Recent publications

2019

  1. Abdulhaqq, S.A., Martinez, M., Kang, G., Rodriguez, I.V., Nichols, S.M., Beaumont, D., Joseph, J., Azzoni, L., Yin, X., Wise, M., Weiner, D., Liu, Q., Foulkes, A., Münch, J., Kirchhoff, F., Coutifaris C., Tomaras, G.D., Sariol, C., Marx, P.A., Li, Q., Kraiselburd E.N., and Montaner L.J. (2019). Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques. Nat Commun 10, 3753.
  2. Benkirane M, Berkhout B, Borrow P, Fassati A, Fujii M, Garcia-Martinez JV, Margolis D, Nijhuis M, Parent L, Strebel K, Venter F, Kirchhoff F, Lever A, Ross S, Mak J. (2019). A trip down memory lane with Retrovirology. Retrovirology 16(1):22.
  3. Braun E, Hotter D, Koepke L, Zech F, Groß R, Müller J, Wombacher R, Sutter K, Dittmer U, Winkler M, Simmons G, Pöhlmann S, Münch J, Fackler OT, Kirchhoff F and Sauter D. (2019). Guanylate-binding proteins 2 and 5 exert broad antiviral activity by inhibiting furin-mediated processing of viral envelope proteins. Cell Reports 27(7):2092-2104).
  4. Buffalo CZ, Stuerzel C, Heusinger E, Kmiec D, Kirchhoff F, Hurley J, Ren X. (2019). Structural basis for tetherin antagonism as a barrier to zoonotic lentiviral transmission. Cell Host & Microbe 26, 1-10.
  5. Conzelmann, C., Zou, M., Groß, R., Harms, M., Röcker, A., Riedel, C.U., Münch, J., and Müller, J.A. (2019). Storage-Dependent Generation of Potent Anti-ZIKV Activity in Human Breast Milk. Viruses 2019 Jun 28;11(7).
  6. Frich, C.K., Krüger, F., Walther, R., Domar, C., Andersen, A.H.F., Tvilum, A., Dagnæs-Hansen, F., Denton, P.W., Tolstrup, M., Paludan, S.R., Münch, J., and Zelikin, A.N. (2019). Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs. J Control Release 294, 298-310.
  7. Full, F., van Gent, M., Sparrer, K.M.J., Chiang, C., Zurenski, M.A., Scherer, M., Brockmeyer, N.H., Heinzerling, L., Stürzl, M., Korn, K., Stamminger, T., Ensser, A., and Gack, M.U. (2019). Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity. Nature Microbiology 4, 164-176.
  8. Hotter D, Bosso M, Jønsson KL, Krapp C, Stürzel CM, Das A, Littwitz-Salomon E, Berkhout B, Russ A, Wittmann S, Gramberg T, Zheng Y, Martins LJ, Planelles V, Jakobsen MR, Hahn BH, Dittmer U, Sauter D, Kirchhoff F. (2019). IFI16 sequesters Sp1 to restrict HIV-1 transcription but is evaded by subtype C strains. Cell Host & Microbe 25(6):858-872.
  9. Krüger, F., Kumar, V., Monge, P., Conzelmann, C., Smith, N., Gothelf, K.V., Tolstrup, M., Münch, J., and Zelikin, A.N. (2019). Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues. Advanced Science 6, 1802095.
  10. Kmiec D, Srinivasachar S, Kirchhoff F. (2019). Potential roles of Nef and Vpu in HIV-1 latency. Future Virology 14, doi.org/10.2217/fvl-2018-0214.
  11. Langer, S., Hammer, C., Hopfensperger, K., Klein, L., Hotter, D., De Jesus, P.D., Herbert, K.M., Pache, L., Smith, N., van der Merwe, Johannes A., et al. (2019). HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses. Elife 8
  12. Lippold, S., Braun, B., Krüger, F., Harms, M., Müller, J.A., Groß, R., Münch, J., and von Einem, J. (2019). Natural Inhibitor of Human Cytomegalovirus in Human Seminal Plasma. J. Virol. 93,
  13. Prévost J, Pickering S, Mumby M, Medjahed H, Gendron-Lepage G, Delgado G, Dirk B, Dikeakos J, Stuerzel C, Sauter D, Kirchhoff F, Bibollet-Ruche F, Hahn B.H, Dubé M, Kaufmann D, Neil S, Finzi A, and Richard J. (2019). Upregulation of BST-2 by type I IFNs reduce the capacity of Vpu to protect HIV-1-infected cells from NK cell responses. mBio 10(3). pii: e01113-19.
  14. Romero‐Molina, S., Ruiz‐Blanco, Y.B., Harms, M., Münch, J., and Sanchez‐Garcia, E. (2019). PPI‐Detect: A support vector machine model for sequence‐based prediction of protein–protein interactions. Journal of Computational Chemistry 40, 1233-1242.
  15. Sauter, D., and Kirchhoff, F. (2019). Key Viral Adaptations Preceding the AIDS Pandemic. Cell Host Microbe, 25, 27-38.
  16. Smith N, Rodero MP, Bekaddour N, Bondet V, Ruiz-Blanco Y.B, Harms M, Mayer B, Badder-Meunier B, Quartier P, Bodemer C, Baudouin V, Dieudonné Y, Kirchhoff F, Sanchez Garcia E, Charbit B, Leboulanger N, Jahrsdörfer B, Richard Y, Korganow AS, Münch J, Nisole S, Duffy D, Herbeuval JP. (2019). Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement-A new target for lupus treatment. Science Adv. 5: eaav9019.
  17. Thans TVS, Akko JI, Niehrs A, Garcia-Beltran WF, Richert L, Stürzel CM, Ford CT, Li H, Ochsenbauer C, Kappes JC, Hahn BH, Kirchhoff F, Martrus G, Sauter D, Altfeld M, and Hölzemer A. (2019). Primary HIV-1 strains use Nef to downmodulate HLA-E surface expression. J Virol, pii: JVI.00719-19.
  18. Walter, K., Tiwary, K., Trajkovic-Arsic, M., Hidalgo-Sastre, A., Dierichs, L., Liffers, S.T., Gu, J., Gout, J., Schulte, L., Münch, J., et al. (2019). MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo. Stem Cells Int 2019, 8475389.
  19. Yamasoba D, Sato K, Imamura T, Koepke L, Joas S, Reith E, Hotter D, Misawa N, Akaki K, Uehata T, Mino T, Yamashita A, Standley DM, Kirchhoff F, Sauter D, Koyanagi Y and Takeuchi, O. (2019). N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation. Nature Microb. 4: 1532-1544.

2018

  1. Bosso, M., Ständker, L., Kirchhoff, F., and Münch, J. (2018). Exploiting the human peptidome for novel antimicrobial and anticancer agents. Bioorg. Med. Chem. 26, 2719-2726.
  2. Braun, K., Stürzel, C.M., Biskupek, J., Kaiser, U., Kirchhoff, F., and Lindén, M. (2018). Comparison of different cytotoxicity assays for in vitro evaluation of mesoporous silica nanoparticles. Toxicol in Vitro 52, 214-221.
  3. Chiang, J.J., Sparrer, K.M.J., van Gent, M., Lässig, C., Huang, T., Osterrieder, N., Hopfner, K., and Gack, M.U. (2018). Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity. Nat. Immunol. 19, 53-62

  4. Frascaroli, G., Lecher, C., Varani, S., Setz, C., van der Merwe, J., Brune, W., and Mertens, T. (2018). Human Macrophages Escape Inhibition of Major Histocompatibility Complex-Dependent Antigen Presentation by Cytomegalovirus and Drive Proliferation and Activation of Memory CD4+ and CD8+ T Cells. Front Immunol 9, 1129.

  5. Heusinger, E., Deppe, K., Sette, P., Krapp, C., Kmiec, D., Kluge, S.F., Marx, P.A., Apetrei, C., Kirchhoff, F., and Sauter, D. (2018). Preadaptation of SIVsmm facilitated Env-mediated counteraction of human tetherin by HIV-2. J. Virol. 00276.
  6. Hotter, D., and Kirchhoff, F. (2018). Interferons and beyond: Induction of antiretroviral restriction factors. J. Leukoc. Biol. 103, 465-477.
  7. Joas, S., Parrish, E.H., Gnanadurai, C.W., Lump, E., Stürzel, C.,M., Parrish, N.F., Learn, G.H., Sauermann, U., Neumann, B., and Rensing, K.M. (2018). Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity. Nature Communications 9, 1371.
  8. Lodermeyer, V., Ssebyatika, G., Passos, V., Ponnurangam, A., Malassa, A., Ewald, E., Stürzel, C.,M., Kirchhoff, F., Rotger, M., and Falk, C.S. (2018). The Antiviral Activity of the Cellular Glycoprotein LGALS3BP/90K is Species-Specific. J. Virol. 00226.
  9. Mathé, P., Egah, D.Z., Müller, J.A., Shehu, N.Y., Obishakin, E.T., Shwe, D.D., Pam, V.C., Okolo, M.O., Yilgwan, C., Gomerep, S.S., et al. (2018). Low Zika virus seroprevalence among pregnant women in North Central Nigeria, 2016. Journal of Clinical Virology 105, 35-40.
  10. Morris, K.L., Buffalo, C.Z., Stürzel, C.M., Heusinger, E., Kirchhoff, F., Ren, X., and Hurley, J.H. (2018). HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation. Cell 174, 671.e14.
  11. Müller, J.,A., Glöckle, A., Gawanbacht, A., Geyer, M., Münch, J., and Kirchhoff, F. (2018). Reduced Susceptibility to VIRIP-based HIV-1 Entry Inhibitors has a High Genetic Barrier and Severe Fitness Costs. J. Virol. 00733.
  12. Palesch, D., Bosinger, S.E., Tharp, G.K., Vanderford, T.H., Paiardini, M., Chahroudi, A., Johnson, Z.P., Kirchhoff, F., Hahn, B.H., and Norgren, R.B. (2018). Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host. Nature 553, 77.
  13. Richard, J., Prévost, J., Baxter, A.E., von Bredow, B., Ding, S., Medjahed, H., Delgado, G.G., Brassard, N., Stürzel, C.,M., and Kirchhoff, F. (2018). Uninfected Bystander Cells Impact the Measurement of HIV-Specific Antibody-Dependent Cellular Cytotoxicity Responses. mBio 9, 358.
  14. Röcker, A.E., Müller, J.A., Dietzel, E., Harms, M., Krüger, F., Heid, C., Sowislok, A., Riber, C.F., Kupke, A., Lippold, S., et al. (2018). The molecular tweezer CLR01 inhibits Ebola and Zika virus infection. Antiviral Research 152, 26-35.
  15. Röcker, A., R. Roan, N., Kant Yadav, J., Fändrich, M., and Münch, J. (2011). Structure, function and antagonism of semen amyloids. Chemical Communications (Cambridge, England) 48, 19-22.
  16. Sanchez, J.G., Sparrer, K.M.J., Chiang, C., Reis, R.A., Chiang, J.J., Zurenski, M.A., Wan, Y., Gack, M.U., and Pornillos, O. (2018). TRIM25 Binds RNA to Modulate Cellular Anti-viral Defense. J. Mol. Biol. 430, 5280-5293
  17. Sparrer, K.M.J., and Gack, M.U. (2018). TRIM proteins: New players in virus-induced autophagy. PLoS Pathogens 14, e1006787.
  18. Sauter, D., and Kirchhoff, F. (2018). Multilayered and versatile inhibition of cellular antiviral factors by HIV and SIV accessory proteins. Cytokine Growth Factor Rev.
  19. Yamada, E., Nakaoka, S., Klein, L., Reith, E., Langer, S., Hopfensperger, K., Iwami, S., Schreiber, G., Kirchhoff, F., and Koyanagi, Y. (2018). Human-Specific Adaptations in Vpu Conferring Anti-tetherin Activity Are Critical for Efficient Early HIV-1 Replication In Vivo. Cell Host & Microbe 23, 110-120.
  20. van Gent, M., Sparrer, K.M.J., and Gack, M.U. (2018). TRIM Proteins and Their Roles in Antiviral Host Defenses. Annu Rev Virol 5, 385-405.

2017

  1. Bosso, M., Ständker, L., Kirchhoff, F., and Münch, J. (2017). Exploiting the human peptidome for novel antimicrobial and anticancer agents. Bioorg. Med. Chem.
  2. Darcis, G., Van Driessche, B., Bouchat, S., Kirchhoff, F., and Van Lint, C. (2017). Molecular Control of HIV and SIV Latency. Curr. Top. Microbiol. Immunol.
  3. Guidi, N., Sacma, M., Ständker, L., Soller, K., Marka, G., Eiwen, K., Weiss, J.M., Kirchhoff, F., Weil, T., Cancelas, J.A., Florian, M.C., and Geiger, H. (2017). Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells. Embo j. 36, 840-853.
  4. Heusinger, E., and Kirchhoff, F. (2017). Primate Lentiviruses Modulate NF-kappaB Activity by Multiple Mechanisms to Fine-Tune Viral and Cellular Gene Expression. Front. Microbiol. 8, 198.
  5. Hotter, D., Krabbe, T., Reith, E., Gawanbacht, A., Rahm, N., Ayouba, A., Van Driessche, B., Van Lint, C., Peeters, M., Kirchhoff, F., and Sauter, D. (2017). Primate lentiviruses use at least three alternative strategies to suppress NF-kappaB-mediated immune activation. PLoS Pathog. 13, e1006598.
  6. Hotter, D., Sauter, D., and Kirchhoff, F. (2017). Guanylate binding protein 5: Impairing virion infectivity by targeting retroviral envelope glycoproteins. Small GTPases 8, 31-37.
  7. Jonsson, K.L., Laustsen, A., Krapp, C., Skipper, K.A., Thavachelvam, K., Hotter, D., Egedal, J.H., Kjolby, M., Mohammadi, P., Prabakaran, T., et al. (2017). IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. Nat. Commun. 8, 14391.
  8. Körner, C., Simoneau, C.R., Schommers, P., Granoff, M., Ziegler, M., Holzemer, A., Lunemann, S., Chukwukelu, J., Corleis, B., Naranbhai, V., et al. (2017). HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells. Cell. Host Microbe 22, 111-119.e4.
  9. Mack, K., Starz, K., Sauter, D., Langer, S., Bibollet-Ruche, F., Learn, G.H., Sturzel, C.M., Leoz, M., Plantier, J.C., Geyer, M., Hahn, B.H., and Kirchhoff, F. (2017). Efficient Vpu-Mediated Tetherin Antagonism by an HIV-1 Group O Strain. J. Virol. 91, 10.1128/JVI.02177-16. Print 2017 Mar 15.
  10. Manrique, S., Sauter, D., Horenkamp, F.A., Lulf, S., Yu, H., Hotter, D., Anand, K., Kirchhoff, F., and Geyer, M. (2017). Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3. Nat. Commun. 8, 442-017-00481-z.
  11. Müller, J.A., Harms, M., Schubert, A., Mayer, B., Jansen, S., Herbeuval, J.P., Michel, D., Mertens, T., Vapalahti, O., Schmidt-Chanasit, J., and Münch, J. (2017). Development of a high-throughput colorimetric Zika virus infection assay. Med. Microbiol. Immunol. 206, 175-185.
  12. Mwimanzi, F., Toyoda, M., Mahiti, M., Mann, J.K., Martin, J.N., Bangsberg, D., Brockman, M.A., Goulder, P., Kirchhoff, F., Brumme, Z.L., Ndung'u, T., and Ueno, T. (2017). Relative resistance of MHC-B to Nef-mediated downregulation is conserved among primate lentiviruses and influences antiviral T cell responses in HIV-1-infected individuals. J. Virol.
  13. Richard, J., Prevost, J., von Bredow, B., Ding, S., Brassard, N., Medjahed, H., Coutu, M., Melillo, B., Bibollet-Ruche, F., Hahn, B.H., et al. (2017). BST-2 Expression Modulates Small CD4-Mimetic Sensitization of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity. J. Virol. 91, 10.1128/JVI.00219-17. Print 2017 Jun 1.
  14. Riegger, A., Chen, C., Zirafi, O., Daiss, N., Mukherji, D., Walter, K., Tokura, Y., Stöckle, B., Kremer, K., Kirchhoff, F., et al. (2017). Synthesis of Peptide-Functionalized Poly(bis-sulfone) Copolymers Regulating HIV-1 Entry and Cancer Stem Cell Migration. ACS Macro Lett. 6, 241-246.
  15. Roan, N.R., Sandi-Monroy, N., Kohgadai, N., Usmani, S.M., Hamil, K.G., Neidleman, J., Montano, M., Ständker, L., Röcker, A., Cavrois, M., et al. (2017). Semen amyloids participate in spermatozoa selection and clearance. Elife 6, 10.7554/eLife.24888.
  16. Rode, S., Hayn, M., Röcker, A., Sieste, S., Lamla, M., Markx, D., Meier, C., Kirchhoff, F., Walther, P., Fändrich, M., Weil, T., and Münch, J. (2017). Generation and Characterization of Virus-Enhancing Peptide Nanofibrils Functionalized with Fluorescent Labels. Bioconjug. Chem. 28, 1260-1270.
  17. Schandock, F., Riber, C.F., Rocker, A., Müller, J.A., Harms, M., Gajda, P., Zuwala, K., Andersen, A.H.F., Lovschall, K.B., Tolstrup, M., et al. (2017). Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses. Adv. Healthc. Mater. 6, 10.1002/adhm.201700748. Epub 2017 Sep 25.
  18. Smith, N., Pietrancosta, N., Davidson, S., Dutrieux, J., Chauveau, L., Cutolo, P., Dy, M., Scott-Algara, D., Manoury, B., Zirafi, O., et al. (2017). Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement. Nat. Commun. 8, 14253.
  19. Sparrer, K.M.J., Gableske, S., Zurenski, M.A., Parker, Z.M., Full, F., Baumgart, G.J., Kato, J., Pacheco-Rodriguez, G., Liang, C., Pornillos, O., Moss,J., Vaughan, M., and Gack, M.U.  (2017). TRIM23 mediates virus-induced autophagy via activation of TBK1. Nat Microbiol 2, 1543-1557.