AG PD Dr. Dr. Hermann

Cancer stem cells (CSCs), also known as tumor-initiating cells, are a distinct subset of cells within a tumor that share features with stem cells. We have demonstrated previously that these cells play an outstanding role in the malignant progression, chemoresistance, metastasis, and relapse of solid tumors.
In the Stem Cells & Cancer Group, we study CSCs in gastrointestinal tumors, primarily in pancreatic ductal adenocarcinoma (PDAC). The lab has a strong focus on basic research, using genetically engineered mouse models of pancreatic cancer as well as primary human patient tissues and cells. Furthermore we put strong emphasis on translating basic research results into a clinical setting, looking into screening and early detection methods for pancreatic neoplasias.

We are specifically interested in:

• the identification and characterization of new biomarkers for the detection of CSCs

•  the identification and regulation of proteins and signaling pathways that govern key CSC phenotypes, such as stemness, epithelial to mesenchymal transition (EMT), metastasis, and chemoresistance.

• a deeper understanding of CSC-specific features to develop new targeted therapies against pancreatic cancer

•  mechanisms of metastasis and therapy resistance

Frank Arnold, M.Sc.

Tabea Dittrich, cand. med.

Stefanie Hauff, B.Sc.

Kanishka Tiwary, M.Sc.

Tetyana Usachova

Andrea Wißmann, BTA

Click here for complete publication list.

• D'Errico G, Alonso-Nocelo M, Vallespinos M, Hermann PC, Alcalá S, García CP, Martin-Hijano L, Valle S, Earl J, Cassiano C, Lombardia L, Feliu J, Monti MC, Seufferlein T, García-Bermejo L, Martinelli P, Carrato A, Sainz B Jr. Tumor-associated macrophage-secreted 14-3-3ζ signals via AXL to promote pancreatic cancer chemoresistance. Oncogene. 2019 Jul;38(27):5469-5485

• Walter K*, Tiwary K*, Trajkovic-Arsic M, Hidalgo-Sastre A, Schulte LA, Seufferlein T, Sainz B Jr., Siveke JT, Rodriguez-Aznar E, Hermann PC. MEK inhibition targets cancer stem cells and impedes migration of pancreatic cancer cells in vitro and in vivo. Stem Cells Int. 2019 Jun 2;2019:8475389

• Hermann PC, Sainz B Jr. Pancreatic Cancer Stem Cells: A State or an Entity? Semin Cancer Biol. 2018 Dec;53:223-231.

• Berger AW, Schwerdel D, Costa IG, Hackert T, Strobel O, Lam S, Barth TF, Schröppel B, Meining A, Büchler MW, Zenke M, Hermann PC, Seufferlein T *, Kleger A *. Detection of Hot-Spot Mutations in Circulating Cell-Free DNA From Patients With Intraductal Papillary Mucinous Neoplasms of the Pancreas. Gastroenterology. 2016 Aug;151(2):267-70.
• Sainz B Jr, Alcala S, Garcia E, Sanchez-Ripoll Y, Azevedo MM, Cioffi M, Tatari M, Miranda-Lorenzo I, Hidalgo M, Gomez-Lopez G, Cañamero M, Erkan M, Kleeff J, García-Silva S, Sancho P, Hermann PC, Heeschen C. Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment. Gut. 2015 Dec;64(12):1921-35.
• Hermann PC, Sancho P, Canamero M, Martinelli P, Madriles F, Michl P, Gress T, de Pascual R, Gandia L, Guerra MC, Barbacid M, Wagner M, Vieira C, Aicher A, Real FX, Sainz BJ, Heeschen C. Nicotine Promotes Initiation and Progression of KRAS-induced Pancreatic Cancer via Gata6-dependent Dedifferentiation of Acinar Cells in Mice. Gastroenterology. 2014 Nov;147(5):1119-33.e4.
• Hermann PC, Heeschen C. Metastatic cancer stem cells – Quo vadis? Clin Chem. 2013 Aug;59(8):1268-9.
• Lonardo E, Hermann PC, Mueller MT, Huber S, Balic A, Miranda I, Zagorac S, Alcala S, Rodriguez I, Ramirez JC, Torres R, Garcia E, Hidalgo M, Cebrian DA, Heuchel R, Löhr M, Berger F, Bartenstein P, Aicher A, Heeschen C. Nodal/Activin Signaling Drives Self-Renewal and Tumorigenicity of Pancreatic Cancer Stem Cells and Provides a Target for Combined Drug Therapy. Cell Stem Cell 2011 Nov 4; 9(5): 433-446. 
• Gallmeier E *, Hermann PC *, Mueller MT, Machado JG, Ziesch A, De Toni EN, Palagyi A, Eisen C, Ellwart JW, Rivera J, Rubio-Viqueira B, Hidalgo M, Bunz F, Göke B, Heeschen C. Inhibition of ataxia telangiectasia- and Rad3-related function abrogates the in vitro and in vivo tumorigenicity of human colon cancer cells through depletion of the CD133(+) tumor-initiating cell fraction. Stem Cells. 2011 Mar;29(3):418-29. (* shared authorship)
• Hermann PC, Bhaskar S, Cioffi M, Heeschen C. Cancer stem cells in solid tumors. Semin Cancer Biol. 2010 Apr;20(2):77-84.
• Mueller MT, Hermann PC, Huber SL, Leicht SF, Wittauer J, Mustafa M, Bartenstein P, Berger F, Ellwart JW, D’Haese JG, Schoenberg MH, Jauch KW, Hidalgo M, Heeschen C. Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer.  Gastroenterology. 2009 Sep; 137(3): 1102-13.
• Hermann PC, Huber SL, Herrler T, Aicher A, Ellwart JW, Guba M, Bruns CJ, Heeschen C. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer.  Cell Stem Cell.  2007 Sep 13; 1(3): 313-23. 

We currently offer positions for Master Students, a call for PhD students will be opened soon. 

If you are interested in joining our group, please contact the PI directly under patrick.hermann@uni-ulm.de .