Publikationen Prof. Dr. Franz Oswald

1. Oswald, F., P. Rodriguez, B. D. Giaimo, Z. A. Antonello, L. Mira, G. Mittler, V. N. Thiel, K. J. Collins, N. Tabaja, W. Cizelsky, M. Rothe, S. J. Kuhl, M. Kuhl, F. Ferrante, K. Hein, R. A. Kovall, M. Dominguez, and T. Borggrefe. 2016. A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes. Nucleic Acids Res. (epub ahead of print)

2. Borggrefe, T., M. Lauth, A. Zwijsen, D. Huylebroeck, F. Oswald, and B. D. Giaimo. 2016. The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFbeta/BMP and hypoxia pathways. Biochim Biophys Acta 1863:303-13.

3. Qin, R., H. Schmid, C. Munzberg, U. Maass, D. Krndija, G. Adler, T. Seufferlein, A. Liedert, A. Ignatius, F. Oswald, T. Eiseler, and G. von Wichert. 2015. Phosphorylation and turnover of paxillin in focal contacts is controlled by force and defines the dynamic state of the adhesion site. Cytoskeleton (Hoboken) 72:101-12.

4. Munzberg, C., K. Hohn, D. Krndija, U. Maass, D. K. Bartsch, E. P. Slater, F. Oswald, P. Walther, T. Seufferlein, and G. von Wichert. 2015. IGF-1 drives chromogranin A secretion via activation of Arf1 in human neuroendocrine tumour cells. J Cell Mol Med 19:948-59.

5. Hein, K., G. Mittler, W. Cizelsky, M. Kuhl, F. Ferrante, R. Liefke, I. M. Berger, S. Just, J. E. Strang, H. A. Kestler, F. Oswald, and T. Borggrefe. 2015. Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response. Sci Signal 8:ra30.

6. Gittins, J. R., C. D'Angelo, F. Oswald, R. J. Edwards, and J. Wiedenmann. 2015. Fluorescent protein-mediated colour polymorphism in reef corals: multicopy genes extend the adaptation/acclimatization potential to variable light environments. Mol Ecol 24:453-65.

7. Brockmann, B., H. Mastel, F. Oswald, and D. Maier. 2015. Analysis of the interaction between human RITA and Drosophila Suppressor of Hairless. Hereditas 151:209-19.

8. Borggrefe, T., and F. Oswald. 2014. Keeping notch target genes off: a CSL corepressor caught in the act. Structure 22:3-5.

9. Jung, C., G. Mittler, F. Oswald, and T. Borggrefe. 2013. RNA helicase Ddx5 and the noncoding RNA SRA act as coactivators in the Notch signaling pathway. Biochim Biophys Acta 1833:1180-9.

10. Fois, G., M. Weimer, T. Busch, E. T. Felder, F. Oswald, G. von Wichert, T. Seufferlein, P. Dietl, and E. Felder. 2013. Effects of keratin phosphorylation on the mechanical properties of keratin filaments in living cells. Faseb J 27:1322-9.

11. Schmeisser, M. J., B. Baumann, S. Johannsen, G. F. Vindedal, V. Jensen, O. C. Hvalby, R. Sprengel, J. Seither, A. Maqbool, A. Magnutzki, M. Lattke, F. Oswald, T. M. Boeckers, and T. Wirth. 2012. IkappaB kinase/nuclear factor kappaB-dependent insulin-like growth factor 2 (Igf2) expression regulates synapse formation and spine maturation via Igf2 receptor signaling. J Neurosci 32:5688-703.

12. Krndija, D., C. Munzberg, U. Maass, M. Hafner, G. Adler, H. A. Kestler, T. Seufferlein, F. Oswald, and G. von Wichert. 2012. The phosphatase of regenerating liver 3 (PRL-3) promotes cell migration through Arf-activity-dependent stimulation of integrin alpha5 recycling. J Cell Sci 125:3883-92.

13. Hirner, H., C. Gunes, J. Bischof, S. Wolff, A. Grothey, M. Kuhl, F. Oswald, F. Wegwitz, M. R. Bosl, A. Trauzold, D. Henne-Bruns, C. Peifer, F. Leithauser, W. Deppert, and U. Knippschild. 2012. Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo. PLoS One 7:e29709.

14. Wiedenmann, J., S. Gayda, V. Adam, F. Oswald, K. Nienhaus, D. Bourgeois, and G. U. Nienhaus. 2011. From EosFP to mIrisFP: structure-based development of advanced photoactivatable marker proteins of the GFP-family. J Biophotonics 4:377-90.

15. Wacker, S. A., C. Alvarado, G. von Wichert, U. Knippschild, J. Wiedenmann, K. Clauss, G. U. Nienhaus, H. Hameister, B. Baumann, T. Borggrefe, W. Knochel, and F. Oswald. 2011. RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J. Embo J 30:43-56.

16. Giehl, K., M. Bachem, M. Beil, B. O. Bohm, V. Ellenrieder, S. Fulda, T. M. Gress, K. Holzmann, H. A. Kestler, M. Kornmann, A. Menke, P. Moller, F. Oswald, R. M. Schmid, V. Schmidt, R. Schirmbeck, T. Seufferlein, G. von Wichert, M. Wagner, P. Walther, T. Wirth, and G. Adler. 2011. Inflammation, regeneration, and transformation in the pancreas: results of the Collaborative Research Center 518 (SFB 518) at the University of Ulm. Pancreas 40:489-502.

17. Wolff, M., S. Kredel, D. Haasen, J. Wiedenmann, G. U. Nienhaus, B. Kistler, F. Oswald, and R. Heilker. 2010. High content screening of CXCR2-dependent signalling pathways. Comb Chem High Throughput Screen 13:3-15.

18. Schuff, M., D. Siegel, N. Bardine, F. Oswald, C. Donow, and W. Knochel. 2010. FoxO genes are dispensable during gastrulation but required for late embryogenesis in Xenopus laevis. Dev Biol 337:259-73.

19. Liefke, R., F. Oswald, C. Alvarado, D. Ferres-Marco, G. Mittler, P. Rodriguez, M. Dominguez, and T. Borggrefe. 2010. Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex. Genes Dev 24:590-601.

20. Krndija, D., H. Schmid, J. L. Eismann, U. Lother, G. Adler, F. Oswald, T. Seufferlein, and G. von Wichert. 2010. Substrate stiffness and the receptor-type tyrosine-protein phosphatase alpha regulate spreading of colon cancer cells through cytoskeletal contractility. Oncogene 29:2724-38.

21. Fuchs, J., S. Bohme, F. Oswald, P. N. Hedde, M. Krause, J. Wiedenmann, and G. U. Nienhaus. 2010. A photoactivatable marker protein for pulse-chase imaging with superresolution. Nat Methods 7:627-30.

22. Cao, Y., F. Oswald, S. A. Wacker, K. Bundschu, and W. Knochel. 2010. Reversal of Xenopus Oct25 function by disruption of the POU domain structure. J Biol Chem 285:8408-21.

23. Beilke, S., F. Oswald, F. Genze, T. Wirth, G. Adler, and M. Wagner. 2010. The zinc-finger protein KCMF1 is overexpressed during pancreatic cancer development and downregulation of KCMF1 inhibits pancreatic cancer development in mice. Oncogene 29:4058-67.

24. Wiedenmann, J., F. Oswald, and G. U. Nienhaus. 2009. Fluorescent proteins for live cell imaging: opportunities, limitations, and challenges. IUBMB Life 61:1029-42.

25. Wahl, C., W. Muller, F. Leithauser, G. Adler, F. Oswald, J. Reimann, R. Schirmbeck, A. Seier, J. M. Weiss, B. Prochnow, and U. M. Wegenka. 2009. IL-20 receptor 2 signaling down-regulates antigen-specific T cell responses. J Immunol 182:802-10.

26. Siegel, D., M. Schuff, F. Oswald, Y. Cao, and W. Knochel. 2009. Functional dissection of XDppa2/4 structural domains in Xenopus development. Mech Dev 126:974-89.

27. Schwarz, P., P. Strnad, N. Singer, F. Oswald, R. Ehehalt, G. Adler, and H. Kulaksiz. 2009. Identification, sequencing, and cellular localization of hepcidin in guinea pig (Cavia porcellus). J Endocrinol 202:389-96.

28. Schneiderhan, W., M. Scheler, K. H. Holzmann, M. Marx, J. E. Gschwend, M. Bucholz, T. M. Gress, T. Seufferlein, G. Adler, and F. Oswald. 2009. CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models. Gut 58:1391-8.

29. Ludwig, L., F. Oswald, C. Hoang-Vu, H. Dralle, E. Hildt, R. M. Schmid, and W. Karges. 2009. Expression of the Grb2-related RET adapter protein Grap-2 in human medullary thyroid carcinoma. Cancer Lett 275:194-7.

30. Kredel, S., F. Oswald, K. Nienhaus, K. Deuschle, C. Rocker, M. Wolff, R. Heilker, G. U. Nienhaus, and J. Wiedenmann. 2009. mRuby, a bright monomeric red fluorescent protein for labeling of subcellular structures. PLoS One 4:e4391.

31. Herlyn, H., U. Zechner, F. Oswald, A. Pfeufer, H. Zischler, and T. Haaf. 2009. Positive selection at codon 38 of the human KCNE1 (= minK) gene and sporadic absence of 38Ser-coding mRNAs in Gly38Ser heterozygotes. BMC Evol Biol 9:188.

32. Hedde, P. N., J. Fuchs, F. Oswald, J. Wiedenmann, and G. U. Nienhaus. 2009. Online image analysis software for photoactivation localization microscopy. Nat Methods 6:689-90.

33. Brosi, H., M. Reiser, T. Rajasalu, A. Spyrantis, F. Oswald, B. O. Boehm, and R. Schirmbeck. 2009. Processing in the endoplasmic reticulum generates an epitope on the insulin A chain that stimulates diabetogenic CD8 T cell responses. J Immunol 183:7187-95.

34. Borggrefe, T., and F. Oswald. 2009. The Notch signaling pathway: transcriptional regulation at Notch target genes. Cell Mol Life Sci 66:1631-46.

35. Yuan, L., Y. Cao, F. Oswald, and W. Knochel. 2008. IRE1beta is required for mesoderm formation in Xenopus embryos. Mech Dev 125:207-22.

36. von Wichert, G., T. Edenfeld, J. von Blume, H. Krisp, D. Krndija, H. Schmid, F. Oswald, U. Lother, P. Walther, G. Adler, and T. Seufferlein. 2008. Protein kinase D2 regulates chromogranin A secretion in human BON neuroendocrine tumour cells. Cell Signal 20:925-34.

37. Vogt, A., C. D'Angelo, F. Oswald, A. Denzel, C. H. Mazel, M. V. Matz, S. Ivanchenko, G. U. Nienhaus, and J. Wiedenmann. 2008. A green fluorescent protein with photoswitchable emission from the deep sea. PLoS One 3:e3766.

38. Salat, D., R. Liefke, J. Wiedenmann, T. Borggrefe, and F. Oswald. 2008. ETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-Jkappa/SHARP-mediated repression of notch target genes. Mol Cell Biol 28:3502-12.

39. Kredel, S., K. Nienhaus, F. Oswald, M. Wolff, S. Ivanchenko, F. Cymer, A. Jeromin, F. J. Michel, K. D. Spindler, R. Heilker, G. U. Nienhaus, and J. Wiedenmann. 2008. Optimized and far-red-emitting variants of fluorescent protein eqFP611. Chem Biol 15:224-33.

40. D'Angelo, C., A. Denzel, A. Vogt, M. V. Matz, F. Oswald, A. Salih, G. U. Nienhaus, and J. Wiedenmann. 2008. Blue light regulation of host pigment in reef-building corals. Mar Ecol Prog Ser 364:97-106.

41. Cao, Y., D. Siegel, F. Oswald, and W. Knochel. 2008. Oct25 represses transcription of nodal/activin target genes by interaction with signal transducers during Xenopus gastrulation. J Biol Chem 283:34168-77.

42. Wacker, S. A., F. Oswald, J. Wiedenmann, and W. Knochel. 2007. A green to red photoconvertible protein as an analyzing tool for early vertebrate development. Dev Dyn 236:473-80.

43. Oswald, F., F. Schmitt, A. Leutenegger, S. Ivanchenko, C. D'Angelo, A. Salih, S. Maslakova, M. Bulina, R. Schirmbeck, G. U. Nienhaus, M. V. Matz, and J. Wiedenmann. 2007. Contributions of host and symbiont pigments to the coloration of reef corals. Febs J 274:1102-9.

44. Leutenegger, A., C. D'Angelo, M. V. Matz, A. Denzel, F. Oswald, A. Salih, G. U. Nienhaus, and J. Wiedenmann. 2007. It's cheap to be colorful. Anthozoans show a slow turnover of GFP-like proteins. Febs J 274:2496-505.

45. Ivanchenko, S., S. Glaschick, C. Rocker, F. Oswald, J. Wiedenmann, and G. U. Nienhaus. 2007. Two-photon excitation and photoconversion of EosFP in dual-color 4Pi confocal microscopy. Biophys J 92:4451-7.

46. Glaschick, S., C. Rocker, K. Deuschle, J. Wiedenmann, F. Oswald, V. Mailander, and G. U. Nienhaus. 2007. Axial resolution enhancement by 4Pi confocal fluorescence microscopy with two-photon excitation. J Biol Phys 33:433-43.

47. Schneider, G., A. Weber, U. Zechner, F. Oswald, H. M. Friess, R. M. Schmid, and S. Liptay. 2006. GADD45alpha is highly expressed in pancreatic ductal adenocarcinoma cells and required for tumor cell viability. Int J Cancer 118:2405-11.

48. Nienhaus, G. U., K. Nienhaus, A. Holzle, S. Ivanchenko, F. Renzi, F. Oswald, M. Wolff, F. Schmitt, C. Rocker, B. Vallone, W. Weidemann, R. Heilker, H. Nar, and J. Wiedenmann. 2006. Photoconvertible fluorescent protein EosFP: biophysical properties and cell biology applications. Photochem Photobiol 82:351-8.

49. Cao, Y., S. Knochel, F. Oswald, C. Donow, H. Zhao, and W. Knochel. 2006. XBP1 forms a regulatory loop with BMP-4 and suppresses mesodermal and neural differentiation in Xenopus embryos. Mech Dev 123:84-96.

50. Oswald, F., M. Winkler, Y. Cao, K. Astrahantseff, S. Bourteele, W. Knochel, and T. Borggrefe. 2005. RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes. Mol Cell Biol 25:10379-90.

51. Ivanchenko, S., C. Rocker, F. Oswald, J. Wiedenmann, and G. U. Nienhaus. 2005. Targeted Green-Red Photoconversion of EosFP, a Fluorescent Marker Protein. J Biol Phys 31:249-59.

52. Wiedenmann, J., S. Ivanchenko, F. Oswald, F. Schmitt, C. Rocker, A. Salih, K. D. Spindler, and G. U. Nienhaus. 2004. EosFP, a fluorescent marker protein with UV-inducible green-to-red fluorescence conversion. Proc Natl Acad Sci U S A 101:15905-10.

53. Wiedenmann, J., S. Ivanchenko, F. Oswald, and G. U. Nienhaus. 2004. Identification of GFP-like proteins in nonbioluminescent, azooxanthellate anthozoa opens new perspectives for bioprospecting. Mar Biotechnol (NY) 6:270-7.

54. Schneider, G., F. Oswald, C. Wahl, F. R. Greten, G. Adler, and R. M. Schmid. 2002. Cyclosporine inhibits growth through the activating transcription factor/cAMP-responsive element-binding protein binding site in the cyclin D1 promoter. J Biol Chem 277:43599-607.

55. Oswald, F., U. Kostezka, K. Astrahantseff, S. Bourteele, K. Dillinger, U. Zechner, L. Ludwig, M. Wilda, H. Hameister, W. Knochel, S. Liptay, and R. M. Schmid. 2002. SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway. Embo J 21:5417-26.

56. Wahl, C., F. Oswald, U. Simnacher, S. Weiss, R. Marre, and A. Essig. 2001. Survival of Chlamydia pneumoniae-infected Mono Mac 6 cells is dependent on NF-kappaB binding activity. Infect Immun 69:7039-45.

57. Oswald, F., B. Tauber, T. Dobner, S. Bourteele, U. Kostezka, G. Adler, S. Liptay, and R. M. Schmid. 2001. p300 acts as a transcriptional coactivator for mammalian Notch-1. Mol Cell Biol 21:7761-74.

58. Oswald, F., S. Liptay, G. Adler, and R. M. Schmid. 1998. NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa. Mol Cell Biol 18:2077-88.

59. Oswald, F., T. Dobner, and M. Lipp. 1996. The E2F transcription factor activates a replication-dependent human H2A gene in early S phase of the cell cycle. Mol Cell Biol 16:1889-95.

60. Oswald, F., H. Lovec, T. Moroy, and M. Lipp. 1994. E2F-dependent regulation of human MYC: trans-activation by cyclins D1 and A overrides tumour suppressor protein functions. Oncogene 9:2029-36.