Clinical Neuroimaging

 

Clinical neuroimaging focuses on aspects of brain functioning that are relevant to the psychiatric clinic, and may be important for future translation of this kind of knowledge into clinical practice.

 

In the figure: a digital atlas of the frequency of occurrence of large vessels (arterial as well as venous), computed from a database of time-of-flight images, overlaid on a template structural image from the MNI. The digital atlas of vessels is freely available and can be found here.

 

Notwithstanding the enormous increase in knowledge brought about by the last 15-20 years of functional and structural neuroimaging studies, their translational impact on psychiatric practice has been modest. Translational neuroimaging may require rethinking the way we analyse data and develop specific statistical approaches (as opposed to applying techniques developed to localize functional activations). Our group is active in researching statistical techniques that are relevant to translation of neuroimaging into the clinic, such as the development and use of reference imaging databases and the identification of typical sources of variance in the population. We focus on innovative quantitative imaging modalities (such as arterial spin labelling) for the identification of the neural substrate of individual differences that may be of relevance for mental health, as those emerging from genetic polymorphisms or individual differences in spontaneous emotion regulation strategies.

 

The Clinical neuroimaging group is led jointly by

Ass.-Prof. (Univ. Innsbruck) Dr. Roberto Viviani, Department of Psychiatry and Psychotherapy III

Julia C. Stingl, MD, Department of Clinical Pharmacology and Clinical Products. 

 

Statistical analysis of imaging data

The statistical analysis of neuroimaging data is a challenging task. Typical imaging data cover the brain using over 200 000 voxels, whose activity is reciprocally related in complex ways. We focus on the design and analysis of studies using innovative imaging modalities such as perfusion or diffusion imaging. Read more...

 

Genetic and pharmacogenetic imaging

Perfusion imaging studies show differences in basal neural function in genes which may be related to monoaminergic function. Read more...

 

Individual differences in emotion regulation and cognition

Spontaneous regulation of emotions makes use of distinct brain circuits from those used to control emotion using voluntary efforts. Read more...

 

 

 

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