Prof. Dr. biol. hum. Uwe Knippschild

Dipl. Biologe (1989)

Promotion (1992)

Habilitation (2000)

Umhabilitation (2002)

Ernennung zum apl Professor (2008)

Onkologische Forschung

Schwerpunkt Signaltransduktion, Tumorsuppressoren, Onkogene; Proteinkinasen insbesondere CK1

Förderung durch Deutsche Krebshilfe und DFG


Tian X, Traub B, Shi J, Huber N, Schreiner S, Chen G, Zhou S, Henne-Bruns D, Knippschild U, Kornmann M. c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1. Cancer Gene Ther. 2022 Jan;29(1):73-86. doi: 10.1038/s41417-020-00290-5. Epub 2021 Feb 1. PMID: 33526844; PMCID: PMC8761571. IF: 5.854

Smirlis D, Dingli F, Sabatet V, Roth A, Knippschild U, Loew D, Späth GF, Rachidi N. Identification of the Host Substratome of Leishmania-Secreted Casein Kinase 1 Using a SILAC-Based Quantitative Mass Spectrometry Assay. Front Cell Dev Biol. 2022 Jan 3;9:800098. doi: 10.3389/fcell.2021.800098. PMID: 35047509; PMCID: PMC8762337. IF: 6,081

von Drathen T, Ure EM, Kirschner S, Roth A, Meier L, Woolhouse AD, Cameron SA, Knippschild U, Peifer C, Luxenburger A. C5-Iminosugar modification of casein kinase 1δ lead 3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)isoxazole promotes enhanced inhibitor affinity and selectivity. Arch Pharm (Weinheim). 2022 May;355(5):e2100497. doi: 10.1002/ardp.202100497. Epub 2022 Feb 17. PMID: 35174898. IF: 4,631

Xu P, Westhoff MA, Hadzalic A, Debatin KM, Winiarski L, Oleksyszyn J, Wirtz CR, Knippschild U, Burster T. Diisothiocyanate-Derived Mercapturic Acids Are a Promising Partner for Combination Therapies in Glioblastoma. ACS Omega. 2022 Feb 8;7(7):5929-5936. doi: 10.1021/acsomega.1c06169. PMID: 35224353; PMCID: PMC8867792. IF: 4,132

Xing H, Zhang Y, Krämer M, Kissmann AK, Amann V, Raber HF, Weil T, Stieger KR, Knippschild U, Henkel M, Andersson J, Rosenau F. A Polyclonal Aptamer Library for the Specific Binding of the Gut Bacterium Roseburia intestinalis in Mixtures with Other Gut Microbiome Bacteria and Human Stool Samples. Int J Mol Sci. 2022 Jul 13;23(14):7744. doi: 10.3390/ijms23147744. PMID: 35887092; PMCID: PMC9317077. IF: 6,208

Xing H, Zhang Y, Krämer M, Kissmann AK, Henkel M, Weil T, Knippschild U, Rosenau F. A Polyclonal Selex Aptamer Library Directly Allows Specific Labelling of the Human Gut Bacterium Blautia producta without Isolating IndividualAptamers. Molecules. 2022 Sep 3;27(17):5693. doi: 10.3390/molecules27175693. PMID: 36080459; PMCID: PMC9458011. IF: 4,927

Roth A, Sander A, Oswald MS, Gärtner F, Knippschild U, Bischof J. Comprehensive Characterization of CK1δ-Mediated Tau Phosphorylation in Alzheimer's Disease. Front Mol Biosci. 2022 Jun 27;9:872171. doi: 10.3389/fmolb.2022.872171. PMID: 36203870; PMCID: PMC9531328. IF: 6,133

Wesseler F, Lohmann S, Riege D, Halver J, Roth A, Pichlo C, Weber S, Takamiya M, Müller E, Ketzel J, Flegel J, Gihring A, Rastegar S, Bertrand J, Baumann U, Knippschild U, Peifer C, Sievers S, Waldmann H, Schade D. Phenotypic Discovery of Triazolo[1,5-c]quinazolines as a First-In-Class Bone Morphogenetic Protein Amplifier Chemotype. J Med Chem. 2022 Nov 8. doi: 10.1021/acs.jmedchem.2c01199. Epub ahead of print. PMID: 36346705. IF: 8,093

El Hage R, Knippschild U, Arnold T, Hinterseher I. Stem Cell-Based Therapy: A Promising Treatment for Diabetic Foot Ulcer. Biomedicines. 2022 Jun 25;10(7):1507. doi: 10.3390/biomedicines10071507. PMID: 35884812; PMCID: PMC9312797. IF: 4,757

Bagci-Onder T, Kutuk O, Chonghaile TN, Knippschild U. Editorial: Cell Death and Targeted Cancer Therapies. Front Cell Dev Biol. 2022 Jul 6;10:967720. doi: 10.3389/fcell.2022.967720. PMID: 35874828; PMCID: PMC9296767. IF: 6,081

Gihring A, Gärtner F, Schirmer M, Wabitsch M, Knippschild U. Recent Developments in Mouse Trauma Research Models: A Mini-Review. Front Physiol. 2022 Apr 29;13:866617. doi: 10.3389/fphys.2022.866617. PMID: 35574493; PMCID: PMC9101050. IF: 4,755

Roth A, Gihring A, Bischof J, Pan L, Oswald F, Knippschild U. CK1 Is a Druggable Regulator of Microtubule Dynamics and Microtubule-Associated Processes. Cancers (Basel). 2022 Mar 5;14(5):1345. doi: 10.3390/cancers14051345. PMID: 35267653; PMCID: PMC8909099. IF: 6,575


Smirlis D, Dingli F, Sabatet V, Roth A, Knippschild U, Loew D, Spaeth G, Rachidi N. 2021. Identification of the host substratome of Leishmania-secreted casein kinase 1 using a SILAC-based quantitative mass spectrometry assay. Frontiers in Cell and Developmental Biology. epub

Gärtner F, Gihring A, Roth A, Bischof J, Xu P, Elad L, Wabitsch M, Burster T, Uwe Knippschild U. 2021. Obesity prolongs the inflammatory response in mice after severe trauma and attenuates the splenic response to the inflammatory reflex. Front Immunol. epub

Burster T, Gartner F, Bulach C, Zhanapiya A, Gihring A, Knippschild U. 2021. Regulation of MHC I Molecules in Glioblastoma Cells and the Sensitizing of NK Cells. Pharmaceuticals (Basel)  14(3) 10.3390/ph14030236

Burster T, Gartner F, Knippschild U, Zhanapiya A. 2021. Activity-Based Probes to Utilize the Proteolytic Activity of Cathepsin G in Biological Samples. Front Chem  9: p. 628295 10.3389/fchem.2021.628295

Burster T, Traut R, Yermekkyzy Z, Mayer K, Westhoff M A, Bischof J, Knippschild U. 2021. Critical View of Novel Treatment Strategies for Glioblastoma: Failure and Success of Resistance Mechanisms by Glioblastoma Cells. Front Cell Dev Biol  9: p. 695325 10.3389/fcell.2021.695325

Pan L, Hoffmeister P, Turkiewicz A, Huynh N N D, Grosse-Berkenbusch A, Knippschild U, Gebhardt J C M, Baumann B, Borggrefe T, Oswald F. 2021. Transcription Factor RBPJL Is Able to Repress Notch Target Gene Expression but Is Non-Responsive to Notch Activation. Cancers (Basel)  13(19) 10.3390/cancers13195027

Raber H F, Kubiczek D H, Bodenberger N, Kissmann A K, D'Souza D, Xing H, Mayer D, Xu P, Knippschild U, Spellerberg B, Weil T, Rosenau F. 2021. FluCell-SELEX Aptamers as Specific Binding Molecules for Diagnostics of the Health Relevant Gut Bacterium Akkermansia muciniphila. Int J Mol Sci  22(19) 10.3390/ijms221910425

Rachidi N, Knippschild U, Spath G F. 2021. Dangerous Duplicity: The Dual Functions of Casein Kinase 1 in Parasite Biology and Host Subversion. Front Cell Infect Microbiol  11: p. 655700 10.3389/fcimb.2021.655700

Roth A, Gartner F, Mayer K, Beyrle J, Konig I, Knippschild U, Bischof J. 2021. CK1delta-Derived Peptides as Novel Tools Inhibiting the Interactions between CK1delta and APP695 to Modulate the Pathogenic Metabolism of APP. Int J Mol Sci  22(12) 10.3390/ijms22126423

Roth A, Gihring A, Goser F, Peifer C, Knippschild U, Bischof J. 2021. Assessing the Inhibitory Potential of Kinase Inhibitors In Vitro: Major Pitfalls and Suggestions for Improving Comparability of Data Using CK1 Inhibitors as an Example. Molecules  26(16) 10.3390/molecules26164898

Tian X, Traub B, Shi J, Huber N, Schreiner S, Chen G, Zhou S, Henne-Bruns D, Knippschild U, Kornmann M. 2021. c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1. Cancer Gene Ther 10.1038/s41417-020-00290-5

Traub B, Roth A, Kornmann M, Knippschild U, Bischof J. 2021. Stress-activated kinases as therapeutic targets in pancreatic cancer. World J Gastroenterol  27(30): p. 4963-4984 10.3748/wjg.v27.i30.4963

Xu P, Richter J, Blatz A, Gartner F, Alberts R, Azoitei A, Makori WA, Meessen S, Knippschild U, Gunes C. 2020. Downregulation of ORP3 Correlates with Reduced Survival of Colon Cancer Patients with Advanced Nodal Metastasis and of Female Patients with Grade 3 Colon Cancer. Int J Mol Sci 21.

Tian X, Traub B, Xie X, Zhou S, Henne-Bruns D, Knippschild U, Kornmann M. 2020. Opposing Oncogenic Functions of p38 Mitogen-activated Protein Kinase Alpha and Beta in Human Pancreatic Cancer Cells. Anticancer Res 40:5545-5556.

Njeru SN, Kraus J, Meena JK, Lechel A, Katz SF, Kumar M, Knippschild U, Azoitei A, Wezel F, Bolenz C, Leithauser F, Gollowitzer A, Omrani O, Hoischen C, Koeberle A, Kestler HA, Gunes C, Rudolph KL. 2020. Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor. Oncogene 39:1445-1465.

Gärtner F, Knippschild U, Burster T. 2020. Application of an Activity-Based Probe to Determine Proteolytic Activity of Cell Surface Cathepsin G by Mass Cytometry Data Acquisition. ACS Omega 5:28233-28238.

Burster T, Knippschild U, Molnar F, Zhanapiya A. 2020. Cathepsin G and its Dichotomous Role in Modulating Levels of MHC Class I Molecules. Arch Immunol Ther Exp (Warsz) 68:25.

Xu P, Gärtner F, Gihring A, Liu C, Burster T, Wabitsch M, Knippschild U, Paschke S. 2020. Influence of obesity on remodeling of lung tissue and organization of extracellular matrix after blunt thorax trauma. Respir Res 21:238.

Gihring A, Gärtner F, Liu C, Hoenicka M, Wabitsch M, Knippschild U, Xu P. 2020. Influence of Obesity on the Organization of the Extracellular Matrix and Satellite Cell Functions After Combined Muscle and Thorax Trauma in C57BL/6J Mice. Front Physiol 11:849.

Pradas-Juni M, Hansmeier NR, Link JC, Schmidt E, Larsen BD, Klemm P, Meola N, Topel H, Loureiro R, Dhaouadi I, Kiefer CA, Schwarzer R, Khani S, Oliverio M, Awazawa M, Frommolt P, Heeren J, Scheja L, Heine M, Dieterich C, Buning H, Yang L, Cao H, Jesus DF, Kulkarni RN, Zevnik B, Troder SE, Knippschild U, Edwards PA, Lee RG, Yamamoto M, Ulitsky I, Fernandez-Rebollo E, Vallim TQA, Kornfeld JW. 2020. A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism. Nat Commun 11:644.

Xu P, Ianes C, Gärtner F, Liu C, Burster T, Bakulev V, Rachidi N, Knippschild U, Bischof J. 2019. Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D). Gene 715:144005.

Schehr M, Ianes C, Weisner J, Heintze L, Muller MP, Pichlo C, Charl J, Brunstein E, Ewert J, Lehr M, Baumann U, Rauh D, Knippschild U, Peifer C, Herges R. 2019. 2-Azo-, 2-diazocine-thiazols and 2-azo-imidazoles as photoswitchable kinase inhibitors: limitations and pitfalls of the photoswitchable inhibitor approach. Photochem Photobiol Sci 18:1398-1407.

Meng Z, Bohm T, Xu P, Henne-Bruns D, Peifer C, Witt L, Knippschild U, Bischof J. 2019. Kinase activity of casein kinase 1 delta (CK1delta) is modulated by protein kinase C alpha (PKCalpha) by site-specific phosphorylation within the kinase domain of CK1delta. Biochim Biophys Acta Proteins Proteom 1867:710-721.

Luxenburger A, Schmidt D, Ianes C, Pichlo C, Kruger M, von Drathen T, Brunstein E, Gainsford GJ, Baumann U, Knippschild U, Peifer C. 2019. Design, Synthesis and Biological Evaluation of Isoxazole-Based CK1 Inhibitors Modified with Chiral Pyrrolidine Scaffolds. Molecules 24.

Liu C, Witt L, Ianes C, Bischof J, Bammert MT, Baier J, Kirschner S, Henne-Bruns D, Xu P, Kornmann M, Peifer C, Knippschild U. 2019. Newly Developed CK1-Specific Inhibitors Show Specifically Stronger Effects on CK1 Mutants and Colon Cancer Cell Lines. Int J Mol Sci 20.

Giamas G, Hirner H, Shoshiashvili L, Grothey A, Gessert S, Kuhl M, Henne-Bruns D, Vorgias CE, Knippschild U. 2019. Correction: Phosphorylation of CK1delta: identification of Ser(370) as the major phosphorylation site targeted by PKA in vitro and in vivo. Biochem J 476:1221-1225.

Bohm T, Meng Z, Haas P, Henne-Bruns D, Rachidi N, Knippschild U, Bischof J. 2019. The kinase domain of CK1delta can be phosphorylated by Chk1. Biosci Biotechnol Biochem 83:1663-1675.

Bischof J, Gartner F, Zeiser K, Kunz R, Schreiner C, Hoffer E, Burster T, Knippschild U, Zimecki M. 2019. Immune Cells and Immunosenescence. Folia Biol (Praha) 65:53-63.

Kretz AL, Trauzold A, Hillenbrand A, Knippschild U, Henne-Bruns D, von Karstedt S, Lemke J. 2019. TRAILblazing Strategies for Cancer Treatment. Cancers (Basel) 11.

Dimitrakopoulos C, Vrugt B, Flury R, Schraml P, Knippschild U, Wild P, Hoerstrup S, Henne-Bruns D, Wuerl P, Graf R, Breitenstein S, Bond G, Beerenwinkel N, Grochola LF. 2019. Identification and Validation of a Biomarker Signature in Patients With Resectable Pancreatic Cancer via Genome-Wide Screening for Functional Genetic Variants. JAMA Surg 154:e190484.

Liu Y, Zhang L, Li W, Huang Q, Yuan S, Li Y, Liu J, Zhang S, Pin G, Song S, Ray PF, Arnoult C, Cho C, Garcia-Reyes B, Knippschild U, Strauss JF, Zhang Z. 2019. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Reproduction 158:181-197.

Richter J, Kretz AL, Lemke J, Fauler M, Werner JU, Paschke S, Leithauser F, Henne-Bruns D, Hillenbrand A, Knippschild U. 2018. CK1alpha overexpression correlates with poor survival in colorectal cancer. BMC Cancer 18:140.

Garcia-Reyes B, Witt L, Jansen B, Karasu E, Gehring T, Leban J, Henne-Bruns D, Pichlo C, Brunstein E, Baumann U, Wesseler F, Rathmer B, Schade D, Peifer C, Knippschild U. 2018. Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) delta/epsilon. J Med Chem 61:4087-4102.

Garcia-Reyes B, Kretz AL, Ruff JP, von Karstedt S, Hillenbrand A, Knippschild U, Henne-Bruns D, Lemke J. 2018. The Emerging Role of Cyclin-Dependent Kinases (CDKs) in Pancreatic Ductal Adenocarcinoma. Int J Mol Sci 19.

Dolde C, Bischof J, Gruter S, Montada A, Halekotte J, Peifer C, Kalbacher H, Baumann U, Knippschild U, Suter B. 2018. A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1epsilon. J Cell Sci 131.

Bischof J, Kretz AL, Burster T, Henne-Bruns D, Knippschild U, Xu P. 2018. Inhibition of CK1 affects Viability and Survival of Glioblastoma Cells. Biomed J Sci & Tech Res 2.

Cwiklowska K, Westhoff MA, Freisinger S, Dwucet A, Halatsch ME, Knippschild U, Debatin KM, Schirmbeck R, Winiarski L, Oleksyszyn J, Wirtz CR, Burster T. 2018. Viability of glioblastoma stem cells is effectively reduced by diisothiocyanate-derived mercapturic acids. Oncol Lett 16:6181-6187.

Kretz AL, von Karstedt S, Hillenbrand A, Henne-Bruns D, Knippschild U, Trauzold A, Lemke J. 2018. Should We Keep Walking along the Trail for Pancreatic Cancer Treatment? Revisiting TNF-Related Apoptosis-Inducing Ligand for Anticancer Therapy. Cancers (Basel) 10.

Werner JU, Tödter K, Xu P, Lockhart L, Jahnert M, Gottmann P, Schurmann A, Scheja L, Wabitsch M, Knippschild U. 2018. Comparison of Fatty Acid and Gene Profiles in Skeletal Muscle in Normal and Obese C57BL/6J Mice before and after Blunt Muscle Injury. Front Physiol 9:19.

Xu P, Werner JU, Milerski S, Hamp CM, Kuzenko T, Jahnert M, Gottmann P, de Roy L, Warnecke D, Abaei A, Palmer A, Huber-Lang M, Dürselen L, Rasche V, Schurmann A, Wabitsch M, Knippschild U. 2018. Diet-Induced Obesity Affects Muscle Regeneration After Murine Blunt Muscle Trauma-A Broad Spectrum Analysis. Front Physiol 9:674.

Wille C, Eiseler T, Langenberger ST, Richter J, Mizuno K, Radermacher P, Knippschild U, Huber-Lang M, Seufferlein T, Paschke S. 2018. PKD regulates actin polymerization, neutrophil deformability, and transendothelial migration in response to fMLP and trauma. J Leukoc Biol 104:615-630.

Wolff S, Xiao Z, Wittau M, Sussner N, Stöter M, Knippschild U. 2017. Corrigendum to "interaction of casein kinase 1 delta (CK1d) with the light chain LC2 of microtubule associated protein 1A (MAP1A)" [Biochim. Biophys. Acta 1745/2 (2005) 196-2006]. Biochim Biophys Acta Mol Cell Res 1864:1923.

Halekotte J, Witt L, Ianes C, Krüger M, Buhrmann M, Rauh D, Pichlo C, Brunstein E, Luxenburger A, Baumann U, Knippschild U, Bischof J, Peifer C. 2017. Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1delta and Their Structural Relation to p38alpha MAPK. Molecules 22.

Föhr KJ, Knippschild U, Herkommer A, Fauler M, Peifer C, Georgieff M, Adolph O. 2017. State-dependent block of voltage-gated sodium channels by the casein-kinase 1 inhibitor IC261. Invest New Drugs 35:277-289.

Bischof J, Westhoff MA, Wagner JE, Halatsch ME, Trentmann S, Knippschild U, Wirtz CR, Burster T. 2017. Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells. Tumour Biol 39:1010428317692227.

Kretz AL, Schaum M, Richter J, Kitzig EF, Engler CC, Leithauser F, Henne-Bruns D, Knippschild U, Lemke J. 2017. CDK9 is a prognostic marker and therapeutic target in pancreatic cancer. Tumour Biol 39:1010428317694304.

Traub B, Sun L, Ma Y, Xu P, Lemke J, Paschke S, Henne-Bruns D, Knippschild U, Kornmann M. 2017. Endogenously Expressed IL-4Ralpha Promotes the Malignant Phenotype of Human Pancreatic Cancer In Vitro and In Vivo. Int J Mol Sci 18.

Rupakova N, Bakulev V, Knippschild U, Garcia-Reyes B, Eltsov O, Slesarev P, Beliaev N, Slepukhin P, Witt L, Peifer C, Beryozkina T. 2017. Design and synthesis of N-benzimidazol-2-yl-N'-sulfonyl acetamidines. Archive for Organic Chemistry:15.

Richter J, Rudeck S, Kretz AL, Kramer K, Just S, Henne-Bruns D, Hillenbrand A, Leithauser F, Lemke J, Knippschild U. 2016. Decreased CK1delta expression predicts prolonged survival in colorectal cancer patients. Tumour Biol 37:8731-9.

Meng Z, Bischof J, Ianes C, Henne-Bruns D, Xu P, Knippschild U. 2016. CK1delta kinase activity is modulated by protein kinase C alpha (PKCalpha)-mediated site-specific phosphorylation. Amino Acids 48:1185-97.

Krüger M, Kalbacher H, Kastritis PL, Bischof J, Barth H, Henne-Bruns D, Vorgias C, Sarno S, Pinna LA, Knippschild U. 2016. New potential peptide therapeutics perturbing CK1delta/alpha-tubulin interaction. Cancer Lett 375:375-383.

Ianes C, Xu P, Werz N, Meng Z, Henne-Bruns D, Bischof J, Knippschild U. 2016. CK1delta activity is modulated by CDK2/E- and CDK5/p35-mediated phosphorylation. Amino Acids 48:579-92.

Hillenbrand A, Xu P, Zhou S, Blatz A, Weiss M, Hafner S, Henne-Bruns D, Knippschild U. 2016. Circulating adipokine levels and prognostic value in septic patients. J Inflamm (Lond) 13:30.

Giroud M, Pisani DF, Karbiener M, Barquissau V, Ghandour RA, Tews D, Fischer-Posovszky P, Chambard JC, Knippschild U, Niemi T, Taittonen M, Nuutila P, Wabitsch M, Herzig S, Virtanen KA, Langin D, Scheideler M, Amri EZ. 2016. miR-125b affects mitochondrial biogenesis and impairs brite adipocyte formation and function. Mol Metab 5:615-625.

Yokoyama S, Higashi M, Kitamoto S, Oeldorf M, Knippschild U, Kornmann M, Maemura K, Kurahara H, Wiest E, Hamada T, Kitazono I, Goto Y, Tasaki T, Hiraki T, Hatanaka K, Mataki Y, Taguchi H, Hashimoto S, Batra SK, Tanimoto A, Yonezawa S, Hollingsworth MA. 2016. Aberrant methylation of MUC1 and MUC4 promoters are potential prognostic biomarkers for pancreatic ductal adenocarcinomas. Oncotarget 7:42553-42565.

Udelnow A, Henne-Bruns D, Knippschild U, Halangk W, Bruns C, Halloul Z, Wurl P, Grochola LF. 2016. MDM2 SNP 309G Allele Is Associated With Younger Age at Surgery in Chronic Pancreatitis Patients. Pancreas 45:e11-2.

Stracquadanio G, Vrugt B, Flury R, Schraml P, Würl P, Muller TH, Knippschild U, Henne-Bruns D, Breitenstein S, Clavien PA, Graf R, Bond GL, Grochola LF. 2016. CD44 SNPrs187115: A Novel Biomarker Signature that Predicts Survival in Resectable Pancreatic Ductal Adenocarcinoma. Clin Cancer Res 22:6069-6077.

Schmieder M, Henne-Bruns D, Mayer B, Knippschild U, Rolke C, Schwab M, Kramer K. 2016. Comparison of Different Risk Classification Systems in 558 Patients with Gastrointestinal Stromal Tumors after R0-Resection. Front Pharmacol 7:504.

Wolff S, Garcia-Reyes B, Henne-Bruns D, Bischof J, Knippschild U. 2015. Protein kinase CK1 interacts with and phosphorylates RanBPM in vitro. Journal of Molecular Biochemistry 4:8.

Winkler BS, Oltmer F, Richter J, Bischof J, Xu P, Burster T, Leithauser F, Knippschild U. 2015. CK1delta in lymphoma: gene expression and mutation analyses and validation of CK1delta kinase activity for therapeutic application. Front Cell Dev Biol 3:9.

Richter J, Ullah K, Xu P, Alscher V, Blatz A, Peifer C, Halekotte J, Leban J, Vitt D, Holzmann K, Bakulev V, Pinna LA, Henne-Bruns D, Hillenbrand A, Kornmann M, Leithauser F, Bischof J, Knippschild U. 2015. Effects of altered expression and activity levels of CK1delta and varepsilon on tumor growth and survival of colorectal cancer patients. Int J Cancer 136:2799-810.

Lott S, Schmieder M, Mayer B, Henne-Bruns D, Knippschild U, Agaimy A, Schwab M, Kramer K. 2015. Gastrointestinal stromal tumors of the esophagus: evaluation of a pooled case series regarding clinicopathological features and clinical outcome. Am J Cancer Res 5:333-43.

Kramer K, Wolf S, Mayer B, Schmidt SA, Agaimy A, Henne-Bruns D, Knippschild U, Schwab M, Schmieder M. 2015. Frequence, spectrum and prognostic impact of additional malignancies in patients with gastrointestinal stromal tumors. Neoplasia 17:134-40.

Kramer K, Knippschild U, Mayer B, Bogelspacher K, Spatz H, Henne-Bruns D, Agaimy A, Schwab M, Schmieder M. 2015. Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST). BMC Cancer 15:57.

Hillenbrand A, Kiebler B, Schwab C, Scheja L, Xu P, Henne-Bruns D, Wolf AM, Knippschild U. 2015. Prevalence of non-alcoholic fatty liver disease in four different weight related patient groups: association with small bowel length and risk factors. BMC Res Notes 8:290.

Xu P, Fischer-Posovszky P, Bischof J, Radermacher P, Wabitsch M, Henne-Bruns D, Wolf AM, Hillenbrand A, Knippschild U. 2015. Gene expression levels of Casein kinase 1 (CK1) isoforms are correlated to adiponectin levels in adipose tissue of morbid obese patients and site-specific phosphorylation mediated by CK1 influences multimerization of adiponectin. Mol Cell Endocrinol 406:87-101.

Rozin Y, Zhidovinov S, Beryozkina T, Shafran Y, Lubec G, Eltsov O, Slepukhin P, Knippschild U, Bischof J, Dehaen W, Bakulev V. 2015. A novel transformation of beta-1,2,3-thiadiazol-5-yl enamines into thieno[3,3-d]pyridazines. Tetrahedron Letters 56:3.

Stöter M, Kruger M, Banting G, Henne-Bruns D, Knippschild U. 2014. Microtubules depolymerization caused by the CK1 inhibitor IC261 may be not mediated by CK1 blockage. PLoS One 9:e100090.

Richter J, Bischof J, Zaja M, Kohlhof H, Othersen O, Vitt D, Alscher V, Pospiech I, Garcia-Reyes B, Berg S, Leban J, Knippschild U. 2014. Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1delta and epsilon with nanomolar inhibitory activity on cancer cell proliferation. J Med Chem 57:7933-46.

Knippschild U, Kruger M, Richter J, Xu P, Garcia-Reyes B, Peifer C, Halekotte J, Bakulev V, Bischof J. 2014. The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis. Front Oncol 4:96.

Haselmann V, Kurz A, Bertsch U, Hubner S, Olempska-Muller M, Fritsch J, Hasler R, Pickl A, Fritsche H, Annewanter F, Engler C, Fleig B, Bernt A, Roder C, Schmidt H, Gelhaus C, Hauser C, Egberts JH, Heneweer C, Rohde AM, Boger C, Knippschild U, Rocken C, Adam D, Walczak H, Schutze S, Janssen O, Wulczyn FG, Wajant H, Kalthoff H, Trauzold A. 2014. Nuclear death receptor TRAIL-R2 inhibits maturation of let-7 and promotes proliferation of pancreatic and other tumor cells. Gastroenterology 146:278-90.

Radermacher P, Huber-Lang M, Knippschild U, Thiemermann C. 2014. The obesity paradox revisited: does increased body mass protect against circulatory shock? Shock 41:554-5.

Shin AC, Fasshauer M, Filatova N, Grundell LA, Zielinski E, Zhou JY, Scherer T, Lindtner C, White PJ, Lapworth AL, Ilkayeva O, Knippschild U, Wolf AM, Scheja L, Grove KL, Smith RD, Qian WJ, Lynch CJ, Newgard CB, Buettner C. 2014. Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism. Cell Metab 20:898-909.

Efimov I, Bakulev V, Beliaev N, Beryozkina T, Knippschild U, Leban J, Zhi-Jin F, Eltsov O, Slepukhin P, Ezhikova M, Dehaen W. 2014. Reactions of β‐Azolylenamines with Sulfonyl Azides as an Approach to N‐Unsubstituted 1,2,3‐Triazoles and Ethene‐1,2‐diamines. European Journal of Organic Chemistry doi:10.1002/ejoc.201402130:5.

Bischof J, Randoll SJ, Süssner N, Henne-Bruns D, Pinna LA, Knippschild U. 2013. CK1delta kinase activity is modulated by Chk1-mediated phosphorylation. PLoS One 8:e68803.

Wang JC, Thiere M, Henne-Bruns D, Knippschild U, Kornmann M. 2013. Inhibition of pancreatic cancer cell growth in vivo using a tetracycline-inducible cyclin D1 antisense expression system. Pancreas 42:141-8.

Kumar M, Witt B, Knippschild U, Koch S, Meena JK, Heinlein C, Weise JM, Krepulat F, Kuchenbauer F, Iben S, Rudolph KL, Deppert W, Gunes C. 2013. CEBP factors regulate telomerase reverse transcriptase promoter activity in whey acidic protein-T mice during mammary carcinogenesis. Int J Cancer 132:2032-43.

Kornfeld JW, Baitzel C, Konner AC, Nicholls HT, Vogt MC, Herrmanns K, Scheja L, Haumaitre C, Wolf AM, Knippschild U, Seibler J, Cereghini S, Heeren J, Stoffel M, Bruning JC. 2013. Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b. Nature 494:111-5.

Hafner S, Hillenbrand A, Knippschild U, Radermacher P. 2013. The obesity paradox and acute kidney injury: beneficial effects of hyper-inflammation? Crit Care 17:1023.

Eissing L, Scherer T, Todter K, Knippschild U, Greve JW, Buurman WA, Pinnschmidt HO, Rensen SS, Wolf AM, Bartelt A, Heeren J, Buettner C, Scheja L. 2013. De novo lipogenesis in human fat and liver is linked to ChREBP-beta and metabolic health. Nat Commun 4:1528.

Hirner H, Gunes C, Bischof J, Wolff S, Grothey A, Kuhl M, Oswald F, Wegwitz F, Bosl MR, Trauzold A, Henne-Bruns D, Peifer C, Leithauser F, Deppert W, Knippschild U. 2012. Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo. PLoS One 7:e29709.

Bischof J, Leban J, Zaja M, Grothey A, Radunsky B, Othersen O, Strobl S, Vitt D, Knippschild U. 2012. 2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide derivatives as potent inhibitors of CK1delta/epsilon. Amino Acids 43:1577-91.

Knippschild U, Peifer C, Bischof J, Kramer K. 2012. Other tyorisne kinase inhibitors in development and future directions, Tyrosine kinase inhibitors for gastrointestinal stromal tumors, Future Medicine.
Hillenbrand A, Weiss M, Knippschild U, Wolf AM, Huber-Lang M. 2012. Sepsis-Induced Adipokine Change with regard to Insulin Resistance. Int J Inflam 2012:972368.

Hillenbrand A, Fassler J, Huber N, Xu P, Henne-Bruns D, Templin M, Schrezenmeier H, Wolf AM, Knippschild U. 2012. Changed adipocytokine concentrations in colorectal tumor patients and morbidly obese patients compared to healthy controls. BMC Cancer 12:545.

Bischof J, Müller A, Fander M, Knippschild U, Fischer D. 2011. Neurite outgrowth of mature retinal ganglion cells and PC12 cells requires activity of CK1delta and CK1epsilon. PLoS One 6:e20857.

Thal DR, Del Tredici K, Ludolph AC, Hoozemans JJ, Rozemuller AJ, Braak H, Knippschild U. 2011. Stages of granulovacuolar degeneration: their relation to Alzheimer's disease and chronic stress response. Acta Neuropathol 122:577-89.

Udelnow A, Kreyes A, Ellinger S, Landfester K, Walther P, Klapperstueck T, Wohlrab J, Henne-Bruns D, Knippschild U, Würl P. 2011. Omeprazole inhibits proliferation and modulates autophagy in pancreatic cancer cells. PLoS One 6:e20143.

Wacker SA, Alvarado C, von Wichert G, Knippschild U, Wiedenmann J, Clauss K, Nienhaus GU, Hameister H, Baumann B, Borggrefe T, Knöchel W, Oswald F. 2011. RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J. EMBO J 30:43-56.

Hillenbrand A, Weiss M, Knippschild U, Stromeyer HG, Henne-Bruns D, Huber-Lang M, Wolf AM. 2011. Association of adiponectin levels and insulin demand in critically ill patients. Diabetes Metab Syndr Obes 4:45-51.

Utz AC, Hirner H, Blatz A, Hillenbrand A, Schmidt B, Deppert W, Henne-Bruns D, Fischer D, Thal DR, Leithauser F, Knippschild U. 2010. Analysis of cell type-specific expression of CK1 epsilon in various tissues of young adult BALB/c Mice and in mammary tumors of SV40 T-Ag-transgenic mice. J Histochem Cytochem 58:1-15.
Giamas G, Man YL, Hirner H, Bischof J, Kramer K, Khan K, Ahmed SS, Stebbing J, Knippschild U. 2010. Kinases as targets in the treatment of solid tumors. Cell Signal 22:984-1002.
Dorn J, Spatz H, Schmieder M, Barth TF, Blatz A, Henne-Bruns D, Knippschild U, Kramer K. 2010. Cyclin H expression is increased in GIST with very-high risk of malignancy. BMC Cancer 10:350.
Hauk TG, Leibinger M, Muller A, Andreadaki A, Knippschild U, Fischer D. 2010. Stimulation of axon regeneration in the mature optic nerve by intravitreal application of the toll-like receptor 2 agonist Pam3Cys. Invest Ophthalmol Vis Sci 51:459-64.
Hillenbrand A, Knippschild U, Weiss M, Schrezenmeier H, Henne-Bruns D, Huber-Lang M, Wolf AM. 2010. Sepsis induced changes of adipokines and cytokines - septic patients compared to morbidly obese patients. BMC Surg 10:26.

Peifer C, Abadleh M, Bischof J, Hauser D, Schattel V, Hirner H, Knippschild U, Laufer S. 2009. 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta. J Med Chem 52:7618-30.
Löhler J, Hirner H, Schmidt B, Kramer K, Fischer D, Thal DR, Leithauser F, Knippschild U. 2009. Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice. PLoS One 4:e4174.

Brockschmidt C, Hirner H, Huber N, Eismann T, Hillenbrand A, Giamas G, Radunsky B, Ammerpohl O, Bohm B, Henne-Bruns D, Kalthoff H, Leithauser F, Trauzold A, Knippschild U. 2008. Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo. Gut 57:799-806.
Schmieder M, Wolf S, Danner B, Stoehr S, Juchems MS, Wuerl P, Henne-Bruns D, Knippschild U, Hasel C, Kramer K. 2008. p16 expression differentiates high-risk gastrointestinal stromal tumor and predicts poor outcome. Neoplasia 10:1154-62.
Grochola LF, Greither T, Taubert HW, Moller P, Knippschild U, Udelnow A, Henne-Bruns D, Wurl P. 2008. Prognostic relevance of hTERT mRNA expression in ductal adenocarcinoma of the pancreas. Neoplasia 10:973-6.
Grochola LF, Greither T, Taubert H, Moller P, Knippschild U, Udelnow A, Henne-Bruns D, Wurl P. 2008. The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related death. Br J Cancer 99:1083-8.
Kintscher U, Hartge M, Hess K, Foryst-Ludwig A, Clemenz M, Wabitsch M, Fischer-Posovszky P, Barth TF, Dragun D, Skurk T, Hauner H, Bluher M, Unger T, Wolf AM, Knippschild U, Hombach V, Marx N. 2008. T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vasc Biol 28:1304-10.

Giamas G, Hirner H, Shoshiashvili L, Grothey A, Gessert S, Kuhl M, Henne-Bruns D, Vorgias CE, Knippschild U. 2007. Phosphorylation of CK1delta: identification of Ser370 as the major phosphorylation site targeted by PKA in vitro and in vivo. Biochem J 406:389-98.
von Blume J, Knippschild U, Dequiedt F, Giamas G, Beck A, Auer A, Van Lint J, Adler G, Seufferlein T. 2007. Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2. EMBO J 26:4619-33.
Giamas G, Stebbing J, Vorgias CE, Knippschild U. 2007. Protein kinases as targets for cancer treatment. Pharmacogenomics 8:1005-16.

Wolff S, Stoter M, Giamas G, Piesche M, Henne-Bruns D, Banting G, Knippschild U. 2006. Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin. FEBS Lett 580:6477-84.

Wolff S, Xiao Z, Wittau M, Süssner N, Stöter M, Knippschild U. 2005. Interaction of casein kinase 1 delta (CK1 delta) with the light chain LC2 of microtubule associated protein 1A (MAP1A). Biochim Biophys Acta 1745:196-206.
Stöter M, Bamberger AM, Aslan B, Kurth M, Speidel D, Loning T, Frank HG, Kaufmann P, Lohler J, Henne-Bruns D, Deppert W, Knippschild U. 2005. Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells. Oncogene 24:7964-75.
Knippschild U, Wolff S, Giamas G, Brockschmidt C, Wittau M, Würl PU, Eismann T, Stöter M. 2005. The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development. Onkologie 28:508-14.
Knippschild U, Gocht A, Wolff S, Huber N, Lohler J, Stöter M. 2005. The casein kinase 1 family: participation in multiple cellular processes in eukaryotes. Cell Signal 17:675-89.

Winter M, Milne D, Dias S, Kulikov R, Knippschild U, Blattner C, Meek D. 2004. Protein kinase CK1delta phosphorylates key sites in the acidic domain of murine double-minute clone 2 protein (MDM2) that regulate p53 turnover. Biochemistry 43:16356-64.
Ventura RA, Martin-Subero JI, Knippschild U, Gascoyne RD, Delsol G, Mason DY, Siebert R. 2004. Centrosome abnormalities in ALK-positive anaplastic large-cell lymphoma. Leukemia 18:1910-1.

Meek DW, Knippschild U. 2003. Posttranslational modification of MDM2. Mol Cancer Res 1:1017-26.
Martin-Subero JI, Knippschild U, Harder L, Barth TF, Riemke J, Grohmann S, Gesk S, Hoppner J, Moller P, Parwaresch RM, Siebert R. 2003. Segmental chromosomal aberrations and centrosome amplifications: pathogenetic mechanisms in Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma? Leukemia 17:2214-9.
Maritzen T, Löhler J, Deppert W, Knippschild U. 2003. Casein kinase I delta (CKIdelta) is involved in lymphocyte physiology. Eur J Cell Biol 82:369-78.

Behrend L, Stöter M, Kurth M, Rutter G, Heukeshoven J, Deppert W, Knippschild U. 2000. Interaction of casein kinase 1 delta (CK1delta) with post-Golgi structures, microtubules and the spindle apparatus. Eur J Cell Biol 79:240-51.
Behrend L, Milne DM, Stöter M, Deppert W, Campbell LE, Meek DW, Knippschild U. 2000. IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. Oncogene 19:5303-13.

Janus F, Albrechtsen N, Knippschild U, Wiesmüller L, Grosse F, Deppert W. 1999. Different regulation of the p53 core domain activities 3'-to-5' exonuclease and sequence-specific DNA binding. Mol Cell Biol 19:2155-68.

Meek DW, Campbell LE, Jardine LJ, Knippschild U, McKendrick L, Milne DM. 1997. Multi-site phosphorylation of p53 by protein kinases inducible by p53 and DNA damage. Biochem Soc Trans 25:416-9.
Knippschild U, Milne DM, Campbell LE, DeMaggio AJ, Christenson E, Hoekstra MF, Meek DW. 1997. p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs. Oncogene 15:1727-36.
Henning W, Rohaly G, Kolzau T, Knippschild U, Maacke H, Deppert W. 1997. MDM2 is a target of simian virus 40 in cellular transformation and during lytic infection. J Virol 71:7609-18.

Knippschild U, Oren M, Deppert W. 1996. Abrogation of wild-type p53 mediated growth-inhibition by nuclear exclusion. Oncogene 12:1755-65.
Knippschild U, Milne D, Campbell L, Meek D. 1996. p53 N-terminus-targeted protein kinase activity is stimulated in response to wild type p53 and DNA damage. Oncogene 13:1387-93.
Stürzbecher HW, Donzelmann B, Henning W, Knippschild U, Buchhop S. 1996. p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction. EMBO J 15:1992-2002.

Knippschild U, Kolzau T, Deppert W. 1995. Cell-specific transcriptional activation of the mdm2-gene by ectopically expressed wild-type form of a temperature-sensitive mutant p53. Oncogene 11:683-90.

Zerrahn J, Knippschild U, Winkler T, Deppert W. 1993. Independent expression of the transforming amino-terminal domain of SV40 large I antigen from an alternatively spliced third SV40 early mRNA. EMBO J 12:4739-46.

Patschinsky T, Knippschild U, Deppert W. 1992. Species-specific phosphorylation of mouse and rat p53 in simian virus 40-transformed cells. J Virol 66:3846-59.

Knippschild U, Kiefer J, Patschinsky T, Deppert W. 1991. Phenotype-specific phosphorylation of simian virus 40 tsA mutant large T antigens in tsA N-type and A-type transformants. J Virol 65:4414-23.
Deppert W, Kurth M, Graessmann M, Graessmann A, Knippschild U. 1991. Altered phosphorylation at specific sites confers a mutant phenotype to SV40 wild-type large T antigen in a flat revertant of SV40-transformed cells. Oncogene 6:1931-8.

Howard Elder Preis der Universität Dundee für Nachwuchswissenschaftler (1996)

Mitglied der Gesellschaft für Biochemie und Molekularbiologie (GBM)

Editorial Board

The Open Enzyme Inhibition Journal (seit 2008)

Gutachtertätigkeit für folgende Journals:

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  • Deutsche Forschungsgemeinschaft, Welcome Trust (GB), University of Tübingen (Germany), University of Padua (Italy)