Originalarbeiten der AG Barth der letzten 5 Jahre

Barth, H.*, Worek, F., Steinritz, D., Papatheodorou, P., and Huber-Lang, M.* (2023). Trauma-Toxicology: Concepts, Causes, Complications. Naunyn-Schmiedeberg’s Arch. Pharmacol. doi: 10.1007/s00210-023-02845-3.

Schmid, R., Volcic, M., Fischer, S., Qu, Z., Barth, H., Popat, A., Kirchhoff, F., and Lindén, M. (2023). Surface functionalization determines the fate of mesoporous silica nanoparticles in the inflamed gastro-intestinal tract of mice. Sci. Rep. 13(1):20175. doi: 10.1038/s41598-023-47445-6.

Teuber, A., Caniglia, G., Barth, H., Kranz, C., and Mizaikoff, B. (2023). Thin-film waveguide based quantum cascade laser spectroscopy: a novel bacterial sensing platform. Anal Chem. 95(45):16600-16608. doi: 10.1021/acs.analchem.3c02782. Epub 2023 Oct 26.

Schumacher, J., Nienhaus, A., Heber, S., Matylitsky, J., Chaves-Olarte, E., Rodríguez, C., Barth, H.*, and Papatheodorou, P.* (2023). Exploring the inhibitory potential of the antiarrhythmic drug Amiodarone against Clostridioides difficile toxins TcdA and TcdB. Gut and Microbes. 15(2):2256695. doi: 10.1080/19490976.2023.2256695. Epub 2023 Sep 25.

Kling, C., Sommer, A., Almeida-Hernandez, Y., Rodríguez, A., Pérez-Erviti, J. A., Bhadane, R., Ständker, L., Wiese, S., Barth, H., Pupo-Meriño, M., Pulliainen, A. T., Sanchez-Garcia, E., and Ernst, K. (2023). Inhibition of Pertussis toxin by α-defensin-1 and -5: Differential mechanisms of action. Int. J. Mol. Sci. 2023 Jun 23;24(13):10557. doi: 10.3390/ijms241310557.

Heber, S.^§, Borho, J.^§, Stadler, N., Wondany, F., König, I., Michaelis, J., Papatheodorou, P., Barth,H.*, and Fellermann, M.* (2023). The Clostridium botulinum C2 Toxin subunit C2IIa delivers enzymes with positively charged N-termini into the cytosol of target cells. Toxins 15(6), 390; doi.org/10.3390/toxins15060390.

Jia, J., Braune-Yan, M., Lietz, S., Wahba, M., Pulliainen, A. T., Barth, H., and Ernst, K. (2023). Domperidone inhibits Clostridium botulinum C2 toxin and Bordetella pertussis toxin. Toxins 15(7), 412. doi: 10.3390/toxins15070412.

Braune-Yan, M., Jia, J., Wahba, M., Schmid, J., Papatheodorou, P., Barth, H., and Ernst, K. (2023). Hsp70 is required for the cellular uptake of Clostridioides difficile toxin TcdB. Toxins 15(6), 384. doi: 10.3390/toxins15060384.

Gierse, M., Nagel, L., Keim, M., Lucas, S., Speidel, T., Lobmeyer, T., Winter, G., Josten, F., Karaali, S., Fellermann, M., Scheuer, J., Müller, C., van Heijster, F., Skinner, J., Löffler, J., Parker, A., Handwerker, J., Marshall, A., El-Kassem, B., Vassiliou, C., Blanchard, J. W., Eills, J., Barth, H., Jelezko, F., Rasche, V., Schilling, F., Schwartz, I., and Knecht, S. (2023). Parahydrogen-polarized fumarate for preclinical in vivo metabolic magnetic resonance imaging. J. Am. Chem. Soc. 15;145(10):5960-5969. doi: 10.1021/jacs.2c13830.

Bajrami, D., Fischer, S., Barth, H., Hossain, S.I., Cioffi, N., and Mizaikoff, B. (2022). Antimicrobial efficiency of chitosan and its methylated derivative against Lentilactobacillus parabuchneri biofilms. Molecules. 2022 Dec 7;27(24):8647. doi: 10.3390/molecules27248647.

Caniglia, G., Teuber, A., Barth, H., Mizaikoff, B., and Kranz, C. (2022). Atomic force and infrared spectroscopic studies on the role of surface charge for the anti-biofouling properties of polydopamine films. Anal. Bioanal. Chem. 2022 Nov 24. doi: 10.1007/s00216-022-04431-7.

Fellermann, M., Stemmer, M., Noschka, R., Wondany, F., Fischer, S., Michaelis, J., Stenger, S., and Barth, H. (2022). Clostridium botulinum C3 toxin for selective delivery of cargo into dendritic cells and macrophages. Toxins 2022, 14(10), 711; doi.org/10.3390/toxins14100711.

Bajrami, D., Fischer, S., Barth, H., Sarquis, M.A., Ladero, V.M., García, M.F., Sportelli, M.C., Cioffi, N., Kranz, C., and Mizaikoff, B. (2022). In situ monitoring of Lactobacillus parabuchneri biofilm formation via real-time infrared spectroscopy. NPJ Biofilms and Microbiomes 2022 Nov 19;8(1):92. doi: 10.1038/s41522-022-00353-5.

Caniglia, G., Sportelli, M.C., Heinzmann, A., Picca, R.A., Valentini, A., Barth, H., Mizaikoff, B., Cioffi, B., and Kranz, C. (2022). Silver-fluoropolymer (Ag-CFX) films: kinetic study of silver release, and spectroscopic-microscopic insight into the inhibition of P. fluorescens biofilm formation. Analytical Chimica Acta. 1212:339892. doi: 10.1016/j.aca.2022.339892.

Sessler, K,, Schmidt, H., and Barth, H. (2022). Novel aspects of the SubA subunit of the subtilase cytotoxin. Toxins. 14, 156. doi: 10.3390/toxins14020156.

Barthold, L., Heber, S., Schmidt, C.Q., Gradl, M., Weidinger, G., Barth, H.*, and Fischer, S.* (2022). Human α-Defensin-6 neutralizes Clostridioides difficile toxins TcdA and TcdB by direct binding. Int. J. Mol. Sci. 23, 4509.

Eisele, J.^§, Schreiner, S.^§, Borho, J.^§, Fischer, S., Heber, S., Endres, S., Fellermann, M., Wohlgemuth, L., Huber-Lang, M., Fois, G., Fauler, M., Frick, M,, and Barth, H. (2022). The pore-forming subunit C2IIa of the binary Clostridium botulinum C2 toxin reduces the chemotactic translocation of human polymorphonuclear leukocytes. Front. Pharmacol. 11 February 2022 | doi.org/10.3389/fphar.2022.810611.

Heber, S., Barthold, L., Baier, J., Papatheodorou, P., Fois, G., Frick, M., Barth, H.*, and Fischer, S.* (2022). Inhibition of Clostridioides difficile toxins TcdA and TcdB by Ambroxol. Front. Pharmacol. 12:809595.doi: 10.3389/fphar.2021.809595. eCollection 2021.

Naskar, N., Liu, W., Qi, H., Stumper, A., Fischer, S., Diemant, T., Behm, R.J., Kaiser, U., Rau, S., Weil, T., and Chakrabortty, S. (2022). A carbon nanodot based near-infrared photosensitizer with a protein-ruthenium shell for low-power photodynamic applications. ACS Appl. Mater. Interfaces. 2022 Nov 2;14(43):48327-48340. doi: 10.1021/acsami.2c08585.

Ernst, K. (2022). Novel strategies to inhibit Pertussis toxin. Toxins (Basel). 2022 Mar 3;14(3):187. doi: 10.3390/toxins14030187.

Ernst, K. (2022). Requirement of Peptidyl-Prolyl Cis/Trans isomerases and chaperones for cellular uptake of bacterial AB-type toxins. Front. Cell Infect. Microbiol. 2022 Aug 4;12:938015. doi: 10.3389/fcimb.2022.938015.

Papatheodorou, P.*, Kindig, S., Badilla-Lobo, A., Fischer, S., Durgun, E., Thuraisingam, T., Witte, A., Song, S., Aktories, K, Chavez-Olarte, E., Rodriguez, C., and Barth, H. (2021). The compound U18666A inhibits the intoxication of cells by Clostridioides difficile toxins TcdA and TcdB. Front. Microbiol. doi: 10.3389/fmicb.2021.784856.

Hirschenberger, M., Stadler, N., Fellermann, M., Sparrer, K.M.J., Kirchhoff, F., Barth, H.*, and Papatheodorou, P.* CRISPA: A non-viral, transient Cas9 delivery system based on reengineered anthrax toxin. Front. Pharmacol.12:770283. doi: 10.3389/fphar.2021.770283.

Kling, C., Pulliainen, A. T., Barth, H., and Ernst, K. (2021). Human peptides α-defensin-1 and -5 inhibit pertussis toxin. Toxins 13:480. doi.org/10.3390/toxins13070480.

Ernst, K.*^,§, Landenberger, M.^§, Nieleand, J., Nørgaard, K., Frick, M., Fois, G., Benz, R., and Barth, H.* (2021). Characterization and pharmacological inhibition of the pore-forming Clostridioides difficile CDTb toxin. Toxins13:390. doi.org/10.3390/toxins13060390.

Heinisch, L., Krause, M., Roth, A., Barth, H., and Schmidt, H. (2021). Cytotoxic effects of recombinant StxA2-His in absence of its corresponding B-subunit. Toxins13(5):307. doi: 10.3390/toxins13050307.  

Wu, Y., Alam, M.N.A., Balasubramanian, P., Ermakova, A., Fischer, S., Barth, H., Wagner, M., Raabe, M., Jelezko, F., and Weil, T. (2021): Nanodiamond theranostic for light-controlled intracellular heating and nanoscale temperature sensing. Nano Letters. doi: 10.1021/acs.nanolett.1c00043.    

Landenberger, M.^§, Nieland, J.^§, Roeder, M., Nørgaard, M., Papatheodorou, P., Ernst, K.*, and Barth, H. (2021). The cytotoxic effect of Clostridioides difficile pore-forming toxin CDTb. Biochim. Biophys. Acta Biomembr. 1863(6):183603.

Ernst, K.^§,*, Mittler, A.-K.^§, Winkelmann, V., Kling, C.,Eberhardt, N., Anastasia, A., Sonnabend, M., Lochbaum, R., Wirsching, J., Sakari, M., Pulliainen, A. T., Skerry, C., Carbonetti, N. H., Frick, M., and Barth, H.* (2021). Pharmacological targeting of host chaperones protects from pertussis toxin in vitro and in vivo. Sci. Rep. 11(1):5429.

Sessler, K., Papatheodorou, P., Wondany, F., Krause, M., Noettger, S., Bernhardt, D., Michaelis, J., Schmidt, H., and Barth, H. (2021).The enzyme subunit SubA of E. coli subtilase cytotoxin demonstrates comparable intracellular transport and cytotoxic activity as the holotoxin SubAB. Arch. Toxicol. 95(3):975-983.

Ernst, K.^§,*, Sailer, J.^§, and Barth, H.* (2020). Intoxication of mammalian cells with binary clostridial enterotoxins is inhibited by the combination of pharmacological chaperone inhibitors. Naunyn-Schmiedeberg’s Arch. Pharmacol. doi: 10.1007/s00210-020-02029-3.

Jansen, F., Lamla, M., Mauthe, D., Fischer, S., Barth, H., and Kuehne, A.J.C. (2020). Croconaine-based polymer particles as contrast agents for photoacoustic imaging. Macromol. Rapid. Commun.41(22):e2000418. 

Deusser, H., Groh, I., Bakuradze, T., Simson, N., Kaiser, E., Barth, H., and Richling, E. Are compounds membrane-associated or present in the cytosol? (2020). A study using polyphenols in a colon carcinoma cell line model. Curr. Pharmacol. Rep. 6(6). DOI:10.1007/s40495-020-00242-5

Fellermann, M., Huchler, C., Fechter, L., Kolb, T., Wondany, F., Mayer, D., Michaelis, J., Stenger, S., Mellert, K., Möller, P., Barth, T.F.E., Fischer, S.^*, and Barth, H.^* (2020). Clostridial C3 toxins enter and intoxicate human dendritic cells. Toxins 12(9):E563.

Korbmacher, M.^§, Fischer, S.^§,*, Landenberger, M., Papatheodorou, P., Aktories, K., and Barth,H.* (2020). Human α-defensin-5 efficiently neutralizes Clostridioides difficile toxins TcdA, TcdB, and CDT. Front. Pharmacol.11:1204. eCollection 2020.

Felix, I., Lomada, S. K., Barth, H.*, and Wieland, T.* (2020). Bacillus anthracis’ PA63 delivers the tumor metastasis suppressor protein NDPK-A/NME1 into breast cancer cells. Int. J. Mol. Sci.21(9):3295.

Fellermann, M.^§, Wondany, F.^§, Carle, S., Nemeth, J., Sadhanasatish, T., Frick, M., Barth, H.*, and Michaelis, J.* (2020).Super-resolution microscopy unveils transmembrane domain-mediated internalization of cross-reacting material 197 into diphtheria toxin-resistant mouse J774A.1 cells and primary rat fibroblasts in vitro. Arch. Toxicol. 94(5):1753-1761.

Fischer, S., Ückert, A.K., Landenberger, M., Papatheodorou, P., Hoffmann-Richter, C., Mittler, A.K., Ziener, U., Hägele, M., Schwan, C., Müller, M., Kleger, A., Benz, R., Popoff, M. R., Aktories, K., and Barth, H.(2020). Human peptide α-defensin-1 interferes with Clostridioides difficile toxins TcdA, TcdB, and CDT. FASEB J. 34(5):6244-6261.

Wu, Y., Boulogne, C., Carle, S., Podinovskaia, M., Barth, H., Spang, A., Cintrat, J.-C., Gillet, D., and Barbier, J. (2020). Regulation of endo-lysosomal pathway and autophagic flux by broad-spectrum anti-pathogen inhibitor ABMA. FEBS J. 287(15):3184-3199.

Krause, M., Sessler, K., Kaziales, A., Grahl, R., Noettger, S., Barth, H., and Schmidt, H. (2019). Variants of Escherichia coli subtilase cytotoxin subunits show differences in complex formation in vitro. Toxins11, 703.

Heck, A.J.^§, Ostertag, T.^§, Schnell, L., Fischer, S., Agrawalla, B.K., Winterwerber, P., Wirsching, E., Fauler, M., Frick, M., Kuan, S.L.*, Weil, T.*, and Barth, H.* (2019). Supramolecular toxin complexes for targeted pharmacological modulation of polymorphonuclear leukocyte functions. Adv. Healthcare Mater.8(17):e1900665.

Zhu, Z., Schnell, L., Müller, B, Müller, M., Papatheodorou, P., and Barth, H. (2019).The antibiotic bacitracin protects human intestinal epithelial cells and stem cell-derived intestinal organoids from Clostridium difficile toxin TcdB. Stem Cells Int. 2019:4149762.

Stenclova, P., Freisinger, S., Barth, H., Kromka, A., and Mizaikoff, B. (2019). Cyclic changes in the amide bands within Escherichia coli biofilms monitored by real-time infrared attenuated total reflection spectroscopy (IR-ATR). Appl. Spectroscopy. 73, 424-432.

Hoemme, A., Barth, H., Haschke, M., Krähenbühl, S., Strasser, F., Lehner, C., von Kameke, A., Wälti, T., Thürlimann, B., Früh, M., Driessen, C., and Joerger, C. (2019). Prognostic impact of polypharmacy and drug interactions in patients with advanced cancer. Cancer Chemother. Pharmacol.83, 763-774. 

Schnell, L., Felix, I., Müller, B., Sadi, M., von Bank, F., Papatheodorou, P., Popoff, M.R., Aktories, K., Waltenberger, E., Benz, R., Weichbrodt, C., Fauler, M., Frick, M., and Barth, H. (2019). Revisiting an old antibiotic: Bacitracin neutralizes binary bacterial toxins and protects cells from intoxication. FASEB J. 33, 5755-5771.

Gačanin, J., Hedrich, J., Sieste, S., Glaßer, G., Lieberwirth, I., Schilling, C., Fischer, S., Barth, H., Knöll, B., Synatschke, C.V.*, and Weil, T.* (2019). Autonomous ultra-fast self-healing hydrogels by pH-responsive functional nanofiber gelators as cell matrices. Adv. Mater. 31: e1805044.