Setz CS, Khadour A, Renna V, Iype J, Gentner E, He X, Datta M, Young M, Nitschke L, Wienands J, Maity PC, Reth M, Jumaa H. 2019. Pten controls B-cell responsiveness and germinal center reaction by regulating the expression of IgD BCR. EMBO J. 38(11). pii: e100249.

Wilhelm I, Levit-Zerdoun E, Jakob J, Villringer S, Frensch M, Übelhart R, Landi A, Müller P, Imberty A, Thuenauer R, Claudinon J, Jumaa H, Reth M, Eibel H, Hobeika E, Römer W. 2019. Carbohydrate-dependent B cell activation by fucose-binding bacterial lectins. Sci Signal. 12(571). pii: eaao7194.

Iype J, Datta M, Khadour A, Übelhart R, Nicolò A, Rollenske T, Dühren-von Minden M, Wardemann H, Maity PC, Jumaa H. 2019. Differences in Self-Recognition between Secreted Antibody and Membrane-Bound B Cell Antigen Receptor. J Immunol. 202(5):1417-1427.

Maity PC, Datta M, Nicolò A, Jumaa H. 2018. Isotype Specific Assembly of B Cell Antigen Receptors and Synergism With Chemokine Receptor CXCR4. Front Immunol. 9:2988.

Alsadeq A, Lenk L, Vadakumchery A, Cousins A, Vokuhl C, Khadour A, Vogiatzi F, Seyfried F, Meyer LH, Cario G, Hobeika E, Debatin KM, Halsey C, Schrappe M, Schewe DM, Jumaa H. 2018. IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia. Blood. 132(15):1614-1617.

Setz CS, Hug E, Khadour A, Abdelrasoul H, Bilal M, Hobeika E, Jumaa H. 2018. PI3K-Mediated Blimp-1 Activation Controls B Cell Selection and Homeostasis. Cell Rep. 24(2):391-405.

Imkeller K, Scally SW, Bosch A, Martí GP, Costa G, Triller G, Murugan R, Renna V, Jumaa H, Kremsner PG, Sim BKL, Hoffman SL, Mordmüller B, Levashina EA, Julien JP, Wardemann H. 2018. Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope. Science. 360(6395):1358-1362.

Xiao G, Chan LN, Klemm L, Braas D, Chen Z, Geng H, Zhang QC, Aghajanirefah A, Cosgun KN, Sadras T, Lee J, Mirzapoiazova T, Salgia R, Ernst T, Hochhaus A, Jumaa H, Jiang X, Weinstock DM, Graeber TG, Müschen M. 2018. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell. 173(2):470-484.e18.

Abdelrasoul H, Werner M, Setz CS, Okkenhaug K, Jumaa H. 2018. PI3K induces B-cell development and regulates B cell identity. Sci Rep. 8(1):1327.

Jiménez de Oya N, De Giovanni M, Fioravanti J, Übelhart R, Di Lucia P, Fiocchi A, Iacovelli S, Efremov DG, Caligaris-Cappio F, Jumaa H, Ghia P, Guidotti LG, Iannacone M. 2017. Pathogen-specific B-cell receptors drive chronic lymphocytic leukemia by light-chain-dependent cross-reaction with autoantigens. EMBO Mol Med. 9(11):1482-1490.

Dolezal E, Infantino S, Drepper F, Börsig T, Singh A, Wossning T, Fiala GJ, Minguet S, Warscheid B, Tarlinton DM, Jumaa H, Medgyesi D, Reth M. 2017. The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex. Nat Immunol. (8):911-920.

Tsiantoulas D, Kiss M, Bartolini-Gritti B, Bergthaler A, Mallat Z, Jumaa H, Binder CJ. 2017. Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development. Sci Rep. 7(1):3540.

Minici C, Gounari M, Übelhart R, Scarfò L, Dühren-von Minden M, Schneider D, Tasdogan A, Alkhatib A, Agathangelidis A, Ntoufa S, Chiorazzi N, Jumaa H, Stamatopoulos K, Ghia P, Degano M. 2017. Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia. Nat Commun. 8:15746.

Becker M, Hobeika E, Jumaa H, Reth M, Maity PC. 2017. CXCR4 signaling and function require the expression of the IgD-class B-cell antigen receptor.Proc Natl Acad Sci U S A. 114(20):5231-5236.

Alsadeq A, Jumaa H. 2017. Dangerous fusions: a path to cancer for arrested lymphoid progenitors. EMBO J. Mar 15;36(6):705-706.

Benkisser-Petersen M, Buchner M, Dörffel A, Dühren-von-Minden M, Claus R, Kläsener K, Leberecht K, Burger M, Dierks C, Jumaa H, Malavasi F, Reth M, Veelken H, Duyster J, Zirlik K. 2016. Spleen Tyrosine Kinase Is Involved in the CD38 Signal Transduction Pathway in Chronic Lymphocytic Leukemia. PLoS One. 11(12):e0169159.

Hobeika E, Maity PC, Jumaa H. 2016. Control of B Cell Responsiveness by Isotype and Structural Elements of the Antigen Receptor. Trends Immunol. 37(5):310-320.

Shojaee S, Chan LN, Buchner M, Cazzaniga V, Cosgun KN, Geng H, Qiu YH, von Minden MD, Ernst T, Hochhaus A, Cazzaniga G, Melnick A, Kornblau SM, Graeber TG, Wu H, Jumaa H, Müschen M. 2016. PTEN opposes negative selection and enables oncogenic transformation of pre-B cells. Nat Med. 22(4):379-87.

Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. 2016. Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 534(7605):138.

Köhrer S, Havranek O, Seyfried F, Hurtz C, Coffey GP, Kim E, Ten Hacken E, Jäger U, Vanura K, O'Brien S, Thomas DA, Kantarjian H, Ghosh D, Wang Z, Zhang M, Ma W, Jumaa H, Debatin KM, Müschen M, Meyer LH, Davis RE, Burger JA. 2016. Pre-BCR signaling in precursor B-cell acute lymphoblastic leukemia regulates PI3K/AKT, FOXO1 and MYC, and can be targeted by SYK inhibition. Leukemia. 30(6):1246-54.

Köhler M, Röring M, Schorch B, Heilmann K, Stickel N, Fiala GJ, Schmitt LC, Braun S, Ehrenfeld S, Uhl FM, Kaltenbacher T, Weinberg F, Herzog S, Zeiser R, Schamel WW, Jumaa H, Brummer T. 2016. Activation loop phosphorylation regulates B-Raf in vivo and transformation by B-Raf mutants. EMBO J. 35(2):143-61.

Übelhart R, Werner M, Jumaa H. 2016. Assembly and Function of the Precursor B-Cell Receptor. Curr Top Microbiol Immunol. 2016;393:3-25.

Jumaa H. 2015. Tuning B cell responsiveness by antigen receptor isotype. Oncotarget. 6(32):32311-2.

Maity PC, Blount A, Jumaa H, Ronneberger O, Lillemeier BF, Reth M. 2015. B cell antigen receptors of the IgM and IgD classes are clustered in different protein islands that are altered during B cell activation. Sci Signal. 8(394):ra93.

Übelhart R, Jumaa H. 2015. Autoreactivity and the positive selection of B cells. Eur J Immunol. 45(11):2971-7.

Flemming A, Huang QQ, Jin JP, Jumaa H, Herzog S. 2015. A Conditional Knockout Mouse Model Reveals That Calponin-3 Is Dispensable for Early B Cell Development. PLoS One. 10(6):e0128385.

Übelhart R, Hug E, Bach MP, Wossning T, Dühren-von Minden M, Horn AH, Tsiantoulas D, Kometani K, Kurosaki T, Binder CJ, Sticht H, Nitschke L, Reth M, Jumaa H. 2015. Responsiveness of B cells is regulated by the hinge region of IgD. Nat Immunol. 16(5):534-43.

Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. 2015. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 521(7552):357-61.

Schneider D, Dühren-von Minden M, Alkhatib A, Setz C, van Bergen CA, Benkißer-Petersen M, Wilhelm I, Villringer S, Krysov S, Packham G, Zirlik K, Römer W, Buske C, Stevenson FK, Veelken H, Jumaa H. 2015. Lectins from opportunistic bacteria interact with acquired variable-region glycans of surface immunoglobulin in follicular lymphoma. Blood. 125(21):3287-96.

Kumar R, Bach MP, Mainoldi F, Maruya M, Kishigami S, Jumaa H, Wakayama T, Kanagawa O, Fagarasan S, Casola S. 2015. Antibody repertoire diversification through VH gene replacement in mice cloned from an IgA plasma cell. Proc Natl Acad Sci U S A. 112(5):E450-7.

Sen S, Langiewicz M, Jumaa H, Webster NJ. 2015. Deletion of serine/arginine-rich splicing factor 3 in hepatocytes predisposes to hepatocellular carcinoma in mice. Hepatology 61:171-83.

Iacovelli S, Hug E, Bennardo S, Duehren-von Minden M, Gobessi S, Rinaldi A, Suljagic M, Bilbao D, Bolasco G, Eckl-Dorna J, Niederberger V, Autore F, Sica S, Laurenti L, Wang H, Cornall RJ, Clarke SH, Croce CM, Bertoni F, Jumaa H, Efremov DG. 2015. Two types of BCR interactions are positively selected during leukemia development in the Eμ-TCL1 transgenic mouse model of CLL. Blood. 125(10):1578-88.

Surova E, Jumaa H. 2014. The role of BCR isotype in B-cell development and activation. Adv Immunol. 123:101-39.

Decker S, Finter J, Forde AJ, Kissel S, Schwaller J, Mack TS, Kuhn A, Gray N, Follo M, Jumaa H, Burger M, Zirlik K, Pfeifer D, Miduturu CV, Eibel H, Veelken H, Dierks C. 2014. PIM kinases are essential for chronic lymphocytic leukemia cell survival (PIM2/3) and CXCR4-mediated microenvironmental interactions (PIM1). Mol Cancer Ther. 13(5):1231-45.

Bach MP, Schneider D, Jumaa H. 2014., [Autoreactivity in B cell development]. Z Rheumatol. 73(1):62-4.

Bach MP, Hug E, Werner M, Holch J, Sprissler C, Pechloff K, Zirlik K, Zeiser R, Dierks C, Ruland J, Jumaa H. 2014. Premature terminal differentiation protects from deregulated lymphocyte activation by ITK-Syk. J Immunol. 192(3):1024-33.

Hug E, Hobeika E, Reth M, Jumaa H. 2014. Inducible expression of hyperactive Syk in B cells activates Blimp-1-dependent terminal differentiation. Oncogene. 33(28):3730-41.

Sprissler C, Belenki D, Maurer H, Aumann K, Pfeifer D, Klein C, Müller TA, Kissel S, Hülsdünker J, Alexandrovski J, Brummer T, Jumaa H, Duyster J, Dierks C. 2014. Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice. Blood Cancer J. 4:e240.

2013

Yaktapour N, Übelhart R, Schüler J, Aumann K, Dierks C, Burger M, Pfeifer D, Jumaa H, Veelken H, Brummer T, Zirlik K. 2013. Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia. Blood. 122(9):1621-33.

Sen S, Jumaa H, Webster NJ. 2013. Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function. Nat Commun. 4:1336.

Ramezani-Rad P, Geng H, Hurtz C, Chan LN, Chen Z, Jumaa H, Melnick A, Paietta E, Carroll WL, Willman CL, Lefebvre V, Müschen M. 2013. SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia. Blood. 121(1):148-55.

 

2012

Linka RM, Risse SL, Bienemann K, Werner M, Linka Y, Krux F, Synaeve C, Deenen R, Ginzel S, Dvorsky R, Gombert M, Halenius A, Hartig R, Helminen M, Fischer A, Stepensky P, Vettenranta K, Köhrer K, Ahmadian MR, Laws HJ, Fleckenstein B, Jumaa H, Latour S, Schraven B, Borkhardt A. 2012. Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases. Leukemia. 26(5):963-71.

Ta, V. B., M. J. de Bruijn, L. Matheson, M. Zoller, M. P. Bach, H. Wardemann, H. Jumaa, A. Corcoran, and R. W. Hendriks. 2012. Highly restricted usage of Ig H chain VH14 family gene segments in Slp65-deficient pre-B cell leukemia in mice. J Immunol 189:4842-51.

Werner M, Jumaa H. 2012. DOCKing innate to adaptive signaling for persistent antibody production. Nat Immunol 13:525-6.

Alkhatib, A., M. Werner, E. Hug, S. Herzog, C. Eschbach, H. Faraidun, F. Kohler, T. Wossning, and H. Jumaa. 2012. FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination. J Exp Med 209:395-406.

Decker, S., K. Zirlik, L. Djebatchie, D. Hartmann, G. Ihorst, A. Schmitt-Graeff, D. Herchenbach, H. Jumaa, M. Warmuth, H. Veelken, and C. Dierks. 2012. Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL. Blood 119:997-1007.

Duhren-von Minden, M., R. Ubelhart, D. Schneider, T. Wossning, M. P. Bach, M. Buchner, D. Hofmann, E. Surova, M. Follo, F. Kohler, H. Wardemann, K. Zirlik, H. Veelken, and H. Jumaa. 2012. Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling. Nature 489:309-12.

Herzog S, Jumaa H. 2012. Self-recognition and clonal selection: autoreactivity drives the generation of B cells. Curr Opin Immunol 24:166-72.

 

2011

Duy, C., C. Hurtz, S. Shojaee, L. Cerchietti, H. Geng, S. Swaminathan, L. Klemm, S. M. Kweon, R. Nahar, M. Braig, E. Park, Y. M. Kim, W. K. Hofmann, S. Herzog, H. Jumaa, H. P. Koeffler, J. J. Yu, N. Heisterkamp, T. G. Graeber, H. Wu, B. H. Ye, A. Melnick, and M. Muschen. 2011. BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature 473:384-8.

Eschbach, C., M. P. Bach, I. Fidler, R. Pelanda, F. Kohler, K. Rajewsky, and H. Jumaa. 2011. Efficient generation of B lymphocytes by recognition of self-antigens. Eur J Immunol 41:2397-403.

Nahar, R., P. Ramezani-Rad, M. Mossner, C. Duy, L. Cerchietti, H. Geng, S. Dovat, H. Jumaa, B. H. Ye, A. Melnick, and M. Muschen. 2011. Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC. Blood 118:4174-8.

Hurtz, C., K. Hatzi, L. Cerchietti, M. Braig, E. Park, Y. M. Kim, S. Herzog, P. Ramezani-Rad, H. Jumaa, M. C. Muller, W. K. Hofmann, A. Hochhaus, B. H. Ye, A. Agarwal, B. J. Druker, N. P. Shah, A. M. Melnick, and M. Muschen. 2011. BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. J Exp Med 208:2163-74.

 

2010

Buchner, M., C. Baer, G. Prinz, C. Dierks, M. Burger, T. Zenz, S. Stilgenbauer, H. Jumaa, H. Veelken, and K. Zirlik. 2010. Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia. Blood 115:4497-506.

Werner, M., E. Hobeika, and H. Jumaa. 2010. Role of PI3K in the generation and survival of B cells. Immunol Rev 237:55-71.

Duy, C., J. J. Yu, R. Nahar, S. Swaminathan, S. M. Kweon, J. M. Polo, E. Valls, L. Klemm, S. Shojaee, L. Cerchietti, W. Schuh, H. M. Jack, C. Hurtz, P. Ramezani-Rad, S. Herzog, H. Jumaa, H. P. Koeffler, I. M. de Alboran, A. M. Melnick, B. H. Ye, and M. Muschen. 2010. BCL6 is critical for the development of a diverse primary B cell repertoire. J Exp Med 207:1209-21.

Ubelhart, R., M. P. Bach, C. Eschbach, T. Wossning, M. Reth, and H. Jumaa. 2010. N-linked glycosylation selectively regulates autonomous precursor BCR function. Nat Immunol 11:759-65.

 

2009

Buchner, M., S. Fuchs, G. Prinz, D. Pfeifer, K. Bartholome, M. Burger, N. Chevalier, L. Vallat, J. Timmer, J. G. Gribben, H. Jumaa, H. Veelken, C. Dierks, and K. Zirlik. 2009. Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia. Cancer Res 69:5424-32.

Klemm, L., C. Duy, I. Iacobucci, S. Kuchen, G. von Levetzow, N. Feldhahn, N. Henke, Z. Li, T. K. Hoffmann, Y. M. Kim, W. K. Hofmann, H. Jumaa, J. Groffen, N. Heisterkamp, G. Martinelli, M. R. Lieber, R. Casellas, and M. Muschen. 2009. The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia. Cancer Cell 16:232-45.

Huck, K., O. Feyen, T. Niehues, F. Ruschendorf, N. Hubner, H. J. Laws, T. Telieps, S. Knapp, H. H. Wacker, A. Meindl, H. Jumaa, and A. Borkhardt. 2009. Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation. J Clin Invest 119:1350-8.

Herzog, S., M. Reth, and H. Jumaa. 2009. Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling. Nat Rev Immunol 9:195-205.

Trageser, D., I. Iacobucci, R. Nahar, C. Duy, G. von Levetzow, L. Klemm, E. Park, W. Schuh, T. Gruber, S. Herzog, Y. M. Kim, W. K. Hofmann, A. Li, C. T. Storlazzi, H. M. Jack, J. Groffen, G. Martinelli, N. Heisterkamp, H. Jumaa, and M. Muschen. 2009. Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function. J Exp Med 206:1739-53.