The heart is the first organ to form and function in the mammalian embryo. To generate a fully functional heart, complex processes that involve specification and determination of cardiac progenitor cells, the migration of this cell population to the organ-forming region, the differentiation of the precursor cells to specialized cell types, interaction and signaling within and between tissues, elaborate morphogenetic events and remodeling to form the proper shape of the heart, and finally organ growth and functional maturation have to be orchestrated. Even minor alterations in these events often result in serious cardiac malformations. Although detailed anatomic analysis of the developing heart has already been available for a long time, the molecular and cellular mechanisms that regulate cardiogenesis are still largely unknown. The identification and characterization of the genetic and molecular underpinnings of heart development is of critical interest since the wide spectrum of congenital cardiovascular malformations found from the prenatal period into adulthood has challenged clinicians and scientists for decades.

Therefore, the main objective of our workgroup "Molecular Cardiology" is to describe by in vitro (iPSC-derived cardiomyocytes, cell cultures) and in vivo (zebrafish and mouse) functional genomics approaches the genetic, molecular and cellular events leading to the specification and determination of cardiac precursor cells, their differentiation into specialized cardiac cell types, cardiac growth, maturation and function as well as the regeneration of the heart. The long-term goal of our research is to decipher the complex genetic and molecular networks of heart development and function and to use this information for the development of novel therapeutic treatment options for inherited and acquired heart diseases.

Profilbild von Prof. Dr. rer. nat. Steffen Just

Prof. Dr. rer. nat. Steffen Just

Head of Workgroup


Nexilin, is a cardiomyopathy-associated F-actin binding protein, which is expressed specifically in human heart and skeletal muscle. Located at the Z-disks of sarcomeric units, it has an essential role in the maintenance of Z-disks and sarcomere integrity. Identified functions of Nexilin are to protect and stabilize Z-disks from forces generated within muscle contraction. Dilated cardiomyopathy-causing gene variants of Nexilin seem to lose the attachment ability to the sarcomeric scaffolding complex and hence Z-disk alignments become disrupted. To understand the molecular composition of cardiac Z-disks regarding how Nexilin is integrated, we are searching for new protein binding partners.Besides the structural character, Nexilin is also analyzed for its potential functional impact in biochemical signalling, mechanosensation and mechanotransduction.

The development of the vertebrate heart is not only dependent on molecular specifications and morphogenetic movements but also on organ growth. Cardiac growth can be accomplished by either hyperplasia or hypertrophy. Early in embryonic heart development cardiac growth is mainly due to hyperplasic cardiomyocyte proliferation hereby increasing cardiac cell mass. Thereafter the heart enlarges for the most part by hypertrophic expansion of the cardiomyocyte cell volume. The analysis of zebrafish mutants with defects in heart growth can help sheding light onto the molecular mechanisms beneath hyperplasic and hypertrophic processes.

In humans, cardiac infarction leads to myocardial cell death and scar formation, which subsequently lead to heart insufficiency. The zebrafish however has the capability to regenerate the heart completely after myocardial damage. Therefore we aim to understand the molecular pathways orchestrating myocardial regeneration and proliferation in zebrafish to develop therapeutic treatment strategies.

In search for molecules that control cardiac contractility, we isolated the zebrafish mutant main squeeze (msq), which displays progressive heart failure due to a mutation (msqL308P) within the Integrin-linked kinase (ILK) gene. It has been shown that the ILK-Pinch-Parvin (IPP) complex is crucial for mechanotransduction in cardiomyocytes by controlling the expression of the stretch responsive genes anf and vegf via PKB signaling (Bendig et al. 2006). For a better understanding of mechanotransduction in cardiomyocytes it is essential to learn more about the underlying molecular mechanisms. Therefore we investigate known interactors of ILK, by morpholino antisense oligonucleotide mediated gene knockdown in zebrafish.

Another aim is to identify new compounds which are able to reconstitute the cardiac function in msq mutants. In cooperation with the Karlsruher Institute of technology (K.I.T), we developed a high-troughput, fully-automated bioanalytics screening platform (Spomer et al., 2012). This robotics-assisted multicamera microscope allows us to easily screen the therapeutic relevance of small compound libraries on our zebrafish mutants in 96- or 384 well formats.

Myofibrillar myopathies (MFM) are progressive diseases of human heart and skeletal muscle. They are often associated with premature death. The muscle pathology is characterized by desmin-positve protein aggregates and myofibrillar degeneration. Half of all MFM are caused by mutations in genes encoding sarcomeric and extra-sarcomeric proteins (desmin, filamin C, plectin, VCP, FHL1, ZASP, myotilin, and αB-crystallin). Other half of these diseases are due to so far unidentified gene defects. The onset of the progressive muscle symptoms varies depending on the affected gene. FHL1- and plectin-related MFM may manifest either in childhood, adolescence or adulthood. Desmin- and αB-crystallin-related MFM tend to manifest in early and middle adulthood. Whereas disease onset beyond the forth decade of life is typical for myotilin-, ZASP-, VCP and filamin C-gene mutations. Also the clinical value is variable in MFM. Skeletal muscle weakness in the lower extremities is the most frequent initial clinical symptom. Additionally certain patterns of extra skeletal muscle involvement are typical for subtypes of MFM. Cardiac pathology is a characteristic hallmark of MFM due to desmin, αB-crystallin, FHL1 gene mutations. To date, no causative or even ameliorating therapies exist for these numerically significant group of hereditary myopathies. Since the molecular pathomechanism are largely unknown, a good model organism is essential for the identification and further analysis of the suitable illness genes. The obtained findings can later serve as a basis for the development of new therapies.

Some hereditary diseases are fatal for the patients but they are still not completely clarified. One of those is Epidermolysis bullosa simplex with muscular dystrophy (MD-EBS). It is characterized by severe skin blistering associated with muscular involvement and caused by defects in the plectin gene. Plectin is expressed in nearly all mammalian cells and acts as cytoskeletal crosslinker between microfilaments, microtubules and intermediate filaments.

With the aid of transgenic fish lines and knockdowns via morpholino injections, we are trying to characterize Plectin and its isoforms to achieve a better understanding of plectin and related diseases.

By positional cloning we identified a nonsense mutation within the SET- and MYND-domain containing protein 1 gene (smyd1) to be responsible for the flatline phenotype which shows disturbed sarcomere assembly restricted to fast-twitch skeletal muscle and heart muscle leading to loss of contraction. The methyltransferase Smyd1 localizes to the M-line, where it associates with myosin, and the nucleus, where it regulates gene expression. By rescue experiments several human mutation variants were tested because of their relevance of possibly leading to dilatative cardiomyopathies in humans.


  • Profilbild von Prof. Dr. rer. nat. Steffen Just

    Prof. Dr. rer. nat. Steffen Just

    Head of Workgroup

  • Profilbild von Dr. Anja Bühler

    Dr. Anja Bühler


  • Profilbild von Dr. Federica Diofano

    Dr. Federica Diofano


  • Profilbild von Dr. Bernd Gahr

    Dr. Bernd Gahr


  • Profilbild von Dr. Annette Palmer

    Dr. Annette Palmer


  • Profilbild von Dr. Deung-Dae Park

    Dr. Deung-Dae Park


  • Profilbild von Prof. Dr. med. Mirjam Keßler

    Prof. Dr. med. Mirjam Keßler


    Fachärztin für Innere Medizin und Kardiologie

    Zusatzqualifikation Interventionelle Kardiologie

    Zusatzbezeichnung Intensivmedizin

    Zusatzqualifikation Herzinsuffizienz

    • Interventionelle AV-Klappentherapie, invasive und nicht-invasive Herzinsuffizienztherapie
  • Profilbild von PD Dr. med. Karolina Weinmann-Emhardt

    PD Dr. med. Karolina Weinmann-Emhardt

    Leiterin Ablative Elektrophysiologie


    Fachärztin für Innere Medizin und Kardiologie

    Zusatzbezeichnung Intensivmedizin

    Zusatzqualifikation Spezielle Rhythmologie - Invasive Elektrophysiologie und Aktive Herzrhythmusimplantate

    • Invasive und nicht-invasive Elektrophysiologie
  • Profilbild von  Lara Bejatovic

    Lara Bejatovic

    PhD Student

  • Profilbild von  Larissa Hartmann

    Larissa Hartmann

    PhD Student

  • Profilbild von  Juchuan Liu

    Juchuan Liu

    PhD Student

  • Profilbild von  Sujin Kim

    Sujin Kim

    PhD Student

  • Profilbild von  Karin Strele

    Karin Strele


  • Profilbild von  Katrin Vogt

    Katrin Vogt


  • Profilbild von  Sabrina Diebold

    Sabrina Diebold


  • Profilbild von  Renate Durst

    Renate Durst


  • Profilbild von  Jessica Hofmiller

    Jessica Hofmiller


  • Profilbild von  Denise Mann

    Denise Mann


  • Profilbild von  Irina Lengard

    Irina Lengard

  • Profilbild von  Helge Stranz

    Helge Stranz

  • Profilbild von  Gerhard Bückle

    Gerhard Bückle

Dr. Janessa Hofeichner

Dr. Alena Boos

Dr. Amelia Glazier

Dr. Kevin Thiessen

Dr. Isabelle Schneider

Dr. Christoph Paone

Dr. Diana Krattenmacher

Dr. Maryam Shahid

Dr. Monika Kustermann, geb. Forster

Dr. Linda Raphel

Dr. Julia Segert

Dr. Steven Rudeck

Dr. Sofia Hirth

Dr. Muzamil Khan

Dr. John Bührdel

Dr. Daniela Asam

Dr. Linda Manta, geb. Gärtner

Dr. Eva Patzel

Dr. Ina Berger


Regine Baur

Hedwig Frank

Kristin Haugg



J. Hofeichner, B. M. Gahr, M. Huber, A. Boos, W. Rottbauer, S. Just. CRISPR/Cas9-mediated nexilin deficiency interferes with cardiac contractile function in zebrafish in vivo.  Sci Rep. 2023. 13(1):22679.10.1038/s41598-023-50065-9.

L. Meier, B. M. Gahr, A. Roth, A. Gihring, S. Kirschner, C. Woitaske-Proske, J. Baier, C. Peifer, S. Just, U. Knippschild. Zebrafish as model system for the biological characterization of CK1 inhibitors.  Front Pharmacol. 2023. 14:1245246.10.3389/fphar.2023.1245246.

J. Krause, A. Nickel, A. Madsen, H. M. Aitken-Buck, A. M. S. Stoter, J. Schrapers, F. Ojeda, K. Geiger, M. Kern, M. Kohlhaas, E. Bertero, P. Hofmockel, F. Hubner, I. Assum, M. Heinig, C. Muller, A. Hansen, T. Krause, D. D. Park, S. Just, D. Aissi, D. Bornigen, D. Lindner, N. Friedrich, K. Alhussini, C. Bening, R. B. Schnabel, M. Karakas, L. Iacoviello, V. Salomaa, A. Linneberg, H. Tunstall-Pedoe, K. Kuulasmaa, P. Kirchhof, S. Blankenberg, T. Christ, T. Eschenhagen, R. R. Lamberts, C. Maack, J. Stenzig, T. Zeller. An arrhythmogenic metabolite in atrial fibrillation.  J Transl Med. 2023. 21(1):566.10.1186/s12967-023-04420-z.

A. Boos, B. M. Gahr, D. D. Park, V. Braun, A. Buhler, W. Rottbauer, S. Just. Hdac1-deficiency affects the cell cycle axis Cdc25-Cdk1 causing impaired G2/M phase progression and reduced cardiomyocyte proliferation in zebrafish.  Biochem Biophys Res Commun. 2023. 665:98-106.10.1016/j.bbrc.2023.04.116.

S. Michels, D. Kurz, A. Rosenbohm, R. S. Peter, S. Just, H. Bazner, A. Bortlein, C. Dettmers, H. J. Gold, A. Kohler, M. Naumann, P. Ratzka, A. C. Ludolph, D. Rothenbacher, G. Nagel, J. Dorst ,A. L. S. Registry Swabia Study Group. Association of blood lipids with onset and prognosis of amyotrophic lateral sclerosis: results from the ALS Swabia registry.  J Neurol. 2023. 270(6):3082-3090.10.1007/s00415-023-11630-4.

Rayhane Nchioua, Federica Diofano, Sabrina Noettger, Pascal von Maltitz, Steffen Stenger, Fabian Zech, Jan Münch, Konstantin M J Sparrer, Steffen Just, Frank Kirchhoff. Strong attenuation of SARS-CoV-2 Omicron BA.1 and increased replication of the BA.5 subvariant in human cardiomyocytes.Signal Transduct Target Ther. 2022 Dec; 7(1), 395. doi: 10.1038/s41392-022-01256-9.

Francesca Ferrante, Benedetto Daniele Giaimo, Tobias Friedrich, Toshiya Sugino, Daniel Mertens, Sabrina Kugler, Bernd Martin Gahr, Steffen Just, Leiling Pan, Marek Bartkuhn, Michael Potente, Franz Oswald, Tilman Borggrefe.  Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics.  Cell Death Dis. 2022 Jul 12;13(7):600. doi: 10.1038/s41419-022-05052-9.

Philipp Voisard, Federica Diofano, Amelia A Glazier, Wolfgang Rottbauer, Steffen Just. CRISPR/Cas9-Mediated Constitutive Loss of VCP (Valosin-Containing Protein) Impairs Proteostasis and Leads to Defective Striated Muscle Structure and Function In Vivo.  Int J Mol Sci. 2022 Jun 16;23(12):6722. doi: 10.3390/ijms23126722.

Bühler A, Gahr B, Park DD, Bertozzi A, Boos A, Dalvoy M, Pott A, Oswald F, Kovall R, Kühn B, Weidinger G, Rottbauer W, Just S. Histone deacetylase 1 controls cardiomyocyte proliferation during embryonic heart development and cardiac regeneration in zebrafishPLoS Genet. 2021 Nov1;17(11):e1009890.doi:10.1371/journal.pgen.1009890. eCollection 2021 Nov

Park DD, Gahr B, Krause J, Rottbauer W, Zeller T, Just S. Long-Chain Acyl-Carnitines Interfere with Mitochondrial ATP Production Leading to Cardiac Dysfunction in ZebrafishInt J Mol Sci 2021 Aug 6;22(16):8468. doi: 10.3390/ijms22168468.

Caterina Prelli Bozzo , Rayhane Nchioua , Meta Volcic , Lennart Koepke , Jana Krüger , Desiree Schütz , Sandra Heller , Christina M Stürzel , Dorota Kmiec , Carina Conzelmann, Janis Müller , Fabian Zech , Elisabeth Braun , Rüdiger Groß , Lukas Wettstein , Tatjana Weil , Johanna Weiß , Federica Diofano , Armando A Rodríguez Alfonso, Sebastian Wiese, Daniel Sauter, Jan Münch, Christine Goffinet, Alberto Catanese, Michael Schön, Tobias M Boeckers, Steffen Stenger, Kei Sato, Steffen Just, Alexander Kleger, Konstantin M J Sparrer, Frank Kirchhoff. IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro. Nat Commun​​​​​​ 2021 Jul 28;12(1):4584.doi: 10.1038/s41467-021-24817-y.

Sandra Hoffmann, Ralph Roeth, Sabrina Diebold, Jasmin Gogel, David Hassel, Steffen Just, Gudrun A Rappold. Identification and Tissue-Specific Characterization of Novel SHOX-Regulated Genes in Zebrafish Highlights SOX Family Members Among Other GenesFront Genet. 2021 May 27;12:688808. doi: 10.3389/fgene.2021.688808. eCollection 2021.

S Hoffmann, S Schmitteckert, K Raedecke, D Rheinert, S Diebold, R Roeth, B Weiss, M Granzow, B Niesler, A Griesbeck, V Eckstein, W-H Zimmermann, S Just, G A Rappold. Network-driven discovery yields new insight into Shox2-dependent cardiac rhythm controlBiochim Biophys Acta Gene Regul Mech. Apr-May 2021;1864(4-5):194702. doi: 10.1016/j.bbagrm.2021.194702. Epub 2021 Mar 8.

Daniel J Klionsky , Just S. Abdel-Aziz AK et a​​​​​​​l. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)  Autophagy. 2021 Feb 8;1-382.doi:10.1080/15548627.2020.1797280.

Rattka M, Westphal S, Gahr B, Just S, Rottbauer W. Spen deficiency interferes with Connexin 43 expression and leads to heart failure in zebrafish. J Mol Cell Cardiol. 2021 Feb 5;155:25-35.doi: 10.1016/j.yjmcc.2021.01.006

Hao Li, Yangyang Qu, Metze P, Sommerfeld F ,  Just S, Abaei A, Rasche V. Quantification of Biventricular Myocardial Strain Using CMR Feature Tracking: Reproducibility in Small AnimalsBiomed Res Int. 2021 Jan 22;2021:8492705. doi: 10.1155/2021/8492705

Diofano F, Weinmann K, Schneider I, Thiessen K, Rottbauer W, Just SGenetic compensation prevents myopathy and heart failure in an in vivo model of Bag3 deficiency.  PLoS Genet.​​​​​2020 Nov 2;16(11):e1009088. doi: 10.1371/journal.pgen.1009088

Ferrante F; Giaimo BD; Bartkuhn M; Zimmermann T; Close V; Mertens D ; Nist A; Stiewe T; Meier-Soelch J; Kracht M; Just S; Kloble P; Oswald F; Borggrefe T. HDAC3 functions as a positive regulator in Notch signal transduction. Nucleic Acids Res. 2020 Apr 17;48(7):3496-3512. doi: 10.1093/nar/gkaa088.

Li H; Metze P; Abaei A; Rottbauer W; Just S; Lu QH ; Rasche V. Feasibility of real-time cardiac MRI in mice using tiny golden angle radial sparseNMR Biomed. 2020 Jul;33(7):e4300. doi: 10.1002/nbm.4300

Li H; Abaei A; Metze P; Just S; Lu QH; Rasche V. Technical Aspects ofin vivoSmall Animal CMR ImagingFRONTIERS IN PHYSICS, Review, JUN 10 2020, DOI: 10.3389/fphy.2020.00183

Pott A, Rottbauer W, Just S. Streamlining drug discovery assays for cardiovascular disease using zebrafish. Expert Opinion in Drug Discovery. 2019 Oct 01.

Schutera M, Just S, Gierten J, Mikut R, Reischl M, Pylatiuk C. Machine Learning Methods for Automated Quantification of Ventricular Dimensions. Zebrafish. 2019 Sep 19. doi: 10.1089/zeb.2019.1754.

Hoffmann S, Paone C, Sumer SA, Diebold S, Weiss B, Roeth R, Clauss S, Klier I, Kääb S, Schulz A, Wild PS, Ghrib A, Zeller T, Schnabel RB, Just S, Rappold GA. Functional Characterization of Rare Variants in the SHOX2 Gene Identified in Sinus Node Dysfunction and Atrial Fibrillation. Front Genet. 2019 Jul 11;10:648. doi: 10.3389/fgene.2019.00648

Lausser L*, Siegle L*, Rottbauer W, Frank D**,  Just S**, Kestler HA**.  Semantic Multi-Classifier Systems Identify Predictive Processes in Heart Failure Models across Species *equal contribution, **joint senior authors, Biomolecules 2018, 8(4), 158;

Pott A, Just S. Metabolic Profiling of Glucocorticoid Deficiency: A "Fishing" Expedition. EBioMedicine. 2018 Oct 31. pii: S2352-3964(18)30476-6. doi: 10.1016/j.ebiom.2018.10.058.

Pott A*, Shahid M*, Köhler D, Pylatiuk C, Weinmann K, Just S** and Rottbauer W** Therapeutic Chemical Screen Identifies Phosphatase Inhibitors to Reconstitute PKB Phosphorylation and Cardiac Contractility in ILK-Deficient Zebrafish. *equal contribution, **joint senior authors, Biomolecules 2018, 8(4), 153; doi:10.3390/biom8040153

Krämer LM, Brettschneider J, Lennerz JK, Walcher D, Fang L, Rosenbohm A, Balakrishnan K, Benckendorff J, Möller P, Just S, Willem M, Ludolph AC, Thal DR. Amyloid precursor protein-fragments-containing inclusions in cardiomyocytes with basophilic degeneration and its association with cerebral amyloid angiopathy and myocardial fibrosis.Sci Rep. 2018 Nov 9;8(1):16594. doi: 10.1038/s41598-018-34808-7.

Segert J, Schneider I, Berger IM, Rottbauer W, Just S. Mediator complex subunit Med12 regulates cardiac jelly development and AV valve formation in zebrafish. Prog Biophys Mol Biol. 2018 Jul 20. pii: S0079-6107(18)30023-3. doi: 10.1016/j.pbiomolbio.2018.07.010.

Kustermann M, Manta L, Paone C, Kustermann J, Lausser L, Wiesner C, Eichinger L, Clemen CS, Schröder R, Kestler HA, Sandri M, Rottbauer W, Just S. Loss of the novel Vcp (valosin containing protein) interactor Washc4 interferes with autophagy-mediated proteostasis in striated muscle and leads to myopathy in vivo. Autophagy. 2018;14(11):1911-1927. doi: 10.1080/15548627.2018.1491491. Epub 2018 Aug 16.

Helferich AM, Brockmann SJ, Reinders J, Deshpande D, Holzmann K, Brenner D, Andersen PM, Petri S, Thal DR, Michaelis J, Otto M, Just S, Ludolph AC, Danzer KM, Freischmidt A, Weishaupt JH. Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS. Cell Mol Life Sci. 2018 Dec;75(23):4301-4319. doi: 10.1007/s00018-018-2873-1. Epub 2018 Jul 20.

Kramer F, Just S, Zeller T. New Perspectives: Systems medicine in cardiovascular disease. BMC Systems Biology ; 2018 Apr 25. doi:  10.1186/s12918-018-0579-5

Paone C, Diofano F, Park DD, Rottbauer W, Just S. Genetics of Cardiovascular Disease: Fishing for Causality. Frontiers in Cardiovascular Medicine. Front. Cardiovasc. Med., 01 June 2018,

Pott A, Bock S, Berger IM, Frese K, Dahme T, Keßler M, Rinné S, Decher N, Just S*, Rottbauer W*. Mutation of the Na+/K+-ATPase Atp1a1a.1 causes QT interval prolongation and bradycardia in zebrafish. * equal contribution. J Mol Cell Cardiol. 2018 Jul;120:42-52. doi: 10.1016/j.yjmcc.2018.05.005. Epub 2018 May 8.

Keßler M, Kieltsch A, Kayvanpour E, Katus HA, Schoser B, Schessl J, Just S*, Rottbauer W* (2018) A zebrafish model for FHL1-opathy reveals loss-of-function effects of human FHL1 mutations. * equal contribution. Neuromuscular Disorders doi:10.1016/j.nmd.2018.03.001

Silbernagel N, Walecki M, Schäfer MK, Kessler M, Zobeiri M, Rinné S, Kiper AK, Komadowski MA, Vowinkel KS, Wemhöner K, Fortmüller L, Schewe M, Dolga AM, Scekic-Zahirovic J, Matschke LA, Culmsee C, Baukrowitz T, Monassier L, Ullrich ND, Dupuis L, Just S, Budde T, Fabritz L & Decher N. The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. FASEB Journal. In press

Brockmann SJ, Freischmidt A, Oeckl P, Muller K, Ponna SK, Helferich AM, Paone C, Reinders J, Kojer K, Orth M, Jokela M, Auranen M, Udd B, Hermann A, Danzer KM, Lichtner P, Walther P, Ludolph AC, Andersen PM, Otto M, Kursula P, Just S, Weishaupt JH (2018) CHCHD10 mutations p.R15L and p.G66V cause motoneuron disease by haploinsufficiency. Hum Mol Genet doi:10.1093/hmg/ddx436

Paone C, Rudeck S, Etard C, Strahle U, Rottbauer W, Just S (2018) Loss of zebrafish Smyd1a interferes with myofibrillar integrity without triggering the misfolded myosin response. Biochem Biophys Res Commun doi:10.1016/j.bbrc.2018.01.060

Decher N, Ortiz-Bonnin B, Friedrich C, Schewe M, Kiper AK, Rinné S, Seemann G, Peyronnet R, Zumhagen S, Bustos D, Kockskämper J, Kohl P, Just S, González W, Baukrowitz T, Stallmeyer B, Schulze-Bahr E. Sodium permeable and "hypersensitive" TREK-1 channels cause ventricular tachycardia.EMBO Mol Med. 2017 Feb 27, doi: 10.15252/emmm.201606690

Straubinger J, Boldt K, Kuret A, Deng L, Krattenmacher D, Bork N, Desch M, Feil R, Feil S, Nemer M, Ueffing M, Ruth P, Just S, Lukowski R. Amplified pathogenic actions of angiotensin II in cysteine-rich LIM-only protein 4 negative mouse hearts. FASEB Journal. 2017 Jan 30, doi: 10.1096/fj.201601186

Just S, Raphel L, Berger IM, Bühler A, Keßler M, Rottbauer W. Tbx20 Is an Essential Regulator of Embryonic Heart Growth in Zebrafish.2016 Dec 1, doi: 10.1371/journal.pone.0167306. eCollection 2016

Just S, Hirth S, Berger IM, Fishman MC, Rottbauer W. The mediator complex subunit Med10 regulates heart valve formation in zebrafish by controlling Tbx2b-mediated Has2 expression and cardiac jelly formation.Biochem Biophys Res Commun. 2016 Jun 22, doi:10.1016/j.bbrc.2016.06.088

Rudeck S, Etard C, Khan MM, Rottbauer W, Rudolf R, Strähle U, Just S. A compact unc45b-promoter drives muscle-specific expression in zebrafish and mouse.Genesis. 2016 Jun 13, doi: 10.1002/dvg.22953

Richter J, Rudeck S, Kretz AL, Kramer K, Just S, Henne-Bruns D, Hillenbrand A, Leithäuser F, Lemke J, Knippschild U. Decreased CK1δ expression predicts prolonged survival in colorectal cancer patients.Tumour Biol. 2016 Jan 7, doi: 10.1007/s13277-015-4745-8

Hirth S, Bühler A, Bührdel JB, Rudeck S, Dahme T, Rottbauer W, Just S. Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart.PLoS One. 2016 Mar 8, doi: 10.1371/journal.pone.0150323. eCollection 2016

Hoffmann S, Clauss S, Berger IM, Weiß B, Montalbano A, Röth R, Bucher M, Klier I, Wakili R, Seitz H, Schulze-Bahr E, Katus HA, Flachsbart F, Nebel A, Guenther SP, Bagaev E, Rottbauer W, Kääb S, Just S, Rappold GA. Coding and non-coding variants in the SHOX2 gene in patients with early-onset atrial fibrillation.Basic Res Cardiol. 2016 May, doi: 10.1007/s00395-016-0557-2

Bühler A, Kustermann M, Bummer T, Rottbauer W, Sandri M, Just S. Atrogin-1 Deficiency Leads to Myopathy and Heart Failure in Zebrafish.Int J Mol Sci. 2016 Jan 30, doi: 10.3390/ijms17020187

Aherrahrou Z, Schlossarek S, Stoelting S, Klinger M, Geertz B, Weinberger F, Kessler T, Aherrahrou R, Just S, Rottbauer R, Eschenhagen T, Schunkert H, Carrier L, Erdmann J. Knock-out of nexilin in mice leads to dilated cardiomyopathy and endomyocardial fibroelastosis. Basic Res Cardiol. 2016 Jan, doi: 10.1007/s00395-015-0522-5

Kessler M, Rottbauer W, Just S. Recent progress in the use of zebrafish for novel cardiac drug discovery.Expert opinion on drug discovery. 2015 Nov 2, doi: 10.1517/17460441.2015.1078788

Frese KS, Meder B, Keller A, Just S, Haas J, Vogel B, Fischer S, Backes C, Matzas M, Kohler D, Benes V, Katus HA, Rottbauer W. RNA splicing regulated by RBFOX1 is essential for cardiac function in zebrafish.Journal of cell science. 2015 Aug 15, doi: 10.1242/jcs.166850

Clemen CS, Marko M, Strucksberg KH, Behrens J, Wittig I, Gartner L, Winter L, Chevessier F, Matthias J, Turk M, Tangavelou K, Schutz J, Arhzaouy K, Klopffleisch K, Hanisch FG, Rottbauer W, Blumcke I, Just S, Eichinger L, Hofmann A, Schroder R. VCP and PSMF1: Antagonistic regulators of proteasome activity. Biochem Biophys Res Commun. 2015 Aug 7, doi: 10.1016/j.bbrc.2015.06.086

Zebrowski DC, Vergarajauregui S, Wu CC, Piatkowski T, Becker R, Leone M, Hirth S, Ricciardi F, Falk N, Giessl A, Just S, Braun T, Weidinger G, Engel FB. Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes.eLife. 2015 Aug 6, doi: 10.7554/eLife.05563

Buhrdel JB, Hirth S, Kessler M, Westphal S, Forster M, Manta L, Wiche G, Schoser B, Schessl J, Schroder R, Clemen CS, Eichinger L, Furst DO, van der Ven PF, Rottbauer W, Just S. In vivo characterization of human myofibrillar myopathy genes in zebrafish. Biochem Biophys Res Commun. 2015 May 29, doi: 10.1016/j.bbrc.2015.03.149

Hein K, Mittler G, Cizelsky W, Kuhl M, Ferrante F, Liefke R, Berger IM, Just S, Strang JE, Kestler HA, Oswald F and Borggrefe T. Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response.Science signaling. 2015 Mar 24, doi: 10.1126/scisignal.2005892

Kessler M, Berger IM, Just S* and Rottbauer W*. Loss of dihydrolipoyl succinyltransferase (DLST) leads to reduced resting heart rate in the zebrafish. BasicRes Cardiol. 2015 Mar, doi: 10.1007/s00395-015-0468-7, * shared senior authorship

Clemen CS, Stockigt F, Strucksberg KH, Chevessier F, Winter L, Schutz J, Bauer R, Thorweihe JM, Wenzel D, Schlotzer-Schrehardt U, Rasche V, Krsmanovic P, Katus HA, Rottbauer W, Just S, Muller OJ, Friedrich O, Meyer R, Herrmann H, Schrickel JW, Schroder R. The toxic effect of R350P mutant desmin in striated muscle of man and mouse.Acta Neuropathol. 2015 Feb, doi: 10.1007/s00401-014-1363-2

Pott A, Rottbauer W, Just S. Functional genomics in zebrafish as a tool to identify novel antiarrhythmic targets. Current medicinal chemistry. 2014 Apr, 2014;21(11):1320-9. Review

Spomer W, Pfriem A, Alshut R, Just S, Pylatiuk C. High-throughput screening of zebrafish embryos using automated heart detection and imaging.Journal of laboratory automation. 2012 Dec, doi: 10.1177/2211068212464223

Just S, Berger IM, Meder B, Backs J, Keller A, Marquart S, Frese K, Patzel E, Rauch GJ, Katus HA, Rottbauer W. Protein kinase d2 controls cardiac valve formation in zebrafish by regulating histone deacetylase 5 activity.Circulation. 2011 Jul 19, doi: 10.1161/CIRCULATIONAHA.110.003301

Just S, Meder B, Berger IM, Etard C, Trano N, Patzel E, Hassel D, Marquart S, Dahme T, Vogel B, Fishman MC, Katus HA, Strahle U, Rottbauer W. The myosin-interacting protein smyd1 is essential for sarcomere organization.J Cell Sci. 2011 Oct 1, doi: 10.1242/jcs.084772

Hassel D* , Dahme T* , Erdmann J* , Meder B, Huge A, Stoll M, Just S, Hess A, Ehlermann P, Weichenhan D, Grimmler M, Liptau H, Hetzer R, Regitz-Zagrosek V, Fischer C, Nurnberg P, Schunkert H, Katus HA, Rottbauer W. Nexilin mutations destabilize cardiac z-disks and lead to dilated cardiomyopathy. Nat Med. 2009 Nov, doi: 10.1038/nm.2037 * Erstautoren

Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M, Galuppo P, Just S, Rottbauer W, Frantz S, Castoldi M, Soutschek J, Koteliansky V, Rosenwald A, Basson MA, Licht JD, Pena JT, Rouhanifard SH, Muckenthaler MU, Tuschl T, Martin GR, Bauersachs J, Engelhardt S. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.Nature. 2008 Dec 18, doi: 10.1038/nature07511

Rottbauer W*, Just S*, Wessels G, Trano N, Most P, Katus HA, Fishman MC. VEGF-PLC gamma1 pathway controls cardiac contractility in the embryonic heart.Genes Dev. 2005 Jul 1, doi: 10.1101/gad.1319405, * Erstautoren

Job Offers

We currently have no vacancies.

We offer up to two positions each semester.

Our MD students are expected to apply for the program "Experimental Medicine".

If you’re interested feel free to contact Mirjam Glöckler.

We are always looking for interested and motivated students. Feel free to contact Mirjam Glöckler or one of our PostDocs.

Various options for internships are possible. Feel free to contact Mirjam Glöckler or one of our PostDocs.


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