Important publications

Huber-Lang M, Chen T, Halbgebauer R, Billiar T. Hallmarks of the multidimensional immune response to trauma in humans. Nat Immunol. 2026 Sep;27(9):1789-1803.

Messerer DAC, Müller P, Wohlgemuth L, Münnich F, Stukan L, Mohamed AOK, Hagemann JB, Koller AS, Jovanovski D, Lauer S, Traut R, Schöbel L, Thomaß BD, Münnich F, Barth E, Weiss M, Liebold A, Jungwirth B, Huber-Lang M. The cellular response capacity (CRC) as a novel immunomonitoring approach in sepsis. Mil Med Res. 2026 Dec;13(1):100010.

Halbgebauer R, Gonzalez-Ortiz F, Mayer B, Berger C, Bergmann C, Rinderknecht H, Barth E, Wohlgemuth L, Mannes M, Otto M, Tumani H, Relja B, Gebhard F, Huber-Lang M, Zetterberg H, Halbgebauer S, Blennow K. Blood-Based Analysis of Different Tau Variants in Patients With Multiple Traumatic Injuries. JAMA Netw Open. 2026 Feb 2;9(2):e2558573.

Halbgebauer R, Wohlgemuth L, Wrba J, Braumüller S, Kumral E, Lupu L, Morgenstern C, Bettac L, Wiese S, Mayer B, Cinelli P, Rittirsch D, Pape HC, Roselli F, Seufferlein T, Kleger A, Breunig M, Huber-Lang M. Remote Pancreatic Response to Severe Polytrauma Correlates With Clinical Outcome. United European Gastroenterol J. 2026 Feb;14(1):e70168.

Halbgebauer R, Schult L, Borgel O, Maes A, Weißhaupt F, Rastner C, Ast A, Lupu L, Palmer A, Wachter U, Schmidt SA, Boor P, Rösler R, Wiese S, Kerckhofs G, Huber-Lang MS. Pathophysiological response in trauma-related acute kidney injury after blunt thoracic trauma and hemorrhagic shock in male mice. Am J Physiol Renal Physiol. 2025 Aug 1;329(2):F311-F322. doi: 10.1152/ajprenal.00029.2025.

Karasu E, Halbgebauer R, Schütte L, Greven J, Bläsius FM, Zeller J, Winninger O, Braig D, Messerer DAC, Berger B, Feuerstein H, Schultze A, Peter K, Knippschild U, Horst K, Hildebrand F, Eisenhardt SU, Huber-Lang M. A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation. BMC Biol. 2025 Jan 7;23(1):4.

Mannes M, Dopler A, Zolk O, Lang SJ, Halbgebauer R, Höchsmann B, Skerra A, Braun CK, Huber-Lang M, Schrezenmeier H, Schmidt CQ. Complement inhibition at the level of C3 or C5: mechanistic reasons for ongoing terminal pathway activity. Blood. 2021 Jan 28;137(4):443-455. 

Messerer DAC, Halbgebauer R, Nilsson B, Pavenstädt H, Radermacher P, Huber-Lang M: Immunopathophysiology of trauma-related acute kidney injury. Nat Rev Nephrol. 2021 Feb;17(2):91-111.

Li S, Olde Heuvel F, Rehman R, Aousji O, Froehlich A, Li Z, Jark R, Zhang W, Conquest A, Woelfle S, Schoen M, O Meara CC, Reinhardt RL, Voehringer D, Kassubek J, Ludolph A, Huber-Lang M, Knöll B, Morganti-Kossmann MC, Brockmann MM, Boeckers T, Roselli F. Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection. Nat Commun. 2023 Jan 13;14(1):200.

Roselli F, Huber-Lang M: TREM1-ors shake the brain and gut after stroke. Nat Immunol 2019 Aug;20(8):950-952.

Biglarnia AR, Huber-Lang M, Mohlin C, Ekdahl KN, Nilsson B: The multifaceted role of complement in kidney transplantation. Nat Rev Nephrol 14: 767-781 (2018)

Huber-Lang M, Lambris JD, Ward PA: Innate immune responses to trauma. Nat Immunol 19: 327-341 (2018)

Denk S, Neher MD, Messerer DAC, Wiegner R, Nilsson B, Rittirsch D, Nilsson-Ekdahl K, Weckbach S, Ignatius A, Kalbitz M, Gebhard F, Weiss ME, Vogt J, Radermacher P, Kohl J, Lambris JD, Huber-Lang MS: Complement C5a Functions as a Master Switch for the pH Balance in Neutrophils Exerting Fundamental Immunometabolic Effects. J Immunol 198: 4846-4854 (2017)

Braig D, Nero TL, Koch HG, Kaiser B, Wang X, Thiele JR, Morton CJ, Zeller J, Kiefer J, Potempa LA, Mellett NA, Miles LA, Du XJ, Meikle PJ, Huber-Lang M, Stark GB, Parker MW, Peter K, Eisenhardt SU: Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites. Nat Commun 8: 14188 (2017)

Flierl MA, Rittirsch D, Nadeau BA, Chen AJ, Sarma JV, Zetoune FS, McGuire SR, List RP, Day DE, Hoesel LM, Gao H, Van RN, Huber-Lang MS, Neubig RR, Ward PA: Phagocyte-derived catecholamines enhance acute inflammatory injury. Nature 449: 721-725 (2007)

Huber-Lang M, Sarma JV, Zetoune FS, Rittirsch D, Neff TA, McGuire SR, Lambris JD, Warner RL, Flierl MA, Hoesel LM, Gebhard F, Younger JG, Drouin SM, Wetsel RA, Ward PA: Generation of C5a in the absence of C3: a new complement activation pathway. Nat Med 12: 682-687 (2006)

 

All publications on PubMed

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