Publikationen Prof. Dr. Reinhold Schirmbeck

Tumor Immunology:

1.         Stifter, K., Dekhtiarenko, I., Krieger, J., Tissot, A. C., Seufferlein, T., Wagner, M., and Schirmbeck, R. (2020) A tumor-specific neoepitope expressed in homologous/self or heterologous/viral antigens induced comparable effector CD8(+) T-cell responses by DNA vaccination. Vaccine

2.         Stifter, K., Krieger, J., Ruths, L., Gout, J., Mulaw, M., Lechel, A., Kleger, A., Seufferlein, T., Wagner, M., and Schirmbeck, R. (2020) IFN-γ treatment protocol for MHC-I(lo)/PD-L1(+) pancreatic tumor cells selectively restores their TAP-mediated presentation competence and CD8 T-cell priming potential. Journal for immunotherapy of cancer8

3.         Krieger, J., Riedl, P., Stifter, K., Roman-Sosa, G., Seufferlein, T., Wagner, M., and Schirmbeck, R. (2019) Endogenously Expressed Antigens Bind Mammalian RNA via Cationic Domains that Enhance Priming of Effector CD8 T Cells by DNA Vaccination. Mol Ther


Type 1 diabetes:

4.         Spyrantis, A., Krieger, J., Stifter, K., Boehm, B. O., and Schirmbeck, R. (2020) A dominant insulin-specific and islet-destructive T-cell response is sufficient to activate CD8 T cells directed against the fatty-acid receptor GPR40. Cell Mol Immunol17, 659-661

5.         Stifter, K., Schuster, C., Krieger, J., Spyrantis, A., Boehm, B. O., and Schirmbeck, R. (2019) Preproinsulin Designer Antigens Excluded from Endoplasmic Reticulum Suppressed Diabetes Development in NOD Mice by DNA Vaccination. Mol Ther Methods Clin Dev12, 123-133

6.         Cobo-Vuilleumier, N., Lorenzo, P. I., Rodriguez, N. G., Herrera Gomez, I. G., Fuente-Martin, E., Lopez-Noriega, L., Mellado-Gil, J. M., Romero-Zerbo, S. Y., Baquie, M., Lachaud, C. C., Stifter, K., Perdomo, G., Bugliani, M., De Tata, V., Bosco, D., Parnaud, G., Pozo, D., Hmadcha, A., Florido, J. P., Toscano, M. G., de Haan, P., Schoonjans, K., Sanchez Palazon, L., Marchetti, P., Schirmbeck, R., Martin-Montalvo, A., Meda, P., Soria, B., Bermudez-Silva, F. J., St-Onge, L., and Gauthier, B. R. (2018) LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus. Nat Commun9, 1488


Aging immune system:

7.         Leins, H., Mulaw, M., Eiwen, K., Sakk, V., Liang, Y., Denkinger, M., Geiger, H., and Schirmbeck, R. (2018) Aged murine hematopoietic stem cells drive aging-associated immune remodeling. Blood132, 565-576

8.         Ovadya, Y., Landsberger, T., Leins, H., Vadai, E., Gal, H., Biran, A., Yosef, R., Sagiv, A., Agrawal, A., Shapira, A., Windheim, J., Tsoory, M., Schirmbeck, R., Amit, I., Geiger, H., and Krizhanovsky, V. (2018) Impaired immune surveillance accelerates accumulation of senescent cells and aging. Nat Commun9, 5435


Heterogeneity and Evolution in Solid Tumours (HEIST); Dr. André Lechel:

9.         Svinarenko, M., Katz, S. F., Tharehalli, U., Mulaw, M. A., Maier, H. J., Sunami, Y., Fischer, S. K., Chen, Y., Heurich, S., Erkert, L., Tannapfel, A., Wirth, T., Schirmbeck, R., Seufferlein, T., and Lechel, A. (2019) An IKK/NF-kappaB Activation/p53 Deletion Sequence Drives Liver Carcinogenesis and Tumor Differentiation. Cancers (Basel)11

10.       Tharehalli, U., Svinarenko, M., Kraus, J. M., Kuhlwein, S. D., Szekely, R., Kiesle, U., Scheffold, A., Barth, T. F. E., Kleger, A., Schirmbeck, R., Kestler, H. A., Seufferlein, T., Oswald, F., Katz, S. F., and Lechel, A. (2018) YAP Activation Drives Liver Regeneration after Cholestatic Damage Induced by Rbpj Deletion. Int J Mol Sci19