2025
Lietz, S., Sokolowski, L.-M., Rodriguez-Alfonso, A. A., Ständker, L., Vogel, V., Spellerberg, B., Ernst, K., Papatheodorou, P.*, and Barth, H.* (2025). The antimicrobial peptide Angie 5 inhibits TcdA and TcdB from Clostridioides difficile. Cell. Mol. Life Sci. 82(1):265. doi: 10.1007/s00018-025-05799-2.
Xu, L., Silva, M. J. S. A., Coelho, J. A. S., Borho, J., Stadler, N., Barth, H., Kuan, S. L.*, and Weil, T*. (2025). Chemoselective dual functionalization of proteins via 1,6-addition of thiols to trifunctional N-alkylpyridinium. Nat. Commun. 16(1):5278. doi: 10.1038/s41467-025-60237-y
Neudek, K., Kunz, T., Barth, H., and Schmidt, H. (2025). Excess A-subunits of Shiga toxin 2a are produced in enterohemorrhagic Escherichia coli. Sci Rep. 15(1):16712. doi: 10.1038/s41598-025-01342-2. PMID: 40368985.
Duweb, A., Schmiech, M., Ulrich, J., Abdel-Kahaar, E., Pfeiffer, M., El Gaafary, M., Barth, H., Simmet, T., and Syrovets, T. (2025). Comparative analysis of micellar and native formulations of Boswellia serrata oleogum extracts in T-cell-receptor-activated lymphocytes. Biomed. Pharmacother. Mar 28:186:118009. doi: 10.1016/j.biopha.2025.118009.
2024
Caniglia, C., Valavanis, D., Tezcan, G., Magiera, J., Barth, H., Bansmann, J., Kranz, C., and Unwin, P. R. (2024). Antimicrobial effects of silver nanoparticle-microspots on the mechanical properties of single bacteria. Analyst. 2024 Mar 26. doi: 10.1039/d4an00174e.
Ramm, F.§,*, Kaser, D.§, König, I., Fellendorf, J., Wenzel, D., Zemella, A., Papatheodorou, P., Barth, H., and Schmidt, H.* (2024). Synthesis of biologically active Shiga toxins in cell-free systems. Sci. Rep. 2024 Mar 13;14(1):6043. doi: 10.1038/s41598-024-56190-3.
Jia, J.§, Zoeschg, M.§, Barth, H., Pulliainen A. T., and Ernst, K. (2024). The chaperonin TRiC/CCT inhibitor HSF1A protects cells from intoxication with pertussis toxin. Toxins 2024, 16 (1), 36; doi.org/10.3390/toxins16010036.
Papatheodorou, P., Minton, N. P., Aktories, K., and Barth, H. (2024). An updated view on the cellular uptake and mode-of-action of Clostridioides difficile toxins. Adv. Exp. Med. Biol. 2024; 1435:219-247. doi: 10.1007/978-3-031-42108-2_11. PMID: 38175478.
2023
Barth, H.*, Worek, F., Steinritz, D., Papatheodorou, P., and Huber-Lang, M.* (2023). Trauma-Toxicology: Concepts, Causes, Complications. Naunyn-Schmiedeberg's Arch. Pharmacol. doi: 10.1007/s00210-023-02845-3.
Schmid, R., Volcic, M., Fischer, S., Qu, Z., Barth, H., Popat, A., Kirchhoff, F., and Lindén, M. (2023). Surface functionalisation affects the retention and bio-distribution of orally administered mesoporous silica nanoparticles in a colitis mouse model. Sci. Rep. 13(1):20175. doi: 10.1038/s41598-023-47445-6.
Teuber, A., Caniglia, G., Barth, H., Kranz, C., and Mizaikoff, B. (2023). Thin-film waveguide laser spectroscopy: a novel platform for bacterial analysis. Anal Chem. 95(45):16600-16608. doi: 10.1021/acs.analchem.3c02782. Epub 2023 Oct 26.
Schumacher, J., Nienhaus, A., Heber, S., Matylitsky, J., Chaves-Olarte, E., Rodríguez, C., Barth, H.*, and Papatheodorou, P.* (2023). Exploring the inhibitory potential of the antiarrhythmic drug Amiodarone against Clostridioides difficile toxins TcdA and TcdB. Gut and Microbes. 15(2):2256695. doi: 10.1080/19490976.2023.2256695. Epub 2023 Sep 25.
Kling, C., Sommer, A., Almeida-Hernandez, Y., Rodríguez, A., Pérez-Erviti, J. A., Bhadane, R., Ständker, L., Wiese, S., Barth, H., Pupo-Meriño, M., Pulliainen, A. T., Sanchez-Garcia, E., and Ernst, K. (2023). Inhibition of pertussis toxin by α-defensin-1 and -5: Differential mechanisms of action. Int. J. Mol. Sci. 2023 Jun 23;24(13):10557. doi: 10.3390/ijms241310557.
Heber, S.§, Borho, J.§, Stadler, N., Wondany, F., König, I., Michaelis, J., Papatheodorou, P., Barth,H.*, and Fellermann, M.* (2023). The Clostridium botulinum C2 toxin subunit C2IIa delivers enzymes with positively charged N-termini into the cytosol of target cells. Toxins 15(6), 390; doi.org/10.3390/toxins15060390.
Jia, J., Braune-Yan, M., Lietz, S., Wahba, M., Pulliainen, A. T., Barth, H., and Ernst, K. (2023). Domperidone inhibits Clostridium botulinum C2 toxin and Bordetella pertussis toxin. Toxins 15(7), 412. doi: 10.3390/toxins15070412.
Braune-Yan, M., Jia, J., Wahba, M., Schmid, J., Papatheodorou, P., Barth, H., and Ernst, K. (2023). Hsp70 is required for the cellular uptake of Clostridioides difficile toxin TcdB. Toxins 15(6), 384. doi: 10.3390/toxins15060384.
Gierse, M., Nagel, L., Keim, M., Lucas, S., Speidel, T., Lobmeyer, T., Winter, G., Josten, F., Karaali, S., Fellermann, M., Scheuer, J., Müller, C., van Heijster, F., Skinner, J., Löffler, J., Parker, A., Handwerker, J., Marshall, A., El-Kassem, B., Vassiliou, C., Blanchard, J. W., Eills, J., Barth, H., Jelezko, F., Rasche, V., Schilling, F., Schwartz, I., and Knecht, S. (2023). Parahydrogen-polarised fumarate for preclinical in vivo metabolic magnetic resonance imaging. J. Am. Chem. Soc. 15;145(10):5960-5969. doi: 10.1021/jacs.2c13830.
2022
Bajrami, D., Fischer, S., Barth, H., Hossain, S.I., Cioffi, N., and Mizaikoff, B. (2022). Antimicrobial efficiency of chitosan and its methylated derivative against Lentilactobacillus parabuchneri biofilms. Molecules. 2022 Dec 7;27(24):8647. doi: 10.3390/molecules27248647.
Caniglia, G., Teuber, A., Barth, H., Mizaikoff, B., and Kranz, C. (2022). Atomic force and infrared spectroscopic studies on the role of surface charge for the anti-biofouling properties of polydopamine films. Anal. Bioanal. Chem. 2022 Nov 24. doi: 10.1007/s00216-022-04431-7.
Fellermann, M., Stemmer, M., Noschka, R., Wondany, F., Fischer, S., Michaelis, J., Stenger, S., and Barth, H. (2022). Clostridium botulinum C3 toxin for selective delivery of cargo into dendritic cells and macrophages. Toxins 2022, 14(10), 711; doi.org/10.3390/toxins14100711.
Bajrami, D., Fischer, S., Barth, H., Sarquis, M.A., Ladero, V.M., García, M.F., Sportelli, M.C., Cioffi, N., Kranz, C., and Mizaikoff, B. (2022). In situ monitoring of Lactobacillus parabuchneri biofilm formation via real-time infrared spectroscopy. NPJ Biofilms and Microbiomes 2022 Nov 19;8(1):92. doi: 10.1038/s41522-022-00353-5.
Caniglia, G., Sportelli, M.C., Heinzmann, A., Picca, R.A., Valentini, A., Barth, H., Mizaikoff, B., Cioffi, B., and Kranz, C. (2022). Silver-fluoropolymer (Ag-CFX) films: kinetic study of silver release, and spectroscopic-microscopic insight into the inhibition of P. fluorescens biofilm formation. Analytical Chimica Acta. 1212:339892. doi: 10.1016/j.aca.2022.339892.
Sessler, K, Schmidt, H., and Barth, H. (2022). Novel aspects of the SubA subunit of the subtilase cytotoxin. Toxins. 14, 156. doi: 10.3390/toxins14020156.
Barthold, L., Heber, S., Schmidt, C.Q., Gradl, M., Weidinger, G., Barth, H.*, and Fischer, S.* (2022). Human α-Defensin-6 neutralises Clostridioides difficile toxins TcdA and TcdB by direct binding. Int. J. Mol. Sci. 23, 4509.
Eisele, J.§, Schreiner, S.§, Borho, J.§, Fischer, S., Heber, S., Endres, S., Fellermann, M., Wohlgemuth, L., Huber-Lang, M., Fois, G., Fauler, M., Frick, M,, and Barth, H. (2022). The pore-forming subunit C2IIa of the binary Clostridium botulinum C2 toxin reduces the chemotactic translocation of human polymorphonuclear leukocytes. Front. Pharmacol. 11 February 2022 | doi.org/10.3389/fphar.2022.810611.
Heber, S., Barthold, L., Baier, J., Papatheodorou, P., Fois, G., Frick, M., Barth, H.*, and Fischer, S.* (2022). Inhibition of Clostridioides difficile toxins TcdA and TcdB by Ambroxol. Front. Pharmacol. 12:809595.doi: 10.3389/fphar.2021.809595. eCollection 2021.
Naskar, N., Liu, W., Qi, H., Stumper, A., Fischer, S., Diemant, T., Behm, R.J., Kaiser, U., Rau, S., Weil, T., and Chakrabortty, S. (2022). A carbon nanodot based near-infrared photosensitizer with a protein-ruthenium shell for low-power photodynamic applications. ACS Appl. Mater. Interfaces. 2022 Nov 2;14(43):48327-48340. doi: 10.1021/acsami.2c08585.
Ernst, K. (2022). Novel strategies to inhibit Pertussis toxin. Toxins (Basel). 2022 Mar 3;14(3):187. doi: 10.3390/toxins14030187.
Ernst, K. (2022). Requirement of peptidyl-prolyl Cis/Trans isomerases and chaperones for cellular uptake of bacterial AB-type toxins. Front. Cell Infect. Microbiol. 2022 Aug 4;12:938015. doi: 10.3389/fcimb.2022.938015.
2021
Papatheodorou, P.*, Kindig, S., Badilla-Lobo, A., Fischer, S., Durgun, E., Thuraisingam, T., Witte, A., Song, S., Aktories, K, Chavez-Olarte, E., Rodriguez, C., and Barth, H. (2021). The compound U18666A inhibits the intoxication of cells by Clostridioides difficile toxins TcdA and TcdB. Front. Microbiol. doi: 10.3389/fmicb.2021.784856.
Hirschenberger, M., Stadler, N., Fellermann, M., Sparrer, K.M.J., Kirchhoff, F., Barth, H.*, and Papatheodorou, P.* CRISPA: A non-viral, transient Cas9 delivery system based on reengineered anthrax toxin. Front. Pharmacol.12:770283. doi: 10.3389/fphar.2021.770283.
Kling, C., Pulliainen, A. T., Barth, H., and Ernst, K. (2021). Human peptides α-defensin-1 and -5 inhibit pertussis toxin. Toxins 13:480. doi.org/10.3390/toxins13070480.
Ernst, K.*,§, Landenberger, M.§, Nieleand, J., Nørgaard, K., Frick, M., Fois, G., Benz, R., and Barth, H.* (2021). Characterisation and pharmacological inhibition of the pore-forming Clostridioides difficile CDTb toxin. Toxins13:390. doi.org/10.3390/toxins13060390.
Heinisch, L., Krause, M., Roth, A., Barth, H., and Schmidt, H. (2021). Cytotoxic effects of recombinant StxA2-His in absence of its corresponding B-subunit. Toxins13(5):307. doi: 10.3390/toxins13050307.
Wu, Y., Alam, M.N.A., Balasubramanian, P., Ermakova, A., Fischer, S., Barth, H., Wagner, M., Raabe, M., Jelezko, F., and Weil, T. (2021): Nanodiamond theranostic for light-controlled intracellular heating and nanoscale temperature sensing. Nano Letters. doi: 10.1021/acs.nanolett.1c00043.
Landenberger, M.§, Nieland, J.§, Roeder, M., Nørgaard, M., Papatheodorou, P., Ernst, K.*, and Barth, H. (2021). The cytotoxic effect of Clostridioides difficile pore-forming toxin CDTb. Biochim. Biophys. Acta Biomembr. 1863(6):183603.
Ernst, K.§,*, Mittler, A.-K.§, Winkelmann, V., Kling, C.,Eberhardt, N., Anastasia, A., Sonnabend, M., Lochbaum, R., Wirsching, J., Sakari, M., Pulliainen, A. T., Skerry, C., Carbonetti, N. H., Frick, M., and Barth, H.* (2021). Pharmacological targeting of host chaperones protects from pertussis toxin in vitro and in vivo. Sci. Rep. 11(1):5429.
Sessler, K., Papatheodorou, P., Wondany, F., Krause, M., Noettger, S., Bernhardt, D., Michaelis, J., Schmidt, H., and Barth, H. (2021).The enzyme subunit SubA of E. coli subtilase cytotoxin demonstrates comparable intracellular transport and cytotoxic activity as the holotoxin SubAB. Arch. Toxicol. 95(3):975-983.