Originalarbeiten der AG Barth der letzten 5 Jahre

Sportelli, M.C., Caniglia, G., Izzi, M., Picca, R.A., Heber, S., Barth, H., Mizaikoff, B., Cioffi, N., and Kranz, C. (2026) Study of the synergistic antimicrobial effect of Cu/Chitosan composite materials on Escherichia coli. ACS Omega. doi.org/10.1021/acsomega.6c03637.

Qi, J., Li, W., Dheenadayalan, R. P., Yordanov Yosifov, D., Drewes, C., Wist, M., Wieczorek, M., Schmid, V., Hobeika, E., Gao, X., Endres, S., Schneider, C., Riecke, A., Barth, H., Gierschik, P., Siebert, R., Tausch, E., Stilgenbauer, S., Jebaraj, B.M.C.J. (2026). PLCG2 Exon-Skipped Variants: Insights into Their Potential Role in Chronic Lymphocytic Leukemia. Blood Adv. Jun :bloodadvances.2025019077. doi: 10.1182/bloodadvances.2025019077.

Lietz, S., Barth, H. (2026). The battle against pertussis: Exploitation of endogenous proteins as toxin-inhibitors. (Review).  Toxins (Basel). 2026 Apr 29;18(5):208. doi: 10.3390/toxins18050208.

Lietz, S., Barth, H. (2026). Novel endogenous protein-based strategies to inhibit clinically relevant bacterial AB-type toxins including pertussis toxin. (Review). Arch Toxicol. 2026 Apr 17. doi: 10.1007/s00204-026-04372-5.

Kistermann, S.^§, Heber, S.^§, Fischer, S., Sichau, J., Schmidt, C. Q., Mannes, M., Huber-Lang, M., Barth, H. (2026). A host defense role for fibrinogen by direct binding of Clostridium botulinum C2 toxin. Cell Mol Life Sci. 2026 May 19;83(1):208. doi: 10.1007/s00018-026-06253-7.

König, I., Oßwald, K., Schneider, L., Barth, H., Papatheodorou, P. (2026). Pharmacological inhibition of host cell neddylation reduces intoxication of cells by Diphtheria toxin and clostridial enterotoxins TcdB and C2. Microbiol Spectr. 2026 Apr 2;14(5):e0387225. doi: 10.1128/spectrum.03872-25.

Stadler, N., Gao, B., Silva, M. J., Borho, J., Haunschild, E., Koynov, K., Haffner-Luntzer, M., Ignatius, A., Weidinger, G., Kuan, S. L., Weil, T., Barth, H. (2025). Multifunctional peptide-based biohybrid for targeted reduction of metastatic breast carcinoma-associated osteolysis. J. Funct. Biomater. 16(11), 399. doi.org/10.3390/jfb16110399.

Lietz, S., Sokolowski, L.-M., Beyschlag, A., Siewert, A., Rodríguez, A. A., Preising, N., Ständker, L., Wiese, S., Köhler, J., Weidinger, G., Münch, J., Pulliainen, A. T., Ernst, K., Barth, H. (2025). An endogenous human peptide derived from α1-antitrypsin as novel pharmacological inhibitor of Bordetella pertussis toxin. Naunyn-Schmiedeberg’s Arch. Pharmacol. Nov 17. doi: 10.1007/s00210-025-04744-1.

Heber, S., Zeller, L., Fischer, S., Kistermann, S., Papatheodorou, P., Barth, H. (2025). Pentasaccharide anticoagulant Fondaparinux inhibits diphtheria toxin. Biomed. Pharmacother. 192:118705. doi: 10.1016/j.biopha.2025.118705.

Lietz, S., Sokolowski, L.-M., Rodriguez-Alfonso, A. A., Ständker, L., Vogel, V., Spellerberg, B., Ernst, K., Papatheodorou, P.*, and Barth, H.* (2025). The antimicrobial peptide Angie 5 inhibits TcdA and TcdB from Clostridioides difficile. Cell. Mol. Life Sci. 82(1):265. doi: 10.1007/s00018-025-05799-2.

Xu, L., Silva, M. J. S. A., Coelho, J. A. S., Borho, J., Stadler, N., Barth, H., Kuan, S. L.*, and Weil, T*. (2025). Chemoselective dual functionalization of proteins via 1,6-addition of thiols to trifunctional N-alkylpyridinium. Nat. Commun. 16(1):5278. doi: 10.1038/s41467-025-60237-y

Neudek, K., Kunz, T., Barth, H., and Schmidt, H. (2025). Excess A-subunits of Shiga toxin 2a are produced in enterohemorrhagic Escherichia coli. Sci Rep. 15(1):16712. doi: 10.1038/s41598-025-01342-2. PMID: 40368985.

Duweb, A., Schmiech, M., Ulrich, J., Abdel-Kahaar, E., Pfeiffer, M., El Gaafary, M., Barth, H., Simmet, T., and Syrovets, T. (2025). Comparative analysis of micellar and native formulations of Boswellia serrata oleogum extracts in T-cell-receptor-activated lymphocytes. Biomed. Pharmacother. Mar 28:186:118009. doi: 10.1016/j.biopha.2025.118009.

Lietz, S., Sommer, A., Sokolowski L.-M., Kling, C., Rodriguez Alfonso, A. A., Preising, N., Alpizar-Pedraza, D., King, J., Streit, L., Schröppel, B., van Erp, R., Barth, E., Schneider, M., Münch, J., Michaelis, J., Ständker, L., Wiese, S., Barth, H*, Pulliainen, A. T., Scanlon, K., and Ernst, K.* Alpha-1 antitrypsin inhibits pertussis toxin. J. Biol. Chem. 300(12):107950. doi: 10.1016/j.jbc.2024.107950.

Lietz, S., Sokolowski, L.-M., Barth, H.*, and Ernst, K.*. Alpha-1 antitrypsin inhibits Clostridium botulinum C2 toxin, Corynebacterium diphtheriae diphtheria toxin and Bacillus anthracis fusion toxin. Sci. Rep. 14(1):21257. doi: 10.1038/s41598-024-71706-7.

Borho, J., Kögel, M., Eckert, A., and Barth, H. (2024). Repurposing FDA-approved disulfiram for targeted inhibition of diphtheria toxin and the binary protein toxins of Clostridium botulinum and Bacillus anthracis. Front. Pharmacol. 15:1455696. doi: 10.3389/fphar.2024.1455696.

Freisem, D., Rodriguez-Alfonso A. A., Lawrenz, J., Zhou, Z., Monecke, T., Preising, N., Endres, S., Wiese, S., Ständker, L., Kuan, S.-H., Weil, T., Niessing, D., Barth, H., Kirchhoff, F., Harms, M., Münch, J., and Sparrer, K. M. J. (2024). A naturally occurring 22-amino acid fragment of human hemoglobin A inhibits autophagy and HIV-1. Cell. Mol. Life Sci.

Jia, J., Lietz, S. Pulliainen, A. T., Barth, H.*, and Ernst, K.* (2024). The antiarrhythmic drugs amiodarone and dronedarone inhibit intoxication of cells with pertussis toxin. Naunyn-Schmiedeberg’s Arch. Pharmacol. 2024. doi: 10.1007/s00210-024-03247-9.

Matylitsky, J., Krieg, A., Schumacher, J., Borho, J., Barth, H.*, and Papatheodorou, P.* (2024). Inhibition of Clostridioides difficile toxins TcdA and TcdB by the Amiodarone derivative Dronedarone. Naunyn-Schmiedeberg’s Arch. Pharmacol. 2024. doi: 10.1007/s00210-024-03248-8.

Caniglia, C., Valavanis, D., Tezcan, G., Magiera, J., Barth, H., Bansmann, J., Kranz, C., and Unwin, P. R. (2024). Antimicrobial effects of silver nanoparticle-microspots on the mechanical properties of single bacteria. Analyst. 2024 Mar 26. doi: 10.1039/d4an00174e.

Ramm, F.^§,*, Kaser, D.^§, König, I., Fellendorf, J., Wenzel, D., Zemella, A., Papatheodorou, P., Barth, H., and Schmidt, H.* (2024). Synthesis of biologically active Shiga toxins in cell-free systems. Sci. Rep. 2024 Mar 13;14(1):6043. doi: 10.1038/s41598-024-56190-3.

Jia, J.^§, Zoeschg, M.^§, Barth, H., Pulliainen A. T., and Ernst, K. (2024). The chaperonin TRiC/CCT inhibitor HSF1A protects cells from intoxication with pertussis toxin. Toxins 2024, 16 (1), 36; doi.org/10.3390/toxins16010036

Papatheodorou, P., Minton, N. P., Aktories, K., and Barth, H. (2024). An updated view on the cellular uptake and mode-of-action of Clostridioides difficile toxins. Adv. Exp. Med. Biol. 2024; 1435:219-247. doi: 10.1007/978-3-031-42108-2_11. PMID: 38175478.

Barth, H.*, Worek, F., Steinritz, D., Papatheodorou, P., and Huber-Lang, M.* (2023). Trauma-Toxicology: Concepts, Causes, Complications. Naunyn-Schmiedeberg’s Arch. Pharmacol. doi: 10.1007/s00210-023-02845-3.

Schmid, R., Volcic, M., Fischer, S., Qu, Z., Barth, H., Popat, A., Kirchhoff, F., and Lindén, M. (2023). Surface functionalization affects the retention and bio-distribution of orally administered mesoporous silica nanoparticles in a colitis mouse model. Sci. Rep. 13(1):20175. doi: 10.1038/s41598-023-47445-6.

Teuber, A., Caniglia, G., Barth, H., Kranz, C., and Mizaikoff, B. (2023). Thin-film waveguide laser spectroscopy: a novel platform for bacterial analysis. Anal Chem. 95(45):16600-16608. doi: 10.1021/acs.analchem.3c02782. Epub 2023 Oct 26.

Schumacher, J., Nienhaus, A., Heber, S., Matylitsky, J., Chaves-Olarte, E., Rodríguez, C., Barth, H.*, and Papatheodorou, P.* (2023). Exploring the inhibitory potential of the antiarrhythmic drug Amiodarone against Clostridioides difficile toxins TcdA and TcdB. Gut and Microbes. 15(2):2256695. doi: 10.1080/19490976.2023.2256695. Epub 2023 Sep 25.

Kling, C., Sommer, A., Almeida-Hernandez, Y., Rodríguez, A., Pérez-Erviti, J. A., Bhadane, R., Ständker, L., Wiese, S., Barth, H., Pupo-Meriño, M., Pulliainen, A. T., Sanchez-Garcia, E., and Ernst, K. (2023). Inhibition of Pertussis toxin by α-defensin-1 and -5: Differential mechanisms of action. Int. J. Mol. Sci. 2023 Jun 23;24(13):10557. doi: 10.3390/ijms241310557.

Heber, S.^§, Borho, J.^§, Stadler, N., Wondany, F., König, I., Michaelis, J., Papatheodorou, P., Barth,H.*, and Fellermann, M.* (2023). The Clostridium botulinum C2 Toxin subunit C2IIa delivers enzymes with positively charged N-termini into the cytosol of target cells. Toxins 15(6), 390; doi.org/10.3390/toxins15060390.

Jia, J., Braune-Yan, M., Lietz, S., Wahba, M., Pulliainen, A. T., Barth, H., and Ernst, K. (2023). Domperidone inhibits Clostridium botulinum C2 toxin and Bordetella pertussis toxin. Toxins 15(7), 412. doi: 10.3390/toxins15070412.

Braune-Yan, M., Jia, J., Wahba, M., Schmid, J., Papatheodorou, P., Barth, H., and Ernst, K. (2023). Hsp70 is required for the cellular uptake of Clostridioides difficile toxin TcdB. Toxins 15(6), 384. doi: 10.3390/toxins15060384.

Gierse, M., Nagel, L., Keim, M., Lucas, S., Speidel, T., Lobmeyer, T., Winter, G., Josten, F., Karaali, S., Fellermann, M., Scheuer, J., Müller, C., van Heijster, F., Skinner, J., Löffler, J., Parker, A., Handwerker, J., Marshall, A., El-Kassem, B., Vassiliou, C., Blanchard, J. W., Eills, J., Barth, H., Jelezko, F., Rasche, V., Schilling, F., Schwartz, I., and Knecht, S. (2023). Parahydrogen-polarized fumarate for preclinical in vivo metabolic magnetic resonance imaging. J. Am. Chem. Soc. 15;145(10):5960-5969. doi: 10.1021/jacs.2c13830.

Bajrami, D., Fischer, S., Barth, H., Hossain, S.I., Cioffi, N., and Mizaikoff, B. (2022). Antimicrobial efficiency of chitosan and its methylated derivative against Lentilactobacillus parabuchneri biofilms. Molecules. 2022 Dec 7;27(24):8647. doi: 10.3390/molecules27248647.

Caniglia, G., Teuber, A., Barth, H., Mizaikoff, B., and Kranz, C. (2022). Atomic force and infrared spectroscopic studies on the role of surface charge for the anti-biofouling properties of polydopamine films. Anal. Bioanal. Chem. 2022 Nov 24. doi: 10.1007/s00216-022-04431-7.

Fellermann, M., Stemmer, M., Noschka, R., Wondany, F., Fischer, S., Michaelis, J., Stenger, S., and Barth, H. (2022). Clostridium botulinum C3 toxin for selective delivery of cargo into dendritic cells and macrophages. Toxins 2022, 14(10), 711; doi.org/10.3390/toxins14100711.

Bajrami, D., Fischer, S., Barth, H., Sarquis, M.A., Ladero, V.M., García, M.F., Sportelli, M.C., Cioffi, N., Kranz, C., and Mizaikoff, B. (2022). In situ monitoring of Lactobacillus parabuchneri biofilm formation via real-time infrared spectroscopy. NPJ Biofilms and Microbiomes 2022 Nov 19;8(1):92. doi: 10.1038/s41522-022-00353-5.

Caniglia, G., Sportelli, M.C., Heinzmann, A., Picca, R.A., Valentini, A., Barth, H., Mizaikoff, B., Cioffi, B., and Kranz, C. (2022). Silver-fluoropolymer (Ag-CFX) films: kinetic study of silver release, and spectroscopic-microscopic insight into the inhibition of P. fluorescens biofilm formation. Analytical Chimica Acta. 1212:339892. doi: 10.1016/j.aca.2022.339892.

Sessler, K,, Schmidt, H., and Barth, H. (2022). Novel aspects of the SubA subunit of the subtilase cytotoxin. Toxins. 14, 156. doi: 10.3390/toxins14020156.

Barthold, L., Heber, S., Schmidt, C.Q., Gradl, M., Weidinger, G., Barth, H.*, and Fischer, S.* (2022). Human α-Defensin-6 neutralizes Clostridioides difficile toxins TcdA and TcdB by direct binding. Int. J. Mol. Sci. 23, 4509.

Eisele, J.^§, Schreiner, S.^§, Borho, J.^§, Fischer, S., Heber, S., Endres, S., Fellermann, M., Wohlgemuth, L., Huber-Lang, M., Fois, G., Fauler, M., Frick, M,, and Barth, H. (2022). The pore-forming subunit C2IIa of the binary Clostridium botulinum C2 toxin reduces the chemotactic translocation of human polymorphonuclear leukocytes. Front. Pharmacol. 11 February 2022 | doi.org/10.3389/fphar.2022.810611.

Heber, S., Barthold, L., Baier, J., Papatheodorou, P., Fois, G., Frick, M., Barth, H.*, and Fischer, S.* (2022). Inhibition of Clostridioides difficile toxins TcdA and TcdB by Ambroxol. Front. Pharmacol. 12:809595.doi: 10.3389/fphar.2021.809595. eCollection 2021.

Naskar, N., Liu, W., Qi, H., Stumper, A., Fischer, S., Diemant, T., Behm, R.J., Kaiser, U., Rau, S., Weil, T., and Chakrabortty, S. (2022). A carbon nanodot based near-infrared photosensitizer with a protein-ruthenium shell for low-power photodynamic applications. ACS Appl. Mater. Interfaces. 2022 Nov 2;14(43):48327-48340. doi: 10.1021/acsami.2c08585.

Ernst, K. (2022). Novel strategies to inhibit Pertussis toxin. Toxins (Basel). 2022 Mar 3;14(3):187. doi: 10.3390/toxins14030187.

Ernst, K. (2022). Requirement of Peptidyl-Prolyl Cis/Trans isomerases and chaperones for cellular uptake of bacterial AB-type toxins. Front. Cell Infect. Microbiol. 2022 Aug 4;12:938015. doi: 10.3389/fcimb.2022.938015.