Publikationen Prof. Dr. rer. med. Alexander Kleger

Originalarbeiten
  • Open Surgical versus Minimal Invasive Necrosectomy of the Pancreas-A Retrospective Multicenter Analysis of the German Pancreatitis Study Group. Rasch S, Phillip V, Reichel S, Rau B, Zapf C, Rosendahl J, Halm U, Zachäus M, Müller M, Kleger A, Neesse A, Hampe J, Ellrichmann M, Rückert F, Strauß P, Arlt A, Ellenrieder V, Gress TM, Hartwig W, Klar E, Mössner J, Post S, Schmid RM, Seufferlein T, Siech M, Werner J, Will U, Algül H. PLoS One. 2016 Sep 26;11(9):e0163651. doi: 10.1371/journal.pone.0163651. eCollection 2016.
  • [IgG4-associated diseases : State of the art].Kleger A, Seufferlein T. Radiologe. 2016 Sep 15. [Epub ahead of print] German.
  • Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling. Hohwieler M, Illing A, Hermann PC, Mayer T, Stockmann M, Perkhofer L, Eiseler T, Antony JS, Müller M, Renz S, Kuo CC, Lin Q, Sendler M, Breunig M, Kleiderman SM, Lechel A, Zenker M, Leichsenring M, Rosendahl J, Zenke M, Sainz B Jr, Mayerle J, Costa IG, Seufferlein T, Kormann M, Wagner M, Liebau S, Kleger A. Gut. 2016 Sep 15. pii: gutjnl-2016-312423. d
  • Circulating cell-free DNA is a reliable tool to detect hot spot mutations in intraductal papillary mucinous neoplasms of the pancreas. Berger A, Schwerdel D, Costa IG, Hackert T, Strobel O, Lam S, Barth T, Schröppel B, Meining A, Büchler MW, Zenke M, Hermann PC, Seufferlein T#, Kleger A#. Gastroenterology, 2016, Aug;151(2):267-70. # corresponding authors.
  • Cortactin is a scaffolding platform for the E-cadherin adhesion complex and is regulated by protein kinase D1 phosphorylation. Sroka R, Van Lint J, Katz SF, Schneider MR, Kleger A, Paschke S, Seufferlein T, Eiseler T. J Cell Sci. 2016 Jun 15;129(12):2416-29. doi: 10.1242/jcs.184721. Epub 2016 May 13.
  • Lost but still missed: A New Chapter about TBX3 in pluripotency and fate decision, Ilg M, Liebau S, Kleger A. J Cell Sign, 2016, in press
  • Tbx3 fosters pancreatic cancer growth by increased angiogenesis and activin/nodal-dependent induction of stemness. Perkhofer L, Walter K, Costa IG, Carrasco MC, Eiseler T, Hafner S, Genze F, Zenke M, Bergmann W, Illing A, Hohwieler M, Köhntop R, Lin Q, Holzmann KH, Seufferlein T, Wagner M, Liebau S, Hermann PC#, Kleger A#, Müller M. Stem Cell Res. 2016 Aug 10 # corresponding authors
  • „Miniguts“ from plucked human hair meet Crohn´s disease. Hohwieler M1, Renz S, Liebau S, Lin Q, Lechel A, Klaus J, Perkhofer L, Zenke M, Seufferlein T, Illing A, Müller M, Kleger A. Z Gastroenterol, 2016,  2016 Aug;54(8):748-59
  • A dynamic role of Tbx3 in the pluripotency circuitry. Ronan Russell, Marcus Ilg, Qiong Lin, Guangming Wu, Leonhard Linta, Meike Hohwieler, André Lechel, Wendy Bergmann, Pavan Kumar P., Moritz Klingenstein, Olena Sakk, Stefanie Raab, Anne Moon, Martin Zenke, Thomas Seufferlein, Hans Schöler, Anett Illing, Stefan Liebau, Alexander Kleger. Stem Cell Reports, in press
  • TBX3 knockdown decreases reprogramming efficiency of human cells. Klingenstein M, Raab S, Achberger K, Kleger A#, Liebau S#, Linta L#. Stem Cells Int., 2015, in press. # corresponding authors.
  • Loss of ATM accelerates pancreatic cancer formation and Epithelial-Mesenchymal-Transition. Russell R, Perkhofer L, Liebau S, Lin Q, Lechel A, Feld FM, Zenke M, Illing A, Hartmann D, von Figura G, Weissinger SE, Rudolph KL, Möller P, Lennerz JK, Seufferlein T, Wagner M#, Kleger A#. Nature Communications, in press. # corresponding authors.
  • A time frame permissive for Protein Kinase D2 activity to direct angiogenesis in mouse embryonic stem cells. Martin Müller, Jana Schröer, Ninel Azoitei, Tim Eiseler, Wendy Bergmann, Ralf Köhntop, Qiong Lin, Martin Zenke, Felicitas Genze, Clair Weidgang, Thomas Seufferlein, Stefan Liebau#, Alexander Kleger#. Scientific Reports, in press. # corresponding authors.
  • Self-expandable metal stents for persisting esophageal variceal bleeding after band ligation or injection-therapy: A retrospective study. Martin Müller, Thomas Seufferlein, Martin Wagner, Alexander Kleger. PLoS One, PLoS One. 2015 Jun 22;10(6):e0126525. TBX3 Directs Cell-Fate Decision toward Mesendoderm. Weidgang CE*, Russell R*, Tata PR*, Kühl SJ, Illing A, Müller M, Lin Q, Brunner C, Boeckers TM, Bauer B, Kartikasari AER, Guo Y, Radenz M, Bernemann C, Weiß M, Seufferlein S, Zenke M, Iacovino M, Kyba M, Schöler HR, Kühl M, Liebau S#, and Kleger A#. Stem Cell Reports, ISSCR and Cell Press, 2013 Aug 29;1(3):248-65. *equal contribution. # corresponding authors.
  • Absence of FLICE-Inhibitory Protein Is a Novel Independent Prognostic Marker for Very Short Survival in Pancreatic Ductal Adenocarcinoma. Schmid SJ,* Glatzel MC,* Welke C, Kornmann M, Kleger A, Barth TFE, Fulda S, Lennerz JK, and Möller. Pancreas, 2013, Oct;42(7):1114-9. *equal contribution.
  • Definitive Endoderm Formation from Plucked Human Hair-Derived Induced Pluripotent Stem Cells and SK Channel Regulation. Illing A*, Stockmann M*, Telugu NS, Linta L, Russell R, Müller M, Seufferlein T, Liebau S#, Kleger A#. Stem Cells Int, 2013;2013:360573. *equal contribution. # corresponding authors.
  • Microarray-Based Comparisons of Ion Channel Expression Patterns: Human Keratinocytes to Reprogrammed hiPSCs to Differentiated Neuronal and Cardiac Progeny. Linta L, Stockmann M, Lin Q, Lechel A, Proepper Ch, Boeckers TM, Kleger A#, Liebau L#. Stem Cells Int, 2013, 2013:784629. # corresponding authors.
  • Calcium activated potassium channel expression during human iPS cell-derived neurogenesis. Linta L, Boeckers TM, Kleger A#, Liebau S#. Ann Anat. 2013 Mar 28. # corresponding authors.
  • Increased Reprogramming Capacity of Mouse Liver Progenitor Cells, Compared With Differentiated Liver Cells, Requires the BAF Complex. Kleger A* #, Mahaddalkar P *, Katz SF, Lechel A, Ju JY, Loya K, Lin Q, Hartmann D, Liebau S, Kraus J, Cantz T, Kestler HA, Zaehres H, Schöler H, Rudolph KL #. Gastroenterology. 2012 Apr;142(4):907-17. *equal contribution. # corresponding authors.
  • Developmental and functional nature of human iPSC derived motoneurons. Stockmann M, Linta L, Föhr KJ, Boeckers A, Ludolph AC, Kuh GF, Udvardi PT, Proepper C, Storch A, Kleger A, Liebau S, Boeckers TM. Stem Cell Reviews and Reports, 2011 Nov 3. [Epub ahead of print].
  • Ca2+-activated K+-Channels - New Tools to induce Cardiac Commitment from Pluripotent Stem Cells in Mice and Men. Müller M*, Stockmann M*, Malan D, Wolheim A, Tischendorf M, Linta L, Katz SF, Lin Q, Latz S, Brunner C, Wobus AM, Zenke M, Wartenberg M, Boeckers TB, von Wichert G, Fleischmann BF, Liebau S #, Kleger A #. Stem Cell Reviews and Reports, 2012 Sep;8(3):720-40. *equal contribution. # corresponding authors.
  • An inducible expression system of the calcium activated potassium channel 4 to study the differential impact on embryonic stem cells. Liebau S, Tischendorf M, Ansorge D, Linta L, Stockmann M, Weidgang C, Iacovino M, Boeckers T, Kyba M, Kleger A. Stem Cells Int. 2011;2011:456815.
  • Protein kinase D2 is a novel regulator of glioblastoma growth and tumor formation.
  • Azoitei N *, Kleger A*, Schoo N, Thal D, Brunner C, Pusapati GV, Filatova A, Genze F, Möller P, Acker T, Kuefer R, Van Lint J, Baust H, Adler G, Seufferlein T. *equal contribution. Neuro Oncol. 2011 Jul;13(7):710-24. * equal contribution.
  • Rat embryonic fibroblasts improve reprogramming of human keratinocytes into induced pluripotent stem cells.
  • Linta L, Stockmann M, Böckers A, Böckers TM, Kleger A # and Liebau S #. Stem Cells Dev. 2012 Apr 10;21(6):965-76. [Epub 2011 Aug 5]. # Corresponding authors.
  • Telomerase gene mutations are associated with cirrhosis formation.
  • Hartmann D, Srivastava U, Thaler M, Kleinhans KN, N'kontchou G, Scheffold A, Bauer K, Kratzer RF, Kloos N, Katz SF, Song Z, Begus-Nahrmann Y, Kleger A, von Figura G, Strnad P, Lechel A, Günes C, Potthoff A, Deterding K, Wedemeyer H, Ju Z, Song G, Xiao F, Gillen S, Schrezenmeier H, Mertens T, Ziol M, Friess H, Jarek M, Manns MP, Beaugrand M, Rudolph KL. Hepatology. 2011 May;53(5):1608-17.
  • An SK3 Channel/nWASP/Abi-1 complex is involved in early neurogenesis.
  • Liebau S, Steinestel J, Linta L, Kleger A, Storch A, Schoen M, Steinestel K, Proepper C, Bockmann J, Schmeisser MJ, Boeckers TM. PLoS One. 2011 Mar;6(3):e14599.
  • Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice.
  • von Figura G, Wagner M, Nalapareddy K, Hartmann D, Kleger A, Adler G, Rudolph KL. PLoS One. 2011 Feb 22;6(2):e17122.
  • Protein kinase D2 is an essential regulator of murine myoblast differentiation.
  • Kleger A *, Loebnitz C *, Pusapati GV, Müller M, Tümpel S, Illing A, Hartmann D, Brunner C, Liebau S, Adler G, Seufferlein T. PLoS One. 2011 Jan 27;6(1):e14599. * equal contribution. Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells.
  • Kleger A, Seufferlein T, Malan D, Tischendorf M, Storch A, Wolheim A, Protze S, Porzner M, Proepper C, Brunner C, Katz SF, Pusapati GV, Bullinger L, Köhntopp R, Giehl K, Spyrantis A, Wittekindt O, Lin Q, Zenke M, Fleischmann BK, Wartenberg M, Wobus AM, Boeckers TM and Liebau S. Circulation. 2010 Nov 2;122(18):1823-36 Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours.
  • Azoitei N, Kleger A *, Pusapati GV *, Möller P, Küfer R, Genze F, Wagner M, van Lint J, Adler G, Seufferlein T. GUT. 2010 Oct;59(10):1316-30. *equal contribution. The bioactive lipid sphingosylphosphorylcholine induces differentiation of mouse embryonic stem cells and human promyelocytic leukaemia cells.
  • Kleger A, Busch T, Liebau S, Prelle K, Paschke S, Beil M, Rolletschek A, Wobus AM, Wolf E, Adler G, Seufferlein T. Cell Signal. 2007 Feb;19(2):367-77
  • Mesodermal cell types induce neurogenesis from adult human hippocampal progenitor cells. Herrmann A, Maisel M, Liebau S, Gerlach M, Kleger A, Schwarz J, Kim KS, Antoniadis G, Lerche H, Storch A. J Neurochem. 2006; 98 (2): 629-40
Fallberichte
  • An exceptional cause of epigastric pain. Schulte-Kemna L, Kornmann M, Kleger A. Gastroenterology, 2016, in press
  • A rare cause of upper GI bleeding and wasting disease. van Erp RJ, Schröppel B, Barth TF, Seufferlein T, Schmidt SA, Meining A, Kleger A. GUT. 2015 Oct 28
  • Case report: Fecal transplantation therapy in refractory clostridium difficile colitis.
  • Kleger A, Schnell J, Essig A, Wagner M, Bommer M, Seufferlein T, Härter G: Dtsch Arztebl Int. 2013 Feb;110(7):108
  • First reported case of disease: Peliosis hepatis as cardinal symptom of Hodgkin's lymphoma. Kleger A #, Bommer M, Kunze M, Klaus J, Leithaeuser F, Wegener M, Adler G, Dikopoulos N. Oncologist. 2009 Nov;14(11):1088-94. # Corresponding author.