The study is the first to perform a combined analysis of viral distribution and the local immune response in human BoDV-1 encephalitis. Based on four fatal cases, we observed a regionally accentuated viral load, particularly in the basal ganglia and hippocampus, which was associated with lymphocytic infiltration as well as microglial and astrocytic activation. The findings indicate a pronounced innate immune response alongside comparatively limited adaptive immune signatures, which may contribute to insufficient viral clearance and severe tissue damage.
New Publication in the Field of Human Bornavirus Research
On May 14, 2026, our article “Multimodal Profiling of Immune Responses Reveals Innate-Adaptive Immune Imbalance in Human Bornavirus Encephalitis” was published in the journal Acta Neuropathologica Communications.
