Prof. Dr. biol. hum. Uwe Knippschild

Dipl. Biologe (1989)

Promotion (1992)

Habilitation (2000)

Umhabilitation (2002)

Ernennung zum apl Professor (2008)

Onkologische Forschung

Schwerpunkt Signaltransduktion, Tumorsuppressoren, Onkogene; Proteinkinasen insbesondere CK1

Förderung durch Deutsche Krebshilfe und DFG

Bischof, J., M.A. Westhoff, J.E. Wagner, M.E. Halatsch, S. Trentmann, U. Knippschild, C.R. Wirtz, and T. Burster, Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells. Tumor Biology, 2017. 39(3). epub

Dolde, C., J. Bischof, S. Gruter, A. Montada, J. Halekotte, C. Peifer, H. Kalbacher, U. Baumann, U. Knippschild, and B. Suter, The RNA helicase activity of DDX§X is controlled by CK1epsilon to be a solely CK1 kinase activator. Journal of Cell Science, 2017

Fohr, K.J., U. Knippschild, A. Herkommer, M. Fauler, C. Peifer, M. Georgieff, and O. Adolph, State-dependent block of voltage-gated sodium channels by the casein-kinase 1 inhibitor IC261. Investigational New Drugs, 2017. 35(3): p. 277-289.epub

Halekotte, J., L. Witt, C. Ianes, M. Kruger, M. Buhrmann, D. Rauh, C. Pichlo, E. Brunstein, A. Luxenburger, U. Baumann, U. Knippschild, J. Bischof, and C. Peifer, Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1 delta and Their Structural Relation to p38 alpha MAPK. Molecules, 2017. 22(4).epub

Kretz, A.L., M. Schaum, J. Richter, E.F. Kitzig, C.C. Engler, F. Leithauser, D. Henne-Bruns, U. Knippschild, and J. Lemke, CDK9 is a prognostic marker and therapeutic target in pancreatic cancer. Tumor Biology, 2017. 39(2).epub

Rupakova, N.A., V.A. Bakulev, U. Knippschild, B. Garcia-Reyes, O.S. Eltsov, G.P. Slesarev, N. Beliaev, P.A. Slepukhin, L. Witt, C. Peifer, and T.V. Beryozkina, Design and synthesis of N-benzimidazol-2-yl-N'-sulfonyl acetamidines. Arkivoc, 2017: p. 225-240. epub

Traub, B., L. Sun, Y.S. Ma, P.F. Xu, J. Lemke, S. Paschke, D. Henne-Bruns, U. Knippschild, and M. Kornmann, Endogenously Expressed IL-4R alpha Promotes the Malignant Phenotype of Human Pancreatic Cancer In Vitro and In Vivo. International Journal of Molecular Sciences, 2017. 18(4). epub

Wolff, S., Z.Y. Xiao, M. Wittau, N. Sussner, M. Stoter, and U. Knippschild, Iinteraction of casein kinase 1 delta (CK1 'delta') with the light chain LC2 of microtubule associated protein 1A (MAP1A) (vol 1745, pg 196, 2005). Biochimica Et Biophysica Acta-Molecular Cell Research, 2017. 1864(10): p. 1923-1923. epub

Ianes, C., P. Xu, N. Werz, Z. Meng, D. Henne-Bruns, J. Bischof, and U. Knippschild, CK1delta activity is modulated by CDK2/E- and CDK5/p35-mediated phosphorylation. Amino Acids, 2016. 48(2): p. 579-92.epub

Kruger, M., H. Kalbacher, P.L. Kastritis, J. Bischof, H. Barth, D. Henne-Bruns, C. Vorgias, S. Sarno, L.A. Pinna, and U. Knippschild, New potential peptide therapeutics perturbing CK1delta/alpha-tubulin interaction. Cancer Lett, 2016. 375(2): p. 375-83. epub

Meng, Z., J. Bischof, C. Ianes, D. Henne-Bruns, P. Xu, and U. Knippschild, CK1delta kinase activity is modulated by protein kinase C alpha (PKCalpha)-mediated site-specific phosphorylation. Amino Acids, 2016. epub

Richter, J., S. Rudeck, A.L. Kretz, K. Kramer, S. Just, D. Henne-Bruns, A. Hillenbrand, F. Leithauser, J. Lemke, and U. Knippschild, Decreased CK1delta expression predicts prolonged survival in colorectal cancer patients. Tumour Biol, 2016. epub

Stracquadanio, G., B. Vrugt, R. Flury, P. Schraml, P. Wurl, T.H. Muller, U. Knippschild, D. Henne-Bruns, S. Breitenstein, P.A. Clavien, R. Graf, G.L. Bond, and L.F. Grochola, CD44 SNP rs187115: A novel biomarker signature that predicts survival in resectable pancreatic ductal adenocarcinoma. Clin Cancer Res, 2016. epub

Udelnow, A., D. Henne-Bruns, U. Knippschild, W. Halangk, C. Bruns, Z. Halloul, P. Wurl, and L.F. Grochola, MDM2 SNP 309G Allele Is Associated With Younger Age at Surgery in Chronic Pancreatitis Patients. Pancreas, 2016. 45(4): p. e11-2. epub

Yokoyama, S., M. Higashi, S. Kitamoto, M. Oeldorf, U. Knippschild, M. Kornmann, K. Maemura, H. Kurahara, E. Wiest, T. Hamada, I. Kitazono, Y. Goto, T. Tasaki, T. Hiraki, K. Hatanaka, Y. Mataki, H. Taguchi, S. Hashimoto, S.K. Batra, A. Tanimoto, S. Yonezawa, and M.A. Hollingsworth, Aberrant methylation of MUC1 and MUC4 promoters are potential prognostic biomarkers for pancreatic ductal adenocarcinomas. Oncotarget, 2016.epub

Hillenbrand, A., B. Kiebler, C. Schwab, L. Scheja, P. Xu, D. Henne-Bruns, A.M. Wolf, and U. Knippschild, Prevalence of non-alcoholic fatty liver disease in four different weight related patient groups: association with small bowel length and risk factors. BMC Res Notes, 2015. 8: p. 290.epub

Kramer, K., U. Knippschild, B. Mayer, K. Bogelspacher, H. Spatz, D. Henne-Bruns, A. Agaimy, M. Schwab, and M. Schmieder, Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumor (GIST). BMC Cancer, 2015. 15(1): p. 1054.epub

Kramer, K., S. Wolf, B. Mayer, S.A. Schmidt, A. Agaimy, D. Henne-Bruns, U. Knippschild, M. Schwab, and M. Schmieder, Frequence, spectrum and prognostic impact of additional malignancies in patients with gastrointestinal stromal tumors. Neoplasia, 2015. 17(1): p. 134-40.epub

Lott, S., M. Schmieder, B. Mayer, D. Henne-Bruns, U. Knippschild, A. Agaimy, M. Schwab, and K. Kramer, Gastrointestinal stromal tumors of the esophagus: evaluation of a pooled case series regarding clinicopathological features and clinical outcome. Am J Cancer Res, 2015. 5(1): p. 333-43.epub

Rozin, Y., S. Zhidovinov, T. Beryozkina, Y. Shafran, G. Lubec, O. Eltsov, P. Slepukhin, U. Knippschild, J. Bischof, W. Dehaen, and V. Bakulev, A novel transformation of ß- 1,2,3-thiadiazol-5-yl enamines into thienol[2,3-d]pyridazines. Tetrahedron Letters, 2015. 56: p. 1545-1547

Winkler, B.S., F. Oltmer, J. Richter, J. Bischof, P. Xu, T. Burster, F. Leithauser, and U. Knippschild, CK1delta in lymphoma: gene expression and mutation analyses and validation of CK1delta kinase activity for therapeutic application. Front Cell Dev Biol, 2015. 3: p. 9. epub

Wolff, S., B. García-Reyes, D. Henne-Bruns, J. Bischof, and U. Knippschild, Protein kinase CK1 interacts with and phosphorylates RanBPM in vitro. Journal of Molecular Biochemistry 2015. 4: p. 11-19. epub

Xu, P., P. Fischer-Posovszky, J. Bischof, P. Radermacher, M. Wabitsch, D. Henne-Bruns, A.M. Wolf, A. Hillenbrand, and U. Knippschild, Gene expression levels of Casein kinase 1 (CK1) isoforms are correlated to adiponectin levels in adipose tissue of morbid obese patients and site-specific phosphorylation mediated by CK1 influences multimerization of adiponectin. Mol Cell Endocrinol, 2015. 406: p. 87-101. epub

Efimov, I., V. Bakulev, N. Beliaev, T. Beryozkina, U. Knippschild, J. Leban, F. Zhi-Jin, O. Eltsov, P. Slepukhin, M. Ezhikova, and W. Dehaen, Reactions of ß-Azolylenamines with Sulfonyl Azides as an Approach to N-Unsubstituted 1,2,3-Triazoles and Ethene-1,2-diamines. EurJOC, 2014. 15: p. 1-7

Haselmann, V., A. Kurz, U. Bertsch, S. Hubner, M. Olempska-Muller, J. Fritsch, R. Hasler, A. Pickl, H. Fritsche, F. Annewanter, C. Engler, B. Fleig, A. Bernt, C. Roder, H. Schmidt, C. Gelhaus, C. Hauser, J.H. Egberts, C. Heneweer, A.M. Rohde, C. Boger, U. Knippschild, C. Rocken, D. Adam, H. Walczak, S. Schutze, O. Janssen, F.G. Wulczyn, H. Wajant, H. Kalthoff, and A. Trauzold, Nuclear death receptor TRAIL-R2 inhibits maturation of let-7 and promotes proliferation of pancreatic and other tumor cells. Gastroenterology, 2014. 146(1): p. 278-90. epub

Knippschild, U., M. Kruger, J. Richter, P. Xu, B. Garcia-Reyes, C. Peifer, J. Halekotte, V. Bakulev, and J. Bischof, The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis. Front Oncol, 2014. 4: p. 96. epub

Radermacher, P., M. Huber-Lang, U. Knippschild, and C. Thiemermann, The obesity paradox revisited: does increased body mass protect against circulatory shock? Shock, 2014. 41(6): p. 554-5. epub

Richter, J., J. Bischof, M. Zaja, H. Kohlhof, O. Othersen, D. Vitt, V. Alscher, I. Pospiech, B. Garcia-Reyes, S. Berg, J. Leban, and U. Knippschild, Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1delta and epsilon with nanomolar inhibitory activity on cancer cell proliferation. J Med Chem, 2014. 57(19): p. 7933-46. epub

Richter, J., K. Ullah, P. Xu, V. Alscher, A. Blatz, C. Peifer, J. Halekotte, J. Leban, D. Vitt, K. Holzmann, V. Bakulev, L.A. Pinna, D. Henne-Bruns, A. Hillenbrand, M. Kornmann, F. Leithauser, J. Bischof, and U. Knippschild, Effects of altered expression and activity levels of CK1delta and varepsilon on tumor growth and survival of colorectal cancer patients. Int J Cancer, 2014. epub

Shin, A.C., M. Fasshauer, N. Filatova, L.A. Grundell, E. Zielinski, J.Y. Zhou, T. Scherer, C. Lindtner, P.J. White, A.L. Lapworth, O. Ilkayeva, U. Knippschild, A.M. Wolf, L. Scheja, K.L. Grove, R.D. Smith, W.J. Qian, C.J. Lynch, C.B. Newgard, and C. Buettner, Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism. Cell Metab, 2014. 20(5): p. 898-909. epub

Stoter, M., M. Kruger, G. Banting, D. Henne-Bruns, and U. Knippschild, Microtubules depolymerization caused by the CK1 inhibitor IC261 may be not mediated by CK1 blockage. PLoS One, 2014. 9(6): p. e100090. epub

Bischof, J., S.J. Randoll, N. Sussner, D. Henne-Bruns, L.A. Pinna, and U. Knippschild, CK1delta Kinase Activity Is Modulated by Chk1-Mediated Phosphorylation. PLoS One, 2013. 8(7): p. e68803. epub

Eissing, L., T. Scherer, K. Todter, U. Knippschild, J.W. Greve, W.A. Buurman, H.O. Pinnschmidt, S.S. Rensen, A.M. Wolf, A. Bartelt, J. Heeren, C. Buettner, and L. Scheja, De novo lipogenesis in human fat and liver is linked to ChREBP-beta and metabolic health. Nature Communications, 2013

Hafner, S., A. Hillenbrand, U. Knippschild, and P. Radermacher, The obesity paradox and acute kidney injury: beneficial effects of hyper-inflammation? Crit Care, 2013. 17(6): p. 1023. epub

Kornfeld, J.W., C. Baitzel, A.C. Konner, H.T. Nicholls, M.C. Vogt, K. Herrmanns, L. Scheja, C. Haumaitre, A.M. Wolf, U. Knippschild, J. Seibler, S. Cereghini, J. Heeren, M. Stoffel, and J.C. Bruning, Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b. Nature, 2013. 494(7435): p. 111-5. epub

Wang, J.C., M. Thiere, D. Henne-Bruns, U. Knippschild, and M. Kornmann, Inhibition of pancreatic cancer cell growth in vivo using a tetracycline-inducible cyclin D1 antisense expression system. Pancreas, 2013. 42(1): p. 141-8. epub

Bischof, J., J. Leban, M. Zaja, A. Grothey, B. Radunsky, O. Othersen, S. Strobl, D. Vitt, and U. Knippschild, 2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide derivatives as potent inhibitors of CK1delta/epsilon. Amino Acids, 2012. 43: p. 577-91. Epub 2012 Feb 14. epub

Hillenbrand, A., J. Fassler, X.P. Huber N., D. Henne-Bruns, M. Templin, H. Schrezenmeier, A. Wolf, and U. Knippschild, Changed adipocytokine concentrations in colorectal tumor patients and morbidly obese patients compared to healthy controls. BMC Cancer, 2012 epub

Hillenbrand, A., M. Weiss, U. Knippschild, A.M. Wolf, and M. Huber-Lang, Sepsis-Induced Adipokine Change with regard to Insulin Resistance. Int J Inflam, 2012. 2012: p. 972368. epub

Hirner, H., C. Gunes, J. Bischof, S. Wolff, A. Grothey, M. Kuhl, F. Oswald, F. Wegwitz, M.R. Bosl, A. Trauzold, D. Henne-Bruns, C. Peifer, F. Leithauser, W. Deppert, and U. Knippschild, Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo. PLoS One, 2012. 7(1): p. e29709. epub

Knippschild, U., C. Peifer, J. Bischof, and K. Kramer, Other tryosine kinase inhibitors in development and further directions. In Emerging tyrosine kinase inhibitors for gastrointestinal stromal tumor Future medicine LTD, 2012: p. 50-63

Kumar, M., B. Witt, U. Knippschild, S. Koch, J.K. Meena, C. Heinlein, J.M. Weise, F. Krepulat, F. Kuchenbauer, S. Iben, K.L. Rudolph, W. Deppert, and C. Gunes, CEBP factors regulate TERT promoter activity in WAP-T mice during mammary carcinogenesis. Int J Cancer, 2012. epub

Bischof, J., A. Muller, M. Fander, U. Knippschild, and D. Fischer, Neurite Outgrowth of Mature Retinal Ganglion Cells and PC12 Cells Requires Activity of CK1delta and CK1epsilon. PLoS One, 2011. 6(6): p. e20857. epub

Hillenbrand, A., M. Weiss, U. Knippschild, H.G. Stromeyer, D. Henne-Bruns, M. Huber-Lang, and A.M. Wolf, Association of adiponectin levels and insulin demand in critically ill patients. Diabetes Metab Syndr Obes, 2011. 4: p. 45-51. epub

Thal, D.R., K. Del Tredici, A.C. Ludolph, J.J. Hoozemans, A.J. Rozemuller, H. Braak, and U. Knippschild, Stages of granulovacuolar degeneration: their relation to Alzheimer's disease and chronic stress response. Acta Neuropathol, 2011. 122: p. 577-89. epub

Udelnow, A., A. Kreyes, S. Ellinger, K. Landfester, P. Walther, T. Klapperstueck, J. Wohlrab, D. Henne-Bruns, U. Knippschild, and P. Wurl, Omeprazole inhibits proliferation and modulates autophagy in pancreatic cancer cells. PLoS One, 2011. 6(5): p. e20143. epub

Wacker, S.A., C. Alvarado, G. von Wichert, U. Knippschild, J. Wiedenmann, K. Clauss, G.U. Nienhaus, H. Hameister, B. Baumann, T. Borggrefe, W. Knochel, and F. Oswald, RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J. EMBO J, 2011. 30(1): p. 43-56. epub

Dorn, J., H. Spatz, M. Schmieder, T.F. Barth, A. Blatz, D. Henne-Bruns, U. Knippschild, and K. Kramer, Cyclin H expression is increased in GIST with very-high risk of malignancy. BMC Cancer, 2010. 10(1): p. 350. epub

Giamas, G., Y.L. Man, H. Hirner, J. Bischof, K. Kramer, K. Khan, S.S. Lavina Ahmed, J. Stebbing, and U. Knippschild, Kinases as targets in the treatment of solid tumors. Cellular Signalling, 2010. 22(7): p. 84-1002. epub

Hauk, T.G., M. Leibinger, A. Muller, A. Andreadaki, U. Knippschild, and D. Fischer, Stimulation of axon regeneration in the mature optic nerve by intravitreal application of the toll-like receptor 2 agonist Pam3Cys. Invest Ophthalmol Vis Sci, 2010. 51(1): p. 459-64. epub

Hillenbrand, A., U. Knippschild, M. Weiss, H. Schrezenmeier, D. Henne-Bruns, M. Huber-Lang, and A.M. Wolf, Sepsis induced changes of adipokines and cytokines - septic patients compared to morbidly obese patients. BMC Surg, 2010. 10: p. 26. epub

Utz, A.C., H. Hirner, A. Blatz, A. Hillenbrand, B. Schmidt, W. Deppert, D. Henne-Bruns, D. Fischer, D.R. Thal, F. Leithauser, and U. Knippschild, Analysis of cell type-specific expression of CK1 epsilon in various tissues of young adult BALB/c Mice and in mammary tumors of SV40 T-Ag-transgenic mice. J Histochem Cytochem, 2010. 58(1): p. 1-15. epub

Giamas, G., L. Castellano, Q. Feng, U. Knippschild, J. Jacob, R.S. Thomas, R.C. Coombes, C.L. Smith, L.R. Jiao, and J. Stebbing, CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions. Nucleic Acids Res, 2009. 37(9): p. 3110-23. epub

Lohler, J., H. Hirner, B. Schmidt, K. Kramer, D. Fischer, D.R. Thal, F. Leithauser, and U. Knippschild, Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice. PLoS One, 2009. 4(1): p. e4174. epub

Peifer, C., M. Abadleh, J. Bischof, D. Hauser, V. Schattel, H. Hirner, U. Knippschild, and S. Laufer, 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta. J Med Chem, 2009. 52(23): p. 7618-30. epub

Brockschmidt, C., H. Hirner, N. Huber, T. Eismann, A. Hillenbrand, G. Giamas, B. Radunsky, O. Ammerpohl, B. Bohm, D. Henne-Bruns, H. Kalthoff, F. Leithauser, A. Trauzold, and U. Knippschild, Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo. Gut, 2008. 57(6): p. 799-806. epub

Grochola, L.F., T. Greither, H. Taubert, P. Moller, U. Knippschild, A. Udelnow, D. Henne-Bruns, and P. Wurl, The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related death. Br J Cancer, 2008. 99(7): p. 1083-8. epub

Grochola, L.F., T. Greither, H.W. Taubert, P. Moller, U. Knippschild, A. Udelnow, D. Henne-Bruns, and P. Wurl, Prognostic relevance of hTERT mRNA expression in ductal adenocarcinoma of the pancreas. Neoplasia, 2008. 10(9): p. 973-6. epub

Kintscher, U., M. Hartge, K. Hess, A. Foryst-Ludwig, M. Clemenz, M. Wabitsch, P. Fischer-Posovszky, T.F. Barth, D. Dragun, T. Skurk, H. Hauner, M. Bluher, T. Unger, A.M. Wolf, U. Knippschild, V. Hombach, and N. Marx, T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vasc Biol, 2008. 28(7): p. 1304-10. epub

Schmieder, M., S. Wolf, B. Danner, S. Stoehr, M.S. Juchems, P. Wuerl, D. Henne-Bruns, U. Knippschild, C. Hasel, and K. Kramer, p16 expression differentiates high-risk gastrointestinal stromal tumor and predicts poor outcome. Neoplasia, 2008. 10(10): p. 1154-62. epub

Giamas, G., H. Hirner, L. Shoshiashvili, A. Grothey, S. Gessert, M. Kuhl, D. Henne-Bruns, C.E. Vorgias, and U. Knippschild, Phosphorylation of CK1delta: identification of Ser370 as the major phosphorylation site targeted by PKA in vitro and in vivo. Biochem J, 2007. 406(3): p. 389-98. epub

Giamas, G., J. Stebbing, C.E. Vorgias, and U. Knippschild, Protein kinases as targets for cancer treatment. Pharmacogenomics, 2007. 8(8): p. 1005-16. epub

von Blume, J., U. Knippschild, F. Dequiedt, G. Giamas, A. Beck, A. Auer, J. Van Lint, G. Adler, and T. Seufferlein, Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2. EMBO J, 2007. 26(22): p. 4619-33. epub

Wolff, S., M. Stoter, G. Giamas, M. Piesche, D. Henne-Bruns, G. Banting, and U. Knippschild, Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin. FEBS Lett, 2006. 580(27): p. 6477-84. epub

Knippschild, U., A. Gocht, S. Wolff, N. Huber, J. Lohler, and M. Stoter, The casein kinase 1 family: participation in multiple cellular processes in eukaryotes. Cellulra Signalling, 2005. 17(6): p. 675-89. epub

Knippschild, U., S. Wolff, G. Giamas, C. Brockschmidt, M. Wittau, P.U. Wurl, T. Eismann, and M. Stoter, The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development. Onkologie, 2005. 28(10): p. 508-14. epub

Stoter, M., A.M. Bamberger, B. Aslan, M. Kurth, D. Speidel, T. Loning, H.G. Frank, P. Kaufmann, J. Lohler, D. Henne-Bruns, W. Deppert, and U. Knippschild, Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells. Oncogene, 2005. 24(54): p. 7964-75. epub

Wolff, S., Z. Xiao, M. Wittau, N. Sussner, M. Stoter, and U. Knippschild, Interaction of casein kinase 1 delta (CK1delta) with the light chain LC2 of microtubule associated protein 1A (MAP1A). Biochim Biophys Acta, 2005. 1745(2): p. 196-206. epub

Ventura, R.A., J.I. Martin-Subero, U. Knippschild, R.D. Gascoyne, G. Delsol, D.Y. Mason, and R. Siebert, Centrosome abnormalities in ALK-positive anaplastic large-cell lymphoma. Leukemia, 2004. 18(11): p. 1910-1. epub

Winter, M., D. Milne, S. Dias, R. Kulikov, U. Knippschild, C. Blattner, and D. Meek, Protein kinase CK1delta phosphorylates key sites in the acidic domain of murine double-minute clone 2 protein (MDM2) that regulate p53 turnover. Biochemistry, 2004. 43(51): p. 16356-64. epub

Maritzen, T., J. Lohler, W. Deppert, and U. Knippschild, Casein kinase I delta (CKIdelta) is involved in lymphocyte physiology. Eur J Cell Biol, 2003. 82(7): p. 369-78. epub

Martin-Subero, J.I., U. Knippschild, L. Harder, T.F. Barth, J. Riemke, S. Grohmann, S. Gesk, J. Hoppner, P. Moller, R.M. Parwaresch, and R. Siebert, Segmental chromosomal aberrations and centrosome amplifications: pathogenetic mechanisms in Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma? Leukemia, 2003. 17(11): p. 2214-9. epub

Meek, D.W. and U. Knippschild, Posttranslational modification of MDM2. Mol Cancer Res, 2003. 1(14): p. 1017-26. epub

Behrend, L., D.M. Milne, M. Stoter, W. Deppert, L.E. Campbell, D.W. Meek, and U. Knippschild, IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. Oncogene, 2000. 19(47): p. 5303-13. epub

Behrend, L., M. Stoter, M. Kurth, G. Rutter, J. Heukeshoven, W. Deppert, and U. Knippschild, Interaction of casein kinase 1 delta (CK1delta) with post-Golgi structures, microtubules and the spindle apparatus. Eur J Cell Biol, 2000. 79(4): p. 240-51. epub

Janus, F., N. Albrechtsen, U. Knippschild, L. Wiesmuller, F. Grosse, and W. Deppert, Different regulation of the p53 core domain activities 3'-to-5' exonuclease and sequence-specific DNA binding. Mol Cell Biol, 1999. 19(3): p. 2155-68. epub

Henning, W., G. Rohaly, T. Kolzau, U. Knippschild, H. Maacke, and W. Deppert, MDM2 is a target of simian virus 40 in cellular transformation and during lytic infection. J Virol, 1997. 71(10): p. 7609-18. epub

Knippschild, U., D.M. Milne, L.E. Campbell, A.J. DeMaggio, E. Christenson, M.F. Hoekstra, and D.W. Meek, p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs. Oncogene, 1997. 15(14): p. 1727-36. epub

Meek, D.W., L.E. Campbell, L.J. Jardine, U. Knippschild, L. McKendrick, and D.M. Milne, Multi-site phosphorylation of p53 by protein kinases inducible by p53 and DNA damage. Biochem Soc Trans, 1997. 25(2): p. 416-9. epub

Knippschild, U., D. Milne, L. Campbell, and D. Meek, p53 N-terminus-targeted protein kinase activity is stimulated in response to wild type p53 and DNA damage. Oncogene, 1996. 13(7): p. 1387-93. epub

Knippschild, U., M. Oren, and W. Deppert, Abrogation of wild-type p53 mediated growth-inhibition by nuclear exclusion. Oncogene, 1996. 12(8): p. 1755-65. epub

Sturzbecher, H.W., B. Donzelmann, W. Henning, U. Knippschild, and S. Buchhop, p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction. Embo J, 1996. 15(8): p. 1992-2002. epub

Knippschild, U., T. Kolzau, and W. Deppert, Cell-specific transcriptional activation of the mdm2-gene by ectopically expressed wild-type form of a temperature-sensitive mutant p53. Oncogene, 1995. 11(4): p. 683-90. epub

Zerrahn, J., U. Knippschild, T. Winkler, and W. Deppert, Independent expression of the transforming amino-terminal domain of SV40 large I antigen from an alternatively spliced third SV40 early mRNA. Embo J, 1993. 12(12): p. 4739-46. epub

Patschinsky, T., U. Knippschild, and W. Deppert, Species-specific phosphorylation of mouse and rat p53 in simian virus 40-transformed cells. J Virol, 1992. 66(6): p. 3846-59. epub

Deppert, W., M. Kurth, M. Graessmann, A. Graessmann, and U. Knippschild, Altered phosphorylation at specific sites confers a mutant phenotype to SV40 wild-type large T antigen in a flat revertant of SV40-transformed cells. Oncogene, 1991. 6(10): p. 1931-8. epub

Knippschild, U., J. Kiefer, T. Patschinsky, and W. Deppert, Phenotype-specific phosphorylation of simian virus 40 tsA mutant large T antigens in tsA N-type and A-type transformants. J Virol, 1991. 65(8): p. 4414-23. epub

Bischof, J., M.A. Westhoff, J.E. Wagner, M.E. Halatsch, S. Trentmann, U. Knippschild, C.R. Wirtz, and T. Burster, Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells. Tumor Biology, 2017. 39(3). epub

Dolde, C., J. Bischof, S. Gruter, A. Montada, J. Halekotte, C. Peifer, H. Kalbacher, U. Baumann, U. Knippschild, and B. Suter, The RNA helicase activity of DDX§X is controlled by CK1epsilon to be a solely CK1 kinase activator. Journal of Cell Science, 2017

Fohr, K.J., U. Knippschild, A. Herkommer, M. Fauler, C. Peifer, M. Georgieff, and O. Adolph, State-dependent block of voltage-gated sodium channels by the casein-kinase 1 inhibitor IC261. Investigational New Drugs, 2017. 35(3): p. 277-289.epub

Halekotte, J., L. Witt, C. Ianes, M. Kruger, M. Buhrmann, D. Rauh, C. Pichlo, E. Brunstein, A. Luxenburger, U. Baumann, U. Knippschild, J. Bischof, and C. Peifer, Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1 delta and Their Structural Relation to p38 alpha MAPK. Molecules, 2017. 22(4).epub

Kretz, A.L., M. Schaum, J. Richter, E.F. Kitzig, C.C. Engler, F. Leithauser, D. Henne-Bruns, U. Knippschild, and J. Lemke, CDK9 is a prognostic marker and therapeutic target in pancreatic cancer. Tumor Biology, 2017. 39(2).epub

Rupakova, N.A., V.A. Bakulev, U. Knippschild, B. Garcia-Reyes, O.S. Eltsov, G.P. Slesarev, N. Beliaev, P.A. Slepukhin, L. Witt, C. Peifer, and T.V. Beryozkina, Design and synthesis of N-benzimidazol-2-yl-N'-sulfonyl acetamidines. Arkivoc, 2017: p. 225-240. epub

Traub, B., L. Sun, Y.S. Ma, P.F. Xu, J. Lemke, S. Paschke, D. Henne-Bruns, U. Knippschild, and M. Kornmann, Endogenously Expressed IL-4R alpha Promotes the Malignant Phenotype of Human Pancreatic Cancer In Vitro and In Vivo. International Journal of Molecular Sciences, 2017. 18(4). epub

Wolff, S., Z.Y. Xiao, M. Wittau, N. Sussner, M. Stoter, and U. Knippschild, Iinteraction of casein kinase 1 delta (CK1 'delta') with the light chain LC2 of microtubule associated protein 1A (MAP1A) (vol 1745, pg 196, 2005). Biochimica Et Biophysica Acta-Molecular Cell Research, 2017. 1864(10): p. 1923-1923. epub

Ianes, C., P. Xu, N. Werz, Z. Meng, D. Henne-Bruns, J. Bischof, and U. Knippschild, CK1delta activity is modulated by CDK2/E- and CDK5/p35-mediated phosphorylation. Amino Acids, 2016. 48(2): p. 579-92.epub

Kruger, M., H. Kalbacher, P.L. Kastritis, J. Bischof, H. Barth, D. Henne-Bruns, C. Vorgias, S. Sarno, L.A. Pinna, and U. Knippschild, New potential peptide therapeutics perturbing CK1delta/alpha-tubulin interaction. Cancer Lett, 2016. 375(2): p. 375-83. epub

Meng, Z., J. Bischof, C. Ianes, D. Henne-Bruns, P. Xu, and U. Knippschild, CK1delta kinase activity is modulated by protein kinase C alpha (PKCalpha)-mediated site-specific phosphorylation. Amino Acids, 2016. epub

Richter, J., S. Rudeck, A.L. Kretz, K. Kramer, S. Just, D. Henne-Bruns, A. Hillenbrand, F. Leithauser, J. Lemke, and U. Knippschild, Decreased CK1delta expression predicts prolonged survival in colorectal cancer patients. Tumour Biol, 2016. epub

Stracquadanio, G., B. Vrugt, R. Flury, P. Schraml, P. Wurl, T.H. Muller, U. Knippschild, D. Henne-Bruns, S. Breitenstein, P.A. Clavien, R. Graf, G.L. Bond, and L.F. Grochola, CD44 SNP rs187115: A novel biomarker signature that predicts survival in resectable pancreatic ductal adenocarcinoma. Clin Cancer Res, 2016. epub

Udelnow, A., D. Henne-Bruns, U. Knippschild, W. Halangk, C. Bruns, Z. Halloul, P. Wurl, and L.F. Grochola, MDM2 SNP 309G Allele Is Associated With Younger Age at Surgery in Chronic Pancreatitis Patients. Pancreas, 2016. 45(4): p. e11-2. epub

Yokoyama, S., M. Higashi, S. Kitamoto, M. Oeldorf, U. Knippschild, M. Kornmann, K. Maemura, H. Kurahara, E. Wiest, T. Hamada, I. Kitazono, Y. Goto, T. Tasaki, T. Hiraki, K. Hatanaka, Y. Mataki, H. Taguchi, S. Hashimoto, S.K. Batra, A. Tanimoto, S. Yonezawa, and M.A. Hollingsworth, Aberrant methylation of MUC1 and MUC4 promoters are potential prognostic biomarkers for pancreatic ductal adenocarcinomas. Oncotarget, 2016.epub

Hillenbrand, A., B. Kiebler, C. Schwab, L. Scheja, P. Xu, D. Henne-Bruns, A.M. Wolf, and U. Knippschild, Prevalence of non-alcoholic fatty liver disease in four different weight related patient groups: association with small bowel length and risk factors. BMC Res Notes, 2015. 8: p. 290.epub

Kramer, K., U. Knippschild, B. Mayer, K. Bogelspacher, H. Spatz, D. Henne-Bruns, A. Agaimy, M. Schwab, and M. Schmieder, Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumor (GIST). BMC Cancer, 2015. 15(1): p. 1054.epub

Kramer, K., S. Wolf, B. Mayer, S.A. Schmidt, A. Agaimy, D. Henne-Bruns, U. Knippschild, M. Schwab, and M. Schmieder, Frequence, spectrum and prognostic impact of additional malignancies in patients with gastrointestinal stromal tumors. Neoplasia, 2015. 17(1): p. 134-40.epub

Lott, S., M. Schmieder, B. Mayer, D. Henne-Bruns, U. Knippschild, A. Agaimy, M. Schwab, and K. Kramer, Gastrointestinal stromal tumors of the esophagus: evaluation of a pooled case series regarding clinicopathological features and clinical outcome. Am J Cancer Res, 2015. 5(1): p. 333-43.epub

Rozin, Y., S. Zhidovinov, T. Beryozkina, Y. Shafran, G. Lubec, O. Eltsov, P. Slepukhin, U. Knippschild, J. Bischof, W. Dehaen, and V. Bakulev, A novel transformation of ß- 1,2,3-thiadiazol-5-yl enamines into thienol[2,3-d]pyridazines. Tetrahedron Letters, 2015. 56: p. 1545-1547

Winkler, B.S., F. Oltmer, J. Richter, J. Bischof, P. Xu, T. Burster, F. Leithauser, and U. Knippschild, CK1delta in lymphoma: gene expression and mutation analyses and validation of CK1delta kinase activity for therapeutic application. Front Cell Dev Biol, 2015. 3: p. 9. epub

Wolff, S., B. García-Reyes, D. Henne-Bruns, J. Bischof, and U. Knippschild, Protein kinase CK1 interacts with and phosphorylates RanBPM in vitro. Journal of Molecular Biochemistry 2015. 4: p. 11-19. epub

Xu, P., P. Fischer-Posovszky, J. Bischof, P. Radermacher, M. Wabitsch, D. Henne-Bruns, A.M. Wolf, A. Hillenbrand, and U. Knippschild, Gene expression levels of Casein kinase 1 (CK1) isoforms are correlated to adiponectin levels in adipose tissue of morbid obese patients and site-specific phosphorylation mediated by CK1 influences multimerization of adiponectin. Mol Cell Endocrinol, 2015. 406: p. 87-101. epub

Efimov, I., V. Bakulev, N. Beliaev, T. Beryozkina, U. Knippschild, J. Leban, F. Zhi-Jin, O. Eltsov, P. Slepukhin, M. Ezhikova, and W. Dehaen, Reactions of ß-Azolylenamines with Sulfonyl Azides as an Approach to N-Unsubstituted 1,2,3-Triazoles and Ethene-1,2-diamines. EurJOC, 2014. 15: p. 1-7

Haselmann, V., A. Kurz, U. Bertsch, S. Hubner, M. Olempska-Muller, J. Fritsch, R. Hasler, A. Pickl, H. Fritsche, F. Annewanter, C. Engler, B. Fleig, A. Bernt, C. Roder, H. Schmidt, C. Gelhaus, C. Hauser, J.H. Egberts, C. Heneweer, A.M. Rohde, C. Boger, U. Knippschild, C. Rocken, D. Adam, H. Walczak, S. Schutze, O. Janssen, F.G. Wulczyn, H. Wajant, H. Kalthoff, and A. Trauzold, Nuclear death receptor TRAIL-R2 inhibits maturation of let-7 and promotes proliferation of pancreatic and other tumor cells. Gastroenterology, 2014. 146(1): p. 278-90. epub

Knippschild, U., M. Kruger, J. Richter, P. Xu, B. Garcia-Reyes, C. Peifer, J. Halekotte, V. Bakulev, and J. Bischof, The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis. Front Oncol, 2014. 4: p. 96. epub

Radermacher, P., M. Huber-Lang, U. Knippschild, and C. Thiemermann, The obesity paradox revisited: does increased body mass protect against circulatory shock? Shock, 2014. 41(6): p. 554-5. epub

Richter, J., J. Bischof, M. Zaja, H. Kohlhof, O. Othersen, D. Vitt, V. Alscher, I. Pospiech, B. Garcia-Reyes, S. Berg, J. Leban, and U. Knippschild, Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1delta and epsilon with nanomolar inhibitory activity on cancer cell proliferation. J Med Chem, 2014. 57(19): p. 7933-46. epub

Richter, J., K. Ullah, P. Xu, V. Alscher, A. Blatz, C. Peifer, J. Halekotte, J. Leban, D. Vitt, K. Holzmann, V. Bakulev, L.A. Pinna, D. Henne-Bruns, A. Hillenbrand, M. Kornmann, F. Leithauser, J. Bischof, and U. Knippschild, Effects of altered expression and activity levels of CK1delta and varepsilon on tumor growth and survival of colorectal cancer patients. Int J Cancer, 2014. epub

Shin, A.C., M. Fasshauer, N. Filatova, L.A. Grundell, E. Zielinski, J.Y. Zhou, T. Scherer, C. Lindtner, P.J. White, A.L. Lapworth, O. Ilkayeva, U. Knippschild, A.M. Wolf, L. Scheja, K.L. Grove, R.D. Smith, W.J. Qian, C.J. Lynch, C.B. Newgard, and C. Buettner, Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism. Cell Metab, 2014. 20(5): p. 898-909. epub

Stoter, M., M. Kruger, G. Banting, D. Henne-Bruns, and U. Knippschild, Microtubules depolymerization caused by the CK1 inhibitor IC261 may be not mediated by CK1 blockage. PLoS One, 2014. 9(6): p. e100090. epub

Bischof, J., S.J. Randoll, N. Sussner, D. Henne-Bruns, L.A. Pinna, and U. Knippschild, CK1delta Kinase Activity Is Modulated by Chk1-Mediated Phosphorylation. PLoS One, 2013. 8(7): p. e68803. epub

Eissing, L., T. Scherer, K. Todter, U. Knippschild, J.W. Greve, W.A. Buurman, H.O. Pinnschmidt, S.S. Rensen, A.M. Wolf, A. Bartelt, J. Heeren, C. Buettner, and L. Scheja, De novo lipogenesis in human fat and liver is linked to ChREBP-beta and metabolic health. Nature Communications, 2013

Hafner, S., A. Hillenbrand, U. Knippschild, and P. Radermacher, The obesity paradox and acute kidney injury: beneficial effects of hyper-inflammation? Crit Care, 2013. 17(6): p. 1023. epub

Kornfeld, J.W., C. Baitzel, A.C. Konner, H.T. Nicholls, M.C. Vogt, K. Herrmanns, L. Scheja, C. Haumaitre, A.M. Wolf, U. Knippschild, J. Seibler, S. Cereghini, J. Heeren, M. Stoffel, and J.C. Bruning, Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b. Nature, 2013. 494(7435): p. 111-5. epub

Wang, J.C., M. Thiere, D. Henne-Bruns, U. Knippschild, and M. Kornmann, Inhibition of pancreatic cancer cell growth in vivo using a tetracycline-inducible cyclin D1 antisense expression system. Pancreas, 2013. 42(1): p. 141-8. epub

Bischof, J., J. Leban, M. Zaja, A. Grothey, B. Radunsky, O. Othersen, S. Strobl, D. Vitt, and U. Knippschild, 2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide derivatives as potent inhibitors of CK1delta/epsilon. Amino Acids, 2012. 43: p. 577-91. Epub 2012 Feb 14. epub

Hillenbrand, A., J. Fassler, X.P. Huber N., D. Henne-Bruns, M. Templin, H. Schrezenmeier, A. Wolf, and U. Knippschild, Changed adipocytokine concentrations in colorectal tumor patients and morbidly obese patients compared to healthy controls. BMC Cancer, 2012 epub

Hillenbrand, A., M. Weiss, U. Knippschild, A.M. Wolf, and M. Huber-Lang, Sepsis-Induced Adipokine Change with regard to Insulin Resistance. Int J Inflam, 2012. 2012: p. 972368. epub

Hirner, H., C. Gunes, J. Bischof, S. Wolff, A. Grothey, M. Kuhl, F. Oswald, F. Wegwitz, M.R. Bosl, A. Trauzold, D. Henne-Bruns, C. Peifer, F. Leithauser, W. Deppert, and U. Knippschild, Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo. PLoS One, 2012. 7(1): p. e29709. epub

Knippschild, U., C. Peifer, J. Bischof, and K. Kramer, Other tryosine kinase inhibitors in development and further directions. In Emerging tyrosine kinase inhibitors for gastrointestinal stromal tumor Future medicine LTD, 2012: p. 50-63

Kumar, M., B. Witt, U. Knippschild, S. Koch, J.K. Meena, C. Heinlein, J.M. Weise, F. Krepulat, F. Kuchenbauer, S. Iben, K.L. Rudolph, W. Deppert, and C. Gunes, CEBP factors regulate TERT promoter activity in WAP-T mice during mammary carcinogenesis. Int J Cancer, 2012. epub

Bischof, J., A. Muller, M. Fander, U. Knippschild, and D. Fischer, Neurite Outgrowth of Mature Retinal Ganglion Cells and PC12 Cells Requires Activity of CK1delta and CK1epsilon. PLoS One, 2011. 6(6): p. e20857. epub

Hillenbrand, A., M. Weiss, U. Knippschild, H.G. Stromeyer, D. Henne-Bruns, M. Huber-Lang, and A.M. Wolf, Association of adiponectin levels and insulin demand in critically ill patients. Diabetes Metab Syndr Obes, 2011. 4: p. 45-51. epub

Thal, D.R., K. Del Tredici, A.C. Ludolph, J.J. Hoozemans, A.J. Rozemuller, H. Braak, and U. Knippschild, Stages of granulovacuolar degeneration: their relation to Alzheimer's disease and chronic stress response. Acta Neuropathol, 2011. 122: p. 577-89. epub

Udelnow, A., A. Kreyes, S. Ellinger, K. Landfester, P. Walther, T. Klapperstueck, J. Wohlrab, D. Henne-Bruns, U. Knippschild, and P. Wurl, Omeprazole inhibits proliferation and modulates autophagy in pancreatic cancer cells. PLoS One, 2011. 6(5): p. e20143. epub

Wacker, S.A., C. Alvarado, G. von Wichert, U. Knippschild, J. Wiedenmann, K. Clauss, G.U. Nienhaus, H. Hameister, B. Baumann, T. Borggrefe, W. Knochel, and F. Oswald, RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J. EMBO J, 2011. 30(1): p. 43-56. epub

Dorn, J., H. Spatz, M. Schmieder, T.F. Barth, A. Blatz, D. Henne-Bruns, U. Knippschild, and K. Kramer, Cyclin H expression is increased in GIST with very-high risk of malignancy. BMC Cancer, 2010. 10(1): p. 350. epub

Giamas, G., Y.L. Man, H. Hirner, J. Bischof, K. Kramer, K. Khan, S.S. Lavina Ahmed, J. Stebbing, and U. Knippschild, Kinases as targets in the treatment of solid tumors. Cellular Signalling, 2010. 22(7): p. 84-1002. epub

Hauk, T.G., M. Leibinger, A. Muller, A. Andreadaki, U. Knippschild, and D. Fischer, Stimulation of axon regeneration in the mature optic nerve by intravitreal application of the toll-like receptor 2 agonist Pam3Cys. Invest Ophthalmol Vis Sci, 2010. 51(1): p. 459-64. epub

Hillenbrand, A., U. Knippschild, M. Weiss, H. Schrezenmeier, D. Henne-Bruns, M. Huber-Lang, and A.M. Wolf, Sepsis induced changes of adipokines and cytokines - septic patients compared to morbidly obese patients. BMC Surg, 2010. 10: p. 26. epub

Utz, A.C., H. Hirner, A. Blatz, A. Hillenbrand, B. Schmidt, W. Deppert, D. Henne-Bruns, D. Fischer, D.R. Thal, F. Leithauser, and U. Knippschild, Analysis of cell type-specific expression of CK1 epsilon in various tissues of young adult BALB/c Mice and in mammary tumors of SV40 T-Ag-transgenic mice. J Histochem Cytochem, 2010. 58(1): p. 1-15. epub

Giamas, G., L. Castellano, Q. Feng, U. Knippschild, J. Jacob, R.S. Thomas, R.C. Coombes, C.L. Smith, L.R. Jiao, and J. Stebbing, CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions. Nucleic Acids Res, 2009. 37(9): p. 3110-23. epub

Lohler, J., H. Hirner, B. Schmidt, K. Kramer, D. Fischer, D.R. Thal, F. Leithauser, and U. Knippschild, Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice. PLoS One, 2009. 4(1): p. e4174. epub

Peifer, C., M. Abadleh, J. Bischof, D. Hauser, V. Schattel, H. Hirner, U. Knippschild, and S. Laufer, 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta. J Med Chem, 2009. 52(23): p. 7618-30. epub

Brockschmidt, C., H. Hirner, N. Huber, T. Eismann, A. Hillenbrand, G. Giamas, B. Radunsky, O. Ammerpohl, B. Bohm, D. Henne-Bruns, H. Kalthoff, F. Leithauser, A. Trauzold, and U. Knippschild, Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo. Gut, 2008. 57(6): p. 799-806. epub

Grochola, L.F., T. Greither, H. Taubert, P. Moller, U. Knippschild, A. Udelnow, D. Henne-Bruns, and P. Wurl, The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related death. Br J Cancer, 2008. 99(7): p. 1083-8. epub

Grochola, L.F., T. Greither, H.W. Taubert, P. Moller, U. Knippschild, A. Udelnow, D. Henne-Bruns, and P. Wurl, Prognostic relevance of hTERT mRNA expression in ductal adenocarcinoma of the pancreas. Neoplasia, 2008. 10(9): p. 973-6. epub

Kintscher, U., M. Hartge, K. Hess, A. Foryst-Ludwig, M. Clemenz, M. Wabitsch, P. Fischer-Posovszky, T.F. Barth, D. Dragun, T. Skurk, H. Hauner, M. Bluher, T. Unger, A.M. Wolf, U. Knippschild, V. Hombach, and N. Marx, T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vasc Biol, 2008. 28(7): p. 1304-10. epub

Schmieder, M., S. Wolf, B. Danner, S. Stoehr, M.S. Juchems, P. Wuerl, D. Henne-Bruns, U. Knippschild, C. Hasel, and K. Kramer, p16 expression differentiates high-risk gastrointestinal stromal tumor and predicts poor outcome. Neoplasia, 2008. 10(10): p. 1154-62. epub

Giamas, G., H. Hirner, L. Shoshiashvili, A. Grothey, S. Gessert, M. Kuhl, D. Henne-Bruns, C.E. Vorgias, and U. Knippschild, Phosphorylation of CK1delta: identification of Ser370 as the major phosphorylation site targeted by PKA in vitro and in vivo. Biochem J, 2007. 406(3): p. 389-98. epub

Giamas, G., J. Stebbing, C.E. Vorgias, and U. Knippschild, Protein kinases as targets for cancer treatment. Pharmacogenomics, 2007. 8(8): p. 1005-16. epub

von Blume, J., U. Knippschild, F. Dequiedt, G. Giamas, A. Beck, A. Auer, J. Van Lint, G. Adler, and T. Seufferlein, Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2. EMBO J, 2007. 26(22): p. 4619-33. epub

Wolff, S., M. Stoter, G. Giamas, M. Piesche, D. Henne-Bruns, G. Banting, and U. Knippschild, Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin. FEBS Lett, 2006. 580(27): p. 6477-84. epub

Knippschild, U., A. Gocht, S. Wolff, N. Huber, J. Lohler, and M. Stoter, The casein kinase 1 family: participation in multiple cellular processes in eukaryotes. Cellulra Signalling, 2005. 17(6): p. 675-89. epub

Knippschild, U., S. Wolff, G. Giamas, C. Brockschmidt, M. Wittau, P.U. Wurl, T. Eismann, and M. Stoter, The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development. Onkologie, 2005. 28(10): p. 508-14. epub

Stoter, M., A.M. Bamberger, B. Aslan, M. Kurth, D. Speidel, T. Loning, H.G. Frank, P. Kaufmann, J. Lohler, D. Henne-Bruns, W. Deppert, and U. Knippschild, Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells. Oncogene, 2005. 24(54): p. 7964-75. epub

Wolff, S., Z. Xiao, M. Wittau, N. Sussner, M. Stoter, and U. Knippschild, Interaction of casein kinase 1 delta (CK1delta) with the light chain LC2 of microtubule associated protein 1A (MAP1A). Biochim Biophys Acta, 2005. 1745(2): p. 196-206. epub

Ventura, R.A., J.I. Martin-Subero, U. Knippschild, R.D. Gascoyne, G. Delsol, D.Y. Mason, and R. Siebert, Centrosome abnormalities in ALK-positive anaplastic large-cell lymphoma. Leukemia, 2004. 18(11): p. 1910-1. epub

Winter, M., D. Milne, S. Dias, R. Kulikov, U. Knippschild, C. Blattner, and D. Meek, Protein kinase CK1delta phosphorylates key sites in the acidic domain of murine double-minute clone 2 protein (MDM2) that regulate p53 turnover. Biochemistry, 2004. 43(51): p. 16356-64. epub

Maritzen, T., J. Lohler, W. Deppert, and U. Knippschild, Casein kinase I delta (CKIdelta) is involved in lymphocyte physiology. Eur J Cell Biol, 2003. 82(7): p. 369-78. epub

Martin-Subero, J.I., U. Knippschild, L. Harder, T.F. Barth, J. Riemke, S. Grohmann, S. Gesk, J. Hoppner, P. Moller, R.M. Parwaresch, and R. Siebert, Segmental chromosomal aberrations and centrosome amplifications: pathogenetic mechanisms in Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma? Leukemia, 2003. 17(11): p. 2214-9. epub

Meek, D.W. and U. Knippschild, Posttranslational modification of MDM2. Mol Cancer Res, 2003. 1(14): p. 1017-26. epub

Behrend, L., D.M. Milne, M. Stoter, W. Deppert, L.E. Campbell, D.W. Meek, and U. Knippschild, IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. Oncogene, 2000. 19(47): p. 5303-13. epub

Behrend, L., M. Stoter, M. Kurth, G. Rutter, J. Heukeshoven, W. Deppert, and U. Knippschild, Interaction of casein kinase 1 delta (CK1delta) with post-Golgi structures, microtubules and the spindle apparatus. Eur J Cell Biol, 2000. 79(4): p. 240-51. epub

Janus, F., N. Albrechtsen, U. Knippschild, L. Wiesmuller, F. Grosse, and W. Deppert, Different regulation of the p53 core domain activities 3'-to-5' exonuclease and sequence-specific DNA binding. Mol Cell Biol, 1999. 19(3): p. 2155-68. epub

Henning, W., G. Rohaly, T. Kolzau, U. Knippschild, H. Maacke, and W. Deppert, MDM2 is a target of simian virus 40 in cellular transformation and during lytic infection. J Virol, 1997. 71(10): p. 7609-18. epub

Knippschild, U., D.M. Milne, L.E. Campbell, A.J. DeMaggio, E. Christenson, M.F. Hoekstra, and D.W. Meek, p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs. Oncogene, 1997. 15(14): p. 1727-36. epub

Meek, D.W., L.E. Campbell, L.J. Jardine, U. Knippschild, L. McKendrick, and D.M. Milne, Multi-site phosphorylation of p53 by protein kinases inducible by p53 and DNA damage. Biochem Soc Trans, 1997. 25(2): p. 416-9. epub

Knippschild, U., D. Milne, L. Campbell, and D. Meek, p53 N-terminus-targeted protein kinase activity is stimulated in response to wild type p53 and DNA damage. Oncogene, 1996. 13(7): p. 1387-93. epub

Knippschild, U., M. Oren, and W. Deppert, Abrogation of wild-type p53 mediated growth-inhibition by nuclear exclusion. Oncogene, 1996. 12(8): p. 1755-65. epub

Sturzbecher, H.W., B. Donzelmann, W. Henning, U. Knippschild, and S. Buchhop, p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction. Embo J, 1996. 15(8): p. 1992-2002. epub

Knippschild, U., T. Kolzau, and W. Deppert, Cell-specific transcriptional activation of the mdm2-gene by ectopically expressed wild-type form of a temperature-sensitive mutant p53. Oncogene, 1995. 11(4): p. 683-90. epub

Zerrahn, J., U. Knippschild, T. Winkler, and W. Deppert, Independent expression of the transforming amino-terminal domain of SV40 large I antigen from an alternatively spliced third SV40 early mRNA. Embo J, 1993. 12(12): p. 4739-46. epub

Patschinsky, T., U. Knippschild, and W. Deppert, Species-specific phosphorylation of mouse and rat p53 in simian virus 40-transformed cells. J Virol, 1992. 66(6): p. 3846-59. epub

Deppert, W., M. Kurth, M. Graessmann, A. Graessmann, and U. Knippschild, Altered phosphorylation at specific sites confers a mutant phenotype to SV40 wild-type large T antigen in a flat revertant of SV40-transformed cells. Oncogene, 1991. 6(10): p. 1931-8. epub

Knippschild, U., J. Kiefer, T. Patschinsky, and W. Deppert, Phenotype-specific phosphorylation of simian virus 40 tsA mutant large T antigens in tsA N-type and A-type transformants. J Virol, 1991. 65(8): p. 4414-23. epub

Howard Elder Preis der Universität Dundee für Nachwuchswissenschaftler (1996)

Mitglied der Gesellschaft für Biochemie und Molekularbiologie (GBM)
 

Editorial Board

The Open Enzyme Inhibition Journal (seit 2008)

Gutachtertätigkeit für folgende Journals:

  • Genes & Development, Oncogene, GUT, Nucleic Acid Research, Carcinogenesis, Neuroscience Letters, PLOS One, Biochemical Journal, FEBS Journal, FEBS Letters, JHC, Mol Biol Rep, Pharmacogenetics, British Journal of Cancer, Cancer Gene Therapy, BMC Gastroenterology, Gene, Journal of Biomedicine and Biotechnology, Journal of Cellular and Molecular Medicine, Molecular Biology Reports, Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Medical Sciences Monitor
  • Deutsche Forschungsgemeinschaft, Welcome Trust (GB), University of Tübingen (Germany), University of Padua (Italy)