Molekulare Mechanismen der Neurodegeneration (AG Danzer)

Since 06/2021 Prof. Dr. Karin Danzer has been appointed as W3 Professor at DZNE in Ulm.

Further information is also available on our DZNE website: DZNE Mechanismen der Propagation - Prof. Dr. Karin Danzer

Research

The research focus of my group is to study pathomechanisms underlying neurodegenerative diseases with particular focus on amyotrophic lateral sclerosis (ALS) and Parkinson's disease. We aim to understand why neuropathology, starting from a local focus, spreads to different areas. In vitro, in vivo, and with human patient material, we investigate protein aggregation mechanisms, inflammatory processes, and gene expression regulation processes at the single cell level. We hope to understand why individual cell populations are particularly vulnerable and which factors play a role in this. In particular, we focus on the aggregating proteins alpha synuclein and TDP43.

For alpha synuclein we could already show in animal models that a transfer of alpha synuclein oligomers from neurons to neurons or even to non-neuronal populations takes place. Currently, we are also investigating the spread of TDP43 pathology in an ALS mouse model. Besides investigating spreading mechanisms in PD and ALS, we are also interested in epigenetic changes in ALS or PD patient blood or human brain tissue analyzed by multiomic single cell sequencing (mRNA and ATAC sequencing).

Our new insight could have direct impact on clinical diagnostics and provide new therapeutic intervention options in Parkinson's disease, amyotrophic lateral sclerosis and other neurodegenerative diseases.

Kooperationen

Prof. Dr. Pamela J. McLean
Department of Neuroscience
MayoClinic Florida,  
Jacksonville, USA
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Prof. Dr. Bradely T. Hyman
Massachussetts General Hospital and Harvard Medical School
Building 114, Charlestown Navy Yard
114 16th Street, Room 2003
Boston, USA
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Prof. Dr. Tiago Outeiro
University of Göttingen Medical School
Dept. of NeuroDegeneration and Restaurative Research
Waldweg 33
37073 Göttingen
Germany   
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Prof. Dr. Ana Martin-Villalba
DKFZ German Cancer Research Center
Molecular Neurobiology
Im Neuenheimer Feld 581
69120 Heidelberg
Germany
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Dr. med. Anja Schneider
German Center for Neurodegenerative Diseases (DZNE)  
Von-Siebold-Str.5
37075 Göttingen
Germany
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Prof. Dr. Bastian Hengerer
Boehringer Ingelheim Pharma GmbH & Co. KG
Department CNS diseases  
Birkendorferstr. 65
88400 Biberach
Germany
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Dr. Olaf Mundigl
Roche Diagnostics GmbH & Co.KG
Nonnenwald 2  
82377 Penzberg
Germany
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Prof. Dr. Thomas Wirth/ Dr. Bernd Baumann
Institute of Physiological Chemistry
Ulm University
Albert-Einstein-Allee 11
89081 Ulm
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Jun.-Prof. Dr. rer. nat. Steffen Just
Klinik für Innere Medizin II
AG Molekulargenetik
Ulm University
Albert-Einstein-Allee 23
89081 Ulm

 
Publikationen
  • Ruf WP, Freischmidt A, Grozdanov V, Roth V, Brockmann SJ, Mollenhauer B, Martin D, Haslinger B, Fundel-Clemens K, Otto M, Arnim CV, Holzmann K, Ludolph AC, Weishaupt JH, Danzer KM. Protein Binding Partners of Dysregulated miRNAs in Parkinson's Disease Serum. Cells. 2021 Apr 2;10(4):791. doi: 10.3390/cells10040791. PMID: 33918274; PMCID: PMC8065836.
  • Freischmidt A, Goswami A, Limm K, Zimyanin VL, Demestre M, Glaß H, Holzmann K, Helferich AM, Brockmann SJ, Tripathi P, Yamoah A, Poser I, Oefner PJ, Böckers TM, Aronica E, Ludolph AC, Andersen PM, Hermann A, Weis J, Reinders J, Danzer KM, Weishaupt JH. A serum microRNA sequence reveals fragile X protein pathology in amyotrophic lateral sclerosis. Brain. 2021 May 7;144(4):1214-1229. doi: 10.1093/brain/awab018. PMID: 33871026; PMCID: PMC8105042.
  • Rahman AA, Soto-Avellaneda A, Yong Jin H, Stojkovska I, Lai NK, Albright JE, Webb AR, Oe E, Valarde JP, Oxford AE, Urquhart PE, Wagner B, Brown C, Amado I, Vasquez P, Lehning N, Grozdanov V, Pu X, Danzer KM, Morrison BE. Enhanced Hyaluronan Signaling and Autophagy Dysfunction by VPS35 D620N. Neuroscience. 2020 Jun 13:S0306-4522(20)30379-1. doi: 10.1016/j.neuroscience.2020.06.009. Epub ahead of print. PMID: 32540366.
  • Grozdanov V, Danzer KM. Intracellular Alpha-Synuclein and Immune Cell Function. Front Cell Dev Biol. 2020 Oct 15;8:562692. doi: 10.3389/fcell.2020.562692. PMID: 33178682; PMCID: PMC7594520.
  • Kiechle M, Grozdanov V, Danzer KM. The Role of Lipids in the Initiation of α-Synuclein Misfolding. Front Cell Dev Biol. 2020 Sep 15;8:562241. doi: 10.3389/fcell.2020.562241. PMID: 33042996; PMCID: PMC7523214.

  • Sieverding K, Ulmer J, Bruno C, Satoh T, Tsao W, Freischmidt A, Akira S, Wong PC, Ludolph AC, Danzer KM, Lobsiger CS, Brenner D, Weishaupt JH. Hemizygous
    deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43<sup>G298S</sup> transgenic mice. Exp Neurol. 2021 Jan;335:113496. doi: 10.1016/j.expneurol.2020.113496. Epub 2020 Oct 8. PMID: 33038415.

  • Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS, Brenner D, Weishaupt JH.
    Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. Brain Commun. 2020 Aug 21;2(2):fcaa133. doi: 10.1093/braincomms/fcaa133. PMID: 33005894; PMCID: PMC7519725.

  • Michel D, Danzer KM, Groß R, Conzelmann C, Müller JA, Freischmidt A, Weishaupt JH, Heller S, Münch J, Michel M, Stamminger T, Kleger A, Otto M. Rapid, convenient and efficient kit-independent detection of SARS-CoV-2 RNA. J Virol Methods. 2020 Dec;286:113965. doi: 10.1016/j.jviromet.2020.113965. Epub 2020 Sep 3. PMID: 32891677; PMCID: PMC7468345.

  • Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. Brenner D, Sieverding K, Bruno C, Lüningschrör P, Buck E, Mungwa S, Fischer L, Brockmann SJ, Ulmer J, Bliederhäuser C, Philibert CE, Satoh T, Akira S, Boillée S, Mayer B, Sendtner M, Ludolph AC, Danzer KM, Lobsiger CS, Freischmidt A, Weishaupt JH. J Exp Med. 2019 Feb 4;216(2):267-278. doi: 10.1084/jem.20180729. Epub 2019 Jan 11. PMID:30635357
  • Yilmaz R, Müller K, Brenner D, Volk AE, Borck G, Hermann A, Meitinger T, Strom TM, Danzer KM, Ludolph AC, Andersen PM, Weishaupt JH; German ALS Network MND-NET. SQSTM1/p62 variants in 486 patients with familial ALS from Germany and Sweden. Neurobiol Aging. 2019 Nov 2. pii: S0197-4580(19)30382-3. doi: 10.1016/j.neurobiolaging.2019.10.018. [Epub ahead of print] PubMed PMID: 31859009.
  • Kiechle M, von Einem B, Höfs L, Voehringer P, Grozdanov V, Markx D, Parlato R, Wiesner D, Mayer B, Sakk O, Baumann B, Lukassen S, Liss B, Ekici AB, Ludolph AC, Walther P, Ferger B, McLean PJ, Falkenburger BH, Weishaupt JH, Danzer KM. In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8-16-mer Oligomer Species. Cell Rep. 2019 Nov 26;29(9):2862-2874.e9. doi: 10.1016/j.celrep.2019.10.089. PubMed PMID: 31775051.
  • Brenner D, Rosenbohm A, Yilmaz R, Müller K, Grehl T, Petri S, Meyer T, Grosskreutz J, Weydt P, Ruf W, Neuwirth C, Weber M, Pinto S, Claeys KG, Schrank B, Jordan B, Knehr A, Günther K, Hübers A, Zeller D, Kubisch C, Jablonka S, Sendtner M, Klopstock T, de Carvalho M, Sperfeld A, Borck G, Volk AE, Dorst J, Weis J, Otto M, Schuster J, Del Tredici K, Braak H, Danzer KM, Freischmidt A, Meitinger T, Ludolph AC, Andersen PM, Weishaupt JH; German ALS network MND-NET . Reply: Adult-onset distal spinal muscular atrophy: a new phenotype associated with KIF5A mutations. Brain. 2019 Dec 1;142(12):e67. doi: 10.1093/brain/awz306. PubMed PMID: 31612906.
  • Müller HP, Brenner D, Roselli F, Wiesner D, Abaei A, Gorges M, Danzer KM, Ludolph AC, Tsao W, Wong PC, Rasche V, Weishaupt JH, Kassubek J. Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43 (G298S) ALS mouse model. Transl Neurodegener. 2019 Aug 30;8:27. doi: 10.1186/s40035-019-0163-y. eCollection 2019. PubMed PMID: 31485326; PubMed Central PMCID: PMC6716821.
  • Grozdanov V, Bousset L, Hoffmeister M, Bliederhaeuser C, Meier C, Madiona K, Pieri L, Kiechle M, McLean PJ, Kassubek J, Behrends C, Ludolph AC, Weishaupt JH, Melki R, Danzer KM. Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease. Ann Neurol. 2019 Oct;86(4):593-606. doi: 10.1002/ana.25557. Epub 2019 Aug 15. PubMed PMID: 31343083.
  • Brenner D, Rosenbohm A, Yilmaz R, Müller K, Grehl T, Petri S, Meyer T, Grosskreutz J, Weydt P, Ruf W, Neuwirth C, Weber M, Pinto S, Claeys KG, Schrank B, Jordan B, Knehr A, Günther K, Hübers A, Zeller D, Kubisch C, Jablonka S, Sendtner M, Klopstock T, de Carvalho M, Sperfeld A, Borck G, Volk AE, Dorst J, Weis J, Otto M, Schuster J, Del Tredici K, Braak H, Danzer KM, Freischmidt A, Meitinger T, Ludolph AC, Andersen PM, Weishaupt JH; German ALS network MND-NET. Reply: Adult-onset distal spinal muscular atrophy: a new phenotype associated with KIF5A mutations. Brain. 2019 Dec 1;142(12):e67. doi: 10.1093/brain/awz306. PMID: 31612906.

  • Kiechle M, von Einem B, Höfs L, Voehringer P, Grozdanov V, Markx D, Parlato R, Wiesner D, Mayer B, Sakk O, Baumann B, Lukassen S, Liss B, Ekici AB, Ludolph AC, Walther P, Ferger B, McLean PJ, Falkenburger BH, Weishaupt JH, Danzer KM. In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8-16-mer Oligomer Species. Cell Rep. 2019 Nov 26;29(9):2862-2874.e9. doi: 10.1016/j.celrep.2019.10.089. PMID: 31775051.

  • Yilmaz R, Müller K, Brenner D, Volk AE, Borck G, Hermann A, Meitinger T, Strom TM, Danzer KM, Ludolph AC, Andersen PM, Weishaupt JH; German ALS Network MND-NET. SQSTM1/p62 variants in 486 patients with familial ALS from Germany and Sweden. Neurobiol Aging. 2020 Mar;87:139.e9-139.e15. doi: 10.1016/j.neurobiolaging.2019.10.018. Epub 2019 Nov 2. PMID: 31859009.

  • Müller HP, Brenner D, Roselli F, Wiesner D, Abaei A, Gorges M, Danzer KM, Ludolph AC, Tsao W, Wong PC, Rasche V, Weishaupt JH, Kassubek J. Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the <i>TDP-43</i><sup>G298S</sup> ALS mouse model. Transl Neurodegener. 2019 Aug 30;8:27. doi: 10.1186/s40035-019-0163-y. PMID: 31485326; PMCID: PMC6716821.

  • Grozdanov V, Bousset L, Hoffmeister M, Bliederhaeuser C, Meier C, Madiona K, Pieri L, Kiechle M, McLean PJ, Kassubek J, Behrends C, Ludolph AC, Weishaupt JH, Melki R, Danzer KM. Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease. Ann Neurol. 2019 Oct;86(4):593-606. doi: 10.1002/ana.25557. Epub 2019 Aug 15. PMID: 31343083.

  • Brockmann SJ, Freischmidt A, Oeckl P, Müller K, Ponna SK, Helferich AM, Paone C, Reinders J, Kojer K, Orth M, Jokela M, Auranen M, Udd B, Hermann A, Danzer KM, Lichtner P, Walther P, Ludolph AC, Andersen PM, Otto M, Kursula P, Just S, Weishaupt JH. CHCHD10 mutations p.R15L and p.G66V cause motoneuron disease by haploinsufficiency. Hum Mol Genet. 2018 Feb 15;27(4):706-715. doi: 10.1093/hmg/ddx436. PubMed PMID: 29315381.
  • Brenner D, Yilmaz R, Müller K, Grehl T, Petri S, Meyer T, Grosskreutz J, Weydt P, Ruf W, Neuwirth C, Weber M, Pinto S, Claeys KG, Schrank B, Jordan B, Knehr A, Günther K, Hübers A, Zeller D, Kubisch C, Jablonka S, Sendtner M, Klopstock T, de Carvalho M, Sperfeld A, Borck G, Volk AE, Dorst J, Weis J, Otto M, Schuster J, Del Tredici K, Braak H, Danzer KM, Freischmidt A, Meitinger T, Strom TM, Ludolph AC, Andersen PM, Weishaupt JH; German ALS network MND-NET . Hot-spot KIF5A mutations cause familial ALS. Brain. 2018 Mar 1;141(3):688-697. doi:10.1093/brain/awx370. PubMed PMID: 29342275; PubMed Central PMCID: PMC5837483.
  • Grozdanov V, Danzer KM. Release and uptake of pathologic alpha-synuclein. Cell Tissue Res. 2018 Jul;373(1):175-182. doi: 10.1007/s00441-017-2775-9. Epub 2018 Feb 6. Review. PubMed PMID: 29411106.
  • Helferich AM, Brockmann SJ, Reinders J, Deshpande D, Holzmann K, Brenner D, Andersen PM, Petri S, Thal DR, Michaelis J, Otto M, Just S, Ludolph AC, Danzer KM, Freischmidt A, Weishaupt JH. Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS. Cell Mol Life Sci. 2018 Dec;75(23):4301-4319. doi: 10.1007/s00018-018-2873-1. Epub 2018 Jul 20. PubMed PMID: 30030593.
  • Brenner D, Sieverding K, Bruno C, Lüningschrör P, Buck E, Mungwa S, Fischer L, Brockmann SJ, Ulmer J, Bliederhäuser C, Philibert CE, Satoh T, Akira S, Boillée S, Mayer B, Sendtner M, Ludolph AC, Danzer KM, Lobsiger CS, Freischmidt A, Weishaupt JH. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. J Exp Med. 2019 Feb 4;216(2):267-278. doi: 10.1084/jem.20180729. Epub 2019 Jan 11. PubMed PMID: 30635357; PubMed Central PMCID: PMC6363427.
  • Zondler L, Kostka M, Garidel P, Heinzelmann U, Hengerer B, Mayer B, Weishaupt JH, Gillardon F and Danzer KM. Proteasome impairment by α-synuclein, Plos ONE, accepted
  • von Einem B, Eschbach J, Kiechle M, Wahler A, Thal DR, McLean PJ, Weishaupt JH, Ludolph AC, von Arnim CAF, Danzer KM. The Golgi-localized, gamma ear-containing, ARF-binding (GGA) protein family alters alpha synuclein (α-syn) oligomerization and secretion. Aging (Albany NY). 2017 Jul 15;9(7):1677-1697. doi: 10.18632/aging.101261. PubMed PMID: 28722658.
  • Khalaji S, Zondler L, KleinJan F, Nolte U, Mulaw MA, Danzer KM, Weishaupt JH, Gottschalk KE. Age Increases Monocyte Adhesion on Collagen. Sci Rep. 2017 May 17;7:46532. doi: 10.1038/srep46532. PubMed PMID: 28513618; PubMed Central PMCID: PMC5434452.
  • Bliederhaeuser C, Zondler L, Grozdanov V, Ruf WP, Brenner D, Melrose HL, Bauer P, Ludolph AC, Gillardon F, Kassubek J, Weishaupt JH, Danzer KM. LRRK2 contributes to monocyte dysregulation in Parkinson's disease. Acta Neuropathol Commun. 2016 Nov 24;4(1):123. PubMed PMID: 27884177; PubMed Central PMCID: PMC5123218.
  • Helferich AM, McLean PJ, Weishaupt JH, Danzer KM. Commentary: alpha-synuclein interacts with SOD1 and promotes its oligomerization. J Neurol Neuromedicine. 2016;1(7):28-30. PubMed PMID: 27853754; PubMed Central PMCID: PMC5108581.
  • Bayer H, Lang K, Buck E, Higelin J, Barteczko L, Pasquarelli N, Sprissler J, Lucas T, Holzmann K, Demestre M, Lindenberg KS, Danzer KM, Boeckers T, Ludolph AC, Dupuis L, Weydt P, Witting A. ALS-causing mutations differentially affect PGC-1α expression and function in the brain vs. peripheral tissues. Neurobiol Dis. 2017 Jan;97(Pt A):36-45. doi: 10.1016/j.nbd.2016.11.001. Epub 2016 Nov 3. PubMed PMID: 27818323.
  • Zondler L, Feiler MS, Freischmidt A, Ruf WP, Ludolph AC, Danzer KM, Weishaupt JH. Impaired activation of ALS monocytes by exosomes. Immunol Cell Biol. 2017 Feb;95(2):207-214. doi: 10.1038/icb.2016.89. Epub 2016 Sep 12. PubMed PMID: 27616750.
  • Koch Y, Helferich AM, Steinacker P, Oeckl P, Walther P, Weishaupt JH, Danzer KM, Otto M. Aggregated α-Synuclein Increases SOD1 Oligomerization in a Mouse Model of Amyotrophic Lateral Sclerosis. Am J Pathol. 2016 Aug;186(8):2152-2161. doi: 10.1016/j.ajpath.2016.04.008. Epub 2016 Jun 18. PubMed PMID: 27322773.
  • Linkus B, Wiesner D, Meßner M, Karabatsiakis A, Scheffold A, Rudolph KL, Thal DR, Weishaupt JH, Ludolph AC, Danzer KM. Telomere shortening leads to earlier age of onset in ALS mice. Aging (Albany NY). 2016 Feb;8(2):382-93. PubMed PMID: 26978042; PubMed Central PMCID: PMC4789589.
  • Brenner D, Müller K, Wieland T, Weydt P, Böhm S, Lulé D, Hübers A, Neuwirth C, Weber M, Borck G, Wahlqvist M, Danzer KM, Volk AE, Meitinger T, Strom TM, Otto M, Kassubek J, Ludolph AC, Andersen PM, Weishaupt JH. NEK1 mutations in familial amyotrophic lateral sclerosis. Brain. 2016 May;139(Pt 5):e28. doi: 10.1093/brain/aww033. Epub 2016 Mar 5. PubMed PMID: 26945885.
  • Zondler L, Müller K, Khalaji S, Bliederhäuser C, Ruf WP, Grozdanov V, Thiemann M, Fundel-Clemes K, Freischmidt A, Holzmann K, Strobel B, Weydt P, Witting A, Thal DR, Helferich AM, Hengerer B, Gottschalk KE, Hill O, Kluge M, Ludolph AC, Danzer KM, Weishaupt JH. Peripheral monocytes are functionally altered and invade the CNS in ALS patients. Acta Neuropathol. 2016 Sep;132(3):391-411. doi: 10.1007/s00401-016-1548-y. Epub 2016 Feb 24. PubMed PMID: 26910103.
  • Stuendl A, Kunadt M, Kruse N, Bartels C, Moebius W, Danzer KM, Mollenhauer B, Schneider A. Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies. Brain. 2016 Feb;139(Pt 2):481-94. doi: 10.1093/brain/awv346. Epub 2015 Dec 8. PubMed PMID: 26647156; PubMed Central PMCID: PMC4805087.
  • Helferich AM, Ruf WP, Grozdanov V, Freischmidt A, Feiler MS, Zondler L, Ludolph AC, McLean PJ, Weishaupt JH, Danzer KM. α-synuclein interacts with SOD1 and promotes its oligomerization. Mol Neurodegener. 2015 Dec 8;10:66. doi: 10.1186/s13024-015-0062-3. PubMed PMID: 26643113; PubMed Central PMCID: PMC4672499.
  • Helferich AM, Ruf WP, Grozdanov V, Freischmidt A, Feiler MS, Zondler L, Ludolph AC, McLean PJ, Weishaupt JH, Danzer KM. α-Synuclein interacts with SOD1 and promotes its oligomerization, Mol Neurodeg accepted
  • Stuendl A, Kunadt M, Kruse N, Bartels C, Moebius W, Danzer KM, Mollenhauer B*, Schneider A*. Induction of α-synuclein aggregate formation by cerebrospinal fluid exosomes from patients with Parkinson’s disease and Lewy body dementia, Brain accepted
  • Feiler MS, Strobel B, Freischmidt A, Helferich AM, Kappel J, Brewer BM, Li D, Thal DR, Walther P, Ludolph AC, Danzer KM*, Jochen H. Weishaupt JH*. Cell-to-cell transmission of TDP-43 across axon terminals, J Cell Biol. 2015 Nov 23;211(4):897-911. doi: 10.1083/jcb.201504057.
  • Bliederhaeuser C, Grozdanov V, Speidel A, Zondler L, Ruf WP, Bayer H, Kiechle M, Feiler MS, Freischmidt A, Brenner D, Witting A, Hengerer B, Fändrich M, Ludolph AC, Weishaupt JH, Gillardon F, Danzer KM. Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes. Acta Neuropathol. 2015 Nov 17. [Epub ahead of print]
  • Marroquin M, Stranz S, Müller K, Wieland T, Ruf WP, Brockmann SJ, Danzer KM, Hübers A, Weydt P, Meitinger T, Strom TM, Rosenbohm A, Ludolph AC, Weishaupt JH. Screening for CHCHD10 mutations in a large cohort of sporadic ALS patients: no evidence for pathogenicity of the p.P34S variant, Brain. 2015 Sep 11. pii: awv218. [Epub ahead of print]
  • Freischmidt A, Müller K, Zondler L, Weydt P, Mayer B, von Arnim CA, Hübers A, Dorst J, Otto M, Holzmann K, Ludolph AC, Danzer KM, Weishaupt JH. Serum microRNAs in sporadic amyotrophic lateral sclerosis. Neurobiol Aging. 2015 Sep
  • von Einem B, Wahler A, Schips T, Serrano-Pozo A, Proepper C, Boeckers TM, Rueck A, Wirth T, Hyman BT, Danzer KM, Thal DR, von Arnim CA. The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1). PLoS One. 2015 Jun
  • Wang P, Wilhelm Bohr W, Otto M, Danzer KM, Mizaikoff B. Quantifying amyloid fibrils in protein mixtures via infrared attenuated total reflection spectroscopy. Anal Bioanal Chem. 2015 Apr 14. [Epub ahead of print]
  • Freischmidt A*, Wieland T*, Richter B*, Ruf W*, Schaeffer V, Müller K, Marroquin N, Nordin F, Hübers A, Weydt P, Pinto S, Press R, Millecamps S, Molko N, Bernard E, Desnuelle C, Soriani MH, Dorst J, Graf E, Nordström U, Feiler MS, Putz S, Boeckers TM, Meyer T, Winkler AS, Winkelman J, de Carvalho M, Thal DR, Otto M, Brännström T, Volk AE, Kursula P, Danzer KM, Lichtner P, Dikic I, Meitinger T, Ludolph AC, Strom TM, Andersen PM, Weishaupt JH. Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia. Nat Neurosci. 2015 Mar 24. doi: 10.1038/nn.4000. [Epub ahead of print]
  • Kunadt M, Eckermann K, Stuendl A, Gong J, Russo B, Strauss K, Rai S, Kügler S, Falomir Lockhart L, Schwalbe M, Krumova P, Oliveira LM, Bähr M, Möbius W, Levin J, Giese A, Kruse N, Mollenhauer B, Geiss-Friedlander R, Ludolph AC, Freischmidt A, Feiler MS, Danzer KM, Zweckstetter M, Jovin TM, Simons M, Weishaupt JH*, Schneider A*. Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation. Acta Neuropathol. 2015 Mar 17. [Epub ahead of print]
  • Lázaro DF, Rodrigues EF, Langohr R, Shahpasandzadeh H, Ribeiro T, Guerreiro P, Gerhardt E, Kröhnert K, Klucken J, Pereira MD, Popova B, Kruse N, Mollenhauer B, Rizzoli SO, Braus GH, Danzer KM, Outeiro TF. Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation. PLoS Genet. 2014 Nov 13;10(11):e1004741. doi: 10.1371
  • Eschbach J, von Einem B, Müller K, Bayer H, Scheffold A, Morrison BE, Rudolph KL, Thal DR, Witting A,Weydt P, Otto M, Fauler M, Liss B, McLean PJ, La Spada AR, Ludolph AC, Weishaupt JH, Danzer KM. Mutual exacerbation of PGC-1α deregulation and α-synuclein oligomerization. Ann Neurol. 2014 Nov 1. doi: 10.1002. [Epub ahead of print]
  • Grozdanov V, Bliederhaeuser C, Ruf WP, Roth V, Fundel-Clemens K, Zondler L, Brenner D, Martin-Villalba A, Hengerer B, Kassubek J, Ludolph AC, Weishaupt JH, Danzer KM. Inflammatory dysregulation of blood monocytes in Parkinson's disease patients. Acta Neuropathol. 2014 Nov;128(5):651-63. doi: 10.1007/s00401-014-1345-4. Epub 2014 Oct 5.
  • Freischmidt A, Müller K, Zondler L, Weydt P, Volk AE, Božič AL, Walter M, Bonin M, Mayer B, von Arnim CA, Otto M, Dieterich C, Holzmann K, Andersen PM, Ludolph AC, Danzer KM, Weishaupt JH. Serum microRNAs in patients with genetic amyotrophic lateral sclerosis and pre-manifest mutation carriers. Brain. 2014 Nov;137(Pt 11):2938-50. doi: 10.1093/brain/awu249. Epub 2014 Sep 5.
  • Müller K, Andersen PM, Hübers A, Marroquin N, Volk AE, Danzer KM, Meitinger T, Ludolph AC, Strom TM, Weishaupt JH. Two novel mutations in conserved codons indicate that CHCHD10 is a gene associated with motor neuron disease. Brain. 2014 Dec;137(Pt 12):e309. doi: 10.1093/brain/awu227. Epub 2014 Aug 11.
  • McFarland NR, Dimant H, Kibuuka L, Ebrahimi-Fakhari D, Desjardins CA, Danzer KM, Danzer M, Fan Z, Schwarzschild MA, Hirst W, McLean PJ. Chronic Treatment with Novel Small Molecule Hsp90 Inhibitors Rescues Striatal Dopamine Levels but Not α-Synuclein-Induced Neuronal Cell Loss. PLoS One. 2014 Jan 20;9(1):e86048. doi: 10.1371/journal.pone.0086048. eCollection 2014 Jan 20.
  • Eschbach J, Danzer KM. α-Synuclein in Parkinson's Disease: Pathogenic Function and Translation into Animal Models. Neurodegener Dis. 2013 Sep 24. [Epub ahead of print]
  • Eschbach J, Schwalenstöcker B, Soyal SM, Bayer H, Wiesner D, Akimoto C, Nilsson AC, Birve A, Meyer T, Dupuis L, Danzer KM, Andersen PM, Witting A, Ludolph AC, Patsch W, Weydt P. PGC-1α is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis. Hum Mol Genet. 2013 Sep 1;22(17):3477-84.

2012

  • Danzer KM, Kranich LR, Ruf WP, Cagsal-Getkin O, Winslow AR, Zhu L, Vanderburg CR, McLean PJ. Exosomal cell-to-cell transmission of alpha synuclein oligomers. Mol Neurodegener. 2012 Aug 24;7(1):42. [Epub ahead of print]

2011

  • Vlad C, Lindner K, Karreman C, Schildknecht S, Leist M, Tomczyk N, Rontree J, Langridge J, Danzer K, Ciossek T, Petre A, Gross ML, Hengerer B, Przybylski M.Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry.Chembiochem. 2011 Dec 16;12(18):2740-4. doi: 10.1002/cbic.201100569. Epub 2011 Nov 7.
  • Danzer KM, McLean PJ. Drug targets from Genetics: alpha synuclein. CNS Neurol Disord Drug Targets. 2011 Aug 15. [Epub ahead of print]
  • Welander H, Bontha SV, Näsström T, Karlsson M, Nikolajeff F, Danzer K, Kostka M, Kalimo H, Lannfelt L, Ingelsson M, Bergström J. Gelsolin co-occurs with Lewy bodies in vivo and accelerates α-synuclein aggregation in vitro. Biochem Biophys Res Commun. 2011 Aug 19;412(1):32-8. Epub 2011 Jul 21
  • Hüls S, Högen T, Vassallo N, Danzer KM, Hengerer B, Giese A, Herms J. AMPA-receptor-mediated excitatory synaptic transmission is enhanced by iron-induced α-synuclein oligomers. J Neurochem. 2011 Jun;117(5):868-78. Epub 2011 Apr 26.
  • Danzer KM, Ruf WP, Putcha P, Joyner D, Hashimoto T, Glabe C, Hyman BT, McLean PJ Heat-shock protein 70 modulates toxic extracellular alpha-synuclein oligomers and rescues trans-synaptic toxicity. FASEB J. 2011 Jan;25(1):326-36. Epub 2010 Sep 27.

2009

  • Putcha P, Danzer KM, Kranich L, Scott A, Silinski M, Mabbett S, Hicks CD, Veal JM, Steed PM, Hyman BT, McLean PJ. Brain permeable small molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha synuclein-induced toxicity. J Pharmacol Exp Ther. 2009 Nov 24. [Epub 2009 Nov 24]
  • Danzer KM, Krebs SK, Wolff M, Birk G, Hengerer B. Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology. J Neurochem. 2009 Oct;111(1):192-203. Epub 2009 Aug 4

2008

  • Schnack C*, Danzer KM*, Hengerer B, Gillardon F. Protein interaction arrays indicate an interference of alpha-synuclein oligomers with small GTPase signalling, Neuroscience. 2008 Jul 17;154(4):1450-7. Epub 2008 Feb 29
  • Kostka M*, Högen T*, Danzer KM*, Habeck M, Wirth A, Wagner R, Glabe CG, Finger S, Heinzelmann U, Garidel P, Duan W, Ross CA, Kretzschmar H, Giese A. Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers. J Biol Chem, 2008 Apr 18;283(16):10992-11003. Epub 2008 Feb 7

2007

  • Danzer KM*, Schnack C*, Sutcliffe A, Hengerer B, Gillardon F. Functional protein kinase arrays reveal inhibition of p-21 activated kinase 4 by alpha-synuclein oligomers. J Neurochem, 2007 Dec;103(6):2401-7. Epub 2007 Sep 18.
  • Danzer KM, Haasen D, Karow AR, Moussaud S, Habeck M, Giese A, Kretzschmar H, Hengerer B, Kostka M. Different species of alpha-synuclein oligomers induce calcium influx and seeding. J Neurosci, 2007, Aug 22; 27 (34):9220-32.
  • Gillardon F, Rist W, Kussmaul L, Vogel J, Berg M, Danzer K, Kraut N, Hengerer B. Proteomic and functional alterations in brain mitochondria from Tg2576 mice occur before amyloid plaque deposition. Proteomics. 2007 Feb;7(4):605-16
  • *Co-first authorship
 
Mitarbeiter der AG Danzer

W3 Professor at DZNE Mechanims of Propagation

Telefon: 0731 500 63049

Fax: 0731 500 63050

E-​Mail: karin.danzer@uni-​ulm.de and karin.danzer@dzne.de

Anschrift: Neurology N24 , Albert-​Einstein-Allee 11 , 89081 Ulm

Gebäude: N24

Dr. Eva Buck

M.Sc. Molecular Biosciences

Phone: +49731-500-63061

Fax: +49 731-500-63050

Mail: eva.buck@uni-ulm.de

Dr. Veselin Grozdanov

M.Sc. Biochemistry

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Mail: veselin.grozdanov@uni-ulm.de

Dr. Sarah Tripke

M.Sc. Biochemistry

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Fax: +49-731-500-63050

Mail: sarah.brockmann@uni-ulm.de

Dr. Wolfgang Ruf

Neurologist

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Fax: +49-731-500-63050

Mail: wolfgang.ruf@uni-ulm.de

 

Julia Kühlwein

M.Sc. Biochemistry

Phone: +49731-500-63039

Fax: +49 731-50063050

Mail: julia.kuehlwein@uni-ulm.de

Lisa Streit

M.Sc. Biochemistry

Phone: +49731-500-23361

Fax: +49 731-50063050

Mail: lisa.streit@uni-ulm.de

Verena Bopp

M. Sc. Molecular and Translational Neuroscience

Phone: +49731-500-63039

Fax: +49 731-50063050

Mail: verena.bopp@uni-ulm.de

Ramona Bück

UTA

Phone: +49731-500-63060

Fax: +49731-500-63050

Mail: ramona.bueck@uni-ulm.de

 

Jana Müller

M.Sc. Molecular Cell Biology & Immunology

Mail: jana-sofia-mueller@gmx.de

Daniel Rombach

Molecular and Translational Neuroscience, M.Sc.

Mail: daniel.rombach@uni-ulm.de

Isabel Hagmann

Pharmazeutische Biotechnologie

Phone: +49-731-500-63043

Fax: +49-731-500-63060

Mail: isabel.hagmann@hochschule-bc.de

Bianca Leins

Human medicine

Phone: +49-731-500-63152

Fax: +49-731-500-63060

Mail: bianca.leins@uni-ulm.de

 

 

 
Funding

Baden-Württemberg Ministerium für Wissenschaft, Forschung und Kunst
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Boehringer Ingelheim Ulm University BioCenter (BIU)   
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Emmy Noether Programm
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Roche Deutschland Holding GmbH
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Graduiertenkolleg GRK 1789

Kontakt

Telefon 0731 500 63049

Telefax 0731 500 63050

apl. Prof. Dr. Karin Danzer
Neurology N24
AG Danzer
Albert-Einstein-Allee 11
89081 Ulm