Werdegang
2000 - 2008 Magisterstudium Psychologie Leopold-Franzens Universität Innsbruck
2001 - 2003 Bakkalaureats Studium Philosophie Leopold-Franzens Universität Innsbruck
2003 - 2004 Magisterstudium Philosophie Leopold-Franzens Universität Innsbruck
2008 - 2010 Doktorats Studium Psychologie an der Abteilung für Experimentelle Psychiatrie der Medizinischen Universität Innsbruck unter Anleitung von Herrn ao. Univ.-Professor Dr. med. univ. Gerald Zernig
2010 Promotion über das Thema „Cocaine relapse prevention by social interaction and sigma 1 receptor inactivation: Development of an animal model“
2010 - 2014 Wissenschaftlicher Mitarbeiter am Institut für Klinische und Experimentelle Medizin der Universität Linköping, Schweden (Labor von Herrn Univ. Professor David Engblom). Mitarbeit an den Projekten „Circuits and mechanisms behind sickness-induced aversion and depressive symptoms“ und „Inflammation-induced aversion: Brain Circuitry and Molecular Mechanisms“
2014 - 2020 Assistenz (Junior) Professor am Zentrum für Soziale und Affektive Neurowissenschaften der Universität Linköping (Zentrumleitung Univ. Professor DDr. Markus Heilig). Leitung von Forschungsprojekten über Sigma 2 und Acetylcholin Rezeptoren als molekulare Ziele zur Behandlung von Kokainabhängigkeit.
2016 - 2017 3monatiger Aufenthalt als Gastwissenschaftler am Nationalen Institut für Drogensucht (NIDA) und dem Johns Hopkins Krankenhaus, Baltimore, USA im Labor von Dr. Michael Michaelides
2018 - 2020 Gastlektor am Institut für Psychiatrie und Verhaltenswissenschaften, Stanford School of Medicine, Stanford Universität, USA
2020 - Wissenschaftlicher Mitarbeiter am Lehrstuhl für Forensische Psychiatrie und Psychotherapie der Universität Ulm, Prof. Manuela Dudeck und Stationspsychologe an der Forensischen Psychiatrie BKH Günzburg

 

Publikationen

Wissenschaftliche Artikel

Fritz M, Wallner R, Grohs U, Kemmler G, Saria A, Zernig G. Comparable sensitivities of urine cotinine and breath carbon monoxide at follow-up time points of three months or more in a smoking cessation trial. Pharmacology. 2010, 85(4):234-40. doi: 10.1159/000280435

Fritz M, El Rawas R, Salti A, Klement S, Bardo MT, Kemmler G, Dechant G, Saria A, Zernig G.Reversal of cocaine-conditioned place preference and mesocorticolimbic Zif268 expression by social interaction in rats. Addict Biol. 2011, 16(2):273-84. doi: 10.1111/j.1369-1600.2010.00285.x.

Fritz M, Klement S, El Rawas R, Saria A, Zernig G. Sigma1 receptor antagonist BD1047 enhances reversal of conditioned place preference from cocaine to social interaction.Pharmacology. 2011, 87(1-2):45-8. doi: 10.1159/000322534.

Fritz M, El Rawas R, Klement S, Kummer K, Mayr MJ, Eggart V, Salti A, Bardo MT, Saria A, Zernig G. Differential effects of accumbens core vs. shell lesions in a rat concurrent conditioned place preference paradigm for cocaine vs. social interaction.PLoS One. 2011, 6(10):e26761. doi: 10.1371/journal.pone.0026761.

El Rawas R, Klement S, Kummer KK, Fritz M, Dechant G, Saria A, Zernig G. Brain regions associated with the acquisition of conditioned place preference for cocaine vs. social interaction. Front Behav Neurosci. 2012, 6:63. doi: 10.3389/fnbeh.2012.00063.

El Rawas R, Klement S, Salti A, Fritz M, Dechant G, Saria A, Zernig G. Preventive role of social interaction for cocaine conditioned place preference: correlation with FosB/DeltaFosB and pCREB expression in rat mesocorticolimbic areas. Front Behav Neurosci. 2012, 2;6:8. doi: 10.3389/fnbeh.2012.00008.

Fritz M, Klawonn AM, Nilsson A, Singh AK, Zajdel J, Wilhelms DB, Lazarus M, Löfberg A, Jaarola M, Kugelberg UÖ, Billiar TR, Hackam DJ, Sodhi CP, Breyer MD, Jakobsson J, Schwaninger M, Schütz G, Parkitna JR, Saper CB, Blomqvist A, Engblom D. Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice. J Clin Invest. 2016, 126(2):695-705. doi: 10.1172/JCI83844.

Singh AK, Zajdel J, Mirrasekhian E, Almoosawi N, Frisch I, Klawonn AM, Jaarola M, Fritz M, Engblom D. Prostaglandin-mediated inhibition of serotonin signaling controls the affective component of inflammatory pain. J Clin Invest. 2017, 3;127(4):1370-1374. doi: 10.1172/JCI90678.

Klawonn AM, Nilsson A, Rådberg CF, Lindström SH, Ericson M, Granseth B, Engblom D, Fritz M. The Sigma-2 Receptor Selective Agonist Siramesine (Lu 28-179) Decreases Cocaine-Reinforced Pavlovian Learning and Alters Glutamatergic and Dopaminergic Input to the Striatum. Front Pharmacol. 2017, 8:714. doi: 10.3389/fphar.2017.00714.

Fritz M, Klawonn AM, Jaarola M, Engblom D. Interferon-ɣ mediated signaling in the brain endothelium is critical for inflammation-induced aversion. Brain Behav Immun. 2018, 67:54-58. doi: 10.1016/j.bbi.2017.08.020.

Klawonn AM, Wilhelms DB, Lindström SH, Singh AK, Jaarola M, Wess J, Fritz M, Engblom D. Muscarinic M4 Receptors on Cholinergic and Dopamine D1 Receptor-Expressing Neurons Have Opposing Functionality for Positive Reinforcement and Influence Impulsivity. Front Mol Neurosci. 2018, 11:139. doi: 10.3389/fnmol.2018.00139.

Klawonn AM, Fritz M, Nilsson A, Bonaventura J, Shionoya K, Mirrasekhian E, Karlsson U, Jaarola M, Granseth B, Blomqvist A, Michaelides M, Engblom D.  Motivational valence is determined by striatal melanocortin 4 receptors. J Clin Invest. 2018, 128(7):3160-3170. doi: 10.1172/JCI97854.

Zhao Q, Fritz M, Pfefferbaum A, Sullivan EV, Pohl KM, Zahr NM. Jacobian Maps Reveal Under-reported Brain Regions Sensitive to Extreme Binge Ethanol Intoxication in the Rat. Front Neuroanat. 2018, 12:108. doi: 10.3389/fnana.2018.00108.

Fritz M, Klawonn AM, Zhao Q, Sullivan EV, Zahr NM, Pfefferbaum A. Structural and biochemical imaging reveals systemic LPS-induced changes in the rat brain. J Neuroimmunol. 2020, 348:577367. doi: 10.1016/j.jneuroim.2020.577367.

Fritz M, Shenar R, Cardenas-Morales L, Jäger M, Streb J, Dudeck M, Franke I. Aggressive and Disruptive Behavior Among Psychiatric Patients With Major Depressive Disorder, Schizophrenia, or Alcohol Dependency and the Effect of Depression and Self-Esteem on Aggression. Front Psychiatry. 2020, 11:599828. doi: 10.3389/fpsyt.2020.599828.

Klawonn, A. M., Fritz, M., Castany, S., Pignatelli, M., Canal, C., Simil, F., Tejeda, H. A., Levinsson, J., Jaarola, M., Jakobsson, J., Hidalgo, J., Heilig, M., Bonci, A., & Englom, D. Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons. Immunity, 2021, 54:1-10 doi.org/10.1016/j.immuni.2020.12.016

Review Artikel

Fritz M, Klawonn AM, Zahr NM. Neuroimaging in alcohol use disorder: From mouse to man. J Neurosci Res. 2019, 10.1002/jnr.24423. doi: 10.1002/jnr.24423.

Buchkapitel

Klawonn, A.M., Fritz, M. Immune-to-Brain Signaling Effects on the Neural Substrate for Reward: Behavioral Models of Aversion, Anhedonia, and Despair. Neuromethods, 2021, 165, pp. 145–167