Recent publications

2020

  1. Castro-Gonzalez S, Shi Y, Colomer-Lluch M, Song Y, Mowery K, Almodovar S, Bansal A, Kirchhoff F, Sparrer K, Liang C, Serra-Moreno R. 2020. HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner. Autophagy 1–25.
  2. Groß R, Bauer R, Krüger F, Rücker-Braun E, Olari L-R, Ständker L, Preising N, Rodríguez AA, Conzelmann C, Gerbl F, Sauter D, Kirchhoff F, Hagemann B, Gacanin J, Weil T, Ruiz-Blanco YB, Sanchez-Garcia E, Forssmann W-G, Mankertz A, Santibanez S, Stenger S, Walther P, Wiese S, Spellerberg B, Münch J. 2020. A Placenta Derived C-Terminal Fragment of ß-Hemoglobin With Combined Antibacterial and Antiviral Activity. Front Microbiol 11:508.
  3. Groß R, Conzelmann C, Müller JA, Stenger S, Steinhart K, Kirchhoff F, Münch J. 2020. Detection of SARS-CoV-2 in human breastmilk. Lancet (London, England) 0.
  4. Joas S, Sauermann U, Roshani B, Klippert A, Daskalaki M, Mätz-Rensing K, Stolte-Leeb N, Heigele A, Tharp GK, Gupta PM, Nelson S, Bosinger S, Parodi L, Giavedoni L, Silvestri G, Sauter D, Stahl-Hennig C, Kirchhoff F. 2020. Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion. Cell Rep 30:2261-2274.e7.
  5. Kmiec D, Nchioua R, Sherrill-Mix S, Stürzel CM, Heusinger E, Braun E, Gondim MVP, Hotter D, Sparrer KMJ, Hahn BH, Sauter D, Kirchhoff F. 2020. CpG Frequency in the 5’ Third of the env Gene Determines Sensitivity of Primary HIV-1 Strains to the Zinc-Finger Antiviral Protein. MBio 11.
  6. Nchioua R, Bosso M, Kmiec D, Kirchhoff F. 2020. Cellular factors targeting HIV-1 transcription and viral RNA transcripts. Viruses. MDPI AG.
  7. Prévost J, Edgar CR, Richard J, Trothen SM, Jacob RA, Mumby MJ, Pickering S, Dubé M, Kaufmann DE, Kirchhoff F, Neil SJD, Finzi A, Dikeakos JD. 2020. HIV-1 Vpu downregulates Tim-3 from the surface of infected CD4 + T cells . J Virol.
  8. Vegi NM, Chakrabortty S, Zegota MM, Kuan SL, Stumper A, Rawat VPS, Sieste S, Buske C, Rau S, Weil T, Feuring-Buske M. 2020. Somatostatin receptor mediated targeting of acute myeloid leukemia by photodynamic metal complexes for light induced apoptosis. Sci Rep 10:1–10.

2019

  1. Abdulhaqq SA, Martinez M, Kang G, Rodriguez I V., Nichols SM, Beaumont D, Joseph J, Azzoni L, Yin X, Wise M, Weiner D, Liu Q, Foulkes A, Münch J, Kirchhoff F, Coutifaris C, Tomaras GD, Sariol C, Marx PA, Li Q, Kraiselburd EN, Montaner LJ. 2019. Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques. Nat Commun 10.
  2. Benkirane M, Berkhout B, Borrow P, Fassati A, Fujii M, Garcia-Martinez JV, Margolis D, Nijhuis M, Parent L, Strebel K, Venter F, Kirchhoff F, Lever A, Ross S, Mak J. 2019. A trip down memory lane with Retrovirology. Retrovirology. BioMed Central Ltd.
  3. Braun E, Hotter D, Koepke L, Zech F, Groß R, Sparrer KMJ, Müller JA, Pfaller CK, Heusinger E, Wombacher R, Sutter K, Dittmer U, Winkler M, Simmons G, Jakobsen MR, Conzelmann KK, Pöhlmann S, Münch J, Fackler OT, Kirchhoff F, Sauter D. 2019. Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins. Cell Rep 27:2092-2104.e10.
  4. Braun E, Sauter D. 2019. Furin‐mediated protein processing in infectious diseases and cancer. Clin Transl Immunol 8.
  5. Buffalo CZ, Stürzel CM, Heusinger E, Kmiec D, Kirchhoff F, Hurley JH, Ren X. 2019. Structural Basis for Tetherin Antagonism as a Barrier to Zoonotic Lentiviral Transmission. Cell Host Microbe 26:359-368.e8.
  6. Conzelmann, Zou, Groß, Harms, Röcker, Riedel, Münch, Müller. 2019. Storage-Dependent Generation of Potent Anti-ZIKV Activity in Human Breast Milk. Viruses 11:591.
  7. Denzinger M, Staendker L, Ehlers K, Schneider JM, Schulz T, Hein T, Wiese S, Roecker A, Gross R, Münch J, Bracht H, Barth E, Weiss M, Georgieff M, Schneider EM. 2019. Bioassay for Endothelial Damage Mediators Retrieved by Hemoadsorption. Sci Rep 9.
  8. Frich CK, Krüger F, Walther R, Domar C, Andersen AHF, Tvilum A, Dagnæs-Hansen F, Denton PW, Tolstrup M, Paludan SR, Münch J, Zelikin AN. 2019. Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs. J Control Release 294:298–310.
  9. Full F, van Gent M, Sparrer KMJ, Chiang C, Zurenski MA, Scherer M, Brockmeyer NH, Heinzerling L, Stürzl M, Korn K, Stamminger T, Ensser A, Gack MU. 2019. Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity. Nat Microbiol 4:164–176.
  10. Hotter D, Bosso M, Jønsson KL, Krapp C, Stürzel CM, Das A, Littwitz-Salomon E, Berkhout B, Russ A, Wittmann S, Gramberg T, Zheng Y, Martins LJ, Planelles V, Jakobsen MR, Hahn BH, Dittmer U, Sauter D, Kirchhoff F. 2019. IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation. Cell Host Microbe 25:858-872.e13.
  11. Kmiec D, Srinivasachar S, Kirchhoff F. 2019. Potential roles of Nef and Vpu in HIV-1 latency. Future Virol 14:227–236.
  12. Krüger F, Kumar V, Monge P, Conzelmann C, Smith N, Gothelf K V., Tolstrup M, Münch J, Zelikin AN. 2019. Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues. Adv Sci 6.
  13. Langer S, Hammer C, Hopfensperger K, Klein L, Hotter D, Jesus PDD, Herbert KM, Pache L, Smith N, Merwe JAV Der, Chanda SK, Fellay J, Kirchhoff F, Sauter D. 2019. Hiv-1 vpu is a potent transcriptional suppressor of nf-kb-elicited antiviral immune responses. Elife 8.
  14. Lippold S, Braun B, Krüger F, Harms M, Müller JA, Groß R, Münch J, von Einem J. 2019. Natural Inhibitor of Human Cytomegalovirus in Human Seminal Plasma. J Virol 93.
  15. Prévost J, Pickering S, Mumby MJ, Medjahed H, Gendron-Lepage G, Delgado GG, Dirk BS, Dikeakos JD, Stürzel CM, Sauter D, Kirchhoff F, Bibollet-Ruche F, Hahn BH, Dubé M, Kaufmann DE, Neil SJD, Finzi A, Richard J. 2019. Upregulation of BST-2 by type i interferons reduces the capacity of Vpu to protect HIV-1-infected cells from NK cell responses. MBio 10.
  16. Romero-Molina S, Ruiz-Blanco YB, Harms M, Münch J, Sanchez-Garcia E. 2019. PPI-Detect: A support vector machine model for sequence-based prediction of protein-protein interactions. J Comput Chem 40:1233–1242.
  17. Sauter D, Kirchhoff F. 2019. Key Viral Adaptations Preceding the AIDS Pandemic. Cell Host Microbe. Cell Press.
  18. Smith N, Rodero MP, Bekaddour N, Bondet V, Ruiz-Blanco YB, Harms M, Mayer B, Badder-Meunier B, Quartier P, Bodemer C, Baudouin V, Dieudonné Y, Kirchhoff F, Garcia ES, Charbit1 B, Leboulanger N, Jahrsdörfer B, Richard Y, Korganow AS, Münch J, Nisole S, Duffy D, Herbeuval JP. 2019. Control of TLR7-mediated type i IFN signaling in pDCs through CXCR4 engagement-A new target for lupus treatment. Sci Adv 5.
  19. van Stigt Thans T, Akko JI, Niehrs A, Garcia-Beltran WF, Richert L, Stürzel CM, Ford CT, Li H, Ochsenbauer C, Kappes JC, Hahn BH, Kirchhoff F, Martrus G, Sauter D, Altfeld M, Hölzemer A. 2019. Primary HIV-1 Strains Use Nef To Downmodulate HLA-E Surface Expression. J Virol 93.
  20. Walter K, Tiwary K, Trajkovic-Arsic M, Hidalgo-Sastre A, Dierichs L, Liffers ST, Gu J, Gout J, Schulte LA, Münch J, Seufferlein T, Sainz B, Siveke JT, Rodriguez-Aznar E, Hermann PC. 2019. MEK inhibition targets cancer stem cells and impedes migration of pancreatic cancer cells in vitro and in vivo. Stem Cells Int 2019.
  21. Wu Z, Subramanian N, Jacobsen EM, Sampaio KL, van der Merwe J, Hönig M, Mertens T. 2019. NK cells from RAG-or DCLRE1C-deficient patients inhibit HCMV. Microorganisms 7.
  22. Yamasoba D, Sato K, Ichinose T, Imamura T, Koepke L, Joas S, Reith E, Hotter D, Misawa N, Akaki K, Uehata T, Mino T, Miyamoto S, Noda T, Yamashita A, Standley DM, Kirchhoff F, Sauter D, Koyanagi Y, Takeuchi O. 2019. N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation. Nat Microbiol 4:1532–1544.

2018

  1. Bosso, M., Ständker, L., Kirchhoff, F., and Münch, J. (2018). Exploiting the human peptidome for novel antimicrobial and anticancer agents. Bioorg. Med. Chem. 26, 2719-2726.
  2. Braun, K., Stürzel, C.M., Biskupek, J., Kaiser, U., Kirchhoff, F., and Lindén, M. (2018). Comparison of different cytotoxicity assays for in vitro evaluation of mesoporous silica nanoparticles. Toxicol in Vitro 52, 214-221.
  3. Chiang, J.J., Sparrer, K.M.J., van Gent, M., Lässig, C., Huang, T., Osterrieder, N., Hopfner, K., and Gack, M.U. (2018). Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity. Nat. Immunol. 19, 53-62

  4. Frascaroli, G., Lecher, C., Varani, S., Setz, C., van der Merwe, J., Brune, W., and Mertens, T. (2018). Human Macrophages Escape Inhibition of Major Histocompatibility Complex-Dependent Antigen Presentation by Cytomegalovirus and Drive Proliferation and Activation of Memory CD4+ and CD8+ T Cells. Front Immunol 9, 1129.

  5. Heusinger, E., Deppe, K., Sette, P., Krapp, C., Kmiec, D., Kluge, S.F., Marx, P.A., Apetrei, C., Kirchhoff, F., and Sauter, D. (2018). Preadaptation of SIVsmm facilitated Env-mediated counteraction of human tetherin by HIV-2. J. Virol. 00276.
  6. Hotter, D., and Kirchhoff, F. (2018). Interferons and beyond: Induction of antiretroviral restriction factors. J. Leukoc. Biol. 103, 465-477.
  7. Joas, S., Parrish, E.H., Gnanadurai, C.W., Lump, E., Stürzel, C.,M., Parrish, N.F., Learn, G.H., Sauermann, U., Neumann, B., and Rensing, K.M. (2018). Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity. Nature Communications 9, 1371.
  8. Lodermeyer, V., Ssebyatika, G., Passos, V., Ponnurangam, A., Malassa, A., Ewald, E., Stürzel, C.,M., Kirchhoff, F., Rotger, M., and Falk, C.S. (2018). The Antiviral Activity of the Cellular Glycoprotein LGALS3BP/90K is Species-Specific. J. Virol. 00226.
  9. Mathé, P., Egah, D.Z., Müller, J.A., Shehu, N.Y., Obishakin, E.T., Shwe, D.D., Pam, V.C., Okolo, M.O., Yilgwan, C., Gomerep, S.S., et al. (2018). Low Zika virus seroprevalence among pregnant women in North Central Nigeria, 2016. Journal of Clinical Virology 105, 35-40.
  10. Morris, K.L., Buffalo, C.Z., Stürzel, C.M., Heusinger, E., Kirchhoff, F., Ren, X., and Hurley, J.H. (2018). HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation. Cell 174, 671.e14.
  11. Müller, J.,A., Glöckle, A., Gawanbacht, A., Geyer, M., Münch, J., and Kirchhoff, F. (2018). Reduced Susceptibility to VIRIP-based HIV-1 Entry Inhibitors has a High Genetic Barrier and Severe Fitness Costs. J. Virol. 00733.
  12. Palesch, D., Bosinger, S.E., Tharp, G.K., Vanderford, T.H., Paiardini, M., Chahroudi, A., Johnson, Z.P., Kirchhoff, F., Hahn, B.H., and Norgren, R.B. (2018). Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host. Nature 553, 77.
  13. Richard, J., Prévost, J., Baxter, A.E., von Bredow, B., Ding, S., Medjahed, H., Delgado, G.G., Brassard, N., Stürzel, C.,M., and Kirchhoff, F. (2018). Uninfected Bystander Cells Impact the Measurement of HIV-Specific Antibody-Dependent Cellular Cytotoxicity Responses. mBio 9, 358.
  14. Röcker, A.E., Müller, J.A., Dietzel, E., Harms, M., Krüger, F., Heid, C., Sowislok, A., Riber, C.F., Kupke, A., Lippold, S., et al. (2018). The molecular tweezer CLR01 inhibits Ebola and Zika virus infection. Antiviral Research 152, 26-35.
  15. Röcker, A., R. Roan, N., Kant Yadav, J., Fändrich, M., and Münch, J. (2011). Structure, function and antagonism of semen amyloids. Chemical Communications (Cambridge, England) 48, 19-22.
  16. Sanchez, J.G., Sparrer, K.M.J., Chiang, C., Reis, R.A., Chiang, J.J., Zurenski, M.A., Wan, Y., Gack, M.U., and Pornillos, O. (2018). TRIM25 Binds RNA to Modulate Cellular Anti-viral Defense. J. Mol. Biol. 430, 5280-5293
  17. Sparrer, K.M.J., and Gack, M.U. (2018). TRIM proteins: New players in virus-induced autophagy. PLoS Pathogens 14, e1006787.
  18. Sauter, D., and Kirchhoff, F. (2018). Multilayered and versatile inhibition of cellular antiviral factors by HIV and SIV accessory proteins. Cytokine Growth Factor Rev.
  19. Yamada, E., Nakaoka, S., Klein, L., Reith, E., Langer, S., Hopfensperger, K., Iwami, S., Schreiber, G., Kirchhoff, F., and Koyanagi, Y. (2018). Human-Specific Adaptations in Vpu Conferring Anti-tetherin Activity Are Critical for Efficient Early HIV-1 Replication In Vivo. Cell Host & Microbe 23, 110-120.
  20. van Gent, M., Sparrer, K.M.J., and Gack, M.U. (2018). TRIM Proteins and Their Roles in Antiviral Host Defenses. Annu Rev Virol 5, 385-405.

2017

  1. Bosso, M., Ständker, L., Kirchhoff, F., and Münch, J. (2017). Exploiting the human peptidome for novel antimicrobial and anticancer agents. Bioorg. Med. Chem.
  2. Darcis, G., Van Driessche, B., Bouchat, S., Kirchhoff, F., and Van Lint, C. (2017). Molecular Control of HIV and SIV Latency. Curr. Top. Microbiol. Immunol.
  3. Guidi, N., Sacma, M., Ständker, L., Soller, K., Marka, G., Eiwen, K., Weiss, J.M., Kirchhoff, F., Weil, T., Cancelas, J.A., Florian, M.C., and Geiger, H. (2017). Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells. Embo j. 36, 840-853.
  4. Heusinger, E., and Kirchhoff, F. (2017). Primate Lentiviruses Modulate NF-kappaB Activity by Multiple Mechanisms to Fine-Tune Viral and Cellular Gene Expression. Front. Microbiol. 8, 198.
  5. Hotter, D., Krabbe, T., Reith, E., Gawanbacht, A., Rahm, N., Ayouba, A., Van Driessche, B., Van Lint, C., Peeters, M., Kirchhoff, F., and Sauter, D. (2017). Primate lentiviruses use at least three alternative strategies to suppress NF-kappaB-mediated immune activation. PLoS Pathog. 13, e1006598.
  6. Hotter, D., Sauter, D., and Kirchhoff, F. (2017). Guanylate binding protein 5: Impairing virion infectivity by targeting retroviral envelope glycoproteins. Small GTPases 8, 31-37.
  7. Jonsson, K.L., Laustsen, A., Krapp, C., Skipper, K.A., Thavachelvam, K., Hotter, D., Egedal, J.H., Kjolby, M., Mohammadi, P., Prabakaran, T., et al. (2017). IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. Nat. Commun. 8, 14391.
  8. Körner, C., Simoneau, C.R., Schommers, P., Granoff, M., Ziegler, M., Holzemer, A., Lunemann, S., Chukwukelu, J., Corleis, B., Naranbhai, V., et al. (2017). HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells. Cell. Host Microbe 22, 111-119.e4.
  9. Mack, K., Starz, K., Sauter, D., Langer, S., Bibollet-Ruche, F., Learn, G.H., Sturzel, C.M., Leoz, M., Plantier, J.C., Geyer, M., Hahn, B.H., and Kirchhoff, F. (2017). Efficient Vpu-Mediated Tetherin Antagonism by an HIV-1 Group O Strain. J. Virol. 91, 10.1128/JVI.02177-16. Print 2017 Mar 15.
  10. Manrique, S., Sauter, D., Horenkamp, F.A., Lulf, S., Yu, H., Hotter, D., Anand, K., Kirchhoff, F., and Geyer, M. (2017). Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3. Nat. Commun. 8, 442-017-00481-z.
  11. Müller, J.A., Harms, M., Schubert, A., Mayer, B., Jansen, S., Herbeuval, J.P., Michel, D., Mertens, T., Vapalahti, O., Schmidt-Chanasit, J., and Münch, J. (2017). Development of a high-throughput colorimetric Zika virus infection assay. Med. Microbiol. Immunol. 206, 175-185.
  12. Mwimanzi, F., Toyoda, M., Mahiti, M., Mann, J.K., Martin, J.N., Bangsberg, D., Brockman, M.A., Goulder, P., Kirchhoff, F., Brumme, Z.L., Ndung'u, T., and Ueno, T. (2017). Relative resistance of MHC-B to Nef-mediated downregulation is conserved among primate lentiviruses and influences antiviral T cell responses in HIV-1-infected individuals. J. Virol.
  13. Richard, J., Prevost, J., von Bredow, B., Ding, S., Brassard, N., Medjahed, H., Coutu, M., Melillo, B., Bibollet-Ruche, F., Hahn, B.H., et al. (2017). BST-2 Expression Modulates Small CD4-Mimetic Sensitization of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity. J. Virol. 91, 10.1128/JVI.00219-17. Print 2017 Jun 1.
  14. Riegger, A., Chen, C., Zirafi, O., Daiss, N., Mukherji, D., Walter, K., Tokura, Y., Stöckle, B., Kremer, K., Kirchhoff, F., et al. (2017). Synthesis of Peptide-Functionalized Poly(bis-sulfone) Copolymers Regulating HIV-1 Entry and Cancer Stem Cell Migration. ACS Macro Lett. 6, 241-246.
  15. Roan, N.R., Sandi-Monroy, N., Kohgadai, N., Usmani, S.M., Hamil, K.G., Neidleman, J., Montano, M., Ständker, L., Röcker, A., Cavrois, M., et al. (2017). Semen amyloids participate in spermatozoa selection and clearance. Elife 6, 10.7554/eLife.24888.
  16. Rode, S., Hayn, M., Röcker, A., Sieste, S., Lamla, M., Markx, D., Meier, C., Kirchhoff, F., Walther, P., Fändrich, M., Weil, T., and Münch, J. (2017). Generation and Characterization of Virus-Enhancing Peptide Nanofibrils Functionalized with Fluorescent Labels. Bioconjug. Chem. 28, 1260-1270.
  17. Schandock, F., Riber, C.F., Rocker, A., Müller, J.A., Harms, M., Gajda, P., Zuwala, K., Andersen, A.H.F., Lovschall, K.B., Tolstrup, M., et al. (2017). Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses. Adv. Healthc. Mater. 6, 10.1002/adhm.201700748. Epub 2017 Sep 25.
  18. Smith, N., Pietrancosta, N., Davidson, S., Dutrieux, J., Chauveau, L., Cutolo, P., Dy, M., Scott-Algara, D., Manoury, B., Zirafi, O., et al. (2017). Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement. Nat. Commun. 8, 14253.
  19. Sparrer, K.M.J., Gableske, S., Zurenski, M.A., Parker, Z.M., Full, F., Baumgart, G.J., Kato, J., Pacheco-Rodriguez, G., Liang, C., Pornillos, O., Moss,J., Vaughan, M., and Gack, M.U.  (2017). TRIM23 mediates virus-induced autophagy via activation of TBK1. Nat Microbiol 2, 1543-1557.