Recent Publications

2021

  1. Arnold F, Gout J, Wiese H, Weissinger SE, Roger E, Perkhofer L, Walter K, Scheible J, Bozzo CP, Lechel A, Ettrich TJ, Azoitei N, Hao L, Fürstberger A, Kaminska EK, Sparrer KMJ, Rasche V, Wiese S, Kestler HA, Möller P, Seufferlein T, Frappart P-O, Kleger A. 2021. RINT1 Regulates SUMOylation and the DNA Damage Response to Preserve Cellular Homeostasis in Pancreatic Cancer. Cancer Res 81:1758–1774.
  2. Bosso M, Stürzel CM, Kmiec D, Badarinarayan SS, Braun E, Ito J, Sato K, Hahn BH, Sparrer KMJ, Sauter D, Kirchhoff F. 2021. An additional NF-κB site allows HIV-1 subtype C to evade restriction by nuclear PYHIN proteins. Cell Reports 36:109735.
  3. Brenner S, Braun B, Read C, Weil T, Walther P, Schrader T, Münch J, von Einem J. 2021. The Molecular Tweezer CLR01 Inhibits Antibody-Resistant Cell-to-Cell Spread of Human Cytomegalovirus. 9. Viruses 13:1685.
  4. Castro-Gonzalez S, Shi Y, Colomer-Lluch M, Song Y, Mowery K, Almodovar S, Bansal A, Kirchhoff F, Sparrer K, Liang C, Serra-Moreno R. 2020. HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner. Autophagy 1–25.
  5. Conzelmann C, Groß R, Meister TL, Todt D, Krawczyk A, Dittmer U, Stenger S, Münch J, Steinmann E, Müller JA, Pfaender S. 2021. Pasteurization Inactivates SARS-CoV-2-Spiked Breast Milk. Pediatrics 147.
  6. Cui W, Braun E, Wang W, Tang J, Zheng Y, Slater B, Li N, Chen C, Liu Q, Wang B, Li X, Duan Y, Xiao Y, Ti R, Hotter D, Ji X, Zhang L, Cui J, Xiong Y, Sauter D, Wang Z, Kirchhoff F, Yang H. 2021. Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins. PNAS 118.
  7. Eberle J, Wiehe RS, Gole B, Mattis LJ, Palmer A, Ständker L, Forssmann W-G, Münch J, Gebhardt JCM, Wiesmüller L. 2021. A Fibrinogen Alpha Fragment Mitigates Chemotherapy-Induced MLL Rearrangements. Front Oncol 11.
  8. Enderle AG, Bosso M, Groß R, Heiland M, Bollini M, Culzoni MJ, Münch J, Streb C. 2021. Increased in-vitro Anti-HIV Activity of Caffeinium-functionalized Polyoxometalates. ChemMedChem doi.org/10.1002/cmdc.202100281.
  9. Gilg A, Harms M, Olari L-R, Urbanowitz A-K, Bonig H, Münch J. 2021. Absence of the CXCR4 antagonist EPI-X4 from pharmaceutical human serum albumin preparations. Journal of Translational Medicine 19:190.
  10. González-García M, Morales-Vicente F, Pico ED, Garay H, Rivera DG, Grieshober M, Raluca Olari L, Groß R, Conzelmann C, Krüger F, Zech F, Prelli Bozzo C, Müller JA, Zelikin A, Raber H, Kubiczek D, Rosenau F, Münch J, Stenger S, Spellerberg B, Franco OL, Rodriguez Alfonso AA, Ständker L, Otero-Gonzalez AJ. 2021. Antimicrobial Activity of Cyclic-Monomeric and Dimeric Derivatives of the Snail-Derived Peptide Cm-p5 against Viral and Multidrug-Resistant Bacterial Strains. 5. Biomolecules 11:745.
  11. Gross R, Zanoni M, Seidel A, Conzelmann C, Gilg A, Krnavek D, Erdemci-evin S, Mayer B, Hoffmann M, Poehlmann S, Beil A, Kroschel J, Jahrsdoerfer B, Schrezenmeier H, Kirchhoff F, Muench J, Mueller JA. 2021. Heterologous ChAdOx1 nCoV-19 and BNT162b2 prime-boost vaccination elicits potent neutralizing antibody responses and T cell reactivity. medRxiv 2021.05.30.21257971.
  12. Haehnle B, Lamla M, Sparrer KMJ, Gather MC, Kuehne AJC. 2020. Narrow Stimulated Resonance Raman Scattering and WGM Lasing in Small Conjugated Polymer Particles for Live Cell Tagging and Tracking. Advanced Optical Materials n/a:2001553.
  13. Harms M, Habib MMW, Nemska S, Nicolò A, Gilg A, Preising N, Sokkar P, Carmignani S, Raasholm M, Weidinger G, Kizilsavas G, Wagner M, Ständker L, Abadi AH, Jumaa H, Kirchhoff F, Frossard N, Sanchez-Garcia E, Münch J. 2020. An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation. Acta Pharmaceutica Sinica B doi.org/10.1016/j.apsb.2020.12.005.
  14. Hayn M, Blötz A, Rodríguez A, Vidal S, Preising N, Ständker L, Wiese S, Stürzel CM, Harms M, Gross R, Jung C, Kiene M, Jacob T, Pöhlmann S, Forssmann W-G, Münch J, Sparrer KMJ, Seuwen K, Hahn BH, Kirchhoff F. 2021. Natural cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling. PNAS 118.
  15. Hayn M, Hirschenberger M, Koepke L, Nchioua R, Straub JH, Klute S, Hunszinger V, Zech F, Bozzo CP, Aftab W, Christensen MH, Conzelmann C, Müller JA, Badarinarayan SS, Stürzel CM, Forne I, Stenger S, Conzelmann K-K, Münch J, Schmidt FI, Sauter D, Imhof A, Kirchhoff F, Johannes Sparrer KM. 2021. Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities. Cell Reports 109126.
  16. Hoffmann M, Arora P, Groß R, Seidel A, Hörnich BF, Hahn AS, Krüger N, Graichen L, Hofmann-Winkler H, Kempf A, Winkler MS, Schulz S, Jäck H-M, Jahrsdörfer B, Schrezenmeier H, Müller M, Kleger A, Münch J, Pöhlmann S. 2021. SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies. Cell doi.org/10.1016/j.cell.2021.03.036.
  17. Kaiser LM, Harms M, Sauter D, Rawat VPS, Glitscher M, Hildt E, Tews D, Hunter Z, Münch J, Buske C. 2021. Targeting of CXCR4 by the Naturally Occurring CXCR4 Antagonist EPI-X4 in Waldenström’s Macroglobulinemia. 4. Cancers 13:826.
  18. Kimura I, Konno Y, Uriu K, Hopfensperger K, Sauter D, Nakagawa S, Sato K. 2021. Sarbecovirus ORF6 proteins hamper induction of interferon signaling. Cell Reports 34:108916.
  19. Koepke L, Gack MU, Sparrer KM. 2021. The antiviral activities of TRIM proteins. Current Opinion in Microbiology 59:50–57.
  20. Krüger J, Groß R, Conzelmann C, Müller JA, Koepke L, Sparrer KMJ, Weil T, Schütz D, Seufferlein T, Barth TFE, Stenger S, Heller S, Münch J, Kleger A. 2020. Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell–Derived Intestinal Organoids. Cellular and Molecular Gastroenterology and Hepatology doi.org/10.1016/j.jcmgh.2020.11.003.
  21. McGuire MK, Seppo A, Goga A, Buonsenso D, Collado MC, Donovan SM, Müller JA, Ofman G, Monroy-Valle M, O’Connor DL, Pace RM, Van de Perre P. 2021. Best Practices for Human Milk Collection for COVID-19 Research. Breastfeed Med 16:29–38.
  22. Mohapatra S, Viswanathan GKK, Wettstein L, Arad E, Paul A, Kumar V, Jelinek R, Münch J, Segal D. 2021. Dual concentration-dependent effect of ascorbic acid on PAP(248–286) amyloid formation and SEVI-mediated HIV infection. RSC Chem Biol doi.org/10.1039/D1CB00084E.
  23. Müller JA, Groß R, Conzelmann C, Krüger J, Merle U, Steinhart J, Weil T, Koepke L, Bozzo CP, Read C, Fois G, Eiseler T, Gehrmann J, van Vuuren J, Wessbecher IM, Frick M, Costa IG, Breunig M, Grüner B, Peters L, Schuster M, Liebau S, Seufferlein T, Stenger S, Stenzinger A, MacDonald PE, Kirchhoff F, Sparrer KMJ, Walther P, Lickert H, Barth TFE, Wagner M, Münch J, Heller S, Kleger A. 2021. SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nature Metabolism 1–17.
  24. Nchioua R, Kmiec D, Gaba A, Stürzel CM, Follack T, Patrick S, Kirmaier A, Johnson WE, Hahn BH, Chelico L, Kirchhoff F. 2021. APOBEC3F constitutes a barrier to successful cross-species transmission of SIVsmm to humans. J Virol JVI0080821.
  25. Prelli Bozzo C, Nchioua R, Volcic M, Koepke L, Krüger J, Schütz D, Heller S, Stürzel CM, Kmiec D, Conzelmann C, Müller J, Zech F, Braun E, Groß R, Wettstein L, Weil T, Weiß J, Diofano F, Alfonso AAR, Wiese S, Sauter D, Münch J, Goffinet C, Catanese A, Schön M, Boeckers TM, Stenger S, Sato K, Just S, Kleger A, Sparrer KMJ, Kirchhoff F. 2021. IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro. 1. Nat Commun 12:1–13.
  26. Sauter D, Kirchhoff F. 2021. Evolutionary conflicts and adverse effects of antiviral factors. eLife 10:e65243.
  27. Schütz D, Conzelmann C, Fois G, Groß R, Weil T, Wettstein L, Stenger S, Zelikin A, Hoffmann TK, Frick M, Müller JA, Münch J. 2021. Carrageenan containing over-the-counter nasal and oral sprays inhibit SARS-CoV-2 infection of airway epithelial cultures. American Journal of Physiology-Lung Cellular and Molecular Physiology doi.org/10.1152/ajplung.00552.2020.
  28. Schütz D, Read C, Groß R, Röcker A, Rode S, Annamalai K, Fändrich M, Münch J. 2021. Negatively Charged Peptide Nanofibrils from Immunoglobulin Light Chain Sequester Viral Particles but Lack Cell-Binding and Viral Transduction-Enhancing Properties. ACS Omega 6:7731–7738.
  29. Schütz D, Rode S, Read C, Müller JA, Glocker B, Sparrer KMJ, Fackler OT, Walther P, Münch J. 2021. Viral Transduction Enhancing Effect of EF-C Peptide Nanofibrils Is Mediated by Cellular Protrusions. Advanced Functional Materials n/a:2104814.
  30. Sieste S, Mack T, Lump E, Hayn M, Schütz D, Röcker A, Meier C, Kaygisiz K, Kirchhoff F, Knowles TPJ, Ruggeri FS, Synatschke CV, Münch J, Weil T. 2021. Supramolecular Peptide Nanofibrils with Optimized Sequences and Molecular Structures for Efficient Retroviral Transduction. Advanced Functional Materials 31:2009382.
  31. Sokkar P, Harms M, Stürzel C, Gilg A, Kizilsavas G, Raasholm M, Preising N, Wagner M, Kirchhoff F, Ständker L, Weidinger G, Mayer B, Münch J, Sanchez-Garcia E. 2021. Computational modeling and experimental validation of the EPI-X4/CXCR4 complex allows rational design of small peptide antagonists. Commun Biol 4:1–13.
  32. Sparrer KMJ, Kirchhoff F. 2021. HIV protease: late action to prevent immune detection. Signal Transduct Target Ther 6:157.
  33. Spatz DL, Davanzo R, Müller JA, Powell R, Rigourd V, Yates A, Geddes DT, van Goudoever JB, Bode L. 2021. Promoting and Protecting Human Milk and Breastfeeding in a COVID-19 World. Front Pediatr 8.
  34. Vanshylla K, Held K, Eser TM, Gruell H, Kleipass F, Stumpf R, Jain K, Weiland D, Münch J, Grüttner B, Geldmacher C, Klein F. 2021. CD34T+ Humanized Mouse Model to Study Mucosal HIV-1 Transmission and Prevention. Vaccines (Basel) 9.
  35. Wettstein L, Weil T, Conzelmann C, Müller JA, Groß R, Hirschenberger M, Seidel A, Klute S, Zech F, Prelli Bozzo C, Preising N, Fois G, Lochbaum R, Knaff PM, Mailänder V, Ständker L, Thal DR, Schumann C, Stenger S, Kleger A, Lochnit G, Mayer B, Ruiz-Blanco YB, Hoffmann M, Sparrer KMJ, Pöhlmann S, Sanchez-Garcia E, Kirchhoff F, Frick M, Münch J. 2021. Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection. 1. Nature Communications 12:1726.
  36. Wieland J, Frey S, Rupp U, Essbauer S, Groß R, Münch J, Walther P. 2021. Zika virus replication in glioblastoma cells: electron microscopic tomography shows 3D arrangement of endoplasmic reticulum, replication organelles, and viral ribonucleoproteins. Histochem Cell Biol doi.org/10.1007/s00418-021-02028-2.
  37. Xia S, Lan Q, Zhu Y, Wang C, Xu W, Li Y, Wang L, Jiao F, Zhou J, Hua C, Wang Q, Cai X, Wu Y, Gao J, Liu H, Sun G, Münch J, Kirchhoff F, Yuan Z, Xie Y, Sun F, Jiang S, Lu L. 2021. Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation. Sig Transduct Target Ther 6:1–10.
  38. Zech F, Schniertshauer D, Jung C, Herrmann A, Xie Q, Nchioua R, Bozzo CP, Volcic M, Koepke L, Krueger J, Heller S, Kleger A, Jacob T, Conzelmann K-K, Ensser A, Sparrer KMJ, Kirchhoff F. 2021. Spike mutation T403R allows bat coronavirus RaTG13 to use human ACE2. bioRxiv 2021.05.31.446386.

2020

  1. Bosso M, Kirchhoff F. 2020. Emerging Role of PYHIN Proteins as Antiviral Restriction Factors. 12. Viruses 12:1464.
  2. Bosso M, Prelli-Bozzo C, Hotter D, Volcic M, Stürzel CM, Rammelt A, Ni Y, Urban S, Becker M, Schelhaas M, Wittmann S, Christensen MH, Schmidt FI, Gramberg T, Sparrer KMJ, Sauter D, Kirchhoff F. 2020. Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells. PLoS Pathogens 16:e1008752.
  3. Braun K, Stürzel C, Kirchhoff F, Lindén M. 2020. In Vitro Evaluation of a Peptide-Mesoporous Silica Nanoparticle Drug Release System against HIV-1. Inorganics 8:42.
  4. Castro-Gonzalez S, Shi Y, Colomer-Lluch M, Song Y, Mowery K, Almodovar S, Bansal A, Kirchhoff F, Sparrer K, Liang C, Serra-Moreno R. 2020. HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner. Autophagy 1–25.
  5. Conzelmann C, Gilg A, Groß R, Schütz D, Preising N, Ständker L, Jahrsdörfer B, Schrezenmeier H, Sparrer KMJ, Stamminger T, Stenger S, Münch J, Müller JA. 2020. An enzyme-based immunodetection assay to quantify SARS-CoV-2 infection. Antiviral Research 181:104882.
  6. Conzelmann C, Groß R, Zou M, Krüger F, Görgens A, Gustafsson MO, El Andaloussi S, Münch J, Müller JA. 2020. Salivary extracellular vesicles inhibit Zika virus but not SARS-CoV-2 infection. Journal of Extracellular Vesicles 9:1808281.
  7. Conzelmann C, Müller JA, Perkhofer L, Sparrer KM, Zelikin AN, Münch J, Kleger A. 2020. Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19. Clinical Medicine 20:clinmed.2020-0351.
  8. Groß R, Bauer R, Krüger F, Rücker-Braun E, Olari LR, Ständker L, Preising N, Rodríguez AA, Conzelmann C, Gerbl F, Sauter D, Kirchhoff F, Hagemann B, Gačanin J, Weil T, Ruiz-Blanco YB, Sanchez-Garcia E, Forssmann WG, Mankertz A, Santibanez S, Stenger S, Walther P, Wiese S, Spellerberg B, Münch J. 2020. A Placenta Derived C-Terminal Fragment of β-Hemoglobin With Combined Antibacterial and Antiviral Activity. Frontiers in Microbiology 11:508.
  9. Groß R, Conzelmann C, Müller JA, Stenger S, Steinhart K, Kirchhoff F, Münch J. 2020. Detection of SARS-CoV-2 in human breastmilk. The Lancet 395:1757–1758.
  10. Groß R, Conzelmann C, Müller JA, Reister F, Kirchhoff F, Münch J. 2020. Undermining breastfeeding will not alleviate the COVID-19 pandemic – Authors’ reply. The Lancet 396:1065–1066.
  11. Haehnle B, Lamla M, Sparrer KMJ, Gather MC, Kuehne AJC. 2020. Narrow Stimulated Resonance Raman Scattering and WGM Lasing in Small Conjugated Polymer Particles for Live Cell Tagging and Tracking. Advanced Optical Materials n/a:2001553.
  12. Haeseleer F, Eichholz K, Tareen SU, Iwamoto N, Roederer M, Kirchhoff F, Park H, Okoye AA, Corey L. 2020. Real-Time Killing Assays to Assess the Potency of a New Anti-Simian Immunodeficiency Virus Chimeric Antigen Receptor T Cell. AIDS Research and Human Retroviruses 36:998–1009.
  13. Harms M, Gilg A, Ständker L, Beer AJ, Mayer B, Rasche V, Gruber CW, Münch J. 2020. Microtiter plate-based antibody-competition assay to determine binding affinities and plasma/blood stability of CXCR4 ligands. Scientific Reports 10:16036.
  14. Harms M, Habib MMW, Nemska S, Nicolò A, Gilg A, Preising N, Sokkar P, Carmignani S, Raasholm M, Weidinger G, Kizilsavas G, Wagner M, Ständker L, Abadi AH, Jumaa H, Kirchhoff F, Frossard N, Sanchez-Garcia E, Münch J. 2020. An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation. Acta Pharmaceutica Sinica B doi.org/10.1016/j.apsb.2020.12.005.
  15. Holch A, Bauer R, Olari L-R, Rodriguez AA, Ständker L, Preising N, Karacan M, Wiese S, Walther P, Ruiz-Blanco YB, Sanchez-Garcia E, Schumann C, Münch J, Spellerberg B. 2020. Respiratory ß-2-Microglobulin exerts pH dependent antimicrobial activity. Virulence 11:1402–1414.
  16. Hopfensperger K, Richard J, Stürzel CM, Bibollet-Ruche F, Apps R, Leoz M, Plantier J-C, Hahn BH, Finzi A, Kirchhoff F, Sauter D. 2020. Convergent Evolution of HLA-C Downmodulation in HIV-1 and HIV-2. mBio 11.
  17. Hopfensperger K, Sautera D. 2020. Decreased, deformed, defective-how HIV-1 vpu targets peroxisomes. mBio 11.
  18. Joas S, Sauermann U, Roshani B, Klippert A, Daskalaki M, Mätz-Rensing K, Stolte-Leeb N, Heigele A, Tharp GK, Gupta PM, Nelson S, Bosinger S, Parodi L, Giavedoni L, Silvestri G, Sauter D, Stahl-Hennig C, Kirchhoff F. 2020. Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion. Cell Reports 30:2261-2274.e7.
  19. Kmiec D, Nchioua R, Sherrill-Mix S, Stürzel CM, Heusinger E, Braun E, Gondim MVP, Hotter D, Sparrer KMJ, Hahn BH, Sauter D, Kirchhoff F. 2020. CpG frequency in the 5’ third of the env gene determines sensitivity of primary HIV-1 strains to the zinc-finger antiviral protein. mBio 11.
  20. Koepke L, Winter B, Grenzner A, Regensburger K, Engelhart S, van der Merwe JA, Krebs S, Blum H, Kirchhoff F, Sparrer KMJ. 2020. An improved method for high-throughput quantification of autophagy in mammalian cells. Scientific Reports 10.
  21. Konno Y, Kimura I, Uriu K, Fukushi M, Irie T, Koyanagi Y, Sauter D, Gifford RJ, Nakagawa S, Sato K. 2020. SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant. Cell Reports 32:108185.
  22. Meister TL, Brüggemann Y, Todt D, Conzelmann C, Müller JA, Groß R, Münch J, Krawczyk A, Steinmann J, Steinmann J, Pfaender S, Steinmann E. 2020. Virucidal Efficacy of Different Oral Rinses Against Severe Acute Respiratory Syndrome Coronavirus 2. The Journal of infectious diseases 222:1289–1292.
  23. Mesner D, Hotter D, Kirchhoff F, Jolly C. 2020. Loss of Nef-mediated CD3 down-regulation in the HIV-1 lineage increases viral infectivity and spread. Proceedings of the National Academy of Sciences of the United States of America 117:7382–7391.
  24. Michel D, Danzer KM, Groß R, Conzelmann C, Müller JA, Freischmidt A, Weishaupt JH, Heller S, Münch J, Michel M, Stamminger T, Kleger A, Otto M. 2020. Rapid, convenient and efficient kit-independent detection of SARS-CoV-2 RNA. Journal of Virological Methods 286:113965.
  25. Nchioua R, Bosso M, Kmiec D, Kirchhoff F. 2020. Cellular Factors Targeting HIV-1 Transcription and Viral RNA Transcripts. 5. Viruses 12:495.
  26. Nchioua R, Kmiec D, Müller JA, Conzelmann C, Groß R, Swanson CM, Neil SJD, Stenger S, Sauter D, Münch J, Sparrer KMJ, Kirchhoff F. 2020. Sars-cov-2 is restricted by zinc finger antiviral protein despite preadaptation to the low-cpg environment in humans. mBio 11:1–19.
  27. Prévost J, Edgar CR, Richard J, Trothen SM, Jacob RA, Mumby MJ, Pickering S, Dubé M, Kaufmann DE, Kirchhoff F, Neil SJD, Finzi A, Dikeakos JD. 2020. HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4 + T Cells. Journal of Virology 94.
  28. Prévost J, Tolbert WD, Medjahed H, Sherburn RT, Madani N, Zoubchenok D, Gendron-Lepage G, Gaffney AE, Grenier MC, Kirk S, Vergara N, Han C, Mann BT, Chénine AL, Ahmed A, Chaiken I, Kirchhoff F, Hahn BH, Haim H, Abrams CF, Smith AB, Sodroski J, Pazgier M, Finzi A. 2020. The HIV-1 ENV GP120 inner domain shapes the PHE43 cavity and the CD4 binding site. mBio 11:1–26.
  29. Schütz D, Ruiz-Blanco YB, Münch J, Kirchhoff F, Sanchez-Garcia E, Müller JA. 2020. Peptide and peptide-based inhibitors of SARS-CoV-2 entry. Advanced drug delivery reviews doi.org/10.1016/j.addr.2020.11.007.
  30. Sieste S, Mack T, Lump E, Hayn M, Schütz D, Röcker A, Meier C, Kirchhoff F, Knowles T, Ruggeri FS, Synatschke C, Münch J, Weil T. 2020. Supramolecular Peptide Nanofibrils with Optimized Sequences and Molecular Structures for Efficient Retroviral Transduction. ChemRxiv doi.org/10.26434/CHEMRXIV.13129709.V1.
  31. Sokkar P, Harms M, Stürzel C, Gilg A, Kizilsavas G, Raasholm M, Preising N, Wagner M, Ständker L, Weidinger G, Münch J, Sanchez-Garcia E. 2020. Biomolecular models of EPI-X4 binding to CXCR4 allow the rational optimization of peptides with therapeutic potential. bioRxiv 2020.10.23.352708.
  32. Srinivasachar Badarinarayan S, Shcherbakova I, Langer S, Koepke L, Preising A, Hotter D, Kirchhoff F, Sparrer KMJ, Schotta G, Sauter D. 2020. HIV-1 infection activates endogenous retroviral promoters regulating antiviral gene expression. Nucleic Acids Research 48:10890–10908.
  33. Thoms M, Buschauer R, Ameismeier M, Koepke L, Denk T, Hirschenberger M, Kratzat H, Hayn M, MacKens-Kiani T, Cheng J, Straub JH, Stürzel CM, Fröhlich T, Berninghausen O, Becker T, Kirchhoff F, Sparrer KMJ, Beckmann R. 2020. Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. Science 369:1249–1256.
  34. Vegi NM, Chakrabortty S, Zegota MM, Kuan SL, Stumper A, Rawat VPS, Sieste S, Buske C, Rau S, Weil T, Feuring-Buske M. 2020. Somatostatin receptor mediated targeting of acute myeloid leukemia by photodynamic metal complexes for light induced apoptosis. Scientific Reports 10:1–10.
  35. Volcic M, Sparrer KMJ, Koepke L, Hotter D, Sauter D, Stürzel CM, Scherer M, Stamminger T, Hofmann TG, Arhel NJ, Wiesmüller L, Kirchhoff F. 2020. Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1. Nature Microbiology 5:1247–1261.
  36. Weil T, Groß R, Röcker A, Bravo-Rodriguez K, Heid C, Sowislok A, Le MH, Erwin N, Dwivedi M, Bart SM, Bates P, Wettstein L, Müller JA, Harms M, Sparrer K, Ruiz-Blanco YB, Stürzel CM, von Einem J, Lippold S, Read C, Walther P, Hebel M, Kreppel F, Klärner FG, Bitan G, Ehrmann M, Weil T, Winter R, Schrader T, Shorter J, Sanchez-Garcia E, Münch J. 2020. Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers. Journal of the American Chemical Society 142:17024–17038.

2019

  1. Abdulhaqq SA, Martinez M, Kang G, Rodriguez I V., Nichols SM, Beaumont D, Joseph J, Azzoni L, Yin X, Wise M, Weiner D, Liu Q, Foulkes A, Münch J, Kirchhoff F, Coutifaris C, Tomaras GD, Sariol C, Marx PA, Li Q, Kraiselburd EN, Montaner LJ. 2019. Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques. Nat Commun 10.
  2. Benkirane M, Berkhout B, Borrow P, Fassati A, Fujii M, Garcia-Martinez JV, Margolis D, Nijhuis M, Parent L, Strebel K, Venter F, Kirchhoff F, Lever A, Ross S, Mak J. 2019. A trip down memory lane with Retrovirology. Retrovirology. BioMed Central Ltd.
  3. Braun E, Hotter D, Koepke L, Zech F, Groß R, Sparrer KMJ, Müller JA, Pfaller CK, Heusinger E, Wombacher R, Sutter K, Dittmer U, Winkler M, Simmons G, Jakobsen MR, Conzelmann KK, Pöhlmann S, Münch J, Fackler OT, Kirchhoff F, Sauter D. 2019. Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins. Cell Rep 27:2092-2104.e10.
  4. Braun E, Sauter D. 2019. Furin‐mediated protein processing in infectious diseases and cancer. Clin Transl Immunol 8.
  5. Buffalo CZ, Stürzel CM, Heusinger E, Kmiec D, Kirchhoff F, Hurley JH, Ren X. 2019. Structural Basis for Tetherin Antagonism as a Barrier to Zoonotic Lentiviral Transmission. Cell Host Microbe 26:359-368.e8.
  6. Conzelmann, Zou, Groß, Harms, Röcker, Riedel, Münch, Müller. 2019. Storage-Dependent Generation of Potent Anti-ZIKV Activity in Human Breast Milk. Viruses 11:591.
  7. Denzinger M, Staendker L, Ehlers K, Schneider JM, Schulz T, Hein T, Wiese S, Roecker A, Gross R, Münch J, Bracht H, Barth E, Weiss M, Georgieff M, Schneider EM. 2019. Bioassay for Endothelial Damage Mediators Retrieved by Hemoadsorption. Sci Rep 9.
  8. Frich CK, Krüger F, Walther R, Domar C, Andersen AHF, Tvilum A, Dagnæs-Hansen F, Denton PW, Tolstrup M, Paludan SR, Münch J, Zelikin AN. 2019. Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs. J Control Release 294:298–310.
  9. Full F, van Gent M, Sparrer KMJ, Chiang C, Zurenski MA, Scherer M, Brockmeyer NH, Heinzerling L, Stürzl M, Korn K, Stamminger T, Ensser A, Gack MU. 2019. Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity. Nat Microbiol 4:164–176.
  10. Hotter D, Bosso M, Jønsson KL, Krapp C, Stürzel CM, Das A, Littwitz-Salomon E, Berkhout B, Russ A, Wittmann S, Gramberg T, Zheng Y, Martins LJ, Planelles V, Jakobsen MR, Hahn BH, Dittmer U, Sauter D, Kirchhoff F. 2019. IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation. Cell Host Microbe 25:858-872.e13.
  11. Kmiec D, Srinivasachar S, Kirchhoff F. 2019. Potential roles of Nef and Vpu in HIV-1 latency. Future Virol 14:227–236.
  12. Krüger F, Kumar V, Monge P, Conzelmann C, Smith N, Gothelf K V., Tolstrup M, Münch J, Zelikin AN. 2019. Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues. Adv Sci 6.
  13. Langer S, Hammer C, Hopfensperger K, Klein L, Hotter D, Jesus PDD, Herbert KM, Pache L, Smith N, Merwe JAV Der, Chanda SK, Fellay J, Kirchhoff F, Sauter D. 2019. Hiv-1 vpu is a potent transcriptional suppressor of nf-kb-elicited antiviral immune responses. Elife 8.
  14. Lippold S, Braun B, Krüger F, Harms M, Müller JA, Groß R, Münch J, von Einem J. 2019. Natural Inhibitor of Human Cytomegalovirus in Human Seminal Plasma. J Virol 93.
  15. Prévost J, Pickering S, Mumby MJ, Medjahed H, Gendron-Lepage G, Delgado GG, Dirk BS, Dikeakos JD, Stürzel CM, Sauter D, Kirchhoff F, Bibollet-Ruche F, Hahn BH, Dubé M, Kaufmann DE, Neil SJD, Finzi A, Richard J. 2019. Upregulation of BST-2 by type i interferons reduces the capacity of Vpu to protect HIV-1-infected cells from NK cell responses. MBio 10.
  16. Romero-Molina S, Ruiz-Blanco YB, Harms M, Münch J, Sanchez-Garcia E. 2019. PPI-Detect: A support vector machine model for sequence-based prediction of protein-protein interactions. J Comput Chem 40:1233–1242.
  17. Sauter D, Kirchhoff F. 2019. Key Viral Adaptations Preceding the AIDS Pandemic. Cell Host Microbe. Cell Press.
  18. Smith N, Rodero MP, Bekaddour N, Bondet V, Ruiz-Blanco YB, Harms M, Mayer B, Badder-Meunier B, Quartier P, Bodemer C, Baudouin V, Dieudonné Y, Kirchhoff F, Garcia ES, Charbit1 B, Leboulanger N, Jahrsdörfer B, Richard Y, Korganow AS, Münch J, Nisole S, Duffy D, Herbeuval JP. 2019. Control of TLR7-mediated type i IFN signaling in pDCs through CXCR4 engagement-A new target for lupus treatment. Sci Adv 5.
  19. van Stigt Thans T, Akko JI, Niehrs A, Garcia-Beltran WF, Richert L, Stürzel CM, Ford CT, Li H, Ochsenbauer C, Kappes JC, Hahn BH, Kirchhoff F, Martrus G, Sauter D, Altfeld M, Hölzemer A. 2019. Primary HIV-1 Strains Use Nef To Downmodulate HLA-E Surface Expression. J Virol 93.
  20. Walter K, Tiwary K, Trajkovic-Arsic M, Hidalgo-Sastre A, Dierichs L, Liffers ST, Gu J, Gout J, Schulte LA, Münch J, Seufferlein T, Sainz B, Siveke JT, Rodriguez-Aznar E, Hermann PC. 2019. MEK inhibition targets cancer stem cells and impedes migration of pancreatic cancer cells in vitro and in vivo. Stem Cells Int 2019.
  21. Wu Z, Subramanian N, Jacobsen EM, Sampaio KL, van der Merwe J, Hönig M, Mertens T. 2019. NK cells from RAG-or DCLRE1C-deficient patients inhibit HCMV. Microorganisms 7.
  22. Yamasoba D, Sato K, Ichinose T, Imamura T, Koepke L, Joas S, Reith E, Hotter D, Misawa N, Akaki K, Uehata T, Mino T, Miyamoto S, Noda T, Yamashita A, Standley DM, Kirchhoff F, Sauter D, Koyanagi Y, Takeuchi O. 2019. N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation. Nat Microbiol 4:1532–1544.

2018

  1. Bosso, M., Ständker, L., Kirchhoff, F., and Münch, J. (2018). Exploiting the human peptidome for novel antimicrobial and anticancer agents. Bioorg. Med. Chem. 26, 2719-2726.
  2. Braun, K., Stürzel, C.M., Biskupek, J., Kaiser, U., Kirchhoff, F., and Lindén, M. (2018). Comparison of different cytotoxicity assays for in vitro evaluation of mesoporous silica nanoparticles. Toxicol in Vitro 52, 214-221.
  3. Chiang, J.J., Sparrer, K.M.J., van Gent, M., Lässig, C., Huang, T., Osterrieder, N., Hopfner, K., and Gack, M.U. (2018). Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity. Nat. Immunol. 19, 53-62

  4. Frascaroli, G., Lecher, C., Varani, S., Setz, C., van der Merwe, J., Brune, W., and Mertens, T. (2018). Human Macrophages Escape Inhibition of Major Histocompatibility Complex-Dependent Antigen Presentation by Cytomegalovirus and Drive Proliferation and Activation of Memory CD4+ and CD8+ T Cells. Front Immunol 9, 1129.

  5. Heusinger, E., Deppe, K., Sette, P., Krapp, C., Kmiec, D., Kluge, S.F., Marx, P.A., Apetrei, C., Kirchhoff, F., and Sauter, D. (2018). Preadaptation of SIVsmm facilitated Env-mediated counteraction of human tetherin by HIV-2. J. Virol. 00276.
  6. Hotter, D., and Kirchhoff, F. (2018). Interferons and beyond: Induction of antiretroviral restriction factors. J. Leukoc. Biol. 103, 465-477.
  7. Joas, S., Parrish, E.H., Gnanadurai, C.W., Lump, E., Stürzel, C.,M., Parrish, N.F., Learn, G.H., Sauermann, U., Neumann, B., and Rensing, K.M. (2018). Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity. Nature Communications 9, 1371.
  8. Lodermeyer, V., Ssebyatika, G., Passos, V., Ponnurangam, A., Malassa, A., Ewald, E., Stürzel, C.,M., Kirchhoff, F., Rotger, M., and Falk, C.S. (2018). The Antiviral Activity of the Cellular Glycoprotein LGALS3BP/90K is Species-Specific. J. Virol. 00226.
  9. Mathé, P., Egah, D.Z., Müller, J.A., Shehu, N.Y., Obishakin, E.T., Shwe, D.D., Pam, V.C., Okolo, M.O., Yilgwan, C., Gomerep, S.S., et al. (2018). Low Zika virus seroprevalence among pregnant women in North Central Nigeria, 2016. Journal of Clinical Virology 105, 35-40.
  10. Morris, K.L., Buffalo, C.Z., Stürzel, C.M., Heusinger, E., Kirchhoff, F., Ren, X., and Hurley, J.H. (2018). HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation. Cell 174, 671.e14.
  11. Müller, J.,A., Glöckle, A., Gawanbacht, A., Geyer, M., Münch, J., and Kirchhoff, F. (2018). Reduced Susceptibility to VIRIP-based HIV-1 Entry Inhibitors has a High Genetic Barrier and Severe Fitness Costs. J. Virol. 00733.
  12. Palesch, D., Bosinger, S.E., Tharp, G.K., Vanderford, T.H., Paiardini, M., Chahroudi, A., Johnson, Z.P., Kirchhoff, F., Hahn, B.H., and Norgren, R.B. (2018). Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host. Nature 553, 77.
  13. Richard, J., Prévost, J., Baxter, A.E., von Bredow, B., Ding, S., Medjahed, H., Delgado, G.G., Brassard, N., Stürzel, C.,M., and Kirchhoff, F. (2018). Uninfected Bystander Cells Impact the Measurement of HIV-Specific Antibody-Dependent Cellular Cytotoxicity Responses. mBio 9, 358.
  14. Röcker, A.E., Müller, J.A., Dietzel, E., Harms, M., Krüger, F., Heid, C., Sowislok, A., Riber, C.F., Kupke, A., Lippold, S., et al. (2018). The molecular tweezer CLR01 inhibits Ebola and Zika virus infection. Antiviral Research 152, 26-35.
  15. Röcker, A., R. Roan, N., Kant Yadav, J., Fändrich, M., and Münch, J. (2011). Structure, function and antagonism of semen amyloids. Chemical Communications (Cambridge, England) 48, 19-22.
  16. Sanchez, J.G., Sparrer, K.M.J., Chiang, C., Reis, R.A., Chiang, J.J., Zurenski, M.A., Wan, Y., Gack, M.U., and Pornillos, O. (2018). TRIM25 Binds RNA to Modulate Cellular Anti-viral Defense. J. Mol. Biol. 430, 5280-5293
  17. Sparrer, K.M.J., and Gack, M.U. (2018). TRIM proteins: New players in virus-induced autophagy. PLoS Pathogens 14, e1006787.
  18. Sauter, D., and Kirchhoff, F. (2018). Multilayered and versatile inhibition of cellular antiviral factors by HIV and SIV accessory proteins. Cytokine Growth Factor Rev.
  19. Yamada, E., Nakaoka, S., Klein, L., Reith, E., Langer, S., Hopfensperger, K., Iwami, S., Schreiber, G., Kirchhoff, F., and Koyanagi, Y. (2018). Human-Specific Adaptations in Vpu Conferring Anti-tetherin Activity Are Critical for Efficient Early HIV-1 Replication In Vivo. Cell Host & Microbe 23, 110-120.
  20. van Gent, M., Sparrer, K.M.J., and Gack, M.U. (2018). TRIM Proteins and Their Roles in Antiviral Host Defenses. Annu Rev Virol 5, 385-405.

2017

  1. Bosso, M., Ständker, L., Kirchhoff, F., and Münch, J. (2017). Exploiting the human peptidome for novel antimicrobial and anticancer agents. Bioorg. Med. Chem.
  2. Darcis, G., Van Driessche, B., Bouchat, S., Kirchhoff, F., and Van Lint, C. (2017). Molecular Control of HIV and SIV Latency. Curr. Top. Microbiol. Immunol.
  3. Guidi, N., Sacma, M., Ständker, L., Soller, K., Marka, G., Eiwen, K., Weiss, J.M., Kirchhoff, F., Weil, T., Cancelas, J.A., Florian, M.C., and Geiger, H. (2017). Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells. Embo j. 36, 840-853.
  4. Heusinger, E., and Kirchhoff, F. (2017). Primate Lentiviruses Modulate NF-kappaB Activity by Multiple Mechanisms to Fine-Tune Viral and Cellular Gene Expression. Front. Microbiol. 8, 198.
  5. Hotter, D., Krabbe, T., Reith, E., Gawanbacht, A., Rahm, N., Ayouba, A., Van Driessche, B., Van Lint, C., Peeters, M., Kirchhoff, F., and Sauter, D. (2017). Primate lentiviruses use at least three alternative strategies to suppress NF-kappaB-mediated immune activation. PLoS Pathog. 13, e1006598.
  6. Hotter, D., Sauter, D., and Kirchhoff, F. (2017). Guanylate binding protein 5: Impairing virion infectivity by targeting retroviral envelope glycoproteins. Small GTPases 8, 31-37.
  7. Jonsson, K.L., Laustsen, A., Krapp, C., Skipper, K.A., Thavachelvam, K., Hotter, D., Egedal, J.H., Kjolby, M., Mohammadi, P., Prabakaran, T., et al. (2017). IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. Nat. Commun. 8, 14391.
  8. Körner, C., Simoneau, C.R., Schommers, P., Granoff, M., Ziegler, M., Holzemer, A., Lunemann, S., Chukwukelu, J., Corleis, B., Naranbhai, V., et al. (2017). HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells. Cell. Host Microbe 22, 111-119.e4.
  9. Mack, K., Starz, K., Sauter, D., Langer, S., Bibollet-Ruche, F., Learn, G.H., Sturzel, C.M., Leoz, M., Plantier, J.C., Geyer, M., Hahn, B.H., and Kirchhoff, F. (2017). Efficient Vpu-Mediated Tetherin Antagonism by an HIV-1 Group O Strain. J. Virol. 91, 10.1128/JVI.02177-16. Print 2017 Mar 15.
  10. Manrique, S., Sauter, D., Horenkamp, F.A., Lulf, S., Yu, H., Hotter, D., Anand, K., Kirchhoff, F., and Geyer, M. (2017). Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3. Nat. Commun. 8, 442-017-00481-z.
  11. Müller, J.A., Harms, M., Schubert, A., Mayer, B., Jansen, S., Herbeuval, J.P., Michel, D., Mertens, T., Vapalahti, O., Schmidt-Chanasit, J., and Münch, J. (2017). Development of a high-throughput colorimetric Zika virus infection assay. Med. Microbiol. Immunol. 206, 175-185.
  12. Mwimanzi, F., Toyoda, M., Mahiti, M., Mann, J.K., Martin, J.N., Bangsberg, D., Brockman, M.A., Goulder, P., Kirchhoff, F., Brumme, Z.L., Ndung'u, T., and Ueno, T. (2017). Relative resistance of MHC-B to Nef-mediated downregulation is conserved among primate lentiviruses and influences antiviral T cell responses in HIV-1-infected individuals. J. Virol.
  13. Richard, J., Prevost, J., von Bredow, B., Ding, S., Brassard, N., Medjahed, H., Coutu, M., Melillo, B., Bibollet-Ruche, F., Hahn, B.H., et al. (2017). BST-2 Expression Modulates Small CD4-Mimetic Sensitization of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity. J. Virol. 91, 10.1128/JVI.00219-17. Print 2017 Jun 1.
  14. Riegger, A., Chen, C., Zirafi, O., Daiss, N., Mukherji, D., Walter, K., Tokura, Y., Stöckle, B., Kremer, K., Kirchhoff, F., et al. (2017). Synthesis of Peptide-Functionalized Poly(bis-sulfone) Copolymers Regulating HIV-1 Entry and Cancer Stem Cell Migration. ACS Macro Lett. 6, 241-246.
  15. Roan, N.R., Sandi-Monroy, N., Kohgadai, N., Usmani, S.M., Hamil, K.G., Neidleman, J., Montano, M., Ständker, L., Röcker, A., Cavrois, M., et al. (2017). Semen amyloids participate in spermatozoa selection and clearance. Elife 6, 10.7554/eLife.24888.
  16. Rode, S., Hayn, M., Röcker, A., Sieste, S., Lamla, M., Markx, D., Meier, C., Kirchhoff, F., Walther, P., Fändrich, M., Weil, T., and Münch, J. (2017). Generation and Characterization of Virus-Enhancing Peptide Nanofibrils Functionalized with Fluorescent Labels. Bioconjug. Chem. 28, 1260-1270.
  17. Schandock, F., Riber, C.F., Rocker, A., Müller, J.A., Harms, M., Gajda, P., Zuwala, K., Andersen, A.H.F., Lovschall, K.B., Tolstrup, M., et al. (2017). Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses. Adv. Healthc. Mater. 6, 10.1002/adhm.201700748. Epub 2017 Sep 25.
  18. Smith, N., Pietrancosta, N., Davidson, S., Dutrieux, J., Chauveau, L., Cutolo, P., Dy, M., Scott-Algara, D., Manoury, B., Zirafi, O., et al. (2017). Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement. Nat. Commun. 8, 14253.
  19. Sparrer, K.M.J., Gableske, S., Zurenski, M.A., Parker, Z.M., Full, F., Baumgart, G.J., Kato, J., Pacheco-Rodriguez, G., Liang, C., Pornillos, O., Moss,J., Vaughan, M., and Gack, M.U.  (2017). TRIM23 mediates virus-induced autophagy via activation of TBK1. Nat Microbiol 2, 1543-1557.