Research focus Prof. Kornmann

Gihring, A., F. Gartner, L. Mayer, A. Roth, H. Abdelrasoul, M. Kornmann, L. Elad, and U. Knippschild, Influence of bariatric surgery on the peripheral blood immune system of female patients with morbid obesity revealed by high-dimensional mass cytometry. Front Immunol, 2023. 14: p. 1131893.https://www.ncbi.nlm.nih.gov/pubmed/37266430. 10.3389/fimmu.2023.1131893

Kloth, C., B. Haggenmuller, A. Beck, M. Wagner, M. Kornmann, J.P. Steinacker, N. Steinacker-Stanescu, D. Vogele, M. Beer, M.S. Juchems, and S.A. Schmidt, Diagnostic, Structured Classification and Therapeutic Approach in Cystic Pancreatic Lesions: Systematic Findings with Regard to the European Guidelines. Diagnostics (Basel), 2023. 13(3).https://www.ncbi.nlm.nih.gov/pubmed/36766560. 10.3390/diagnostics13030454

Lu, J., M. Kornmann, and B. Traub, Role of Epithelial to Mesenchymal Transition in Colorectal Cancer. Int J Mol Sci, 2023. 24(19).https://www.ncbi.nlm.nih.gov/pubmed/37834263. 10.3390/ijms241914815

Manzini, G., M. Kornmann, and M. Kremer, Medical education during the COVID-19 pandemic: What students missed and what they did not. A questionnaire-based cross-sectional study. GMS Interdiscip Plast Reconstr Surg DGPW, 2023. 12: p. Doc05.https://www.ncbi.nlm.nih.gov/pubmed/37577727. 10.3205/iprs000175

Seufferlein, T., W. Uhl, M. Kornmann, H. Algul, H. Friess, A. Konig, M. Ghadimi, E. Gallmeier, D.K. Bartsch, M.P. Lutz, R. Metzger, K. Wille, B. Gerdes, C.C. Schimanski, F. Graupe, V. Kunzmann, I. Klein, M. Geissler, L. Staib, D. Waldschmidt, C. Bruns, U. Wittel, S. Fichtner-Feigl, S. Daum, A. Hinke, L. Blome, A. Tannapfel, A. Kleger, A.W. Berger, A.M.R. Kestler, J.S. Schuhbaur, L. Perkhofer, M. Tempero, A.C. Reinacher-Schick, and T.J. Ettrich, Perioperative or only adjuvant gemcitabine plus nab-paclitaxel for resectable pancreatic cancer (NEONAX)-a randomized phase II trial of the AIO pancreatic cancer group. Ann Oncol, 2023. 34(1): p. 91-100.https://www.ncbi.nlm.nih.gov/pubmed/36209981. 10.1016/j.annonc.2022.09.161

Shen, X., A.L. Kretz, S. Schneider, U. Knippschild, D. Henne-Bruns, M. Kornmann, J. Lemke, and B. Traub, Evaluation of CDK9 Inhibition by Dinaciclib in Combination with Apoptosis Modulating izTRAIL for the Treatment of Colorectal Cancer. Biomedicines, 2023. 11(3).https://www.ncbi.nlm.nih.gov/pubmed/36979907. 10.3390/biomedicines11030928

Steinkraus, K.C., M. Muhlberger, S.A. Schmidt, and M. Kornmann, Acinar cystic transformation of the pancreas-a rare case in a young patient. J Surg Case Rep, 2023. 2023(2): p. rjad077.https://www.ncbi.nlm.nih.gov/pubmed/36860359. 10.1093/jscr/rjad077

Vogele, D., S.A. Schmidt, D. Gnutzmann, W.M. Thaiss, T.J. Ettrich, M. Kornmann, M. Beer, and M.S. Juchems, Gastroenteropancreatic Neuroendocrine Tumors-Current Status and Advances in Diagnostic Imaging. Diagnostics (Basel), 2023. 13(17).https://www.ncbi.nlm.nih.gov/pubmed/37685279. 10.3390/diagnostics13172741

Jotten, L., K.C. Steinkraus, B. Traub, S. Graf, A.L. Mihaljevic, M. Kornmann, C.W. Michalski, and F.J. Huttner, Impact of perioperative steroid administration in patients undergoing elective liver resection: meta-analysis. BJS Open, 2022. 6(6).https://www.ncbi.nlm.nih.gov/pubmed/36537738. 10.1093/bjsopen/zrac139

Kleger, A., V. Ellenrieder, H. Friess, P. Michl, M. Schneider, Y. Yang, and M. Kornmann, Discussion: Current Multimodality Treatment Options in Pancreatic Cancer in Clinical Practice - What Is the Future Impact of Molecular Biological Profiling? Visc Med, 2022. 38(1): p. 49-55.https://www.ncbi.nlm.nih.gov/pubmed/35295897. 10.1159/000521847

Kornmann, M. and A. Kleger, Editorial: Multimodality Treatment in Pancreatic Ductal Adenocarcinoma - Current Options and the Future Impact of Molecular Biological Profiling. Visc Med, 2022. 38(1): p. 1-3.https://www.ncbi.nlm.nih.gov/pubmed/35291696. 10.1159/000521419

Scheele, J., J. Lemke, M. Wittau, S. Sander, D. Henne-Bruns, and M. Kornmann, Quality of Life after Rectal Cancer Resection Comparing Anterior Resection, Abdominoperineal Resection, and Complicated Cases. Visc Med, 2022. 38(2): p. 138-149.https://www.ncbi.nlm.nih.gov/pubmed/35614891. 10.1159/000520945

Shi, J., X. Shen, Q. Kang, X. Yang, M. Denzinger, M. Kornmann, and B. Traub, Loss of Interleukin-13-Receptor-Alpha-1 Induces Apoptosis and Promotes EMT in Pancreatic Cancer. Int J Mol Sci, 2022. 23(7).https://www.ncbi.nlm.nih.gov/pubmed/35409019. 10.3390/ijms23073659

Shi, J., X. Yang, Q. Kang, J. Lu, M. Denzinger, M. Kornmann, and B. Traub, JNK inhibitor IX restrains pancreatic cancer through p53 and p21. Front Oncol, 2022. 12: p. 1006131.https://www.ncbi.nlm.nih.gov/pubmed/36568248. 10.3389/fonc.2022.1006131

Steinkraus, K.C., L. Jotten, B. Traub, M. Zaimi, M. Denzinger, C.W. Michalski, M. Kornmann, and F.J. Huttner, Robotic Liver Surgery for Alveolar Echinococcosis: A Single-Centre Experience. Pathogens, 2022. 11(11).https://www.ncbi.nlm.nih.gov/pubmed/36365027. 10.3390/pathogens11111276

Tian, X., B. Traub, J. Shi, N. Huber, S. Schreiner, G. Chen, S. Zhou, D. Henne-Bruns, U. Knippschild, and M. Kornmann, c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1. Cancer Gene Ther, 2022. 29(1): p. 73-86.https://www.ncbi.nlm.nih.gov/pubmed/33526844. 10.1038/s41417-020-00290-5

Beutel, A.K., L. Schutte, J. Scheible, E. Roger, M. Muller, L. Perkhofer, A. Kestler, J.M. Kraus, H.A. Kestler, T.F.E. Barth, J. Lemke, M. Kornmann, T.J. Ettrich, J. Gout, T. Seufferlein, and A. Kleger, A Prospective Feasibility Trial to Challenge Patient-Derived Pancreatic Cancer Organoids in Predicting Treatment Response. Cancers (Basel), 2021. 13(11).https://www.ncbi.nlm.nih.gov/pubmed/34064221. 10.3390/cancers13112539

Brand, M., S. Reimer, J. Reibetanz, S. Flemming, M. Kornmann, and A. Meining, Endoscopic full thickness resection vs. transanal endoscopic microsurgery for local treatment of rectal neuroendocrine tumors - a retrospective analysis. Int J Colorectal Dis, 2021. 36(5): p. 971-976.https://www.ncbi.nlm.nih.gov/pubmed/33215239. 10.1007/s00384-020-03800-x

Chen, K., Q. Wang, M. Kornmann, X. Tian, and Y. Yang, The Role of Exosomes in Pancreatic Cancer From Bench to Clinical Application: An Updated Review. Front Oncol, 2021. 11: p. 644358.https://www.ncbi.nlm.nih.gov/pubmed/33718244. 10.3389/fonc.2021.644358

Kliesch, S., S. Schmidt, D. Wilborn, C. Aigner, W. Albrecht, J. Bedke, M. Beintker, D. Beyersdorff, C. Bokemeyer, J. Busch, J. Classen, M. de Wit, K.P. Dieckmann, T. Diemer, A. Dieing, M. Gockel, B. Gockel-Beining, O.W. Hakenberg, A. Heidenreich, J. Heinzelbecker, K. Herkommer, T. Hermanns, S. Kaufmann, M. Kornmann, J. Kotzerke, S. Krege, G. Kristiansen, A. Lorch, A.C. Muller, K. Oechsle, T. Ohloff, C. Oing, U. Otto, D. Pfister, R. Pichler, H. Recken, O. Rick, Y. Rudolph, C. Ruf, J. Schirren, H. Schmelz, H. Schmidberger, M. Schrader, S. Schweyer, S. Seeling, R. Souchon, C. Winter, C. Wittekind, F. Zengerling, D.H. Zermann, R. Zillmann, and P. Albers, Management of Germ Cell Tumours of the Testis in Adult Patients. German Clinical Practice Guideline Part I: Epidemiology, Classification, Diagnosis, Prognosis, Fertility Preservation, and Treatment Recommendations for Localized Stages. Urol Int, 2021. 105(3-4): p. 169-180.https://www.ncbi.nlm.nih.gov/pubmed/33412555. 10.1159/000510407

Kliesch, S., S. Schmidt, D. Wilborn, C. Aigner, W. Albrecht, J. Bedke, M. Beintker, D. Beyersdorff, C. Bokemeyer, J. Busch, J. Classen, M. de Wit, K.P. Dieckmann, T. Diemer, A. Dieing, M. Gockel, B. Gockel-Beining, O.W. Hakenberg, A. Heidenreich, J. Heinzelbecker, K. Herkommer, T. Hermanns, S. Kaufmann, M. Kornmann, J. Kotzerke, S. Krege, G. Kristiansen, A. Lorch, A.C. Muller, K. Oechsle, T. Ohloff, C. Oing, U. Otto, D. Pfister, R. Pichler, H. Recken, O. Rick, Y. Rudolph, C. Ruf, J. Schirren, H. Schmelz, H. Schmidberger, M. Schrader, S. Schweyer, S. Seeling, R. Souchon, C. Winter, C. Wittekind, F. Zengerling, D.H. Zermann, R. Zillmann, and P. Albers, Management of Germ Cell Tumours of the Testes in Adult Patients: German Clinical Practice Guideline, PART II - Recommendations for the Treatment of Advanced, Recurrent, and Refractory Disease and Extragonadal and Sex Cord/Stromal Tumours and for the Management of Follow-Up, Toxicity, Quality of Life, Palliative Care, and Supportive Therapy. Urol Int, 2021. 105(3-4): p. 181-191.https://www.ncbi.nlm.nih.gov/pubmed/33486494. 10.1159/000511245

Lakemeyer, L., S. Sander, M. Wittau, D. Henne-Bruns, M. Kornmann, and J. Lemke, Diagnostic and Prognostic Value of CEA and CA19-9 in Colorectal Cancer. Diseases, 2021. 9(1).https://www.ncbi.nlm.nih.gov/pubmed/33802962. 10.3390/diseases9010021

Link, K.H., M. Kornmann, L. Staib, E.D. Kreuser, W. Gaus, E. Rottinger, P. Suhr, C. Maulbecker-Armstrong, P. Danenberg, K. Danenberg, M. Schatz, S. Sander, Z.L. Ji, J.T. Li, S.Y. Peng, R. Bittner, H.G. Beger, and B. Traub, Patient-centered developments in colon- and rectal cancer with a multidisciplinary international team: From translational research to national guidelines. World J Gastrointest Surg, 2021. 13(12): p. 1597-1614.https://www.ncbi.nlm.nih.gov/pubmed/35070066. 10.4240/wjgs.v13.i12.1597

Ruff, J.P., A.L. Kretz, M. Kornmann, D. Henne-Bruns, J. Lemke, and B. Traub, The Novel, Orally Bioavailable CDK9 Inhibitor Atuveciclib Sensitises Pancreatic Cancer Cells to TRAIL-induced Cell Death. Anticancer Res, 2021. 41(12): p. 5973-5985.https://www.ncbi.nlm.nih.gov/pubmed/34848451. 10.21873/anticanres.15416

Shi, J., X. Song, B. Traub, M. Luxenhofer, and M. Kornmann, Involvement of IL-4, IL-13 and Their Receptors in Pancreatic Cancer. Int J Mol Sci, 2021. 22(6).https://www.ncbi.nlm.nih.gov/pubmed/33804263. 10.3390/ijms22062998

Song, X., B. Traub, J. Shi, and M. Kornmann, Possible Roles of Interleukin-4 and -13 and Their Receptors in Gastric and Colon Cancer. Int J Mol Sci, 2021. 22(2).https://www.ncbi.nlm.nih.gov/pubmed/33450900. 10.3390/ijms22020727

Steinacker, J.P., N. Steinacker-Stanescu, T. Ettrich, M. Kornmann, K. Kneer, A. Beer, M. Beer, and S.A. Schmidt, Computed Tomography-Based Tumor Heterogeneity Analysis Reveals Differences in a Cohort with Advanced Pancreatic Carcinoma under Palliative Chemotherapy. Visc Med, 2021. 37(1): p. 77-83.https://www.ncbi.nlm.nih.gov/pubmed/33718486. 10.1159/000506656

Tian, X., B. Traub, J. Shi, N. Huber, S. Schreiner, G. Chen, S. Zhou, D. Henne-Bruns, U. Knippschild, and M. Kornmann, c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1. Cancer Gene Ther, 2021.https://www.ncbi.nlm.nih.gov/pubmed/33526844. 10.1038/s41417-020-00290-5

Traub, B., K.H. Link, and M. Kornmann, Curing pancreatic cancer. Semin Cancer Biol, 2021. 76: p. 232-246.https://www.ncbi.nlm.nih.gov/pubmed/34062264. 10.1016/j.semcancer.2021.05.030

Traub, B., A. Roth, M. Kornmann, U. Knippschild, and J. Bischof, Stress-activated kinases as therapeutic targets in pancreatic cancer. World J Gastroenterol, 2021. 27(30): p. 4963-4984.https://www.ncbi.nlm.nih.gov/pubmed/34497429. 10.3748/wjg.v27.i30.4963

Tian, X., B. Traub, X. Xie, S. Zhou, D. Henne-Bruns, U. Knippschild, and M. Kornmann, Opposing Oncogenic Functions of p38 Mitogen-activated Protein Kinase Alpha and Beta in Human Pancreatic Cancer Cells. Anticancer Res, 2020. 40(10): p. 5545-5556.https://www.ncbi.nlm.nih.gov/pubmed/32988878. 10.21873/anticanres.14567

Yokoyama, S., T. Hamada, M. Higashi, K. Matsuo, K. Maemura, H. Kurahara, M. Horinouchi, T. Hiraki, T. Sugimoto, T. Akahane, S. Yonezawa, M. Kornmann, S.K. Batra, M.A. Hollingsworth, and A. Tanimoto, Predicted Prognosis of Patients with Pancreatic Cancer by Machine Learning. Clin Cancer Res, 2020. 26(10): p. 2411-2421.https://www.ncbi.nlm.nih.gov/pubmed/31992588. 10.1158/1078-0432.CCR-19-1247

Berger, A.W., D. Schwerdel, A. Reinacher-Schick, W. Uhl, H. Algul, H. Friess, K.P. Janssen, A. Konig, M. Ghadimi, E. Gallmeier, D.K. Bartsch, M. Geissler, L. Staib, A. Tannapfel, A. Kleger, A. Beutel, L.A. Schulte, M. Kornmann, T.J. Ettrich, and T. Seufferlein, A Blood-Based Multi Marker Assay Supports the Differential Diagnosis of Early-Stage Pancreatic Cancer. Theranostics, 2019. 9(5): p. 1280-1287.https://www.ncbi.nlm.nih.gov/pubmed/30867830. 10.7150/thno.29247

Liu, C., L. Witt, C. Ianes, J. Bischof, M.T. Bammert, J. Baier, S. Kirschner, D. Henne-Bruns, P. Xu, M. Kornmann, C. Peifer, and U. Knippschild, Newly Developed CK1-Specific Inhibitors Show Specifically Stronger Effects on CK1 Mutants and Colon Cancer Cell Lines. Int J Mol Sci, 2019. 20(24).https://www.ncbi.nlm.nih.gov/pubmed/31817920. 10.3390/ijms20246184

Paschke, S., H. Hebart, R. Goeb, L. Staib, U. Fleck, D. Henne-Bruns, S. Sander, K.H. Link, and M. Kornmann, Adjuvant Chemotherapy of Locally Advanced Colon Cancer: Final Results of a Randomized Trial Comparing 5-Fluorouracil and Folinic Acid with Folfiri. Visc Med, 2019. 35(2): p. 124-132.https://www.ncbi.nlm.nih.gov/pubmed/31192246. 10.1159/000491648

Zhang, Z., J. Li, H. Guo, F. Wang, L. Ma, C. Du, Y. Wang, Q. Wang, M. Kornmann, X. Tian, and Y. Yang, BRM transcriptionally regulates miR-302a-3p to target SOCS5/STAT3 signaling axis to potentiate pancreatic cancer metastasis. Cancer Lett, 2019. 449: p. 215-225.https://www.ncbi.nlm.nih.gov/pubmed/30790683. 10.1016/j.canlet.2019.02.031

Ettrich, T.J., A.W. Berger, L. Perkhofer, S. Daum, A. Konig, A. Dickhut, U. Wittel, K. Wille, M. Geissler, H. Algul, E. Gallmeier, J. Atzpodien, M. Kornmann, R. Muche, N. Prasnikar, A. Tannapfel, A. Reinacher-Schick, W. Uhl, and T. Seufferlein, Neoadjuvant plus adjuvant or only adjuvant nab-paclitaxel plus gemcitabine for resectable pancreatic cancer - the NEONAX trial (AIO-PAK-0313), a prospective, randomized, controlled, phase II study of the AIO pancreatic cancer group. BMC Cancer, 2018. 18(1): p. 1298.https://www.ncbi.nlm.nih.gov/pubmed/30594153. 10.1186/s12885-018-5183-y

Ma, L., X. Tian, H. Guo, Z. Zhang, C. Du, F. Wang, X. Xie, H. Gao, Y. Zhuang, M. Kornmann, H. Gao, and Y. Yang, Long noncoding RNA H19 derived miR-675 regulates cell proliferation by down-regulating E2F-1 in human pancreatic ductal adenocarcinoma. J Cancer, 2018. 9(2): p. 389-399.https://www.ncbi.nlm.nih.gov/pubmed/29344285. 10.7150/jca.21347

Ma, L., F. Wang, C. Du, Z. Zhang, H. Guo, X. Xie, H. Gao, Y. Zhuang, M. Kornmann, H. Gao, X. Tian, and Y. Yang, Long non-coding RNA MEG3 functions as a tumour suppressor and has prognostic predictive value in human pancreatic cancer. Oncol Rep, 2018. 39(3): p. 1132-1140.https://www.ncbi.nlm.nih.gov/pubmed/29328401. 10.3892/or.2018.6178

Manzini, G., T.J. Ettrich, M. Kremer, M. Kornmann, D. Henne-Bruns, D.A. Eikema, P. Schlattmann, and L.C. de Wreede, Advantages of a multi-state approach in surgical research: how intermediate events and risk factor profile affect the prognosis of a patient with locally advanced rectal cancer. BMC Med Res Methodol, 2018. 18(1): p. 23.https://www.ncbi.nlm.nih.gov/pubmed/29439652. 10.1186/s12874-018-0476-z

Paschke, S., S. Jafarov, L. Staib, E.D. Kreuser, C. Maulbecker-Armstrong, M. Roitman, T. Holm, C.C. Harris, K.H. Link, and M. Kornmann, Are Colon and Rectal Cancer Two Different Tumor Entities? A Proposal to Abandon the Term Colorectal Cancer. Int J Mol Sci, 2018. 19(9).https://www.ncbi.nlm.nih.gov/pubmed/30200215. 10.3390/ijms19092577

Scheele, J., S.A. Schmidt, S. Tenzer, D. Henne-Bruns, and M. Kornmann, Overstaging: A Challenge in Rectal Cancer Treatment. Visc Med, 2018. 34(4): p. 301-306.https://www.ncbi.nlm.nih.gov/pubmed/30345289. 10.1159/000488652

Link, K.H., P. Coy, M. Roitman, C. Link, M. Kornmann, and L. Staib, Minimum Volume Discussion in the Treatment of Colon and Rectal Cancer: A Review of the Current Status and Relevance of Surgeon and Hospital Volume regarding Result Quality and the Impact on Health Economics. Visc Med, 2017. 33(2): p. 140-147.https://www.ncbi.nlm.nih.gov/pubmed/28560230. 10.1159/000456044

Traub, B., L. Sun, Y. Ma, P. Xu, J. Lemke, S. Paschke, D. Henne-Bruns, U. Knippschild, and M. Kornmann, Endogenously Expressed IL-4Ralpha Promotes the Malignant Phenotype of Human Pancreatic Cancer In Vitro and In Vivo. Int J Mol Sci, 2017. 18(4).https://www.ncbi.nlm.nih.gov/pubmed/28350325. 10.3390/ijms18040716

Wittau, M., S. Paschke, M. Kurlbaum, J. Scheele, N.S. Ly, E. Hemper, M. Kornmann, D. Henne-Bruns, and J.B. Bulitta, Population Pharmacokinetics and Target Attainment of Ertapenem in Plasma and Tissue Assessed via Microdialysis in Morbidly Obese Patients after Laparoscopic Visceral Surgery. Antimicrob Agents Chemother, 2017. 61(1).https://www.ncbi.nlm.nih.gov/pubmed/27795367. 10.1128/AAC.00952-16

Zhang, Z., F. Wang, C. Du, H. Guo, L. Ma, X. Liu, M. Kornmann, X. Tian, and Y. Yang, BRM/SMARCA2 promotes the proliferation and chemoresistance of pancreatic cancer cells by targeting JAK2/STAT3 signaling. Cancer Lett, 2017. 402: p. 213-224.https://www.ncbi.nlm.nih.gov/pubmed/28602977. 10.1016/j.canlet.2017.05.006

Hemper, E., M. Wittau, J. Lemke, M. Kornmann, and D. Henne-Bruns, Management of a giant perineal condylomata acuminata. GMS Interdiscip Plast Reconstr Surg DGPW, 2016. 5: p. Doc07.https://www.ncbi.nlm.nih.gov/pubmed/26814336. 10.3205/iprs000086

Lemke, J., G. Cammerer, J. Ganser, J. Scheele, P. Xu, S. Sander, D. Henne-Bruns, and M. Kornmann, Survival and Prognostic Factors of Colorectal Liver Metastases After Surgical and Nonsurgical Treatment. Clin Colorectal Cancer, 2016. 15(4): p. e183-e192.https://www.ncbi.nlm.nih.gov/pubmed/27269232. 10.1016/j.clcc.2016.04.007

Lemke, J., S.A. Schmidt, M. Kornmann, K.H. Orend, and D. Henne-Bruns, Challenging the limits in pancreatic surgery: A case report. Int J Surg Case Rep, 2016. 29: p. 151-154.https://www.ncbi.nlm.nih.gov/pubmed/27855353. 10.1016/j.ijscr.2016.10.062

Ma, L., X. Tian, F. Wang, Z. Zhang, C. Du, X. Xie, M. Kornmann, and Y. Yang, The long noncoding RNA H19 promotes cell proliferation via E2F-1 in pancreatic ductal adenocarcinoma. Cancer Biol Ther, 2016. 17(10): p. 1051-1061.https://www.ncbi.nlm.nih.gov/pubmed/27573434. 10.1080/15384047.2016.1219814

Schulte-Kemna, L., M. Kornmann, and A. Kleger, An Exceptional Cause of Epigastric Pain. Gastroenterology, 2016. 150(7): p. e1-e2.https://www.ncbi.nlm.nih.gov/pubmed/27143590. 10.1053/j.gastro.2016.02.002

von Witzleben, A., L.T. Goerttler, J. Lennerz, S. Weissinger, M. Kornmann, R. Mayer-Steinacker, A. von Baer, M. Schultheiss, P. Moller, and T.F. Barth, In chordoma, metastasis, recurrences, Ki-67 index, and a matrix-poor phenotype are associated with patients' shorter overall survival. Eur Spine J, 2016. 25(12): p. 4016-4024.https://www.ncbi.nlm.nih.gov/pubmed/26399506. 10.1007/s00586-015-4242-1

Wang, F., L. Ma, Z. Zhang, X. Liu, H. Gao, Y. Zhuang, P. Yang, M. Kornmann, X. Tian, and Y. Yang, Hedgehog Signaling Regulates Epithelial-Mesenchymal Transition in Pancreatic Cancer Stem-Like Cells. J Cancer, 2016. 7(4): p. 408-17.https://www.ncbi.nlm.nih.gov/pubmed/26918054. 10.7150/jca.13305

Yokoyama, S., M. Higashi, S. Kitamoto, M. Oeldorf, U. Knippschild, M. Kornmann, K. Maemura, H. Kurahara, E. Wiest, T. Hamada, I. Kitazono, Y. Goto, T. Tasaki, T. Hiraki, K. Hatanaka, Y. Mataki, H. Taguchi, S. Hashimoto, S.K. Batra, A. Tanimoto, S. Yonezawa, and M.A. Hollingsworth, Aberrant methylation of MUC1 and MUC4 promoters are potential prognostic biomarkers for pancreatic ductal adenocarcinomas. Oncotarget, 2016. 7(27): p. 42553-42565.https://www.ncbi.nlm.nih.gov/pubmed/27283771. 10.18632/oncotarget.9924

Engler, C.C., J. Lemke, M. Kornmann, T.F. Barth, S.A. Schmidt, and D. Henne-Bruns, Ectopic spleen and liver hemangioma mimicking metastatic pancreatic neuroendocrine tumor. Int J Surg Case Rep, 2015. 17: p. 139-42.https://www.ncbi.nlm.nih.gov/pubmed/26670205. 10.1016/j.ijscr.2015.10.041

Mayer, B., S. Sander, S. Paschke, D. Henne-Bruns, K.H. Link, M. Kornmann, and T. Study Group Oncology of Gastrointestinal, Stratified Survival Analysis After Adjuvant Chemotherapy of Colon Cancer Reveals a Benefit for Older Patients. Anticancer Res, 2015. 35(10): p. 5587-93.https://www.ncbi.nlm.nih.gov/pubmed/26408730.

Richter, J., K. Ullah, P. Xu, V. Alscher, A. Blatz, C. Peifer, J. Halekotte, J. Leban, D. Vitt, K. Holzmann, V. Bakulev, L.A. Pinna, D. Henne-Bruns, A. Hillenbrand, M. Kornmann, F. Leithauser, J. Bischof, and U. Knippschild, Effects of altered expression and activity levels of CK1delta and varepsilon on tumor growth and survival of colorectal cancer patients. Int J Cancer, 2015. 136(12): p. 2799-810.https://www.ncbi.nlm.nih.gov/pubmed/25404202. 10.1002/ijc.29346

Scheele, J., J. Lemke, M. Meier, S. Sander, D. Henne-Bruns, and M. Kornmann, Quality of Life After Sphincter-Preserving Rectal Cancer Resection. Clin Colorectal Cancer, 2015. 14(4): p. e33-40.https://www.ncbi.nlm.nih.gov/pubmed/26164498. 10.1016/j.clcc.2015.05.012

von Witzleben, A., L.T. Goerttler, R. Marienfeld, H. Barth, A. Lechel, K. Mellert, M. Bohm, M. Kornmann, R. Mayer-Steinacker, A. von Baer, M. Schultheiss, A.M. Flanagan, P. Moller, S. Bruderlein, and T.F. Barth, Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway. Cancer Res, 2015. 75(18): p. 3823-31.https://www.ncbi.nlm.nih.gov/pubmed/26183925. 10.1158/0008-5472.CAN-14-3270

Hofmann, S., T.F. Barth, M. Kornmann, and D. Henne-Bruns, Appendix carcinoid associated with the Peutz-Jeghers syndrome. Int J Surg Case Rep, 2014. 5(12): p. 964-7.https://www.ncbi.nlm.nih.gov/pubmed/25460448. 10.1016/j.ijscr.2014.06.024

Lemke, J., D. Schafer, S. Sander, D. Henne-Bruns, and M. Kornmann, Survival and prognostic factors in pancreatic and ampullary cancer. Anticancer Res, 2014. 34(6): p. 3011-20.https://www.ncbi.nlm.nih.gov/pubmed/24922667.

Lemke, J., J. Scheele, T. Kapapa, S. von Karstedt, C.R. Wirtz, D. Henne-Bruns, and M. Kornmann, Brain metastases in gastrointestinal cancers: is there a role for surgery? Int J Mol Sci, 2014. 15(9): p. 16816-30.https://www.ncbi.nlm.nih.gov/pubmed/25247579. 10.3390/ijms150916816

Liu, X., X. Tian, F. Wang, Y. Ma, M. Kornmann, and Y. Yang, BRG1 promotes chemoresistance of pancreatic cancer cells through crosstalking with Akt signalling. Eur J Cancer, 2014. 50(13): p. 2251-62.https://www.ncbi.nlm.nih.gov/pubmed/24953335. 10.1016/j.ejca.2014.05.017

Scheele, J., J. Lemke, T.F. Barth, M. Juchems, M. Wittau, M. Kornmann, and D. Henne-Bruns, Chondroid hamartoma of the liver. GMS Interdiscip Plast Reconstr Surg DGPW, 2014. 3: p. Doc16.https://www.ncbi.nlm.nih.gov/pubmed/26504727. 10.3205/iprs000057

Thomaidis, T., A. Maderer, A. Formentini, S. Bauer, M. Trautmann, M. Schwarz, W. Neumann, J.M. Kittner, A. Schad, K.H. Link, J.W. Rey, A. Weinmann, A. Hoffman, P.R. Galle, M. Kornmann, and M. Moehler, Proteins of the VEGFR and EGFR pathway as predictive markers for adjuvant treatment in patients with stage II/III colorectal cancer: results of the FOGT-4 trial. J Exp Clin Cancer Res, 2014. 33: p. 83.https://www.ncbi.nlm.nih.gov/pubmed/25272957. 10.1186/s13046-014-0083-8

Fensterer, H., C. Schade-Brittinger, H.H. Muller, S. Tebbe, J. Fass, U. Lindig, U. Settmacher, W.E. Schmidt, A. Marten, M.P. Ebert, M. Kornmann, R. Hofheinz, E. Endlicher, C. Brendel, P.J. Barth, D.K. Bartsch, P. Michl, T.M. Gress, and O. Arbeitsgemeinschaft Internistische, Multicenter phase II trial to investigate safety and efficacy of gemcitabine combined with cetuximab as adjuvant therapy in pancreatic cancer (ATIP). Ann Oncol, 2013. 24(10): p. 2576-2581.https://www.ncbi.nlm.nih.gov/pubmed/23897705. 10.1093/annonc/mdt270

Kornmann, M., L. Staib, T. Wiegel, M. Kron, D. Henne-Bruns, K.H. Link, A. Formentini, and T. Study Group Oncology of Gastrointestinal, Long-term results of 2 adjuvant trials reveal differences in chemosensitivity and the pattern of metastases between colon cancer and rectal cancer. Clin Colorectal Cancer, 2013. 12(1): p. 54-61.https://www.ncbi.nlm.nih.gov/pubmed/23107590. 10.1016/j.clcc.2012.07.005

Lemke, J., J. Scheele, T. Kapapa, C.R. Wirtz, D. Henne-Bruns, and M. Kornmann, Brain metastasis in pancreatic cancer. Int J Mol Sci, 2013. 14(2): p. 4163-73.https://www.ncbi.nlm.nih.gov/pubmed/23429199. 10.3390/ijms14024163

Schmid, S.J., M.C. Glatzel, C. Welke, M. Kornmann, A. Kleger, T.F. Barth, S. Fulda, J.K. Lennerz, and P. Moller, Absence of FLICE-inhibitory protein is a novel independent prognostic marker for very short survival in pancreatic ductal adenocarcinoma. Pancreas, 2013. 42(7): p. 1114-9.https://www.ncbi.nlm.nih.gov/pubmed/24005232. 10.1097/MPA.0b013e31829655ed

Tsioplis, C., C. Brockschmidt, S. Sander, D. Henne-Bruns, and M. Kornmann, Factors influencing the course of acute appendicitis in adults and children. Langenbecks Arch Surg, 2013. 398(6): p. 857-67.https://www.ncbi.nlm.nih.gov/pubmed/23832465. 10.1007/s00423-013-1096-z

Wang, J.C., M. Thiere, D. Henne-Bruns, U. Knippschild, and M. Kornmann, Inhibition of pancreatic cancer cell growth in vivo using a tetracycline-inducible cyclin D1 antisense expression system. Pancreas, 2013. 42(1): p. 141-8.https://www.ncbi.nlm.nih.gov/pubmed/22722256. 10.1097/MPA.0b013e3182546de5

Cammerer, G., A. Formentini, M. Karletshofer, D. Henne-Bruns, and M. Kornmann, Evaluation of important prognostic clinical and pathological factors in gastric cancer. Anticancer Res, 2012. 32(5): p. 1839-42.https://www.ncbi.nlm.nih.gov/pubmed/22593471.

Formentini, A., P. Braun, H. Fricke, K.H. Link, D. Henne-Bruns, and M. Kornmann, Expression of interleukin-4 and interleukin-13 and their receptors in colorectal cancer. Int J Colorectal Dis, 2012. 27(10): p. 1369-76.https://www.ncbi.nlm.nih.gov/pubmed/22441356. 10.1007/s00384-012-1456-0

Formentini, A., D. Henne-Bruns, and M. Kornmann, Thymidylate synthase and cyclin D1 protein expression in lymph node negative colorectal cancer: role as prognostic factors? Hepatogastroenterology, 2012. 59(118): p. 1859-64.https://www.ncbi.nlm.nih.gov/pubmed/22819905. 10.5754/hge10428

Hofmann, S., M. Kornmann, D. Henne-Bruns, and A. Formentini, Traumatic diaphragmatic ruptures: clinical presentation, diagnosis and surgical approach in adults. GMS Interdiscip Plast Reconstr Surg DGPW, 2012. 1: p. Doc02.https://www.ncbi.nlm.nih.gov/pubmed/26504686. 10.3205/iprs000002

Hofmann, S., J. Vetter, C. Wachter, D. Henne-Bruns, F. Porzsolt, and M. Kornmann, Visual AIDS for multimodal treatment options to support decision making of patients with colorectal cancer. BMC Med Inform Decis Mak, 2012. 12: p. 118.https://www.ncbi.nlm.nih.gov/pubmed/23092310. 10.1186/1472-6947-12-118

Kornmann, M., H. Hebart, K. Danenberg, R. Goeb, L. Staib, M. Kron, D. Henne-Bruns, P. Danenberg, and K.H. Link, Response prediction in metastasised colorectal cancer using intratumoural thymidylate synthase: results of a randomised multicentre trial. Eur J Cancer, 2012. 48(10): p. 1443-51.https://www.ncbi.nlm.nih.gov/pubmed/22133572. 10.1016/j.ejca.2011.11.007

Scheele, J., T.F. Barth, M. Wittau, M. Juchems, D. Henne-Bruns, and M. Kornmann, Cystic teratoma of the pancreas. Anticancer Res, 2012. 32(3): p. 1075-80.https://www.ncbi.nlm.nih.gov/pubmed/22399635.

Tian, X., G. Chen, S. Zhou, D. Henne-Bruns, M. Bachem, and M. Kornmann, Interactions of pancreatic cancer and stellate cells are mediated by FGFR1-III isoform expression. Hepatogastroenterology, 2012. 59(117): p. 1604-8.https://www.ncbi.nlm.nih.gov/pubmed/22683979. 10.5754/hge10366

Tikidzhieva, A., A. Benner, S. Michel, A. Formentini, K.H. Link, W. Dippold, M. von Knebel Doeberitz, M. Kornmann, and M. Kloor, Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer: results of the FOGT-4 trial. Br J Cancer, 2012. 106(6): p. 1239-45.https://www.ncbi.nlm.nih.gov/pubmed/22353804. 10.1038/bjc.2012.53

Giehl, K., M. Bachem, M. Beil, B.O. Bohm, V. Ellenrieder, S. Fulda, T.M. Gress, K. Holzmann, H.A. Kestler, M. Kornmann, A. Menke, P. Moller, F. Oswald, R.M. Schmid, V. Schmidt, R. Schirmbeck, T. Seufferlein, G. von Wichert, M. Wagner, P. Walther, T. Wirth, and G. Adler, Inflammation, regeneration, and transformation in the pancreas: results of the Collaborative Research Center 518 (SFB 518) at the University of Ulm. Pancreas, 2011. 40(4): p. 489-502.https://www.ncbi.nlm.nih.gov/pubmed/21483252. 10.1097/MPA.0b013e318214f33a

Lemke, J., T.F. Barth, M. Juchems, T. Kapapa, D. Henne-Bruns, and M. Kornmann, Long-term survival following resection of brain metastases from pancreatic cancer. Anticancer Res, 2011. 31(12): p. 4599-603.https://www.ncbi.nlm.nih.gov/pubmed/22199336.

Chen, G., X. Tian, Z. Liu, S. Zhou, B. Schmidt, D. Henne-Bruns, M. Bachem, and M. Kornmann, Inhibition of endogenous SPARC enhances pancreatic cancer cell growth: modulation by FGFR1-III isoform expression. Br J Cancer, 2010. 102(1): p. 188-95.https://www.ncbi.nlm.nih.gov/pubmed/19920824. 10.1038/sj.bjc.6605440

Kalbitz, M., U. Liener, M. Kornmann, F. Gebhard, and M. Huber-Lang, [Evaluation of an objective structured clinical examination (OSCE) in surgery and orthopedics by medical students]. Unfallchirurg, 2010. 113(9): p. 726-30, 732-3.https://www.ncbi.nlm.nih.gov/pubmed/20700572. 10.1007/s00113-009-1690-2

Kornmann, M., L. Staib, T. Wiegel, E.D. Kreuser, M. Kron, W. Baumann, D. Henne-Bruns, and K.H. Link, Adjuvant chemoradiotherapy of advanced resectable rectal cancer: results of a randomised trial comparing modulation of 5-fluorouracil with folinic acid or with interferon-alpha. Br J Cancer, 2010. 103(8): p. 1163-72.https://www.ncbi.nlm.nih.gov/pubmed/20877353. 10.1038/sj.bjc.6605871

Link, K.H., M. Kornmann, R. Bittner, F. Kockerling, R. Arbogast, I. Gastinger, W. Heitland, D. Henne-Bruns, H. Lang, H. Lippert, M. Mann, H.J. Meyer, M.J. Polonius, S. Post, R. Raab, T. Schiedeck, and V. Schumpelick, [Quality criteria for treatment of colorectal cancer. From a surgeon's viewpoint]. Chirurg, 2010. 81(3): p. 222-30.https://www.ncbi.nlm.nih.gov/pubmed/19760377. 10.1007/s00104-009-1796-7

Scheele, J., T.F. Barth, J. Strassburg, M. Juchems, M. Kornmann, and D. Henne-Bruns, Dermoid cyst of the pancreas. Int J Colorectal Dis, 2010. 25(3): p. 415-6.https://www.ncbi.nlm.nih.gov/pubmed/19802626. 10.1007/s00384-009-0811-2

Song, B., Y. Wang, M.A. Titmus, G. Botchkina, A. Formentini, M. Kornmann, and J. Ju, Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells. Mol Cancer, 2010. 9: p. 96.https://www.ncbi.nlm.nih.gov/pubmed/20433742. 10.1186/1476-4598-9-96

Buttenschoen, K., M.E. Schneider, K. Utz, M. Kornmann, H.G. Beger, and D. Carli Buttenschoen, Effect of major abdominal surgery on endotoxin release and expression of Toll-like receptors 2/4. Langenbecks Arch Surg, 2009. 394(2): p. 293-302.https://www.ncbi.nlm.nih.gov/pubmed/18546014. 10.1007/s00423-008-0357-8

Formentini, A., O. Prokopchuk, J. Strater, J. Kleeff, L.F. Grochola, G. Leder, D. Henne-Bruns, M. Korc, and M. Kornmann, Interleukin-13 exerts autocrine growth-promoting effects on human pancreatic cancer, and its expression correlates with a propensity for lymph node metastases. Int J Colorectal Dis, 2009. 24(1): p. 57-67.https://www.ncbi.nlm.nih.gov/pubmed/18758789. 10.1007/s00384-008-0550-9

Juchems, M.S., A.S. Ernst, M. Kornmann, T.F. Barth, K. Kramer, H.J. Brambs, and A.J. Aschoff, Value of MDCT in preoperative local staging of rectal cancer for predicting the necessity for neoadjuvant radiochemotherapy. Rofo, 2009. 181(12): p. 1168-74.https://www.ncbi.nlm.nih.gov/pubmed/19408213. 10.1055/s-0028-1109356

Siech, M., Z. Zhou, S. Zhou, B. Bair, A. Alt, S. Hamm, H. Gross, J. Mayer, H.G. Beger, X. Tian, M. Kornmann, and M.G. Bachem, Stimulation of stellate cells by injured acinar cells: a model of acute pancreatitis induced by alcohol and fat (VLDL). Am J Physiol Gastrointest Liver Physiol, 2009. 297(6): p. G1163-71.https://www.ncbi.nlm.nih.gov/pubmed/19779015. 10.1152/ajpgi.90468.2008

Song, B., Y. Wang, Y. Xi, K. Kudo, S. Bruheim, G.I. Botchkina, E. Gavin, Y. Wan, A. Formentini, M. Kornmann, O. Fodstad, and J. Ju, Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells. Oncogene, 2009. 28(46): p. 4065-74.https://www.ncbi.nlm.nih.gov/pubmed/19734943. 10.1038/onc.2009.274

Buttenschoen, K., M. Kornmann, D. Berger, G. Leder, H.G. Beger, and C. Vasilescu, Endotoxemia and endotoxin tolerance in patients with ARDS. Langenbecks Arch Surg, 2008. 393(4): p. 473-8.https://www.ncbi.nlm.nih.gov/pubmed/18320210. 10.1007/s00423-008-0317-3

Chen, G., J. Wang, Z. Liu, and M. Kornmann, Exon III splicing of fibroblast growth factor receptor 1 is modulated by growth factors and cyclin D1. Pancreas, 2008. 37(2): p. 159-64.https://www.ncbi.nlm.nih.gov/pubmed/18665077. 10.1097/MPA.0b013e31816618a4

Kornmann, M., A. Formentini, C. Ette, D. Henne-Bruns, M. Kron, S. Sander, W. Baumann, E.D. Kreuser, L. Staib, and K.H. Link, Prognostic factors influencing the survival of patients with colon cancer receiving adjuvant 5-FU treatment. Eur J Surg Oncol, 2008. 34(12): p. 1316-21.https://www.ncbi.nlm.nih.gov/pubmed/18313881. 10.1016/j.ejso.2008.01.019

Kornmann, M. and D. Henne-Bruns, [Quality for the data basis of evidence-based medicine: rectal cancer and preoperative 5 x 5 irradiation]. Zentralbl Chir, 2008. 133(1): p. 20-4.https://www.ncbi.nlm.nih.gov/pubmed/18278697. 10.1055/s-2008-1004663

Kornmann, M., D. Henne-Bruns, and F. Porzsolt, Neoadjuvant treatment of rectal carcinoma: assessment of health care services by physicians and lay persons. J Clin Oncol, 2008. 26(30): p. 4866-8.https://www.ncbi.nlm.nih.gov/pubmed/18711174. 10.1200/JCO.2008.16.2891

Kornmann, M., F. Porzsolt, and D. Henne-Bruns, [Lay assessment of health care services using therapy for rectal cancer as an example]. Zentralbl Chir, 2008. 133(2): p. 148-55.https://www.ncbi.nlm.nih.gov/pubmed/18415902. 10.1055/s-2008-1004772

Xi, Y., A. Formentini, G. Nakajima, M. Kornmann, and J. Ju, Validation of biomarkers associated with 5-fluorouracil and thymidylate synthase in colorectal cancer. Oncol Rep, 2008. 19(1): p. 257-62.https://www.ncbi.nlm.nih.gov/pubmed/18097604.

Formentini, A., S. Sander, S. Denzer, J. Straeter, D. Henne-Bruns, and M. Kornmann, Thymidylate synthase expression in resectable and unresectable pancreatic cancer: role as predictive or prognostic marker? Int J Colorectal Dis, 2007. 22(1): p. 49-55.https://www.ncbi.nlm.nih.gov/pubmed/16538493. 10.1007/s00384-006-0111-z

Liu, Z., T. Ishiwata, S. Zhou, S. Maier, D. Henne-Bruns, M. Korc, M. Bachem, and M. Kornmann, Human fibroblast growth factor receptor 1-IIIb is a functional fibroblast growth factor receptor expressed in the pancreas and involved in proliferation and movement of pancreatic ductal cells. Pancreas, 2007. 35(2): p. 147-57.https://www.ncbi.nlm.nih.gov/pubmed/17632321. 10.1097/mpa.0b013e318053e7e3

Liu, Z., N. Neiss, S. Zhou, D. Henne-Bruns, M. Korc, M. Bachem, and M. Kornmann, Identification of a fibroblast growth factor receptor 1 splice variant that inhibits pancreatic cancer cell growth. Cancer Res, 2007. 67(6): p. 2712-9.https://www.ncbi.nlm.nih.gov/pubmed/17363592. 10.1158/0008-5472.CAN-06-3843

Liu, Z.B., Y.M. Yang, Q.L. Qiao, Y.L. Wan, M. Kornmann, and Y.T. Huang, [The role of human fibroblast growth factor receptor 1-IIIb isoform in proliferation of pancreatic ductal cells and its effects to mitogen-activated protein kinase]. Zhonghua Yi Xue Za Zhi, 2006. 86(40): p. 2812-6.https://www.ncbi.nlm.nih.gov/pubmed/17200012.

Xi, Y., A. Formentini, M. Chien, D.B. Weir, J.J. Russo, J. Ju, M. Kornmann, and J. Ju, Prognostic Values of microRNAs in Colorectal Cancer. Biomark Insights, 2006. 2: p. 113-121.https://www.ncbi.nlm.nih.gov/pubmed/18079988.

Hofmann, C., K. Buttenschoen, J. Straeter, D. Henne-Bruns, and M. Kornmann, Pre-clinical evaluation of the activity of irinotecan as a basis for regional chemotherapy. Anticancer Res, 2005. 25(2A): p. 795-804.https://www.ncbi.nlm.nih.gov/pubmed/15868911.

Link, K.H., M. Kornmann, L. Staib, M. Redenbacher, M. Kron, H.G. Beger, and T. Study Group Oncology of Gastrointestinal, Increase of survival benefit in advanced resectable colon cancer by extent of adjuvant treatment: results of a randomized trial comparing modulation of 5-FU + levamisole with folinic acid or with interferon-alpha. Ann Surg, 2005. 242(2): p. 178-87.https://www.ncbi.nlm.nih.gov/pubmed/16041207. 10.1097/01.sla.0000171033.65639.a9

Link, K.H., T.A. Sagban, M. Morschel, K. Tischbirek, M. Holtappels, V. Apell, K. Zayed, M. Kornmann, and L. Staib, Colon cancer: survival after curative surgery. Langenbecks Arch Surg, 2005. 390(2): p. 83-93.https://www.ncbi.nlm.nih.gov/pubmed/15455234. 10.1007/s00423-004-0508-5

Prokopchuk, O., Y. Liu, D. Henne-Bruns, and M. Kornmann, Interleukin-4 enhances proliferation of human pancreatic cancer cells: evidence for autocrine and paracrine actions. Br J Cancer, 2005. 92(5): p. 921-8.https://www.ncbi.nlm.nih.gov/pubmed/15714203. 10.1038/sj.bjc.6602416

Formentini, A., D. Henne-Bruns, and M. Kornmann, Thymidylate synthase expression and prognosis of patients with gastrointestinal cancers receiving adjuvant chemotherapy: a review. Langenbecks Arch Surg, 2004. 389(5): p. 405-13.https://www.ncbi.nlm.nih.gov/pubmed/15309542. 10.1007/s00423-004-0510-y

Hillenbrand, A., A. Formentini, L. Staib, S. Sander, D. Salonga, K. Danenberg, P. Danenberg, and M. Kornmann, A longterm follow-up study of thymidylate synthase as a predictor for survival of patients with liver tumours receiving hepatic arterial infusion chemotherapy. Eur J Surg Oncol, 2004. 30(4): p. 407-13.https://www.ncbi.nlm.nih.gov/pubmed/15063894. 10.1016/j.ejso.2004.01.012

Guthoff, I., E. Lotspeich, C. Fester, I. Wallin, M. Schatz, H. Ehrsson, and M. Kornmann, Hepatic artery infusion using oxaliplatin in combination with 5-fluorouracil, folinic acid and mitomycin C: oxaliplatin pharmacokinetics and feasibility. Anticancer Res, 2003. 23(6D): p. 5203-8.https://www.ncbi.nlm.nih.gov/pubmed/14981990.

Kornmann, M., H.G. Beger, and K.H. Link, Chemosensitivity testing and test-directed chemotherapy in human pancreatic cancer. Recent Results Cancer Res, 2003. 161: p. 180-95.https://www.ncbi.nlm.nih.gov/pubmed/12528808. 10.1007/978-3-642-19022-3_15

Kornmann, M., W. Schwabe, S. Sander, M. Kron, J. Strater, S. Polat, E. Kettner, H.F. Weiser, W. Baumann, H. Schramm, P. Hausler, K. Ott, D. Behnke, L. Staib, H.G. Beger, and K.H. Link, Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil. Clin Cancer Res, 2003. 9(11): p. 4116-24.https://www.ncbi.nlm.nih.gov/pubmed/14519634.

Kornmann, M., T. Ishiwata, K. Matsuda, M.E. Lopez, K. Fukahi, G. Asano, H.G. Beger, and M. Korc, IIIc isoform of fibroblast growth factor receptor 1 is overexpressed in human pancreatic cancer and enhances tumorigenicity of hamster ductal cells. Gastroenterology, 2002. 123(1): p. 301-13.https://www.ncbi.nlm.nih.gov/pubmed/12105858. 10.1053/gast.2002.34174

Kornmann, M. and K.H. Link, Conversion of locally inoperable primary rectal cancer with multiple liver metastases to an option for cure after local down-staging and hepatic arterial infusion chemotherapy. Langenbecks Arch Surg, 2002. 387(2): p. 90-3.https://www.ncbi.nlm.nih.gov/pubmed/12111261. 10.1007/s00423-002-0295-9

Kornmann, M., K.H. Link, I. Galuba, K. Ott, W. Schwabe, P. Hausler, P. Scholz, J. Strater, S. Polat, B. Leibl, E. Kettner, C. Schlichting, W. Baumann, H. Schramm, U. Hecker, K. Ridwelski, J.H. Vogt, K.U. Zerbian, F. Schutze, E.D. Kreuser, D. Behnke, and H.G. Beger, Association of time to recurrence with thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression in stage II and III colorectal cancer. J Gastrointest Surg, 2002. 6(3): p. 331-7.https://www.ncbi.nlm.nih.gov/pubmed/12022983. 10.1016/s1091-255x(02)00018-5

Strater, J., H. Walczak, T. Pukrop, L. Von Muller, C. Hasel, M. Kornmann, T. Mertens, and P. Moller, TRAIL and its receptors in the colonic epithelium: a putative role in the defense of viral infections. Gastroenterology, 2002. 122(3): p. 659-66.https://www.ncbi.nlm.nih.gov/pubmed/11874999. 10.1053/gast.2002.31889

Kornmann, M., M. Lopez, H. Beger, and M. Korc, Expression of the IIIc Variant of FGF Receptor-1 Confers Mitogenic Responsiveness to Heparin and FGF-5 in TAKA-1 Pancreatic Ductal Cells. Int J Gastrointest Cancer, 2001. 29(2): p. 85-92.https://www.ncbi.nlm.nih.gov/pubmed/12754391.

Kornmann, M., M.E. Lopez, H.G. Beger, and M. Korc, Expression of the IIIc variant of FGF receptor-1 confers mitogenic responsiveness to heparin and FGF-5 in TAKA-1 pancreatic ductal cells. Int J Pancreatol, 2001. 29(2): p. 85-92.https://www.ncbi.nlm.nih.gov/pubmed/11876253. 10.1385/IJGC:29:2:085

Link, K.H., L. Staib, M. Kornmann, A. Formentini, M. Schatz, P. Suhr, P. Messer, E. Rottinger, H.G. Beger, and T. Forschungsgruppe Onkologie Gastrointestinale, Surgery, radio- and chemotherapy for multimodal treatment of rectal cancer. Swiss Surg, 2001. 7(6): p. 256-74.https://www.ncbi.nlm.nih.gov/pubmed/11771444. 10.1024/1023-9332.7.6.256

Link, K.H., E. Sunelaitis, M. Kornmann, M. Schatz, F. Gansauge, G. Leder, A. Formentini, L. Staib, J. Pillasch, and H.G. Beger, Regional chemotherapy of nonresectable colorectal liver metastases with mitoxantrone, 5-fluorouracil, folinic acid, and mitomycin C may prolong survival. Cancer, 2001. 92(11): p. 2746-53.https://www.ncbi.nlm.nih.gov/pubmed/11753947. 10.1002/1097-0142(20011201)92:11<2746::aid-cncr10098>3.0.co;2-q

Itakura, J., T. Ishiwata, B. Shen, M. Kornmann, and M. Korc, Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer. Int J Cancer, 2000. 85(1): p. 27-34.https://www.ncbi.nlm.nih.gov/pubmed/10585578. 10.1002/(sici)1097-0215(20000101)85:1<27::aid-ijc5>3.0.co;2-8

Kleeff, J., M. Kornmann, H. Sawhney, and M. Korc, Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells. Int J Cancer, 2000. 86(3): p. 399-407.https://www.ncbi.nlm.nih.gov/pubmed/10760829. 10.1002/(sici)1097-0215(20000501)86:3<399::aid-ijc15>3.0.co;2-g

Kornmann, M., U. Butzer, J. Blatter, H.G. Beger, and K.H. Link, Pre-clinical evaluation of the activity of gemcitabine as a basis for regional chemotherapy of pancreatic and colorectal cancer. Eur J Surg Oncol, 2000. 26(6): p. 583-7.https://www.ncbi.nlm.nih.gov/pubmed/11034810. 10.1053/ejso.2000.0951

Kornmann, M., H. Fakler, U. Butzer, H.G. Beger, and K.H. Link, Oxaliplatin exerts potent in vitro cytotoxicity in colorectal and pancreatic cancer cell lines and liver metastases. Anticancer Res, 2000. 20(5A): p. 3259-64.https://www.ncbi.nlm.nih.gov/pubmed/11062751.

Kornmann, M., T. Ishiwata, J. Kleeff, H.G. Beger, and M. Korc, Fas and Fas-ligand expression in human pancreatic cancer. Ann Surg, 2000. 231(3): p. 368-79.https://www.ncbi.nlm.nih.gov/pubmed/10714630. 10.1097/00000658-200003000-00010

Kornmann, M., T. Ishiwata, H. Maruyama, H.G. Beger, and M. Korc, Coexpression of FAS and FAS-ligand in chronic pancreatitis: correlation with apoptosis. Pancreas, 2000. 20(2): p. 123-8.https://www.ncbi.nlm.nih.gov/pubmed/10707926. 10.1097/00006676-200003000-00003

Leder, G.H., J. Pillasch, M. Kornmann, P.V. Danenberg, and K.H. Link, Theoretical considerations and in vitro concentration response studies with two human colorectal carcinoma cell lines. The rational experimental base for clinical studies in regional chemotherapy. Gan To Kagaku Ryoho, 2000. 27(4): p. 565-77.https://www.ncbi.nlm.nih.gov/pubmed/10790999.

Link, K.H., M. Kornmann, U. Butzer, G. Leder, E. Sunelaitis, J. Pillasch, D. Salonga, K.D. Danenberg, P.V. Danenberg, and H.G. Beger, Thymidylate synthase quantitation and in vitro chemosensitivity testing predicts responses and survival of patients with isolated nonresectable liver tumors receiving hepatic arterial infusion chemotherapy. Cancer, 2000. 89(2): p. 288-96.https://www.ncbi.nlm.nih.gov/pubmed/10918158.

Kornmann, M., K.D. Danenberg, N. Arber, H.G. Beger, P.V. Danenberg, and M. Korc, Inhibition of cyclin D1 expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes. Cancer Res, 1999. 59(14): p. 3505-11.https://www.ncbi.nlm.nih.gov/pubmed/10416617.

Kornmann, M., J. Kleeff, W. Debinski, and M. Korc, Pancreatic cancer cells express interleukin-13 and -4 receptors, and their growth is inhibited by Pseudomonas exotoxin coupled to interleukin-13 and -4. Anticancer Res, 1999. 19(1A): p. 125-31.https://www.ncbi.nlm.nih.gov/pubmed/10226533.

Kornmann, M., P. Tangvoranuntakul, and M. Korc, TGF-beta-1 up-regulates cyclin D1 expression in COLO-357 cells, whereas suppression of cyclin D1 levels is associated with down-regulation of the type I TGF-beta receptor. Int J Cancer, 1999. 83(2): p. 247-54.https://www.ncbi.nlm.nih.gov/pubmed/10471535. 10.1002/(sici)1097-0215(19991008)83:2<247::aid-ijc17>3.0.co;2-0

Link, K.H., M. Kornmann, A. Formentini, G. Leder, E. Sunelaitis, M. Schatz, J. Pressmar, and H.G. Beger, Regional chemotherapy of non-resectable liver metastases from colorectal cancer - literature and institutional review. Langenbecks Arch Surg, 1999. 384(4): p. 344-53.https://www.ncbi.nlm.nih.gov/pubmed/10473854. 10.1007/s004230050212

Link, K.H., M. Kornmann, G. Leder, A.F. Pillasch, E. Sunelaitis, M. Schatz, J. Pressmar, and H.G. Beger, Basic research supported developments of chemotherapy in nonresectable isolated colorectal liver metastases to a protocol of hepatic artery infusion using mitoxantrone, 5-FU + folinic acid and mitomycin C. Gan To Kagaku Ryoho, 1999. 26(3): p. 269-81.https://www.ncbi.nlm.nih.gov/pubmed/10065089.

Link, K.H., G. Leder, A. Formentini, G. Fortnagel, M. Kornmann, M. Schatz, and H.G. Beger, Surgery and multimodal treatments in pancreatic cancer--a review on the basis of future multimodal treatment concepts. Gan To Kagaku Ryoho, 1999. 26(1): p. 10-40.https://www.ncbi.nlm.nih.gov/pubmed/9987495.

Link, K.H., J. Pillasch, A. Formentini, E. Sunelaitis, G. Leder, F. Safi, M. Kornmann, and H.G. Beger, Downstaging by regional chemotherapy of non-resectable isolated colorectal liver metastases. Eur J Surg Oncol, 1999. 25(4): p. 381-8.https://www.ncbi.nlm.nih.gov/pubmed/10419708. 10.1053/ejso.1999.0661

Ishiwata, T., M. Kornmann, H.G. Beger, and M. Korc, Enhanced fibroblast growth factor 5 expression in stromal and exocrine elements of the pancreas in chronic pancreatitis. Gut, 1998. 43(1): p. 134-9.https://www.ncbi.nlm.nih.gov/pubmed/9771418. 10.1136/gut.43.1.134

Kornmann, M., N. Arber, and M. Korc, Inhibition of basal and mitogen-stimulated pancreatic cancer cell growth by cyclin D1 antisense is associated with loss of tumorigenicity and potentiation of cytotoxicity to cisplatinum. J Clin Invest, 1998. 101(2): p. 344-52.https://www.ncbi.nlm.nih.gov/pubmed/9435306. 10.1172/JCI1323

Kornmann, M., H.G. Beger, and M. Korc, Role of fibroblast growth factors and their receptors in pancreatic cancer and chronic pancreatitis. Pancreas, 1998. 17(2): p. 169-75.https://www.ncbi.nlm.nih.gov/pubmed/9700949. 10.1097/00006676-199808000-00010

Kornmann, M., T. Ishiwata, N. Arber, H.G. Beger, and M. Korc, Increased cyclin D1 expression in chronic pancreatitis. Pancreas, 1998. 17(2): p. 158-62.https://www.ncbi.nlm.nih.gov/pubmed/9700947. 10.1097/00006676-199808000-00008

Kornmann, M., T. Ishiwata, J. Itakura, P. Tangvoranuntakul, H.G. Beger, and M. Korc, Increased cyclin D1 in human pancreatic cancer is associated with decreased postoperative survival. Oncology, 1998. 55(4): p. 363-9.https://www.ncbi.nlm.nih.gov/pubmed/9663429. 10.1159/000011879

Kornmann, M., H. Maruyama, U. Bergmann, P. Tangvoranuntakul, H.G. Beger, M.F. White, and M. Korc, Enhanced expression of the insulin receptor substrate-2 docking protein in human pancreatic cancer. Cancer Res, 1998. 58(19): p. 4250-4.https://www.ncbi.nlm.nih.gov/pubmed/9766646.

Link, K.H., G. Leder, J. Pillasch, U. Butzer, L. Staib, M. Kornmann, U. Bruckner, and H.G. Beger, In vitro concentration response studies and in vitro phase II tests as the experimental basis for regional chemotherapeutic protocols. Semin Surg Oncol, 1998. 14(3): p. 189-201.https://www.ncbi.nlm.nih.gov/pubmed/9548601. 10.1002/(sici)1098-2388(199804/05)14:3<189::aid-ssu2>3.0.co;2-4

Ishiwata, T., U. Bergmann, M. Kornmann, M. Lopez, H.G. Beger, and M. Korc, Altered expression of insulin-like growth factor II receptor in human pancreatic cancer. Pancreas, 1997. 15(4): p. 367-73.https://www.ncbi.nlm.nih.gov/pubmed/9361090. 10.1097/00006676-199711000-00006

Kornmann, M., T. Ishiwata, H.G. Beger, and M. Korc, Fibroblast growth factor-5 stimulates mitogenic signaling and is overexpressed in human pancreatic cancer: evidence for autocrine and paracrine actions. Oncogene, 1997. 15(12): p. 1417-24.https://www.ncbi.nlm.nih.gov/pubmed/9333017. 10.1038/sj.onc.1201307

Kornmann, M., K.H. Link, H.J. Lenz, J. Pillasch, R. Metzger, U. Butzer, G.H. Leder, M. Weindel, F. Safi, K.D. Danenberg, H.G. Beger, and P.V. Danenberg, Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy. Cancer Lett, 1997. 118(1): p. 29-35.https://www.ncbi.nlm.nih.gov/pubmed/9310257. 10.1016/s0304-3835(97)00220-6

Bergmann, U., H. Funatomi, M. Kornmann, H.G. Beger, and M. Korc, Increased expression of insulin receptor substrate-1 in human pancreatic cancer. Biochem Biophys Res Commun, 1996. 220(3): p. 886-90.https://www.ncbi.nlm.nih.gov/pubmed/8607861. 10.1006/bbrc.1996.0500

Bergmann, U., H. Funatomi, M. Kornmann, T. Ishiwata, H. Beger, and M. Korc, Insulin-like growth factor II activates mitogenic signaling in pancreatic cancer cells via IRS-1. Int J Oncol, 1996. 9(3): p. 487-92.https://www.ncbi.nlm.nih.gov/pubmed/21541539. 10.3892/ijo.9.3.487

Link, K.H., M. Kornmann, G.H. Leder, U. Butzer, J. Pillasch, L. Staib, F. Gansauge, and H.G. Beger, Regional chemotherapy directed by individual chemosensitivity testing in vitro: a prospective decision-aiding trial. Clin Cancer Res, 1996. 2(9): p. 1469-74.https://www.ncbi.nlm.nih.gov/pubmed/9816322.

Kornmann M. Zwerchfell. In: Lehrbuch für Chirurgie. Ed. Henne-Bruns D. Duale Reihe, Thieme Verlag, Stuttgart. 2012; 4. Auflage: 288-297.

Patent - IL-4 receptor and IL-13 as prognostic markers for colon and pancreas tumors. United States Patent Application 20100111969 (www.freepatentsonline.com/y2010/0111969.html)