Visit by Scott Lowe at IMOS

We are pleased to publish an impression of the recent visit of our esteemed guest Scott Lowe to the IMOS.

Throughout his visit, Scott Lowe engaged with our Team in Seminars, Presentations and Discussions. He generously shared his expertise, sparking thought-provoking conversations and inspiring new ideas. 

We also had a lot of fun with an extraordinary personality.




Deutscher Krebskongress 2024 Berlin

Presentation of Johann Gout

"Treatment response prediction and tumor evolution captured in patient-derived organoids."



DPC, Berlin

Annnual Meeting of the German Pancreas Club,



Congrats to Elodie Roger

Poster Prize Winner at the DPC in Berlin

UEG Week 2023 Kopenhagen




Top Abstract Award

Congratulations to Paul Lopatta

" Oncogenic KRAS und GNAS signalling collectively drive dysplasia in an iPSC-derived organoid model for cystic pancreatic neoplasia."



Congrats to

Dr. Elodie Roger: best presentation award in the moderated poster session titled "Mechanisms of pancreatic cancer" 

Dharini Srinivasan:best presentation award in the moderated poster session titled "Pancreatic Cancer: From bench to bedside"

Dr. Sandra HellerNational Scholar Award for Germany, for promising investigators at a junior level with the highest scoring abstract accepted for presentation at UEG Week from Germany.

11th GSCN Annual Conference 2023 Ulm

GSCN 2023 Young Investigators Award

Congratulations to Meike Hohwieler



Public outreach event

Public event in Ulm, vhs Ulm, Einsteinhaus.
Short films present the research of the scientists, and the discussion revolves around the status and future of stem cell research and new treatment options.

Film about Prof. Kleger and his research at IMOS

                                                                 PhD completed!

                                              Jana successfully defended her PhD thesis.





RegioTV Beitrag: Eine künstliche Bauchspeicheldrüse aus Stammzellen 

The German Cancer Award is one of the highest honors in oncology and is awarded annually in the categories "Clinical Research", "Translational Research" and "Experimental Research" for outstanding work in the German-speaking world.


For his pioneering and innovative research approaches in cancer medicine,
Prof. Dr. Alexander Kleger receives the
German Cancer Award 2023 in the category "Experimental Research".

The team of Alexander Kleger's Institute of Molecular Oncology and Stem Cell Biology was one of the first to succeed in culturing exocrine pancreatic organoids, i.e. cell structures consisting exclusively of cells of the pancreatic duct or glandular tissue, from human pluripotent stem cells. These are used to better observe the development of precancerous tumors and to create customized model tumors for further research. Since pancreatic cancer is one of the most aggressive forms of tumor, this experimental work is also highly relevant clinically.

For further information, please visit the website of the German Cancer Award


DPC 2023 Munich

We congratulate Anna Härle for the Hans-Chiari Award of the German Pancreas Club (munich) and

Sarah Merz for the received Poster Award.


IMOS Director Alex and Rüdiger Groß, our collaboration partner on SARS CoV2 from molecular virology, summarize the current knowledge on covid-19 and diabetes in nature metabolism. 

COVID-19 and diabetes - where are we now?

Foundation of the

Institute of Molecular Oncology and Stem Cell Biology (IMOS)

Dr. med. Michael Melzer received  Ursula M. Händel-Tierschutzpreis 2022

DFG - Deutsche Forschungsgemeinschaft - Ursula M. Händel-Tierschutzpreis 2022

IMOS members participate at the NEONAX trial examining perioperative or adjuvant chemotherapy with gemcitabine plus nab-paclitaxel in respectable PDAC

published in Annals of Oncology


Congrats to the Study Leaders Thomas Seufferlein and Thomas Ettrich (Internal Medicine 1).


Sarah Merz

best presentation in abstract session

UEGW 2022, Wien

Ulrike celebrated 25 years at Ulm University.


Congrats to Meike Hohwieler.

She received the Adolf-Kußmaul-Preis.



UEG Travel Grant for Anna Härle

Anna is grateful to receive a UEG Travel Grant to attend in-person the UEG Week 2022 (October 8-11, 2022) in Vienna (Austria) and present her data on nutrient stress adaptation and metabolic reprogramming in ATM-deficient PDACs.


Organoids at the PUB:The Porcine Urinary Bladder Serves as a Pancreatic Niche for Advanced Cancer Modeling

Congrats to Michael Melzers most recent paper. The PUB becomes a new standard model at IMOS


Hans-Chiari award from the German Pancreas Club to Johann

At the 41st Annual Meeting of the German Pancreas Club in Lübeck, Germany (virtual), Johann Gout was awarded with the prestigious Hans-Chiari award for experimental pancreas research. Johann presented there the latest progresses on our project “Autonomous roles of ATM and P53 during pancreatic cancer carcinogenesis”. Congratulations!


Check out our latest article "Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation" published in Communications Biology.



Best Presentation award for Dharini at the HEIST Annual Cancer Day

Presenting her most recent data at the HEIST Annual Cancer Day 2021, Dharini Srinivasan was awarded with the Best Presentation award. Congrats! 



An international team led by French and German researchers has uncovered that mutations in the ONECUT1 gene can trigger forms of diabetes.

Press release SWP

Publication in Nature Medicine

"Mutations and variants of ONECUT1 in diabetes"


PhD completed!

Markus successfully defended his PhD thesis.


PhD completed!

Time to celebrate! Frank and Jessica successfully defended their PhD thesis today. Congratulations!!

Pancreatic tumors from the laboratory
Organoids help to understand cancer development

Publication in Cell Stem Cell 

"Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells"


Video shooting

We shot today our first video abstract highlighting our recently published article in Gut.

"DNA damage repair as a target in pancreatic cancer: state-​of-the-art and future perspectives".

Big thanks to our photographer Jan Haselhofer! And to the new movie stars!

Watch our Video Abstract on youtube



Ulm study proves that SARS-CoV-2 also infects the pancreas

The results were published in Nature Metabolism

"SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas

Jessica Merkle (M.Sc.) receives Travel Grant and Abstract Prize at the DPC congress in Halle (Saale).


United European Gastroenterology Week in Barcelona:

Dr. rer. nat. Sandra Heller and Frank Arnold (M.Sc.) receive Travel Grant/Poster Prize.


Deutscher Pankreas Club (DPC) congress:

Markus Breunig (M. Sc.) and Dr. rer. nat. Karolin Walter receive Travel Grant/Abstract Prize.



Dr. Johann Gout, Jessica Merkle (M.Sc.) and Frank Arnold (M.Sc.) receive Travel Grants at the United European Gastroenterology Week.



Jahrestagung der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS).

Jessica Merkle (M.Sc.) receives Otto-Porges Prize.

Markus Breunig (M.Sc.) receives Rudolf-Schindler Abstract Prize.

Frank Arnold (M.Sc.) receives Travel Grant.



Alexander Kleger honored by UEG Rising Star 2018.


Annual Meeting of the German Pancreatic Club in Ulm.

M. Sc. Frank Arnold receives Abstract Prize and Dr. rer. nat. Meike Hohwieler receives Poster Prize.

Tailored therapies for ATM-mutated cancer, Perkhofer et al.  “ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage” goes online.

Kleger lab receives 3 Travel Grants 1.000 € for abstracts of Dr. rer. nat. Meike Hohwieler, Markus Breunig
and Dr. med. Lukas Perkohofer.

Dr. med. Lukas Perkhofer receives prestigious Martin Gülzow-Award at the DGVS.

The professional society awards the Martin Gülzow Prize for fundamental and pioneering work in the field of clinical gastroenterology. In 2017, it goes to Dr. Lukas Perkhofer from Ulm for his work entitled "Loss of ATM generates genomic instability and enables new therapeutic strategies for pancreatic ductal carcinoma". The award is kindly supported by MSD SHARP & DOHME GMBH.


Dr. rer. nat. Meike Hohwieler receives Otto-Porges Preis at72. Jahrestagung der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS).


Sandra Heller receives the 10.000 £ Lush Prize for Animal-free diabetes modelling on an iPSC chip platform.


Markus Breunig receives Poster Prize when attending the Stem Cell Society Singapore Meeting.


Liebau and Kleger lab dissect the process of reprogramming toward induced pluripotency.


Defense Lukas Perkhofer

Defense Dr. rer. nat. Meike Hohwieler und Dr. rer. nat. Clair Weidgang

Dr. rer. nat. Meike Hohwieler receives best poster ward at the 4th Annual Conference of the GSCN in Hannover.

Kleger lab publishes key work on liquid biopsies and benign pancreatic tumours.

Alexander Kleger receives Top Abstract Award at the UEG week endowed with 10.000 €.

Habilitation Alexander Kleger