Molecular and Familial Tumour Board (MoFa)
The Molecular and Familial Tumour Board (MoFa) is the heart of the ZPM Ulm. Here, the results of molecular diagnostics are jointly analysed and discussed by an interdisciplinary panel of experts consisting of oncologists, radiologists, human geneticists, molecular pathologists, bioinformaticians/systems medicine specialists, molecular biologists and pharmacologists (optional). It is discussed whether certain molecular changes in the tumour can form the basis for a therapy or whether there is a possibility of inclusion in a therapy study.
MoFa Board
Date: Wednesday,
fortnightly,
11:30 to approx. 13:00
Participation: Via video conference for cooperation partners
Patient registration:
Send the required documents
to the CCCU secretariat by fax or post
Address: Comprehensive Cancer Centre Ulm (CCCU)
Secretariat
Albert-Einstein-Allee 23
89081 Ulm
Tel: 0731 500-56056
Fax: 0731 500-56055
E-mail: sekr.cccu@uniklinik-ulm.de
Alternatively: Possibility of personal presentation of the
patient by making an appointment in the corresponding
university outpatient clinic of the University Hospital
Admission criteria and required documents
When will there be a performance at MoFa?
- Patients with rare or
advanced tumours
- Systemic treatment is indicated
- Approved therapies are no longer available for this
indication
- Molecular genetic testing
should be performed or is planned
Your treating oncologist will assess whether you fulfil the approval criteria
.
What documents are required?
- Registration form MoFa
- Organ board decision
- Current doctor's letter including course and details
of previous therapies
- Histology of the primary tumour and histological
findings during the course (if available)
- If applicable, imaging (findings with CD) - If applicable, findings of a previous molecular genetic examination - Research consent (broad consent). Imaging (findings with CD)
- If applicable, findings of a previous molecular
genetic test
- Research consent
(broad consent, registry studies)
All forms for registration in the MoFa and for recommendation for participation in the model project genome sequencing
in accordance with § 64e SGB V can be found here.
Procedure of the Molecular and Familial Tumour Board
Registration of patients:
In the case of external practitioners , by sending the required documents to the CCCU secretariat by fax or post. Alternatively, patients can be seen in person at the relevant university outpatient clinic at Ulm University Hospital (UKU) by appointment.
After the patient documents have been checked for completeness, registration at the MoFa is carried out by the staff at the ZPMU.
In the case of internal patients, this is done by the doctors at the UKU.
Initial presentation at the MoFa: Recommendation of molecular pathological and genetic diagnostics. Participation of regional practitioners is possible via video conference.
After the initial presentation and after each re-presentation in the MoFa, a board decision is made after approval by the head board physician.
Re-presentation at the MoFa: Evaluation of the findings after the analyses have been carried out. If a treatment rationale is present, a treatment recommendation is issued. It is also checked whether the patient can be included in a clinical trial.
In the case of an off-label therapy recommendation:
In the case of internal registration, a standardised cost coverage application is submitted by the ZPMU.
In the case of external enrolment, support from the ZPMU is optional.
Therapy is carried out after approval of the application:
Internally at the UKU.
Externally usually by the co-operation partner, alternatively at the UKU.
Re-presentation at the MoFa:
If therapy is implemented, approx. every 3 months for therapy evaluation.
Specialist disciplines involved
- Clinic for Dermatology and Allergology
- Clinic for Diagnostic and Interventional Radiology
- Clinic for Gynaecology and Obstetrics
- Clinic for Ear, Nose and Throat Medicine
- Clinic for Cardiac, Thoracic and Vascular Surgery
- Clinic for Internal Medicine I
- Clinic for Internal Medicine II
- Clinic for Internal Medicine III
- Clinic for Paediatrics and Adolescent Medicine
- Clinic for Neurosurgery
- Clinic for Neurology
- Clinic for Nuclear Medicine
- Clinic for Radiotherapy and Radiooncology
- Clinic for Urology and Paediatric Urology
- Comprehensive Cancer Centre Ulm (CCCU)
- Institute of Epidemiology and Medical Biometry, University of Ulm
- Institute for Experimental Tumour Research
- Institute of Human Genetics
- Institute of Immunology
- Institute for Medical Systems Biology, University of Ulm
- Institute of Molecular Oncology and Stem Cell Biology (IMOS)
- Institute of Pathology
- Centre for Imaging
- Centre for Clinical Studies
- Centre for Rare Diseases
- CCCU co-operation partners
- ZPMU co-operation partners