Neuroproteomics and Biomarker Research (AG Oeckl)


The major focus of our group is the discovery, validation and implementation of fluid biomarkers for neurodegenerative diseases such as Alzheimer´s disease, amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Parkinson´s disease etc. to support (early) diagnosis, prognosis, disease monitoring and development of novel drugs.

We use mass spectrometry and immunoassays to study biomarker candidates mainly in human cerebrospinal fluid (CSF) and blood (serum/plasma). We have a high technical expertise in the use of mass spectrometry in biomarker research including discovery (shotgun proteomics) and validation (targeted mass spectrometry, MRM) studies and we are equipped with state-of-the-art mass spectrometers (e.g. Thermo Exploris 480 with FAIMS). In addition, we use highly sensitve immunoassays such as ELISA, Simoa or Ella in our biomarker research. Our work includes both the application of already available assays and the development of own assays. Together with collaboration partners, we also apply proteomics to study mechanisms of neurodegenerative diseases in preclinical models or clinical samples.

The group is associated to the German Center for Neurodegenerative Diseases Ulm (DZNE) via the group „Translational Mass Spectrometry and Biomarker Research“ led by Patrick Oeckl (

Group members

PD Dr. biol. hum. Patrick Öckl, PhD

c/o Center for Biomedical Research (ZMBF), Helmholtzstr. 8/1, 89081 Ulm

Tel. 0731 500 63143

Fax: 0731 500 12 63143


Dr. rer. nat. Besnik Muqaku, PhD (DZNE)


Tel. 0731 500 63143


Jakub Vávra, MSc

Research assistant

Tel. 0731 500 63143


Stephen Meier

Tel. 0731 500 63120


Funding & Publications

Our research is/was funded by:

ALS Association

ALS Finding a Cure

Alzheimer Forschung Initiative e.V.

Charcot Foundation

DZNE Innovation-to-application

Michael J. Fox Foundation

  • Barba L, Abu-Rumeileh S, Halbgebauer S, Bellomo G, Paoletti FP, Gaetani L, Oeckl P, Steinacker P, Massa F, Parnetti L, Otto M. CSF Synaptic Biomarkers in AT(N)-Based Subgroups of Lewy Body Disease. Neurology. 2023 May 15:10.1212/WNL.0000000000207371. doi: 10.1212/WNL.0000000000207371. Epub ahead of print. PMID: 37188538.
  • Oeckl P, Janelidze S, Halbgebauer S, Stomrud E, Palmqvist S, Otto M, Hansson O. Higher plasma β-synuclein indicates early synaptic degeneration in Alzheimer's disease. Alzheimers Dement. 2023 Apr 27. doi: 10.1002/alz.13103. Epub ahead of print. PMID: 37186338.
  • Oeckl P, Bluma M, Bucci M, Halbgebauer S, Chiotis K, Sandebring-Matton A, Ashton NJ, Molfetta GD, Grötschel L, Kivipelto M, Blennow K, Zetterberg H, Savitcheva I, Nordberg A, Otto M. Blood β-synuclein is related to amyloid PET positivity in memory clinic patients. Alzheimers Dement. 2023 Apr 13. doi: 10.1002/alz.13046. Epub ahead of print. PMID: 37052206.
  • Oeckl P, Anderl-Straub S, Danek A, Diehl-Schmid J, Fassbender K, Fliessbach K, Halbgebauer S, Huppertz HJ, Jahn H, Kassubek J, Kornhuber J, Landwehrmeyer B, Lauer M, Prudlo J, Schneider A, Schroeter ML, Steinacker P, Volk AE, Wagner M, Winkelmann J, Wiltfang J, Ludolph AC, Otto M; FTLD Consortium. Relationship of serum beta-synuclein with blood biomarkers and brain atrophy. Alzheimers Dement. 2023 Apr;19(4):1358-1371. doi: 10.1002/alz.12790. Epub 2022 Sep 21. PMID: 36129098.
  • Barba L, Abu Rumeileh S, Bellomo G, Paolini Paoletti F, Halbgebauer S, Oeckl P, Steinacker P, Massa F, Gaetani L, Parnetti L, Otto M. Cerebrospinal fluid β-synuclein as a synaptic biomarker for preclinical Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2023 Jan;94(1):83-86. doi: 10.1136/jnnp-2022-329124. Epub 2022 Aug 9. PMID: 35944974.
  • Devos D, Labreuche J, Rascol O, Corvol JC, Duhamel A, Guyon Delannoy P, Poewe W, Compta Y, Pavese N, Růžička E, Dušek P, Post B, Bloem BR, Berg D, Maetzler W, Otto M, Habert MO, Lehericy S, Ferreira J, Dodel R, Tranchant C, Eusebio A, Thobois S, Marques AR, Meissner WG, Ory-Magne F, Walter U, de Bie RMA, Gago M, Vilas D, Kulisevsky J, Januario C, Coelho MVS, Behnke S, Worth P, Seppi K, Ouk T, Potey C, Leclercq C, Viard R, Kuchcinski G, Lopes R, Pruvo JP, Pigny P, Garçon G, Simonin O, Carpentier J, Rolland AS, Nyholm D, Scherfler C, Mangin JF, Chupin M, Bordet R, Dexter DT, Fradette C, Spino M, Tricta F, Ayton S, Bush AI, Devedjian JC, Duce JA, Cabantchik I, Defebvre L, Deplanque D, Moreau C; FAIRPARK-II Study Group. Trial of Deferiprone in Parkinson's Disease. N Engl J Med. 2022 Dec 1;387(22):2045-2055. doi: 10.1056/NEJMoa2209254. PMID: 36449420.
  • Gómez de San José N, Goossens J, Al Shweiki MR, Halbgebauer S, Oeckl P, Steinacker P, Danzer KM, Graf H, Schönfeldt-Lecuona C, Belbin O, Lleó A, Vanmechelen E, Otto M. Glutamate receptor 4 as a fluid biomarker for the diagnosis of psychiatric disorders. J Psychiatr Res. 2022 Dec;156:390-397. doi: 10.1016/j.jpsychires.2022.10.010. Epub 2022 Oct 17. PMID: 36323141.
  • Halbgebauer S, Steinacker P, Riedel D, Oeckl P, Anderl-Straub S, Lombardi J, von Arnim CAF, Nagl M, Giese A, Ludolph AC, Otto M. Visinin-like protein 1 levels in blood and CSF as emerging markers for Alzheimer's and other neurodegenerative diseases. Alzheimers Res Ther. 2022 Nov 22;14(1):175. doi: 10.1186/s13195-022-01122-4. PMID: 36419075; PMCID: PMC9682835.
  • Traub J, Otto M, Sell R, Göpfert D, Homola G, Steinacker P, Oeckl P, Morbach C, Frantz S, Pham M, Störk S, Stoll G, Frey A. Serum phosphorylated tau protein 181 and neurofilament light chain in cognitively impaired heart failure patients. Alzheimers Res Ther. 2022 Oct 10;14(1):149. doi: 10.1186/s13195-022-01087-4. PMID: 36217177; PMCID: PMC9549648.
  • Witzel S, Mayer K, Oeckl P. Biomarkers for amyotrophic lateral sclerosis. Curr Opin Neurol. 2022 Oct 1;35(5):699-704. doi: 10.1097/WCO.0000000000001094. Epub 2022 Aug 4. PMID: 35942674.
  • Massa F, Halbgebauer S, Barba L, Oeckl P, Gómez de San José N, Bauckneht M, Lanfranchi F, Vigo T, Arnaldi D, Pardini M, Morbelli S, Chincarini A, Barthel H, Otto M, Nobili F. Exploring the brain metabolic correlates of process-specific CSF biomarkers in patients with MCI due to Alzheimer's disease: preliminary data. Neurobiol Aging. 2022 Sep;117:212-221. doi: 10.1016/j.neurobiolaging.2022.03.019. Epub 2022 May 16. PMID: 35780561.
  • Barschke P, Abu-Rumeileh S, Al Shweiki MHDR, Barba L, Paolini Paoletti F, Oeckl P, Steinacker P, Halbgebauer S, Gaetani L, Lewerenz J, Ludolph AC, Landwehrmeyer GB, Parnetti L, Otto M. Cerebrospinal fluid levels of proenkephalin and prodynorphin are differentially altered in Huntington's and Parkinson's disease. J Neurol. 2022 Sep;269(9):5136-5143. doi: 10.1007/s00415-022-11187-8. Epub 2022 Jun 23. PMID: 35737109; PMCID: PMC9363351.
  • Halbgebauer R, Halbgebauer S, Oeckl P, Steinacker P, Weihe E, Schafer MK, Roselli F, Gebhard F, Huber-Lang M, Otto M. Neurochemical Monitoring of Traumatic Brain Injury by the Combined Analysis of Plasma Beta-Synuclein, NfL, and GFAP in Polytraumatized Patients. Int J Mol Sci. 2022 Aug 25;23(17):9639. doi: 10.3390/ijms23179639. PMID: 36077033; PMCID: PMC9456193.
  • Halbgebauer S, Steinacker P, Hengge S, Oeckl P, Abu Rumeileh S, Anderl- Straub S, Lombardi J, Von Arnim CAF, Giese A, Ludolph AC, Otto M. CSF levels of SNAP-25 are increased early in Creutzfeldt-Jakob and Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2022 Aug 22:jnnp-2021-328646. doi: 10.1136/jnnp-2021-328646. Epub ahead of print. PMID: 35995553.
  • Traub J, Otto M, Sell R, Homola GA, Steinacker P, Oeckl P, Morbach C, Frantz S, Pham M, Störk S, Stoll G, Frey A. Serum glial fibrillary acidic protein indicates memory impairment in patients with chronic heart failure. ESC Heart Fail. 2022 Aug;9(4):2626-2634. doi: 10.1002/ehf2.13986. Epub 2022 May 25. PMID: 35611842; PMCID: PMC9288738.
  • Buck E, Oeckl P, Grozdanov V, Bopp V, Kühlwein JK, Ruf WP, Wiesner D, Roselli F, Weishaupt JH, Ludolph AC, Otto M, Danzer KM. Increased NF-L levels in the TDP-43<sup>G298S</sup> ALS mouse model resemble NF-L levels in ALS patients. Acta Neuropathol. 2022 Jul;144(1):161-164. doi: 10.1007/s00401-022-02436-1. Epub 2022 May 18. PMID: 35585288; PMCID: PMC9217825.
  • Oeckl P, Wagemann O, Halbgebauer S, Anderl-Straub S, Nuebling G, Prix C, Loosli SV, Wlasich E, Danek A, Steinacker P, Ludolph AC, Levin J, Otto M. Serum Beta-Synuclein Is Higher in Down Syndrome and Precedes Rise of pTau181. Ann Neurol. 2022 Jul;92(1):6-10. doi: 10.1002/ana.26360. Epub 2022 Apr 12. PMID: 35340050.
  • Muqaku B, Oeckl P. Peptidomic Approaches and Observations in Neurodegenerative Diseases. Int J Mol Sci. 2022 Jun 30;23(13):7332. doi: 10.3390/ijms23137332. PMID: 35806335; PMCID: PMC9266836.
  • Oeckl P, Anderl-Straub S, Von Arnim CAF, Baldeiras I, Diehl-Schmid J, Grimmer T, Halbgebauer S, Kort AM, Lima M, Marques TM, Ortner M, Santana I, Steinacker P, Verbeek MM, Volk AE, Ludolph AC, Otto M. Serum GFAP differentiates Alzheimer's disease from frontotemporal dementia and predicts MCI-to-dementia conversion. J Neurol Neurosurg Psychiatry. 2022 Apr 27:jnnp-2021-328547. doi: 10.1136/jnnp-2021-328547. Epub ahead of print. PMID: 35477892.
  • Halbgebauer S, Abu-Rumeileh S, Oeckl P, Steinacker P, Roselli F, Wiesner D, Mammana A, Beekes M, Kortazar-Zubizarreta I, Perez de Nanclares G, Capellari S, Giese A, Castilla J, Ludolph AC, Žáková D, Parchi P, Otto M. Blood β-Synuclein and Neurofilament Light Chain During the Course of Prion Disease. Neurology. 2022 Apr 5;98(14):e1434-e1445. doi: 10.1212/WNL.0000000000200002. Epub 2022 Feb 2. PMID: 35110380.
  • Barba L, Paolini Paoletti F, Bellomo G, Gaetani L, Halbgebauer S, Oeckl P, Otto M, Parnetti L. Alpha and Beta Synucleins: From Pathophysiology to Clinical Application as Biomarkers. Mov Disord. 2022 Apr;37(4):669-683. doi: 10.1002/mds.28941. Epub 2022 Feb 5. PMID: 35122299; PMCID: PMC9303453.
  • Abdelhak A, Foschi M, Abu-Rumeileh S, Yue JK, D'Anna L, Huss A, Oeckl P, Ludolph AC, Kuhle J, Petzold A, Manley GT, Green AJ, Otto M, Tumani H. Blood GFAP as an emerging biomarker in brain and spinal cord disorders. Nat Rev Neurol. 2022 Mar;18(3):158-172. doi: 10.1038/s41582-021-00616-3. Epub 2022 Feb 3. PMID: 35115728.
  • Abu-Rumeileh S, Barschke P, Oeckl P, Baiardi S, Mammana A, Mastrangelo A, Al Shweiki MR, Steinacker P, Ladogana A, Capellari S, Otto M, Parchi P. Prodynorphin and Proenkephalin in Cerebrospinal Fluid of Sporadic Creutzfeldt- Jakob Disease. Int J Mol Sci. 2022 Feb 12;23(4):2051. doi: 10.3390/ijms23042051. PMID: 35216166; PMCID: PMC8877714.
  • Gómez de San José N, Massa F, Halbgebauer S, Oeckl P, Steinacker P, Otto M. Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration. J Neural Transm (Vienna). 2022 Feb;129(2):207-230. doi: 10.1007/s00702-021-02411-2. Epub 2021 Aug 30. PMID: 34460014; PMCID: PMC8866268.
  • Halbgebauer S, Steinacker P, Verde F, Weishaupt J, Oeckl P, von Arnim C, Dorst J, Feneberg E, Mayer B, Rosenbohm A, Silani V, Ludolph AC, Otto M. Comparison of CSF and serum neurofilament light and heavy chain as differential diagnostic biomarkers for ALS. J Neurol Neurosurg Psychiatry. 2022 Jan;93(1):68-74. doi: 10.1136/jnnp-2021-327129. Epub 2021 Aug 20. PMID: 34417339.

  • Steinacker P, Al Shweiki MR, Oeckl P, Graf H, Ludolph AC, Schönfeldt-Lecuona C, Otto M. Glial fibrillary acidic protein as blood biomarker for differential diagnosis and severity of major depressive disorder. J Psychiatr Res. 2021 Dec;144:54-58. doi: 10.1016/j.jpsychires.2021.09.012. Epub 2021 Sep 2. PMID: 34600287.
  • Thompson AG, Oeckl P, Feneberg E, Bowser R, Otto M, Fischer R, Kessler B, Turner MR. Advancing mechanistic understanding and biomarker development in amyotrophic lateral sclerosis. Expert Rev Proteomics. 2021 Nov;18(11):977-994. doi: 10.1080/14789450.2021.2004890. Epub 2021 Dec 2. PMID: 34758687.
  • Witzel S, Frauhammer F, Steinacker P, Devos D, Pradat PF, Meininger V, Halbgebauer S, Oeckl P, Schuster J, Anders S, Dorst J, Otto M, Ludolph AC. Neurofilament light and heterogeneity of disease progression in amyotrophic lateral sclerosis: development and validation of a prediction model to improve interventional trials. Transl Neurodegener. 2021 Aug 26;10(1):31. doi: 10.1186/s40035-021-00257-y. PMID: 34433481; PMCID: PMC8390195.
  • Steinacker P, Feneberg E, Halbgebauer S, Witzel S, Verde F, Oeckl P, Van Damme P, Gaur N, Gray E, Grosskreutz J, Jardel CG, Kachanov M, Kuhle J, Lamari F, Maceski A, Del Mar Amador M, Mayer B, Morelli C, Petri S, Poesen K, Raaphorst J, Salachas F, Silani V, Turner MR, Verbeek MM, Volk AE, Weishaupt JH, Weydt P, Ludolph AC, Otto M. Chitotriosidase as biomarker for early stage amyotrophic lateral sclerosis: a multicenter study. Amyotroph Lateral Scler Frontotemporal Degener. 2021 May;22(3-4):276-286. doi: 10.1080/21678421.2020.1861023. Epub 2021 Feb 12. PMID: 33576252.
  • Halbgebauer S, Oeckl P, Steinacker P, Yilmazer-Hanke D, Anderl-Straub S, von Arnim C, Froelich L, Gomes LA, Hausner L, Huss A, Jahn H, Weishaupt J, Ludolph AC, Thal DR, Otto M. Beta-synuclein in cerebrospinal fluid as an early diagnostic marker of Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2021 Apr;92(4):349-356. doi: 10.1136/jnnp-2020-324306. Epub 2020 Dec 30. PMID: 33380492.
  • Al Shweiki MR, Oeckl P, Pachollek A, Steinacker P, Barschke P, Halbgebauer S, Anderl-Straub S, Lewerenz J, Ludolph AC, Bernhard Landwehrmeyer G, Otto M. Cerebrospinal Fluid Levels of Prodynorphin-Derived Peptides are Decreased in Huntington's Disease. Mov Disord. 2021 Feb;36(2):492-497. doi: 10.1002/mds.28300. Epub 2020 Oct 2. PMID: 33006791.
  • Gray E, Oeckl P, Amador MDM, Andreasson U, An J, Blennow K, Bowser R, De Schaepdryver M, Heslegrave A, Kuhle J, Maceski A, Koel-Simmelink M, Lamari F, Lombardi V, Malaspina A, Nilsson I, Poesen K, Salachas F, Steinacker P, Teunissen CE, Van Damme P, Zetterberg H, Ludolph A, Jeromin A, Turner MR, Otto M. A multi-center study of neurofilament assay reliability and inter-laboratory variability. Amyotroph Lateral Scler Frontotemporal Degener. 2020 Aug;21(5-6):452-458. doi: 10.1080/21678421.2020.1779300. Epub 2020 Jun 19. PMID: 32558597.
  • van Steenoven I, Koel-Simmelink MJA, Vergouw LJM, Tijms BM, Piersma SR, Pham TV, Bridel C, Ferri GL, Cocco C, Noli B, Worley PF, Xiao MF, Xu D, Oeckl P, Otto M, van der Flier WM, de Jong FJ, Jimenez CR, Lemstra AW, Teunissen CE. Identification of novel cerebrospinal fluid biomarker candidates for dementia with Lewy bodies: a proteomic approach. Mol Neurodegener. 2020 Jun 18;15(1):36. doi: 10.1186/s13024-020-00388-2. PMID: 32552841; PMCID: PMC7301448.
  • Al Shweiki MR, Oeckl P, Steinacker P, Barschke P, Dorner-Ciossek C, Hengerer B, Schönfeldt-Lecuona C, Otto M. Proteomic analysis reveals a biosignature of decreased synaptic protein in cerebrospinal fluid of major depressive disorder. Transl Psychiatry. 2020 May 12;10(1):144. doi: 10.1038/s41398-020-0825-7. PMID: 32398672; PMCID: PMC7217933.
  • Barschke P, Oeckl P, Steinacker P, Al Shweiki MR, Weishaupt JH, Landwehrmeyer GB, Anderl-Straub S, Weydt P, Diehl-Schmid J, Danek A, Kornhuber J, Schroeter ML, Prudlo J, Jahn H, Fassbender K, Lauer M, van der Ende EL, van Swieten JC, Volk AE, Ludolph AC, Otto M; German FTLD consortium. Different CSF protein profiles in amyotrophic lateral sclerosis and frontotemporal dementia with <i>C9orf72</i> hexanucleotide repeat expansion. J Neurol Neurosurg Psychiatry. 2020 May;91(5):503-511. doi: 10.1136/jnnp-2019-322476. Epub 2020 Mar 4. PMID: 32132225.
  • Al Shweiki MR, Oeckl P, Steinacker P, Barschke P, Pryce C, Dorner-Ciossek C, Schönfeldt-Lecuona C, Hengerer B, Otto M. S-ketamine induces acute changes in the proteome of the mouse amygdala. J Proteomics. 2020 Mar 30;216:103679. doi: 10.1016/j.jprot.2020.103679. Epub 2020 Feb 4. PMID: 32032757.
  • Abu-Rumeileh S, Oeckl P, Baiardi S, Halbgebauer S, Steinacker P, Capellari S, Otto M, Parchi P. CSF Ubiquitin Levels Are Higher in Alzheimer's Disease than in Frontotemporal Dementia and Reflect the Molecular Subtype in Prion Disease. Biomolecules. 2020 Mar 25;10(4):497. doi: 10.3390/biom10040497. PMID: 32218217; PMCID: PMC7226617.
  • Oeckl P, Halbgebauer S, Anderl-Straub S, von Arnim CAF, Diehl-Schmid J, Froelich L, Grimmer T, Hausner L, Denk J, Jahn H, Steinacker P, Weishaupt JH, Ludolph AC, Otto M. Targeted Mass Spectrometry Suggests Beta-Synuclein as Synaptic Blood Marker in Alzheimer's Disease. J Proteome Res. 2020 Mar 6;19(3):1310-1318. doi: 10.1021/acs.jproteome.9b00824. Epub 2020 Feb 26. PMID: 32101007.
  • Oeckl P, Weydt P, Thal DR, Weishaupt JH, Ludolph AC, Otto M. Proteomics in cerebrospinal fluid and spinal cord suggests UCHL1, MAP2 and GPNMB as biomarkers and underpins importance of transcriptional pathways in amyotrophic lateral sclerosis. Acta Neuropathol. 2020 Jan;139(1):119-134. doi: 10.1007/s00401-019-02093-x. Epub 2019 Nov 7. PMID: 31701227.
  • Abu-Rumeileh S, Steinacker P, Polischi B, Mammana A, Bartoletti-Stella A, Oeckl P, Baiardi S, Zenesini C, Huss A, Cortelli P, Capellari S, Otto M, Parchi P. CSF biomarkers of neuroinflammation in distinct forms and subtypes of neurodegenerative dementia. Alzheimers Res Ther. 2019 Dec 31;12(1):2. doi: 10.1186/s13195-019-0562-4. PMID: 31892365; PMCID: PMC6937795.
  • Oeckl P, Otto M. A Review on MS-Based Blood Biomarkers for Alzheimer's Disease. Neurol Ther. 2019 Dec;8(Suppl 2):113-127. doi: 10.1007/s40120-019-00165-4. Epub 2019 Dec 12. PMID: 31833028; PMCID: PMC6908529.
  • van Steenoven I, Noli B, Cocco C, Ferri GL, Oeckl P, Otto M, Koel-Simmelink MJA, Bridel C, van der Flier WM, Lemstra AW, Teunissen CE. VGF Peptides in Cerebrospinal Fluid of Patients with Dementia with Lewy Bodies. Int J Mol Sci. 2019 Sep 20;20(19):4674. doi: 10.3390/ijms20194674. PMID: 31547145; PMCID: PMC6801397.
  • Rué L, Oeckl P, Timmers M, Lenaerts A, van der Vos J, Smolders S, Poppe L, de Boer A, Van Den Bosch L, Van Damme P, Weishaupt JH, Ludolph AC, Otto M, Robberecht W, Lemmens R. Reduction of ephrin-A5 aggravates disease progression in amyotrophic lateral sclerosis. Acta Neuropathol Commun. 2019 Jul 12;7(1):114. doi: 10.1186/s40478-019-0759-6. PMID: 31300041; PMCID: PMC6626434.
  • Al Shweiki MR, Steinacker P, Oeckl P, Hengerer B, Danek A, Fassbender K, Diehl-Schmid J, Jahn H, Anderl-Straub S, Ludolph AC, Schönfeldt-Lecuona C, Otto M. Neurofilament light chain as a blood biomarker to differentiate psychiatric disorders from behavioural variant frontotemporal dementia. J Psychiatr Res. 2019 Jun;113:137-140. doi: 10.1016/j.jpsychires.2019.03.019. Epub 2019 Mar 24. PMID: 30953863.
  • Marques TM, van Rumund A, Oeckl P, Kuiperij HB, Esselink RAJ, Bloem BR, Otto M, Verbeek MM. Serum NFL discriminates Parkinson disease from atypical parkinsonisms. Neurology. 2019 Mar 26;92(13):e1479-e1486. doi: 10.1212/WNL.0000000000007179. Epub 2019 Feb 27. PMID: 30814322.
  • Devos D, Moreau C, Kyheng M, Garçon G, Rolland AS, Blasco H, Gelé P, Timothée Lenglet T, Veyrat-Durebex C, Corcia P, Dutheil M, Bede P, Jeromin A, Oeckl P, Otto M, Meininger V, Danel-Brunaud V, Devedjian JC, Duce JA, Pradat PF. A ferroptosis-based panel of prognostic biomarkers for Amyotrophic Lateral Sclerosis. Sci Rep. 2019 Feb 27;9(1):2918. doi: 10.1038/s41598-019-39739-5. Erratum in: Sci Rep. 2020 Feb 19;10(1):3312. PMID: 30814647; PMCID: PMC6393674.
  • Verde F, Steinacker P, Weishaupt JH, Kassubek J, Oeckl P, Halbgebauer S, Tumani H, von Arnim CAF, Dorst J, Feneberg E, Mayer B, Müller HP, Gorges M, Rosenbohm A, Volk AE, Silani V, Ludolph AC, Otto M. Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2019 Feb;90(2):157-164. doi: 10.1136/jnnp-2018-318704. Epub 2018 Oct 11. PMID: 30309882.
  • Oeckl P, Halbgebauer S, Anderl-Straub S, Steinacker P, Huss AM, Neugebauer H, von Arnim CAF, Diehl-Schmid J, Grimmer T, Kornhuber J, Lewczuk P, Danek A; Consortium for Frontotemporal Lobar Degeneration German; Ludolph AC, Otto M. Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer's Disease and Correlates with Cognitive Impairment. J Alzheimers Dis. 2019;67(2):481-488. doi: 10.3233/JAD-180325. PMID: 30594925.
  • Oeckl P, Weydt P, Steinacker P, Anderl-Straub S, Nordin F, Volk AE, Diehl- Schmid J, Andersen PM, Kornhuber J, Danek A, Fassbender K, Fliessbach K; German Consortium for Frontotemporal Lobar Degeneration; Jahn H, Lauer M, Müller K, Knehr A, Prudlo J, Schneider A, Thal DR, Yilmazer-Hanke D, Weishaupt JH, Ludolph AC, Otto M. Different neuroinflammatory profile in amyotrophic lateral sclerosis and frontotemporal dementia is linked to the clinical phase. J Neurol Neurosurg Psychiatry. 2019 Jan;90(1):4-10. doi: 10.1136/jnnp-2018-318868. Epub 2018 Sep 17. PMID: 30224549.
  • Steinacker P, Anderl-Straub S, Diehl-Schmid J, Semler E, Uttner I, von Arnim CAF, Barthel H, Danek A, Fassbender K, Fliessbach K, Foerstl H, Grimmer T, Huppertz HJ, Jahn H, Kassubek J, Kornhuber J, Landwehrmeyer B, Lauer M, Maler JM, Mayer B, Oeckl P, Prudlo J, Schneider A, Volk AE, Wiltfang J, Schroeter ML, Ludolph AC, Otto M; FTLDc study group. Serum neurofilament light chain in behavioral variant frontotemporal dementia. Neurology. 2018 Oct 9;91(15):e1390-e1401. doi: 10.1212/WNL.0000000000006318. Epub 2018 Sep 12. PMID: 30209235.
  • Moreau C, Danel V, Devedjian JC, Grolez G, Timmerman K, Laloux C, Petrault M, Gouel F, Jonneaux A, Dutheil M, Lachaud C, Lopes R, Kuchcinski G, Auger F, Kyheng M, Duhamel A, Pérez T, Pradat PF, Blasco H, Veyrat-Durebex C, Corcia P, Oeckl P, Otto M, Dupuis L, Garçon G, Defebvre L, Cabantchik ZI, Duce J, Bordet R, Devos D. Could Conservative Iron Chelation Lead to Neuroprotection in Amyotrophic Lateral Sclerosis? Antioxid Redox Signal. 2018 Sep 10;29(8):742-748. doi: 10.1089/ars.2017.7493. Epub 2018 Feb 8. PMID: 29287521; PMCID: PMC6067092.
  • Verde F, Steinacker P, Oeckl P, Weishaupt JH, Rosenbohm A, Silani V, Ludolph AC, Otto M. Chromogranin A levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Neurobiol Aging. 2018 Jul;67:21-22. doi: 10.1016/j.neurobiolaging.2018.02.017. Epub 2018 Feb 27. PMID: 29609078.
  • Schmid S, Goldberg-Bockhorn E, Schwarz S, Rotter N, Kassubek J, Del Tredici K, Pinkhardt E, Otto M, Ludolph AC, Oeckl P. Alpha-synuclein is present in dental calculus but not altered in Parkinson's disease patients in comparison to controls. J Neurol. 2018 Jun;265(6):1334-1337. doi: 10.1007/s00415-018-8847-2. Epub 2018 Mar 29. PMID: 29600388.
  • Lewczuk P, Riederer P, O'Bryant SE, Verbeek MM, Dubois B, Visser PJ, Jellinger KA, Engelborghs S, Ramirez A, Parnetti L, Jack CR Jr, Teunissen CE, Hampel H, Lleó A, Jessen F, Glodzik L, de Leon MJ, Fagan AM, Molinuevo JL, Jansen WJ, Winblad B, Shaw LM, Andreasson U, Otto M, Mollenhauer B, Wiltfang J, Turner MR, Zerr I, Handels R, Thompson AG, Johansson G, Ermann N, Trojanowski JQ, Karaca I, Wagner H, Oeckl P, van Waalwijk van Doorn L, Bjerke M, Kapogiannis D, Kuiperij HB, Farotti L, Li Y, Gordon BA, Epelbaum S, Vos SJB, Klijn CJM, Van Nostrand WE, Minguillon C, Schmitz M, Gallo C, Lopez Mato A, Thibaut F, Lista S, Alcolea D, Zetterberg H, Blennow K, Kornhuber J; Members of the WFSBP Task Force Working on this Topic: Peter Riederer, Carla Gallo, Dimitrios Kapogiannis, Andrea Lopez Mato, Florence Thibaut. Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry. World J Biol Psychiatry. 2018 Jun;19(4):244-328. doi: 10.1080/15622975.2017.1375556. Epub 2017 Oct 27. PMID: 29076399; PMCID: PMC5916324.
  • Guo Q, Bin Huang, Cheng J, Seefelder M, Engler T, Pfeifer G, Oeckl P, Otto M, Moser F, Maurer M, Pautsch A, Baumeister W, Fernández-Busnadiego R, Kochanek S. The cryo-electron microscopy structure of huntingtin. Nature. 2018 Mar 1;555(7694):117-120. doi: 10.1038/nature25502. Epub 2018 Feb 21. PMID: 29466333; PMCID: PMC5837020.
  • Steinacker P, Verde F, Fang L, Feneberg E, Oeckl P, Roeber S, Anderl-Straub S, Danek A, Diehl-Schmid J, Fassbender K, Fliessbach K, Foerstl H, Giese A, Jahn H, Kassubek J, Kornhuber J, Landwehrmeyer GB, Lauer M, Pinkhardt EH, Prudlo J, Rosenbohm A, Schneider A, Schroeter ML, Tumani H, von Arnim CAF, Weishaupt J, Weydt P, Ludolph AC, Yilmazer Hanke D, Otto M; FTLDc study group. Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression. J Neurol Neurosurg Psychiatry. 2018 Mar;89(3):239-247. doi: 10.1136/jnnp-2017-317138. Epub 2017 Nov 15. PMID: 29142138.
  • Brockmann SJ, Freischmidt A, Oeckl P, Müller K, Ponna SK, Helferich AM, Paone C, Reinders J, Kojer K, Orth M, Jokela M, Auranen M, Udd B, Hermann A, Danzer KM, Lichtner P, Walther P, Ludolph AC, Andersen PM, Otto M, Kursula P, Just S, Weishaupt JH. CHCHD10 mutations p.R15L and p.G66V cause motoneuron disease by haploinsufficiency. Hum Mol Genet. 2018 Feb 15;27(4):706-715. doi: 10.1093/hmg/ddx436. PMID: 29315381.
  • Oeckl P, Steinacker P, Otto M. Comparison of Internal Standard Approaches for SRM Analysis of Alpha-Synuclein in Cerebrospinal Fluid. J Proteome Res. 2018 Jan 5;17(1):516-523. doi: 10.1021/acs.jproteome.7b00660. Epub 2017 Dec 21. PMID: 29183121.
  • Feneberg E, Oeckl P, Steinacker P, Verde F, Barro C, Van Damme P, Gray E, Grosskreutz J, Jardel C, Kuhle J, Koerner S, Lamari F, Amador MDM, Mayer B, Morelli C, Muckova P, Petri S, Poesen K, Raaphorst J, Salachas F, Silani V, Stubendorff B, Turner MR, Verbeek MM, Weishaupt JH, Weydt P, Ludolph AC, Otto M. Multicenter evaluation of neurofilaments in early symptom onset amyotrophic lateral sclerosis. Neurology. 2018 Jan 2;90(1):e22-e30. doi: 10.1212/WNL.0000000000004761. Epub 2017 Dec 6. PMID: 29212830.
  • Barschke P, Oeckl P, Steinacker P, Ludolph A, Otto M. Proteomic studies in the discovery of cerebrospinal fluid biomarkers for amyotrophic lateral sclerosis. Expert Rev Proteomics. 2017 Sep;14(9):769-777. doi: 10.1080/14789450.2017.1365602. Epub 2017 Aug 14. PMID: 28799854.
  • Lehmer C, Oeckl P, Weishaupt JH, Volk AE, Diehl-Schmid J, Schroeter ML, Lauer M, Kornhuber J, Levin J, Fassbender K, Landwehrmeyer B; German Consortium for Frontotemporal Lobar Degeneration; Schludi MH, Arzberger T, Kremmer E, Flatley A, Feederle R, Steinacker P, Weydt P, Ludolph AC, Edbauer D, Otto M. Poly-GP in cerebrospinal fluid links <i>C9orf72</i>-associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD. EMBO Mol Med. 2017 Jul;9(7):859-868. doi: 10.15252/emmm.201607486. PMID: 28408402; PMCID: PMC5494528.
  • Al Shweiki MR, Oeckl P, Steinacker P, Hengerer B, Schönfeldt-Lecuona C, Otto M. Major depressive disorder: insight into candidate cerebrospinal fluid protein biomarkers from proteomics studies. Expert Rev Proteomics. 2017 Jun;14(6):499-514. doi: 10.1080/14789450.2017.1336435. PMID: 28562112.
  • Steinacker P, Semler E, Anderl-Straub S, Diehl-Schmid J, Schroeter ML, Uttner I, Foerstl H, Landwehrmeyer B, von Arnim CA, Kassubek J, Oeckl P, Huppertz HJ, Fassbender K, Fliessbach K, Prudlo J, Roßmeier C, Kornhuber J, Schneider A, Volk AE, Lauer M, Danek A, Ludolph AC, Otto M; FTLDc Study Group. Neurofilament as a blood marker for diagnosis and monitoring of primary progressive aphasias. Neurology. 2017 Mar 7;88(10):961-969. doi: 10.1212/WNL.0000000000003688. Epub 2017 Feb 8. PMID: 28179468.
  • Steinacker P, Huss A, Mayer B, Grehl T, Grosskreutz J, Borck G, Kuhle J, Lulé D, Meyer T, Oeckl P, Petri S, Weishaupt J, Ludolph AC, Otto M. Diagnostic and prognostic significance of neurofilament light chain NF-L, but not progranulin and S100B, in the course of amyotrophic lateral sclerosis: Data from the German MND-net. Amyotroph Lateral Scler Frontotemporal Degener. 2017 Feb;18(1-2):112-119. doi: 10.1080/21678421.2016.1241279. Epub 2016 Nov 5. PMID: 27819158.
  • Steinacker P, Blennow K, Halbgebauer S, Shi S, Ruf V, Oeckl P, Giese A, Kuhle J, Slivarichova D, Zetterberg H, Otto M. Neurofilaments in blood and CSF for diagnosis and prediction of onset in Creutzfeldt-Jakob disease. Sci Rep. 2016 Dec 8;6:38737. doi: 10.1038/srep38737. PMID: 27929120; PMCID: PMC5144074.
  • Huss AM, Halbgebauer S, Öckl P, Trebst C, Spreer A, Borisow N, Harrer A, Brecht I, Balint B, Stich O, Schlegel S, Retzlaff N, Winkelmann A, Roesler R, Lauda F, Yildiz Ö, Voß E, Muche R, Rauer S, Bergh FT, Otto M, Paul F, Wildemann B, Kraus J, Ruprecht K, Stangel M, Buttmann M, Zettl UK, Tumani H. Importance of cerebrospinal fluid analysis in the era of McDonald 2010 criteria: a German-
  • Austrian retrospective multicenter study in patients with a clinically isolated syndrome. J Neurol. 2016 Dec;263(12):2499-2504. doi: 10.1007/s00415-016-8302-1. Epub 2016 Oct 11. PMID: 27730374; PMCID: PMC5110610.
  • Oeckl P, Ferger B. Increased susceptibility of G-protein coupled receptor 6 deficient mice to MPTP neurotoxicity. Neuroscience. 2016 Nov 19;337:218-223. doi: 10.1016/j.neuroscience.2016.09.021. Epub 2016 Sep 17. PMID: 27651149.
  • Oeckl P, Metzger F, Nagl M, von Arnim CA, Halbgebauer S, Steinacker P, Ludolph AC, Otto M. Alpha-, Beta-, and Gamma-synuclein Quantification in Cerebrospinal Fluid by Multiple Reaction Monitoring Reveals Increased Concentrations in Alzheimer's and Creutzfeldt-Jakob Disease but No Alteration in Synucleinopathies. Mol Cell Proteomics. 2016 Oct;15(10):3126-3138. doi: 10.1074/mcp.M116.059915. Epub 2016 Aug 9. PMID: 27507836; PMCID: PMC5054339.
  • Rudinskiy N, Fuerer C, Demurtas D, Zamorano S, De Piano C, Herrmann AG, Spires-Jones TL, Oeckl P, Otto M, Frosch MP, Moniatte M, Hyman BT, Schmid AW. Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint. Alzheimers Dement. 2016 Sep;12(9):996-1013. doi: 10.1016/j.jalz.2016.03.011. Epub 2016 Apr 26. PMID: 27130892.
  • Koch Y, Helferich AM, Steinacker P, Oeckl P, Walther P, Weishaupt JH, Danzer KM, Otto M. Aggregated α-Synuclein Increases SOD1 Oligomerization in a Mouse Model of Amyotrophic Lateral Sclerosis. Am J Pathol. 2016 Aug;186(8):2152-2161. doi: 10.1016/j.ajpath.2016.04.008. Epub 2016 Jun 18. PMID: 27322773.
  • Oeckl P, Steinacker P, Feneberg E, Otto M. Neurochemical biomarkers in the diagnosis of frontotemporal lobar degeneration: an update. J Neurochem. 2016 Aug;138 Suppl 1:184-92. doi: 10.1111/jnc.13669. Epub 2016 Jun 15. PMID: 27186717.
  • Oeckl P, Jardel C, Salachas F, Lamari F, Andersen PM, Bowser R, de Carvalho M, Costa J, van Damme P, Gray E, Grosskreutz J, Hernández-Barral M, Herukka SK, Huss A, Jeromin A, Kirby J, Kuzma-Kozakiewicz M, Amador Mdel M, Mora JS, Morelli C, Muckova P, Petri S, Poesen K, Rhode H, Rikardsson AK, Robberecht W, Rodríguez Mahillo AI, Shaw P, Silani V, Steinacker P, Turner MR, Tüzün E, Yetimler B, Ludolph AC, Otto M. Multicenter validation of CSF neurofilaments as diagnostic biomarkers for ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2016 Jul- Aug;17(5-6):404-13. doi: 10.3109/21678421.2016.1167913. Epub 2016 Apr 11. PMID: 27415180.
  • Halbgebauer S, Öckl P, Wirth K, Steinacker P, Otto M. Protein biomarkers in Parkinson's disease: Focus on cerebrospinal fluid markers and synaptic proteins. Mov Disord. 2016 Jun;31(6):848-60. doi: 10.1002/mds.26635. Epub 2016 May 2. PMID: 27134134.
  • Halbgebauer S, Nagl M, Klafki H, Haußmann U, Steinacker P, Oeckl P, Kassubek J, Pinkhardt E, Ludolph AC, Soininen H, Herukka SK, Wiltfang J, Otto M. Modified serpinA1 as risk marker for Parkinson's disease dementia: Analysis of baseline data. Sci Rep. 2016 May 17;6:26145. doi: 10.1038/srep26145. PMID: 27184740; PMCID: PMC4868992.
  • Wang T, Riegger A, Lamla M, Wiese S, Oeckl P, Otto M, Wu Y, Fischer S, Barth H, Kuan SL, Weil T. Water-soluble allyl sulfones for dual site-specific labelling of proteins and cyclic peptides. Chem Sci. 2016 May 1;7(5):3234-3239. doi: 10.1039/c6sc00005c. Epub 2016 Jan 29. PMID: 29997815; PMCID: PMC6006486.
  • Halbgebauer S, Huss A, Buttmann M, Steinacker P, Oeckl P, Brecht I, Weishaupt A, Tumani H, Otto M. Detection of intrathecal immunoglobulin G synthesis by capillary isoelectric focusing immunoassay in oligoclonal band negative multiple sclerosis. J Neurol. 2016 May;263(5):954-960. doi: 10.1007/s00415-016-8094-3. Epub 2016 Mar 19. PMID: 26995358.
  • Weydt P, Oeckl P, Huss A, Müller K, Volk AE, Kuhle J, Knehr A, Andersen PM, Prudlo J, Steinacker P, Weishaupt JH, Ludolph AC, Otto M. Neurofilament levels as biomarkers in asymptomatic and symptomatic familial amyotrophic lateral sclerosis. Ann Neurol. 2016 Jan;79(1):152-8. doi: 10.1002/ana.24552. Epub 2015 Dec 17. PMID: 26528863.
  • Steinacker P, Feneberg E, Weishaupt J, Brettschneider J, Tumani H, Andersen PM, von Arnim CA, Böhm S, Kassubek J, Kubisch C, Lulé D, Müller HP, Muche R, Pinkhardt E, Oeckl P, Rosenbohm A, Anderl-Straub S, Volk AE, Weydt P, Ludolph AC, Otto M. Neurofilaments in the diagnosis of motoneuron diseases: a prospective study on 455 patients. J Neurol Neurosurg Psychiatry. 2016 Jan;87(1):12-20. doi: 10.1136/jnnp-2015-311387. Epub 2015 Aug 21. PMID: 26296871.
  • Oeckl P, Steinacker P, Feneberg E, Otto M. Cerebrospinal fluid proteomics and protein biomarkers in frontotemporal lobar degeneration: Current status and future perspectives. Biochim Biophys Acta. 2015 Jul;1854(7):757-68. doi: 10.1016/j.bbapap.2014.12.010. Epub 2014 Dec 17. PMID: 25526887.
  • Oeckl P, Steinacker P, von Arnim CA, Straub S, Nagl M, Feneberg E, Weishaupt JH, Ludolph AC, Otto M. Intact protein analysis of ubiquitin in cerebrospinal fluid by multiple reaction monitoring reveals differences in Alzheimer's disease and frontotemporal lobar degeneration. J Proteome Res. 2014 Nov 7;13(11):4518-25. doi: 10.1021/pr5006058. Epub 2014 Aug 13. PMID: 25091646.
  • Oeckl P, Hengerer B, Ferger B. G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease. Exp Neurol. 2014 Jul;257:1-9. doi: 10.1016/j.expneurol.2014.04.010. Epub 2014 Apr 18. PMID: 24747358.
  • Oeckl P, Scheffold A, Lechel A, Rudolph KL, Ferger B. Substantial telomere shortening in the substantia nigra of telomerase-deficient mice does not increase susceptibility to MPTP-induced dopamine depletion. Neuroreport. 2014 Mar 26;25(5):335-9. doi: 10.1097/WNR.0000000000000099. PMID: 24525820.
  • Oeckl P, Lattke M, Wirth T, Baumann B, Ferger B. Astrocyte-specific IKK2 activation in mice is sufficient to induce neuroinflammation but does not increase susceptibility to MPTP. Neurobiol Dis. 2012 Dec;48(3):481-7. doi: 10.1016/j.nbd.2012.06.010. Epub 2012 Jun 30. PMID: 22750522.
  • Lehnert S, Jesse S, Rist W, Steinacker P, Soininen H, Herukka SK, Tumani H, Lenter M, Oeckl P, Ferger B, Hengerer B, Otto M. iTRAQ and multiple reaction monitoring as proteomic tools for biomarker search in cerebrospinal fluid of patients with Parkinson's disease dementia. Exp Neurol. 2012 Apr;234(2):499-505. doi: 10.1016/j.expneurol.2012.01.024. Epub 2012 Feb 1. PMID: 22327139.
  • Oeckl P, Ferger B. Simultaneous LC-MS/MS analysis of the biomarkers cAMP and cGMP in plasma, CSF and brain tissue. J Neurosci Methods. 2012 Jan 30;203(2):338-43. doi: 10.1016/j.jneumeth.2011.09.032. Epub 2011 Oct 6. PMID: 22001223.
  • Oeckl P, Steinacker P, Lehnert S, Jesse S, Kretzschmar HA, Ludolph AC, Otto M, Ferger B. CSF concentrations of cAMP and cGMP are lower in patients with Creutzfeldt-Jakob disease but not Parkinson's disease and amyotrophic lateral sclerosis. PLoS One. 2012;7(3):e32664. doi: 10.1371/journal.pone.0032664. Epub 2012 Mar 2. PMID: 22396786; PMCID: PMC3292568.
  • Oeckl P, Ferger B. Analysis of hydroxylation and nitration products of D-phenylalanine for in vitro and in vivo radical determination using high- performance liquid chromatography and photodiode array detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 May 15;877(14-15):1501-8. doi: 10.1016/j.jchromb.2009.03.031. Epub 2009 Mar 25. PMID: 19345620.


Telefon 0731 500 63143

Telefax 0731 500 12 63143

PD Dr. biol. hum. Patrick Öckl, PhD
c/o Center for Biomedical Research (ZMBF)
Helmholtzstr. 8/1
89081 Ulm