph, J.H. Weishaupt, and K.M. Danzer, Mutual exacerbation of peroxisome proliferator-activated receptor gamma coactivator 1alpha deregulation and alpha-synuclein oligomerization. Ann Neurol, 2015. 77(1): p. 15-32.
  • Grozdanov, V., C. Bliederhaeuser, W.P. Ruf, V. Roth, K. Fundel-Clemens, L. Zondler, D. Brenner, A. Martin-Villalba, B. Hengerer, J. Kassubek, A.C. Ludolph, J.H. Weishaupt, and K.M. Danzer, Inflammatory dysregulation of blood monocytes in Parkinson's disease patients. Acta Neuropathol, 2014. 128(5): p. 651-63.
  • Freischmidt, A., K. Muller, L. Zondler, P. Weydt, A.E. Volk, A.L. Bozic, M. Walter, M. Bonin, B. Mayer, C.A. von Arnim, M. Otto, C. Dieterich, K. Holzmann, P.M. Andersen, A.C. Ludolph, K.M. Danzer, and J.H. Weishaupt, Serum microRNAs in patients with genetic amyotrophic lateral sclerosis and pre-manifest mutation carriers. Brain, 2014. 137(Pt 11): p. 2938-50.
  • Müller, K., P.M. Andersen, A. Hubers, N. Marroquin, A.E. Volk, K.M. Danzer, T. Meitinger, A.C. Ludolph, T.M. Strom, and J.H. Weishaupt, Two novel mutations in conserved codons indicate that CHCHD10 is a gene associated with motor neuron disease. Brain, 2014. 137(Pt 12): p. e309.
  • Oeckl, P., P. Steinacker, C.A. von Arnim, S. Straub, M. Nagl, E. Feneberg, J.H. Weishaupt, A.C. Ludolph, and M. Otto, Intact protein analysis of ubiquitin in cerebrospinal fluid by multiple reaction monitoring reveals differences in Alzheimer's disease and frontotemporal lobar degeneration. J Proteome Res, 2014. 13(11): p. 4518-25.
  • Diekstra, F.P., V.M. Van Deerlin, J.C. van Swieten, A. Al-Chalabi, A.C. Ludolph, J.H. Weishaupt, O. Hardiman, J.E. Landers, R.H. Brown, Jr., M.A. van Es, R.J. Pasterkamp, M. Koppers, P.M. Andersen, K. Estrada, F. Rivadeneira, A. Hofman, A.G. Uitterlinden, P. van Damme, J. Melki, V. Meininger, A. Shatunov, C.E. Shaw, P.N. Leigh, P.J. Shaw, K.E. Morrison, I. Fogh, A. Chio, B.J. Traynor, D. Czell, M. Weber, P. Heutink, P.I. de Bakker, V. Silani, W. Robberecht, L.H. van den Berg, and J.H. Veldink, C9orf72 and UNC13A are shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: a genome-wide meta-analysis. Ann Neurol, 2014. 76(1): p. 120-33.
  • Rizik, N., A. Freischmidt, A.C. Ludolph, and J.H. Weishaupt, FXN GAA repeat expansions in amyotrophic lateral sclerosis. J Clin Neurosci, 2014. 21(8): p. 1319-22.
  • Liman, J., S. Deeg, A. Voigt, H. Vossfeldt, C.P. Dohm, A. Karch, J. Weishaupt, J.B. Schulz, M. Bahr, and P. Kermer, CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration. J Neurochem, 2014. 129(6): p. 1013-23.
  • Hubers, A., N. Marroquin, B. Schmoll, S. Vielhaber, M. Just, B. Mayer, J. Hogel, J. Dorst, T. Mertens, W. Just, A. Aulitzky, V. Wais, A.C. Ludolph, C. Kubisch, J.H. Weishaupt, and A.E. Volk, Polymerase chain reaction and Southern blot-based analysis of the C9orf72 hexanucleotide repeat in different motor neuron diseases. Neurobiol Aging, 2014. 35(5): p. 1214 e1-6.
  • Tonges, L., R. Gunther, M. Suhr, J. Jansen, A. Balck, K.A. Saal, E. Barski, T. Nientied, A.A. Gotz, J.C. Koch, B.K. Mueller, J.H. Weishaupt, M.W. Sereda, U.K. Hanisch, M. Bahr, and P. Lingor, Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis. Glia, 2014. 62(2): p. 217-32.
  • Rosenbohm, A., J. Kassubek, P. Weydt, N. Marroquin, A.E. Volk, C. Kubisch, H.J. Huppertz, M. Weber, P.M. Andersen, J.H. Weishaupt, and A.C. Ludolph, Can lesions to the motor cortex induce amyotrophic lateral sclerosis? J Neurol, 2014. 261(2): p. 283-90.
  • Freischmidt, A., K. Muller, A.C. Ludolph, and J.H. Weishaupt, Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis. Acta Neuropathol Commun, 2013. 1(1): p. 42.
  • Hübers, A., J.H. Weishaupt, and A.C. Ludolph, [Genetics of amyotrophic lateral sclerosis]. Nervenarzt, 2013. 84(10): p. 1213-9.
  • Weishaupt, J., A. Kolb-Maurer, S. Lempert, P. Nenoff, S. Uhrlass, H. Hamm, and M. Goebeler, A different kind of hedgehog pathway: tinea manus due to Trichophyton erinacei transmitted by an African pygmy hedgehog (Atelerix albiventris). Mycoses, 2014. 57(2): p. 125-7.
  • Wagner, J., S. Ryazanov, A. Leonov, J. Levin, S. Shi, F. Schmidt, C. Prix, F. Pan-Montojo, U. Bertsch, G. Mitteregger-Kretzschmar, M. Geissen, M. Eiden, F. Leidel, T. Hirschberger, A.A
  • Deeg, J.J. Krauth, W. Zinth, P. Tavan, J. Pilger, M. Zweckstetter, T. Frank, M. Bahr, J.H. Weishaupt, M. Uhr, H. Urlaub, U. Teichmann, M. Samwer, K. Botzel, M. Groschup, H. Kretzschmar, C. Griesinger, and A. Giese, Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol, 2013. 125(6): p. 795-813.
  • Waibel, S., M. Neumann, A. Rosenbohm, A. Birve, A.E. Volk, J.H. Weishaupt, T. Meyer, U. Muller, P.M. Andersen, and A.C. Ludolph, Truncating mutations in FUS/TLS give rise to a more aggressive ALS-phenotype than missense mutations: a clinico-genetic study in Germany. Eur J Neurol, 2013. 20(3): p. 540-6.
  • Ingre, C., J.E. Landers, N. Rizik, A.E. Volk, C. Akimoto, A. Birve, A. Hubers, P.J. Keagle, K. Piotrowska, R. Press, P.M. Andersen, A.C. Ludolph, and J.H. Weishaupt, A novel phosphorylation site mutation in profilin 1 revealed in a large screen of US, Nordic, and German amyotrophic lateral sclerosis/frontotemporal dementia cohorts. Neurobiol Aging, 2013. 34(6): p. 1708 e1-6.
  • Weishaupt, J.H., S. Waibel, A. Birve, A.E. Volk, B. Mayer, T. Meyer, A.C. Ludolph, and P.M. Andersen, A novel optineurin truncating mutation and three glaucoma-associated missense variants in patients with familial amyotrophic lateral sclerosis in Germany. Neurobiol Aging, 2013. 34(5): p. 1516 e9-15.
  • Krumova, P. and J.H. Weishaupt, Sumoylation in neurodegenerative diseases. Cell Mol Life Sci, 2013. 70(12): p. 2123-38.

2012

  • Tonges, L., T. Frank, L. Tatenhorst, K.A. Saal, J.C. Koch, E.M. Szego, M. Bahr, J.H. Weishaupt, and P. Lingor, Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease. Brain, 2012. 135(Pt 11): p. 3355-70.
  • Dibaj, P., J. Zschuntzsch, H. Steffens, J. Scheffel, B. Goricke, J.H. Weishaupt, K. Le Meur, F. Kirchhoff, U.K. Hanisch, E.D. Schomburg, and C. Neusch, Influence of methylene blue on microglia-induced inflammation and motor neuron degeneration in the SOD1(G93A) model for ALS. PLoS One, 2012. 7(8): p. e43963.
  • Ludolph, A.C., J. Brettschneider, and J.H. Weishaupt, Amyotrophic lateral sclerosis. Curr Opin Neurol, 2012. 25(5): p. 530-5.
  • Frank, T., F. Klinker, B.H. Falkenburger, R. Laage, F. Luhder, B. Goricke, A. Schneider, H. Neurath, H. Desel, D. Liebetanz, M. Bahr, and J.H. Weishaupt, Pegylated granulocyte colony-stimulating factor conveys long-term neuroprotection and improves functional outcome in a model of Parkinson's disease. Brain, 2012. 135(Pt 6): p. 1914-25.
  • Weishaupt, J.H., C. Ganser, and M. Bahr, Inflammatory demyelinating CNS disorder in a case of X-linked Charcot-Marie-Tooth disease: positive response to natalizumab. J Neurol, 2012. 259(9): p. 1967-9.
  • Krumova, P. and J.H. Weishaupt, Sumoylation fights "aggregopathies". Cell Cycle, 2012. 11(4): p. 641-2.

2011

  • Krumova P, Meulmeester E, Garrido M, Tirard M, Hsiao HH, Bossis G, Urlaub H, Zweckstetter M, Kugler S, Melchior F, Bähr M, Weishaupt JH. Sumoylation inhibits alpha-synuclein aggregation and toxicity. J Cell Biol 2011; 194: 49-60.

2010

  • Shevtsova Z, Garrido M, Weishaupt J, Saftig P, Bähr M, Luhder F, Kugler S. CNS-expressed cathepsin D prevents lymphopenia in a murine model of congenital neuronal ceroid lipofuscinosis. Am J Pathol 2010; 177: 271-279.

2009

  • Tauber SC, Ebert S, Weishaupt JH, Reich A, Nau R, Gerber J. Stimulation of Toll-like receptor 9 by chronic intraventricular unmethylated cytosine-guanine DNA infusion causes neuroinflammation and impaired spatial memory. J Neuropathol Exp Neurol 2009; 68: 1116-1124.
  • Frank T, Schlachetzki JC, Göricke B, Meuer K, Rohde G, Dietz GP, Bähr M, Schneider A, Weishaupt JH. Both systemic and local application of granulocyte-colony stimulating factor (G-CSF) is neuroprotective after retinal ganglion cell axotomy. BMC Neurosci 2009; 10: 49.
  • Bermel C, Tönges L, Planchamp V, Gillardon F, Weishaupt JH, Dietz GP, Bähr M, Lingor P. Combined inhibition of Cdk5 and ROCK additively increase cell survival, but not the regenerative response in regenerating retinal ganglion cells. Mol Cell Neurosci 2009; 42: 427-437.

2008

  • Rohde G, Kermer P, Reed JC, Bähr M, Weishaupt JH. Neuron-specific overexpression of the co-chaperone Bcl-2-associated athanogene-1 in superoxide dismutase 1(G93A)-transgenic mice. Neuroscience 2008; 157: 844-849.
  • Ganesan S, Rohde G, Eckermann K, Sroka K, Schaefer MK, Dohm CP, Kermer P, Haase G, Wouters F, Bähr M, Weishaupt JH. Mutant SOD1 detoxification mechanisms in intact single cells. Cell Death Differ 2008; 15: 312-321.
  • Dietz GP, Stockhausen KV, Dietz B, Falkenburger BH, Valbuena P, Opazo F, Lingor P, Meuer K, Weishaupt JH, Schulz JB, Bähr M. Membrane-permeable Bcl-xL prevents MPTP-induced dopaminergic neuronal loss in the substantia nigra. J Neurochem 2008; 104: 757-765.

2007

  • Tönges L, Schlachetzki JC, Weishaupt JH, Bähr M. Hematopoietic cytokines--on the verge of conquering neurology. Curr Mol Med 2007; 7: 157-170.
  • Meuer K, Suppanz IE, Lingor P, Planchamp V, Göricke B, Fichtner L, Braus GH, Dietz GP, Jakobs S, Bähr M, Weishaupt JH. Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis. Cell Death Differ 2007; 14: 651-661.
  • Liebetanz D, Baier PC, Paulus W, Meuer K, Bähr M, Weishaupt JH. A highly sensitive automated complex running wheel test to detect latent motor deficits in the mouse MPTP model of Parkinson's disease. Exp Neurol 2007; 205: 207-213.

2006

  • Weishaupt JH, Bartels C, Polking E, Dietrich J, Rohde G, Poeggeler B, Mertens N, Sperling S, Bohn M, Huther G, Schneider A, Bach A, Siren AL, Hardeland R, Bähr M, Nave KA, Ehrenreich H. Reduced oxidative damage in ALS by high-dose enteral melatonin treatment. J Pineal Res 2006; 41: 313-323.
  • Meuer K, Pitzer C, Teismann P, Kruger C, Göricke B, Laage R, Lingor P, Peters K, Schlachetzki JC, Kobayashi K, Dietz GP, Weber D, Ferger B, Schabitz WR, Bach A, Schulz JB, Bähr M, Schneider A, Weishaupt JH. Granulocyte-colony stimulating factor is neuroprotective in a model of Parkinson's disease. J Neurochem 2006; 97: 675-686.
  • Dietz GP, Valbuena PC, Dietz B, Meuer K, Mueller P, Weishaupt JH, Bähr M. Application of a blood-brain-barrier-penetrating form of GDNF in a mouse model for Parkinson's disease. Brain Res 2006; 1082: 61-66.

2005

  • Weishaupt JH, Klöcker N, Bähr M. Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells. J Mol Neurosci 2005; 26: 17-25.

2004

  • Weishaupt JH, Rohde G, Polking E, Siren AL, Ehrenreich H, Bähr M. Effect of erythropoietin axotomy-induced apoptosis in rat retinal ganglion cells. Invest Ophthalmol Vis Sci 2004; 45: 1514-1522.
  • Kilic E, Weishaupt JH, Kilic U, Rohde G, Yulug B, Peters K, Hermann DM, Bähr M. The superoxide dismutase1 (SOD1) G93A mutation does not promote neuronal injury after focal brain ischemia and optic nerve transection in mice. Neuroscience 2004; 128: 359-364.
  • Kermer P, Liman J, Weishaupt JH, Bähr M. Neuronal apoptosis in neurodegenerative diseases: from basic research to clinical application. Neurodegener Dis 2004; 1: 9-19.

2003

  • Weishaupt JH, Neusch C, Bähr M. Cyclin-dependent kinase 5 (CDK5) and neuronal cell death. Cell Tissue Res 2003; 312: 1-8.
  • Weishaupt JH, Kussmaul L, Grotsch P, Heckel A, Rohde G, Romig H, Bähr M, Gillardon F. Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction. Mol Cell Neurosci 2003; 24: 489-502.
  • Weishaupt JH, Diem R, Kermer P, Krajewski S, Reed JC, Bähr M. Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivo. Neurobiol Dis 2003; 13: 124-135.
  • Neusch C, Weishaupt JH, Bähr M. Kir channels in the CNS: emerging new roles and implications for neurological diseases. Cell Tissue Res 2003; 311: 131-138.
  • Jacob S, Finsterbusch J, Weishaupt JH, Khorram-Sefat D, Frahm J, Ehrenreich H. Diffusion tensor imaging for long-term follow-up of corticospinal tract degeneration in amyotrophic lateral sclerosis. Neuroradiology 2003; 45: 598-600.

2002

  • Jacob S, Poeggeler B, Weishaupt JH, Siren AL, Hardeland R, Bähr M, Ehrenreich H. Melatonin as a candidate compound for neuroprotection in amyotrophic lateral sclerosis (ALS): high tolerability of daily oral melatonin administration in ALS patients. J Pineal Res 2002; 33: 186-187.

2001

  • Weishaupt JH, Bähr M. Degeneration of axotomized retinal ganglion cells as a model for neuronal apoptosis in the central nervous system - molecular death and survival pathways. Restor Neurol Neurosci 2001; 19: 19-27.
  • Kermer P, Klöcker N, Weishaupt JH, Bähr M. Transection of the optic nerve in rats: studying neuronal death and survival in vivo. Brain Res Brain Res Protoc 2001; 7: 255-260.
  • Diem R, Meyer R, Weishaupt JH, Bähr M. Reduction of potassium currents and phosphatidylinositol 3-kinase-dependent AKT phosphorylation by tumor necrosis factor-(alpha) rescues axotomized retinal ganglion cells from retrograde cell death in vivo. J Neurosci 2001; 21: 2058-2066.

2000

  • Klöcker N, Kermer P, Weishaupt JH, Labes M, Ankerhold R, Bähr M. Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3'-kinase/protein kinase B signaling. J Neurosci 2000; 20: 6962-6967.

1999

  • Nase G*, Weishaupt J*, Stern P, Singer W, Monyer H. Genetic and epigenetic regulation of NMDA receptor expression in the rat visual cortex. Eur J Neurosci 1999; 11: 4320-4326.(*) equal contribution

1997

  • Ying HS, Weishaupt JH, Grabb M, Canzoniero LM, Sensi SL, Sheline CT, Monyer H, Choi DW. Sublethal oxygen-glucose deprivation alters hippocampal neuronal AMPA receptor expression and vulnerability to kainate-induced death. J Neurosci 1997; 17: 9536-9544
  • Flint AC, Maisch US, Weishaupt JH, Kriegstein AR, Monyer H. NR2A subunit expression shortens NMDA receptor synaptic currents in developing neocortex. J Neurosci 1997; 17: 2469-2476.

Kontakt

Telefon 0731 500 63073

Telefax 0731 500 63050

Prof. Dr. Jochen H. Weishaupt
Neurology Department
Ulm University
Albert-Einstein-Allee 11
89081 Ulm
Germany