apl. Prof. Dr. med. Thomas FE Barth

(Curriculum vitae)

 

Publikationen (PubMed)

 

Profilbild von Prof. Dr. med. Thomas Barth

Prof. Dr. med. Thomas Barth

Oberarzt

Forschungsschwerpunkte

Hämatopathologie mit speziellem Fokus auf der Transformation des nodalen und extraodalen Marginalzonen B-Zell Lymphoms

Mitarbeiter:

Rucha Dugge (HEIST Stipendiatin)
Francesca Spada (HEIST Stipendiatin)

Research Training Group 2254: Heterogeneity and Evolution in Solid Tumours (HEIST)

Genome-wide DNA methylation analysis along the progression of gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type.
Dugge R, Wagener R, Mӧller P, Barth TFE. Br J Haematol. 2021 Feb 16. doi: 10.1111/bjh.17193. Online ahead of print. PMID: 33590882

U-RT1 - A new model for Richter transformation.
Schmid T, Maier J, Martin M, Tasdogan A, Tausch E, Barth TFE, Stilgenbauer S, Bloehdorn J, Möller P, Mellert K. Neoplasia. 2021 Jan;23(1):140-148. doi: 10.1016/j.neo.2020.11.010. Epub 2020 Dec 11. PMID: 33316538 Free PMC article

Successful hematopoietic stem cell transplantation in a 4-1BB deficient patient with EBV-induced lymphoproliferation.
Wildermann C, Alosaimi M, Liebenehm S, Jacobsen EM, Barth TFE, Möller P, Debatin KM, Schulz A, Sirin M, Abosoudah IF, Alkuraya FS, Geha RS, Hönig M. Clin Immunol. 2021 Jan;222:108639. doi: 10.1016/j.clim.2020.108639. Epub 2020 Nov 28. PMID: 33259966

Phase II trial evaluating the efficacy and safety of the anti-CD20 monoclonal antibody obinutuzumab in patients with marginal zone lymphoma.

Grunenberg A, Kaiser LM, Woelfle S, Schmelzle B, Viardot A, Möller P, Barth TF, Muche R, Dreyhaupt J, Buske C. Future Oncol. 2020 May;16(13):817-825. doi: 10.2217/fon-2020-0071. Epub 2020 Mar 30. PMID: 32223334 Clinical Trial.

Unusual transformation of primary extranodal marginal zone B cell lymphoma of the uterus into a nodal follicular lymphoma grade IIIB.
Grunenberg A, Möller P, Viardot A, Teleanu V, Eiermann D, Buske C, Barth TF. Ann Hematol. 2019 Mar;98(3):797-799. doi: 10.1007/s00277-019-03598-x. Epub 2019 Jan 26. PMID: 30683997 No abstract available.

Coincidence of lymphomatoid granulomatosis, chronic myelomonocytic leukemia, and anaplastic T cell lymphoma after methotrexate therapy for rheumatoid arthritis.
Dugge R, Kreipe H, Rosenwald A, Lehmann U, Möller P, Barth TFE, Erlemann R. Ann Hematol. 2019 Feb;98(2):515-517. doi: 10.1007/s00277-018-3434-2. Epub 2018 Jul 7. PMID: 29982850 No abstract available.

Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma.
Barth TFE, Kraus JM, Lausser L, Flossbach L, Schulte L, Holzmann K, Kestler HA, Möller P. Sci Rep. 2017 Jul 20;7(1):5963. doi: 10.1038/s41598-017-05116-3. PMID: 28729720 Free PMC article.

Central nervous system involvement in acute lymphoblastic leukemia is mediated by vascular endothelial growth factor.
Münch V, Trentin L, Herzig J, Demir S, Seyfried F, Kraus JM, Kestler HA, Köhler R, Barth TFE, Te Kronnie G, Debatin KM, Meyer LH. Blood. 2017 Aug 3;130(5):643-654. doi: 10.1182/blood-2017-03-769315. Epub 2017 May 26. PMID: 28550041

Clinical Impact of the Cell-of-Origin Classification and the MYC/ BCL2 Dual Expresser Status in Diffuse Large B-Cell Lymphoma Treated Within Prospective Clinical Trials of the German High-Grade Non-Hodgkin's Lymphoma Study Group.
Staiger AM, Ziepert M, Horn H, Scott DW, Barth TFE, Bernd HW, Feller AC, Klapper W, Szczepanowski M, Hummel M, Stein H, Lenze D, Hansmann ML, Hartmann S, Möller P, Cogliatti S, Lenz G, Trümper L, Löffler M, Schmitz N, Pfreundschuh M, Rosenwald A, Ott G; German High-Grade Lymphoma Study Group. J Clin Oncol. 2017 Aug 1;35(22):2515-2526. doi: 10.1200/JCO.2016.70.3660. Epub 2017 May 19. PMID: 28525305 Clinical Trial.

A novel PTPN1 splice variant upregulates JAK/STAT activity in classical Hodgkin lymphoma cells.
Zahn M, Marienfeld R, Melzner I, Heinrich J, Renner B, Wegener S, Mießner A, Barth TF, Dorsch K, Brüderlein S, Möller P. Blood. 2017 Mar 16;129(11):1480-1490. doi: 10.1182/blood-2016-06-720516. Epub 2017 Jan 12. PMID: 28082443

Prognostic Value of Ki-67 Index, Cytology, and Growth Pattern in Mantle-Cell Lymphoma: Results From Randomized Trials of the European Mantle Cell Lymphoma Network.
Hoster E, Rosenwald A, Berger F, Bernd HW, Hartmann S, Loddenkemper C, Barth TF, Brousse N, Pileri S, Rymkiewicz G, Kodet R, Stilgenbauer S, Forstpointner R, Thieblemont C, Hallek M, Coiffier B, Vehling-Kaiser U, Bouabdallah R, Kanz L, Pfreundschuh M, Schmidt C, Ribrag V, Hiddemann W, Unterhalt M, Kluin-Nelemans JC, Hermine O, Dreyling MH, Klapper W. J Clin Oncol. 2016 Apr 20;34(12):1386-94. doi: 10.1200/JCO.2015.63.8387. Epub 2016 Feb 29. PMID: 26926679

Ectopic spleen and liver hemangioma mimicking metastatic pancreatic neuroendocrine tumor.
Engler CC, Lemke J, Kornmann M, Barth TF, Schmidt SA, Henne-Bruns D. Int J Surg Case Rep. 2015;17:139-42. doi: 10.1016/j.ijscr.2015.10.041. Epub 2015 Nov 6. PMID: 26670205 Free PMC article.

[Detection of the BCR-ABL fusion: Comparative analysis of six commercially available FISH fusion probes].
Knas T, Buck M, Stegelmann F, Möller P, Barth TF. Pathologe. 2015 Jul;36(4):372-84. doi: 10.1007/s00292-015-0040-0. PMID: 26175197 German.

The PCBP1 gene encoding poly(rC) binding protein I is recurrently mutated in Burkitt lymphoma.
Wagener R, Aukema SM, Schlesner M, Haake A, Burkhardt B, Claviez A, Drexler HG, Hummel M, Kreuz M, Loeffler M, Rosolowski M, López C, Möller P, Richter J, Rohde M, Betts MJ, Russell RB, Bernhart SH, Hoffmann S, Rosenstiel P, Schilhabel M, Szczepanowski M, Trümper L, Klapper W, Siebert R; ICGC MMML-Seq-Project; "Molecular Mechanisms in Malignant Lymphomas" Network Project of the Deutsche Krebshilfe. Genes Chromosomes Cancer. 2015 Sep;54(9):555-64. doi: 10.1002/gcc.22268. Epub 2015 Jul 14. PMID: 26173642

Different biological risk factors in young poor-prognosis and elderly patients with diffuse large B-cell lymphoma.
Horn H, Ziepert M, Wartenberg M, Staiger AM, Barth TF, Bernd HW, Feller AC, Klapper W, Stuhlmann-Laeisz C, Hummel M, Stein H, Lenze D, Hartmann S, Hansmann ML, Möller P, Cogliatti S, Pfreundschuh M, Trümper L, Loeffler M, Glass B, Schmitz N, Ott G, Rosenwald A; DSHNHL16. Leukemia. 2015 Jul;29(7):1564-70. doi: 10.1038/leu.2015.43. Epub 2015 Feb 17. PMID: 25687653

KIT mutations in primary mediastinal B-cell lymphoma.
Nagel PD, Stenzinger A, Feld FM, Herrmann MD, Brüderlein S, Barth TF, Marienfeld R, Endris V, Weichert W, Debatin KM, Westhoff MA, Lessel D, Möller P, Lennerz JK. Blood Cancer J. 2014 Aug 22;4(8):e241. doi: 10.1038/bcj.2014.61. PMID: 25148223 Free PMC article. No abstract available.

Potential clinical implications of BRAF mutations in histiocytic proliferations.
Bubolz AM, Weissinger SE, Stenzinger A, Arndt A, Steinestel K, Brüderlein S, Cario H, Lubatschofski A, Welke C, Anagnostopoulos I, Barth TF, Beer AJ, Möller P, Gottstein M, Viardot A, Lennerz JK. Oncotarget. 2014 Jun 30;5(12):4060-70. doi: 10.18632/oncotarget.2061. PMID: 24938183 Free PMC article.

Attenuated measles virus controls pediatric acute B-lineage lymphoblastic leukemia in NOD/SCID mice.
Lühl NC, Zirngibl F, Dorneburg C, Wei J, Dahlhaus M, Barth TF, Meyer LH, Queudeville M, Eckhoff S, Debatin KM, Beltinger C. Haematologica. 2014 Jun;99(6):1050-61. doi: 10.3324/haematol.2013.087205. Epub 2014 Apr 3. PMID: 24700491 Free PMC article.

Leukemic stem cells of acute myeloid leukemia patients carrying NPM1 mutation are candidates for targeted immunotherapy.
Schneider V, Zhang L, Bullinger L, Rojewski M, Hofmann S, Wiesneth M, Schrezenmeier H, Götz M, Botzenhardt U, Barth TF, Döhner K, Döhner H, Greiner J. Leukemia. 2014 Aug;28(8):1759-62. doi: 10.1038/leu.2014.116. Epub 2014 Mar 28. PMID: 24675106 No abstract available.

A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma.
Salaverria I, Martin-Guerrero I, Wagener R, Kreuz M, Kohler CW, Richter J, Pienkowska-Grela B, Adam P, Burkhardt B, Claviez A, Damm-Welk C, Drexler HG, Hummel M, Jaffe ES, Küppers R, Lefebvre C, Lisfeld J, Löffler M, Macleod RA, Nagel I, Oschlies I, Rosolowski M, Russell RB, Rymkiewicz G, Schindler D, Schlesner M, Scholtysik R, Schwaenen C, Spang R, Szczepanowski M, Trümper L, Vater I, Wessendorf S, Klapper W, Siebert R; Molecular Mechanisms in Malignant Lymphoma Network Project; Berlin-Frankfurt-Münster Non-Hodgkin Lymphoma Group. Blood. 2014 Feb 20;123(8):1187-98. doi: 10.1182/blood-2013-06-507996. Epub 2014 Jan 7. PMID: 24398325 Free PMC article.

Biological characterization of adult MYC-translocation-positive mature B-cell lymphomas other than molecular Burkitt lymphoma.
Aukema SM, Kreuz M, Kohler CW, Rosolowski M, Hasenclever D, Hummel M, Küppers R, Lenze D, Ott G, Pott C, Richter J, Rosenwald A, Szczepanowski M, Schwaenen C, Stein H, Trautmann H, Wessendorf S, Trümper L, Loeffler M, Spang R, Kluin PM, Klapper W, Siebert R; Molecular Mechanisms in Malignant Lymphomas Network Project. Haematologica. 2014 Apr;99(4):726-35. doi: 10.3324/haematol.2013.091827. Epub 2013 Oct 31. PMID: 24179151 Free PMC article.

[Gastric lymphoma: still an interdisciplinary challenge].
Barth TF, Floßbach L, Möller P. Pathologe. 2013 May;34(3):210-4. doi: 10.1007/s00292-013-1746-5. PMID: 23568339 Review. German.

No evidence of IGH-MALT1 translocation in the Ma-1 cell line.
Flossbach L, Barth TF, Möller P. Genes Chromosomes Cancer. 2013 Jun;52(6):591-2. doi: 10.1002/gcc.22052. Epub 2013 Mar 18. PMID: 23508779 No abstract available.

Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells.
Lindner S, Dahlke K, Sontheimer K, Hagn M, Kaltenmeier C, Barth TF, Beyer T, Reister F, Fabricius D, Lotfi R, Lunov O, Nienhaus GU, Simmet T, Kreienberg R, Möller P, Schrezenmeier H, Jahrsdörfer B. Cancer Res. 2013 Apr 15;73(8):2468-79. doi: 10.1158/0008-5472.CAN-12-3450. Epub 2013 Feb 5. PMID: 23384943 Free article.

MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma.
Horn H, Ziepert M, Becher C, Barth TF, Bernd HW, Feller AC, Klapper W, Hummel M, Stein H, Hansmann ML, Schmelter C, Möller P, Cogliatti S, Pfreundschuh M, Schmitz N, Trümper L, Siebert R, Loeffler M, Rosenwald A, Ott G; German High-Grade Non-Hodgkin Lymphoma Study Group. Blood. 2013 Mar 21;121(12):2253-63. doi: 10.1182/blood-2012-06-435842. Epub 2013 Jan 18. PMID: 23335369 Free article.

Telomere length in mantle cell lymphoma.
Jebaraj BM, Kienle D, Lechel A, Mertens D, Heuberger M, Ott G, Rosenwald A, Barth TF, Möller P, Zenz T, Döhner H, Stilgenbauer S. Blood. 2013 Feb 14;121(7):1184-7. doi: 10.1182/blood-2012-08-452649. Epub 2012 Dec 14. PMID: 23243283 Free article.

[Round robin test for detection of genomic aberrations in non-Hodgkin lymphoma by in situ hybridization].
Barth TF, Floßbach L, Bernd HW, Bob R, Buck M, Cogliatti SB, Feller AC, Hansmann ML, Hartmann S, Horn H, Klapper W, Kradolfer D, Mattfeldt T, Möller P, Rosenwald A, Stein H, Thorns C, Ott G. Pathologe. 2013 Jul;34(4):329-34. doi: 10.1007/s00292-012-1719-0. PMID: 23179209 German.

Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing.
Richter J, Schlesner M, Hoffmann S, Kreuz M, Leich E, Burkhardt B, Rosolowski M, Ammerpohl O, Wagener R, Bernhart SH, Lenze D, Szczepanowski M, Paulsen M, Lipinski S, Russell RB, Adam-Klages S, Apic G, Claviez A, Hasenclever D, Hovestadt V, Hornig N, Korbel JO, Kube D, Langenberger D, Lawerenz C, Lisfeld J, Meyer K, Picelli S, Pischimarov J, Radlwimmer B, Rausch T, Rohde M, Schilhabel M, Scholtysik R, Spang R, Trautmann H, Zenz T, Borkhardt A, Drexler HG, Möller P, MacLeod RA, Pott C, Schreiber S, Trümper L, Loeffler M, Stadler PF, Lichter P, Eils R, Küppers R, Hummel M, Klapper W, Rosenstiel P, Rosenwald A, Brors B, Siebert R; ICGC MMML-Seq Project. Nat Genet. 2012 Dec;44(12):1316-20. doi: 10.1038/ng.2469. Epub 2012 Nov 11. PMID: 23143595

High-resolution genomic profiling reveals clonal evolution and competition in gastrointestinal marginal zone B-cell lymphoma and its large cell variant.
Flossbach L, Holzmann K, Mattfeldt T, Buck M, Lanz K, Held M, Möller P, Barth TF. Int J Cancer. 2013 Feb 1;132(3):E116-27. doi: 10.1002/ijc.27774. Epub 2012 Sep 1. PMID: 22890838

Human B cells differentiate into granzyme B-secreting cytotoxic B lymphocytes upon incomplete T-cell help.
Hagn M, Sontheimer K, Dahlke K, Brueggemann S, Kaltenmeier C, Beyer T, Hofmann S, Lunov O, Barth TF, Fabricius D, Tron K, Nienhaus GU, Simmet T, Schrezenmeier H, Jahrsdörfer B. Immunol Cell Biol. 2012 Apr;90(4):457-67. doi: 10.1038/icb.2011.64. Epub 2011 Aug 2. PMID: 21808264

Spreading of acute myeloid leukemia cells by trafficking along the peripheral outflow pathway of cerebrospinal fluid.
Schmitt M, Neubauer A, Greiner J, Xu X, Barth TF, Bechter K. Anticancer Res. 2011 Jun;31(6):2343-5. PMID: 21737662

Non-malignant B cells and chronic lymphocytic leukemia cells induce a pro-survival phenotype in CD14+ cells from peripheral blood.
Bhattacharya N, Diener S, Idler IS, Barth TF, Rauen J, Habermann A, Zenz T, Möller P, Döhner H, Stilgenbauer S, Mertens D. Leukemia. 2011 Apr;25(4):722-6. doi: 10.1038/leu.2010.306. Epub 2011 Jan 18. PMID: 21242995 No abstract available.

BCL6 gene rearrangement and protein expression are associated with large cell presentation of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue.
Flossbach L, Antoneag E, Buck M, Siebert R, Mattfeldt T, Möller P, Barth TF. Int J Cancer. 2011 Jul 1;129(1):70-7. doi: 10.1002/ijc.25663. Epub 2010 Dec 1. PMID: 20830719

Immunoblastic morphology but not the immunohistochemical GCB/nonGCB classifier predicts outcome in diffuse large B-cell lymphoma in the RICOVER-60 trial of the DSHNHL.
Ott G, Ziepert M, Klapper W, Horn H, Szczepanowski M, Bernd HW, Thorns C, Feller AC, Lenze D, Hummel M, Stein H, Müller-Hermelink HK, Frank M, Hansmann ML, Barth TF, Möller P, Cogliatti S, Pfreundschuh M, Schmitz N, Trümper L, Loeffler M, Rosenwald A. Blood. 2010 Dec 2;116(23):4916-25. doi: 10.1182/blood-2010-03-276766. Epub 2010 Aug 24. PMID: 20736456 Clinical Trial.

[Current aspects of the pathology and differentiation of extranodal marginal zone B-cell lymphoma, MALT-Type, and gastrointestinal diffuse large B-cell lymphoma].
Flossbach L, Kestler HA, Gress TM, Möller P, Barth TF. Z Gastroenterol. 2010 Aug;48(8):833-8. doi: 10.1055/s-0029-1245421. Epub 2010 Aug 4. PMID: 20687020 Review. German.

CD5+ B cells from individuals with systemic lupus erythematosus express granzyme B.
Hagn M, Ebel V, Sontheimer K, Schwesinger E, Lunov O, Beyer T, Fabricius D, Barth TF, Viardot A, Stilgenbauer S, Hepp J, Scharffetter-Kochanek K, Simmet T, Jahrsdörfer B. Eur J Immunol. 2010 Jul;40(7):2060-9. doi: 10.1002/eji.200940113. PMID: 20394077 Free article.

Loss of HLA-DR expression and immunoblastic morphology predict adverse outcome in diffuse large B-cell lymphoma - analyses of cases from two prospective randomized clinical trials.
Bernd HW, Ziepert M, Thorns C, Klapper W, Wacker HH, Hummel M, Stein H, Hansmann ML, Ott G, Rosenwald A, Müller-Hermelink HK, Barth TF, Möller P, Cogliatti SB, Pfreundschuh M, Schmitz N, Trümper L, Höller S, Löffler M, Feller AC; German High Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL). Haematologica. 2009 Nov;94(11):1569-80. doi: 10.3324/haematol.2009.008862. PMID: 19880780 Free PMC article.

The tumor antigens RHAMM and G250/CAIX are expressed in head and neck squamous cell carcinomas and elicit specific CD8+ T cell responses.
Schmitt A, Barth TF, Beyer E, Borchert F, Rojewski M, Chen J, Guillaume P, Gronau S, Greiner J, Möller P, Riechelmann H, Schmitt M. Int J Oncol. 2009 Mar;34(3):629-39. doi: 10.3892/ijo_00000188. PMID: 19212667

The candidate immunotherapeutical target, the receptor for hyaluronic acid-mediated motility, is associated with proliferation and shows prognostic value in B-cell chronic lymphocytic leukemia.
Giannopoulos K, Mertens D, Bühler A, Barth TF, Idler I, Möller P, Kröber A, Greiner J, Chocholska S, Dmoszyñska A, Roliñski J, Döhner H, Stilgenbauer S, Schmitt M. Leukemia. 2009 Mar;23(3):519-27. doi: 10.1038/leu.2008.338. Epub 2008 Dec 18. PMID: 19092852

New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling.
Martín-Subero JI, Kreuz M, Bibikova M, Bentink S, Ammerpohl O, Wickham-Garcia E, Rosolowski M, Richter J, Lopez-Serra L, Ballestar E, Berger H, Agirre X, Bernd HW, Calvanese V, Cogliatti SB, Drexler HG, Fan JB, Fraga MF, Hansmann ML, Hummel M, Klapper W, Korn B, Küppers R, Macleod RA, Möller P, Ott G, Pott C, Prosper F, Rosenwald A, Schwaenen C, Schübeler D, Seifert M, Stürzenhofecker B, Weber M, Wessendorf S, Loeffler M, Trümper L, Stein H, Spang R, Esteller M, Barker D, Hasenclever D, Siebert R; Molecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe. Blood. 2009 Mar 12;113(11):2488-97. doi: 10.1182/blood-2008-04-152900. Epub 2008 Dec 15. PMID: 19075189

Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2.
Pannicke U, Hönig M, Hess I, Friesen C, Holzmann K, Rump EM, Barth TF, Rojewski MT, Schulz A, Boehm T, Friedrich W, Schwarz K. Nat Genet. 2009 Jan;41(1):101-5. doi: 10.1038/ng.265. Epub 2008 Nov 30. PMID: 19043417

Microarray-based genomic profiling reveals novel genomic aberrations in follicular lymphoma which associate with patient survival and gene expression status.
Schwaenen C, Viardot A, Berger H, Barth TF, Bentink S, Döhner H, Enz M, Feller AC, Hansmann ML, Hummel M, Kestler HA, Klapper W, Kreuz M, Lenze D, Loeffler M, Möller P, Müller-Hermelink HK, Ott G, Rosolowski M, Rosenwald A, Ruf S, Siebert R, Spang R, Stein H, Truemper L, Lichter P, Bentz M, Wessendorf S; Molecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe. Genes Chromosomes Cancer. 2009 Jan;48(1):39-54. doi: 10.1002/gcc.20617. PMID: 18828156

[U-HO1. A new cell line derived from a primary refractory classical Hodgkin lymphoma].
Möller P, Mader A, Barth TF, Brüderlein S. Pathologe. 2008 Nov;29 Suppl 2:317-8. doi: 10.1007/s00292-008-1055-6. PMID: 18820924 German.

MYC stimulates EZH2 expression by repression of its negative regulator miR-26a.
Sander S, Bullinger L, Klapproth K, Fiedler K, Kestler HA, Barth TF, Möller P, Stilgenbauer S, Pollack JR, Wirth T. Blood. 2008 Nov 15;112(10):4202-12. doi: 10.1182/blood-2008-03-147645. Epub 2008 Aug 19. PMID: 18713946

Deletion analysis and alternative splicing define a transactivation inhibitory domain in human oncoprotein REL.
Leeman JR, Weniger MA, Barth TF, Gilmore TD. Oncogene. 2008 Dec 4;27(53):6770-81. doi: 10.1038/onc.2008.284. Epub 2008 Aug 11. PMID: 18695674 Free PMC article.

T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance.
Kintscher U, Hartge M, Hess K, Foryst-Ludwig A, Clemenz M, Wabitsch M, Fischer-Posovszky P, Barth TF, Dragun D, Skurk T, Hauner H, Blüher M, Unger T, Wolf AM, Knippschild U, Hombach V, Marx N. Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1304-10. doi: 10.1161/ATVBAHA.108.165100. Epub 2008 Apr 17. PMID: 18420999

ABF-1 is frequently silenced by promoter methylation in follicular lymphoma, diffuse large B-cell lymphoma and Burkitt's lymphoma.
Ushmorov A, Leithäuser F, Ritz O, Barth TF, Möller P, Wirth T. Leukemia. 2008 Oct;22(10):1942-4. doi: 10.1038/leu.2008.70. Epub 2008 Mar 27. PMID: 18368067 No abstract available.

Genomic aberrations in mantle cell lymphoma detected by interphase fluorescence in situ hybridization. Incidence and clinicopathological correlations.
Sander S, Bullinger L, Leupolt E, Benner A, Kienle D, Katzenberger T, Kalla J, Ott G, Müller-Hermelink HK, Barth TF, Möller P, Lichter P, Döhner H, Stilgenbauer S. Haematologica. 2008 May;93(5):680-7. doi: 10.3324/haematol.12330. Epub 2008 Mar 26. PMID: 18367489

U-HO1, a new cell line derived from a primary refractory classical Hodgkin lymphoma.
Mader A, Bruderlein S, Wegener S, Melzner I, Popov S, Muller-Hermelink HK, Barth TF, Viardot A, Moller P. Cytogenet Genome Res. 2007;119(3-4):204-10. doi: 10.1159/000112062. Epub 2008 Feb 1. PMID: 18253030

[Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in MedB-1 mediastinal lymphoma line].
Barth TF, Melzner I, Wegener S, Bucur AJ, Brüderlein S, Dorsch K, Hasel C, Leithäuser F, Möller P. Verh Dtsch Ges Pathol. 2005;89:234-44. PMID: 18035697 German.

[Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation].
Weniger MA, Melzner I, Menz CK, Wegener S, Bucur AJ, Dorsch K, Mattfeldt T, Barth TF, Möller P. Verh Dtsch Ges Pathol. 2006;90:210-5. PMID: 17867599 German.

Further delineation of chromosomal consensus regions in primary mediastinal B-cell lymphomas: an analysis of 37 tumor samples using high-resolution genomic profiling (array-CGH).
Wessendorf S, Barth TF, Viardot A, Mueller A, Kestler HA, Kohlhammer H, Lichter P, Bentz M, Döhner H, Möller P, Schwaenen C. Leukemia. 2007 Dec;21(12):2463-9. doi: 10.1038/sj.leu.2404919. Epub 2007 Aug 30. PMID: 17728785

ICF syndrome: high variability of the chromosomal phenotype and association with classical Hodgkin lymphoma.
Schuetz C, Barbi G, Barth TF, Hoenig M, Schulz A, Möeller P, Smeets D, de Greef JC, van der Maarel SM, Vogel W, Debatin KM, Friedrich W. Am J Med Genet A. 2007 Sep 1;143A(17):2052-7. doi: 10.1002/ajmg.a.31885. PMID: 17702009

Quantitative gene expression deregulation in mantle-cell lymphoma: correlation with clinical and biologic factors.
Kienle D, Katzenberger T, Ott G, Saupe D, Benner A, Kohlhammer H, Barth TF, Höller S, Kalla J, Rosenwald A, Müller-Hermelink HK, Möller P, Lichter P, Döhner H, Stilgenbauer S. J Clin Oncol. 2007 Jul 1;25(19):2770-7. doi: 10.1200/JCO.2006.08.7999. Epub 2007 Jun 11. PMID: 17563396

Gains of REL in primary mediastinal B-cell lymphoma coincide with nuclear accumulation of REL protein.
Weniger MA, Gesk S, Ehrlich S, Martin-Subero JI, Dyer MJ, Siebert R, Möller P, Barth TF. Genes Chromosomes Cancer. 2007 Apr;46(4):406-15. doi: 10.1002/gcc.20420. PMID: 17243160

[Mediastinal large B-cell lymphoma].
Barth TF, Möller P. Pathologe. 2007 Feb;28(1):36-40. doi: 10.1007/s00292-006-0880-8. PMID: 17195039 German.

Transcriptional profiling suggests that secondary and primary large B-cell lymphomas of the gastrointestinal (GI) tract are blastic variants of GI marginal zone lymphoma.
Barth TF, Barth CA, Kestler HA, Michl P, Weniger MA, Buchholz M, Möller P, Gress T. J Pathol. 2007 Feb;211(3):305-13. doi: 10.1002/path.2096. PMID: 17152084

Chromosomal breakpoints affecting immunoglobulin loci are recurrent in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma.
Martín-Subero JI, Klapper W, Sotnikova A, Callet-Bauchu E, Harder L, Bastard C, Schmitz R, Grohmann S, Höppner J, Riemke J, Barth TF, Berger F, Bernd HW, Claviez A, Gesk S, Frank GA, Kaplanskaya IB, Möller P, Parwaresch RM, Rüdiger T, Stein H, Küppers R, Hansmann ML, Siebert R; Deutsche Krebshilfe Network Project Molecular Mechanisms in Malignant Lymphomas. Cancer Res. 2006 Nov 1;66(21):10332-8. doi: 10.1158/0008-5472.CAN-06-1992. PMID: 17079453 Free article.

Gains of the proto-oncogene BCL11A and nuclear accumulation of BCL11A(XL) protein are frequent in primary mediastinal B-cell lymphoma.
Weniger MA, Pulford K, Gesk S, Ehrlich S, Banham AH, Lyne L, Martin-Subero JI, Siebert R, Dyer MJ, Möller P, Barth TF. Leukemia. 2006 Oct;20(10):1880-2. doi: 10.1038/sj.leu.2404324. Epub 2006 Jul 27. PMID: 16871282 No abstract available.

Diagnosis of Burkitt lymphoma in due time: a practical approach.
Cogliatti SB, Novak U, Henz S, Schmid U, Möller P, Barth TF; Swiss Group for Clinical Cancer Research (SAKK). Br J Haematol. 2006 Aug;134(3):294-301. doi: 10.1111/j.1365-2141.2006.06194.x. PMID: 16848772

A novel fusion of the MALT1 gene and the microtubule-associated protein 4 (MAP4) gene occurs in diffuse large B-cell lymphoma.
Murga Penas EM, Kawadler H, Siebert R, Frank M, Ye H, Hinz K, Becher C, Hummel M, Barth TF, Bokemeyer C, Stein H, Trümper L, Möller P, Marynen P, Du MQ, Yang X, Hansmann ML, Dierlamm J. Genes Chromosomes Cancer. 2006 Sep;45(9):863-73. doi: 10.1002/gcc.20350. PMID: 16804917

Genomic alterations in Hodgkin's lymphoma.
Weniger MA, Barth TF, Möller P. Int J Hematol. 2006 Jun;83(5):379-84. doi: 10.1532/IJH97.06048. PMID: 16787866 Review.

A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling.
Hummel M, Bentink S, Berger H, Klapper W, Wessendorf S, Barth TF, Bernd HW, Cogliatti SB, Dierlamm J, Feller AC, Hansmann ML, Haralambieva E, Harder L, Hasenclever D, Kühn M, Lenze D, Lichter P, Martin-Subero JI, Möller P, Müller-Hermelink HK, Ott G, Parwaresch RM, Pott C, Rosenwald A, Rosolowski M, Schwaenen C, Stürzenhofecker B, Szczepanowski M, Trautmann H, Wacker HH, Spang R, Loeffler M, Trümper L, Stein H, Siebert R; Molecular Mechanisms in Malignant Lymphomas Network Project of the Deutsche Krebshilfe. N Engl J Med. 2006 Jun 8;354(23):2419-30. doi: 10.1056/NEJMoa055351. PMID: 16760442

Autologous graft-versus-host disease-like syndrome after an alemtuzumab-containing conditioning regimen and autologous stem cell transplantation for chronic lymphocytic leukemia.
Zenz T, Ritgen M, Dreger P, Kröber A, Barth TF, Schlenk R, Böttcher S, Hallek MJ, Kneba M, Bunjes D, Döhner H, Stilgenbauer S. Blood. 2006 Sep 15;108(6):2127-30. doi: 10.1182/blood-2006-04-007898. Epub 2006 May 25. PMID: 16728696 Clinical Trial.

Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation.
Weniger MA, Melzner I, Menz CK, Wegener S, Bucur AJ, Dorsch K, Mattfeldt T, Barth TF, Möller P. Oncogene. 2006 Apr 27;25(18):2679-84. doi: 10.1038/sj.onc.1209151. PMID: 16532038

Wotherspoon criteria combined with B cell clonality analysis by advanced polymerase chain reaction technology discriminates covert gastric marginal zone lymphoma from chronic gastritis.
Hummel M, Oeschger S, Barth TF, Loddenkemper C, Cogliatti SB, Marx A, Wacker HH, Feller AC, Bernd HW, Hansmann ML, Stein H, Möller P. Gut. 2006 Jun;55(6):782-7. doi: 10.1136/gut.2005.080523. Epub 2006 Jan 19. PMID: 16423889 Free PMC article. Review.

Biallelic deletion within 16p13.13 including SOCS-1 in Karpas1106P mediastinal B-cell lymphoma line is associated with delayed degradation of JAK2 protein.
Melzner I, Weniger MA, Bucur AJ, Brüderlein S, Dorsch K, Hasel C, Leithäuser F, Ritz O, Dyer MJ, Barth TF, Möller P. Int J Cancer. 2006 Apr 15;118(8):1941-4. doi: 10.1002/ijc.21485. PMID: 16287070

Report: workshop on mediastinal grey zone lymphoma.
Poppema S, Kluiver JL, Atayar C, van den Berg A, Rosenwald A, Hummel M, Lenze D, Lammert H, Stein H, Joos S, Barth T, Dyer M, Lichter P, Klein U, Cattoretti G, Gloghini A, Tu Y, Stolovitzky GA, Califano A, Carbone A, Dalla-Favera R, Melzner I, Bucur AJ, Brüderlein S, Dorsch K, Hasel C, Barth TF, Leithäuser F, Möller P. Eur J Haematol Suppl. 2005 Jul;(66):45-52. doi: 10.1111/j.1600-0609.2005.00454.x. PMID: 16007868

Identification and characterization of epitopes of the receptor for hyaluronic acid-mediated motility (RHAMM/CD168) recognized by CD8+ T cells of HLA-A2-positive patients with acute myeloid leukemia.
Greiner J, Li L, Ringhoffer M, Barth TF, Giannopoulos K, Guillaume P, Ritter G, Wiesneth M, Döhner H, Schmitt M. Blood. 2005 Aug 1;106(3):938-45. doi: 10.1182/blood-2004-12-4787. Epub 2005 Apr 12. PMID: 15827130

Expression pattern of intracellular leukocyte-associated proteins in primary mediastinal B cell lymphoma.
Marafioti T, Pozzobon M, Hansmann ML, Gaulard P, Barth TF, Copie-Bergman C, Roberton H, Ventura R, Martín-Subero JI, Gascoyne RD, Pileri SA, Siebert R, Hsi ED, Natkunam Y, Möller P, Mason DY. Leukemia. 2005 May;19(5):856-61. doi: 10.1038/sj.leu.2403702. PMID: 15744341

The NFATc1 transcription factor is widely expressed in white cells and translocates from the cytoplasm to the nucleus in a subset of human lymphomas.
Marafioti T, Pozzobon M, Hansmann ML, Ventura R, Pileri SA, Roberton H, Gesk S, Gaulard P, Barth TF, Du MQ, Leoncini L, Möller P, Natkunam Y, Siebert R, Mason DY. Br J Haematol. 2005 Feb;128(3):333-42. doi: 10.1111/j.1365-2141.2004.05313.x. PMID: 15667535

Dendritic cells generated from acute myeloid leukemia (AML) blasts maintain the expression of immunogenic leukemia associated antigens.
Li L, Reinhardt P, Schmitt A, Barth TF, Greiner J, Ringhoffer M, Döhner H, Wiesneth M, Schmitt M. Cancer Immunol Immunother. 2005 Jul;54(7):685-93. doi: 10.1007/s00262-004-0631-8. Epub 2004 Dec 31. PMID: 15627212

Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line.
Melzner I, Bucur AJ, Brüderlein S, Dorsch K, Hasel C, Barth TF, Leithäuser F, Möller P. Blood. 2005 Mar 15;105(6):2535-42. doi: 10.1182/blood-2004-09-3701. Epub 2004 Nov 30. PMID: 15572583

Homogeneous immunophenotype and paucity of secondary genomic aberrations are distinctive features of endemic but not of sporadic Burkitt's lymphoma and diffuse large B-cell lymphoma with MYC rearrangement.
Barth TF, Müller S, Pawlita M, Siebert R, Rother JU, Mechtersheimer G, Kitinya J, Bentz M, Möller P. J Pathol. 2004 Aug;203(4):940-5. doi: 10.1002/path.1596. PMID: 15258997

Genomic DNA-chip hybridization in t(11;14)-positive mantle cell lymphomas shows a high frequency of aberrations and allows a refined characterization of consensus regions.
Kohlhammer H, Schwaenen C, Wessendorf S, Holzmann K, Kestler HA, Kienle D, Barth TF, Möller P, Ott G, Kalla J, Radlwimmer B, Pscherer A, Stilgenbauer S, Döhner H, Lichter P, Bentz M. Blood. 2004 Aug 1;104(3):795-801. doi: 10.1182/blood-2003-12-4175. Epub 2004 Apr 13. PMID: 15090459

Segmental chromosomal aberrations and centrosome amplifications: pathogenetic mechanisms in Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma?
Martín-Subero JI, Knippschild U, Harder L, Barth TF, Riemke J, Grohmann S, Gesk S, Höppner J, Möller P, Parwaresch RM, Siebert R. Leukemia. 2003 Nov;17(11):2214-9. doi: 10.1038/sj.leu.2403129. PMID: 14523479

Cytogenetic evolution of follicular lymphoma.
Viardot Aa, Barth TF, Möller P, Döhner H, Bentz M. Semin Cancer Biol. 2003 Jun;13(3):183-90. doi: 10.1016/s1044-579x(03)00014-2. PMID: 12959349 Review.

VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics, and outcome.
Kienle D, Kröber A, Katzenberger T, Ott G, Leupolt E, Barth TF, Möller P, Benner A, Habermann A, Müller-Hermelink HK, Bentz M, Lichter P, Dōhner H, Stilgenbauer S. Blood. 2003 Oct 15;102(8):3003-9. doi: 10.1182/blood-2003-05-1383. Epub 2003 Jul 3. PMID: 12842981 Free article.

Hidden gene amplifications in aggressive B-cell non-Hodgkin lymphomas detected by microarray-based comparative genomic hybridization.
Wessendorf S, Schwaenen C, Kohlhammer H, Kienle D, Wrobel G, Barth TF, Nessling M, Möller P, Döhner H, Lichter P, Bentz M. Oncogene. 2003 Mar 6;22(9):1425-9. doi: 10.1038/sj.onc.1206297. PMID: 12618769

Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
Barth TF, Martin-Subero JI, Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Möoller P. Blood. 2003 May 1;101(9):3681-6. doi: 10.1182/blood-2002-08-2577. Epub 2003 Jan 2. PMID: 12511414 Free article.

Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2.
Joos S, Granzow M, Holtgreve-Grez H, Siebert R, Harder L, Martín-Subero JI, Wolf J, Adamowicz M, Barth TF, Lichter P, Jauch A. Int J Cancer. 2003 Feb 10;103(4):489-95. doi: 10.1002/ijc.10845. PMID: 12478664 Free article.

Clinicopathologic correlations of genomic gains and losses in follicular lymphoma.
Viardot A, Möller P, Högel J, Werner K, Mechtersheimer G, Ho AD, Ott G, Barth TF, Siebert R, Gesk S, Schlegelberger B, Döhner H, Bentz M. J Clin Oncol. 2002 Dec 1;20(23):4523-30. doi: 10.1200/JCO.2002.12.006. PMID: 12454108

Pathogenic complexity of gastric B-cell lymphoma.
Barth TF, Bentz M, Leithäuser F, Stilgenbauer S, Siebert R, Schlotter M, Schlenk RF, Döhner H, Möller P. Blood. 2002 Aug 1;100(3):1095-6; author reply 1096-7. doi: 10.1182/blood-2002-02-0423. PMID: 12130478 Free article. No abstract available.

Mediastinal (thymic) large B-cell lymphoma: where do we stand?
Barth TF, Leithäuser F, Joos S, Bentz M, Möller P. Lancet Oncol. 2002 Apr;3(4):229-34. doi: 10.1016/s1470-2045(02)00714-3. PMID: 12067685 Review.

Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2.
Joos S, Menz CK, Wrobel G, Siebert R, Gesk S, Ohl S, Mechtersheimer G, Trümper L, Möller P, Lichter P, Barth TF. Blood. 2002 Feb 15;99(4):1381-7. doi: 10.1182/blood.v99.4.1381. PMID: 11830490

Mediastinal B-cell lymphoma, a lymphoma type with several characteristics unique among diffuse large B-cell lymphomas.
Barth TF, Leithäuser F, Möller P. Ann Hematol. 2001;80 Suppl 3:B49-53. doi: 10.1007/pl00022789. PMID: 11757707 Review.

Molecular aspects of B-cell lymphomas of the gastrointestinal tract.
Barth TF, Bentz M, Döhner H, Möller P. Clin Lymphoma. 2001 Jun;2(1):57-64. doi: 10.3816/clm.2001.n.012. PMID: 11707871 Review.

Molecular-cytogenetic comparison of mucosa-associated marginal zone B-cell lymphoma and large B-cell lymphoma arising in the gastro-intestinal tract.
Barth TF, Bentz M, Leithäuser F, Stilgenbauer S, Siebert R, Schlotter M, Schlenk RF, Döhner H, Möller P. Genes Chromosomes Cancer. 2001 Aug;31(4):316-25. doi: 10.1002/gcc.1150. PMID: 11433522

MedB-1, a human tumor cell line derived from a primary mediastinal large B-cell lymphoma.
Möller P, Brüderlein S, Sträter J, Leithäuser F, Hasel C, Bataille F, Moldenhauer G, Pawlita M, Barth TF. Int J Cancer. 2001 May 1;92(3):348-53. doi: 10.1002/ijc.1211. PMID: 11291070

Gain of chromosome arm 9p is characteristic of primary mediastinal B-cell lymphoma (MBL): comprehensive molecular cytogenetic analysis and presentation of a novel MBL cell line.
Bentz M, Barth TF, Brüderlein S, Bock D, Schwerer MJ, Baudis M, Joos S, Viardot A, Feller AC, Müller-Hermelink HK, Lichter P, Döhner H, Möller P. Genes Chromosomes Cancer. 2001 Apr;30(4):393-401. doi: 10.1002/1098-2264(2001)9999:9999<::aid-gcc1105>3.0.co;2-i. PMID: 11241792

Primary gastric apoptosis-rich T-cell lymphoma co-expressing CD4, CD8, and cytotoxic molecules.
Barth TF, Leithäuser F, Döhner H, Bentz M, Pawlita M, Schmid U, Möller P. Virchows Arch. 2000 Apr;436(4):357-64. doi: 10.1007/s004280050459. PMID: 10834539

t(11;14)-positive mantle cell lymphomas exhibit complex karyotypes and share similarities with B-cell chronic lymphocytic leukemia.
Bentz M, Plesch A, Bullinger L, Stilgenbauer S, Ott G, Müller-Hermelink HK, Baudis M, Barth TF, Möller P, Lichter P, Döhner H. Genes Chromosomes Cancer. 2000 Mar;27(3):285-94. PMID: 10679918

Chromosomal aberrations in lymphomas of the gastrointestinal tract.
Barth TF, Döhner H, Möller P, Bentz M. Leuk Lymphoma. 1999 Dec;36(1-2):25-32. doi: 10.3109/10428199909145946. PMID: 10613447 Review.

Characteristic pattern of chromosomal gains and losses in primary large B-cell lymphomas of the gastrointestinal tract.
Barth TF, Döhner H, Werner CA, Stilgenbauer S, Schlotter M, Pawlita M, Lichter P, Möller P, Bentz M. Blood. 1998 Jun 1;91(11):4321-30. PMID: 9596681

Molecular cytogenetic analysis of low-grade B-cell neoplasias: a comparative genomic hybridization study.
Werner CA, Döhner H, Barth TF, Stilgenbauer S, Plesch A, Lichter P, Bentz M. Recent Results Cancer Res. 1998;144:53-60. doi: 10.1007/978-3-642-46836-0_7. PMID: 9304707 Review. No abstract available.

High-level DNA amplifications are common genetic aberrations in B-cell neoplasms.
Werner CA, Döhner H, Joos S, Trümper LH, Baudis M, Barth TF, Ott G, Möller P, Lichter P, Bentz M. Am J Pathol. 1997 Aug;151(2):335-42. PMID: 9250147 Free PMC article.

High incidence of chromosomal imbalances and gene amplifications in the classical follicular variant of follicle center lymphoma.
Bentz M, Werner CA, Döhner H, Joos S, Barth TF, Siebert R, Schröder M, Stilgenbauer S, Fischer K, Möller P, Lichter P. Blood. 1996 Aug 15;88(4):1437-44. PMID: 8695864 Free article.

Sarkome mit speziellem Fokus auf Chordome (in Zusammenarbeit mit Dr. biol. hum. Kevin Mellert (AG Mellert): DFG-gefördertes Projekt zur Regulation von Brachyury in Chordomen) und zu Riesenzelltumoren des Knochens.

Mitarbeiter:

Julian Giesche (Assistenzarzt; Stipendiat des Kolloq. Experimentelle Medizin der medizinischen Fakultät Ulm)
Cand. med. Benedikt Leinauer (Stipendiat des Kolloq. Experimentelle Medizin der medizinischen Fakultät Ulm)
Cand. med. Vivien Hild
Cand. med. Sophia Arndt (Stipendiatin des Kolloq. Experimentelle Medizin der medizinischen Fakultät Ulm)

Profiling of three H3F3A-mutated and denosumab-treated giant cell tumors of bone points to diverging pathways during progression and malignant transformation.
Hasenfratz M, Mellert K, Marienfeld R, von Baer A, Schultheiss M, Roitman PD, Aponte-Tinao LA, Lehner B, Möller P, Mechtersheimer G, Barth TFE. Sci Rep. 2021 Mar 11;11(1):5709. doi: 10.1038/s41598-021-85319-x. PMID: 33707617 Free PMC article.

[Primary extra-axial chondroid chordoma of the anterior nasal septum: case report of a rare chordoma with literature review].
Holley C, Breining T, Scheithauer M, Möller P, Barth TFE. HNO. 2021 Mar;69(3):221-228. doi: 10.1007/s00106-020-00957-3. Epub 2020 Oct 23. PMID: 33095325 Review. German.

Case Report and Review of the Literature of a Rare Entity of a Uterine Fibroid: A Genital Rhabdomyoma.
Huesmann ST, Wiegand M, Barth TF, Mian E, Widschwendter P, Janni W, Hancke K. Int J Gynecol Pathol. 2021 Jan;40(1):97-101. doi: 10.1097/PGP.0000000000000660. PMID: 31851059

Intra-articular extra-axial chordoma of the wrist: a case report with review of the current literature.
Neumann J, Gersing AS, Barth TF, Boxberg M, Woertler K. Skeletal Radiol. 2019 Dec;48(12):2015-2020. doi: 10.1007/s00256-019-03228-7. Epub 2019 May 18. PMID: 31104146 Review.

Characterization of Three Novel H3F3A-mutated Giant Cell Tumor Cell Lines and Targeting of Their Wee1 Pathway.
Lübbehüsen C, Lüke J, Seeling C, Mellert K, Marienfeld R, von Baer A, Schultheiss M, Möller P, Barth TFE. Sci Rep. 2019 Apr 23;9(1):6458. doi: 10.1038/s41598-019-42611-1. PMID: 31015476 Free PMC article.

Analysis of the CDK4/6 Cell Cycle Pathway in Leiomyosarcomas as a Potential Target for Inhibition by Palbociclib.
>Böhm MJ, Marienfeld R, Jäger D, Mellert K, von Witzleben A, Brüderlein S, Wittau M, von Baer A, Schultheiss M, Mayer-Steinacker R, Rücker FG, Möller P, Bullinger L, Barth TFE. Sarcoma. 2019 Jan 21;2019:3914232. doi: 10.1155/2019/3914232. eCollection 2019. PMID: 30804704 Free PMC article.

[H3F3A mutated multicentric giant cell tumor of bone : A very rare primary bone disease].
Giesche JP, von Baer A, Breining T, Marienfeld R, Mellert K, Lüke J, Schultheiss M, Möller P, Barth TFE. Pathologe. 2018 Sep;39(5):451-456. doi: 10.1007/s00292-018-0460-8.

[Cartilage, bones, chorda : Molecular pathology].
Barth TFE, Möller P, Jundt G. Pathologe. 2018 Mar;39(2):105-106. doi: 10.1007/s00292-018-0422-1. PMID: 29492596 German. No abstract available.

[Notochordal tumors : Benign notochordal tumors and chordomas].
Barth TFE, von Witzleben A, Möller P, Scheil-Bertram S. Pathologe. 2018 Mar;39(2):117-124. doi: 10.1007/s00292-017-0399-1. PMID: 29236139 Review. German.

U-CH17P, -M and -S, a new cell culture system for tumor diversity and progression in chordoma.
Jäger D, Lechel A, Tharehalli U, Seeling C, Möller P, Barth TFE, Mellert K. Int J Cancer. 2018 Apr 1;142(7):1369-1378. doi: 10.1002/ijc.31161. Epub 2017 Nov 27. PMID: 29148152

[New aspects on giant cell tumor of bone].
Lüke J, Hasenfratz M, Möller P, Barth TFE. Pathologe. 2018 Mar;39(2):125-131. doi: 10.1007/s00292-017-0391-9. PMID: 29110035 Review. German.

[Presacral lesion at the rima ani].
Seeling C, Hirte C, Scheuerle A, Möller P, Barth TFE. Pathologe. 2018 Mar;39(2):181-185. doi: 10.1007/s00292-017-0366-x. PMID: 29018939 German.

Biphasic synovial sarcoma of the epiglottis: Case report and literature review.
Wigand MC, Hoffmann TK, Barth TFE, Veit J. Auris Nasus Larynx. 2018 Jun;45(3):617-621. doi: 10.1016/j.anl.2017.06.007. Epub 2017 Jul 6. PMID: 28689931 Review.

HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas.
Jäger D, Barth TFE, Brüderlein S, Scheuerle A, Rinner B, von Witzleben A, Lechel A, Meyer P, Mayer-Steinacker R, Baer AV, Schultheiss M, Wirtz CR, Möller P, Mellert K. Sci Rep. 2017 May 17;7(1):2032. doi: 10.1038/s41598-017-02174-5. PMID: 28515451 Free PMC article.

H3F3A mutation in giant cell tumour of the bone is detected by immunohistochemistry using a monoclonal antibody against the G34W mutated site of the histone H3.3 variant.
Lüke J, von Baer A, Schreiber J, Lübbehüsen C, Breining T, Mellert K, Marienfeld R, Schultheiss M, Möller P, Barth TFE. Histopathology. 2017 Jul;71(1):125-133. doi: 10.1111/his.13190. Epub 2017 Apr 10. PMID: 28211081

In chordoma, metastasis, recurrences, Ki-67 index, and a matrix-poor phenotype are associated with patients' shorter overall survival.
von Witzleben A, Goerttler LT, Lennerz J, Weissinger S, Kornmann M, Mayer-Steinacker R, von Baer A, Schultheiss M, Möller P, Barth TF. Eur Spine J. 2016 Dec;25(12):4016-4024. doi: 10.1007/s00586-015-4242-1. Epub 2015 Sep 23. PMID: 26399506

Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway.
von Witzleben A, Goerttler LT, Marienfeld R, Barth H, Lechel A, Mellert K, Böhm M, Kornmann M, Mayer-Steinacker R, von Baer A, Schultheiss M, Flanagan AM, Möller P, Brüderlein S, Barth TF. Cancer Res. 2015 Sep 15;75(18):3823-31. doi: 10.1158/0008-5472.CAN-14-3270. Epub 2015 Jul 16. PMID: 26183925 Free article.

Imunohistochemical and FISH analysis of MDM2 and CDK4 in a dedifferentiated extraskeletal osteosarcoma arising in the vastus lateralis muscle: differential diagnosis and diagnostic algorithm.
von Baer A, Ehrhardt A, Baumhoer D, Mayer-Steinacker R, Schultheiss M, Abdul-Nou T, Mentzel T, Fend F, Möller P, Jundt G, Barth TF. Pathol Res Pract. 2014 Oct;210(10):698-703. doi: 10.1016/j.prp.2014.05.010. Epub 2014 May 22. PMID: 24974983

Shared Copy Number Variation in Simultaneous Nephroblastoma and Neuroblastoma due to Fanconi Anemia.
Serra A, Eirich K, Winkler AK, Mrasek K, Göhring G, Barbi G, Cario H, Schlegelberger B, Pokora B, Liehr T, Leriche C, Henne-Bruns D, Barth TF, Schindler D. Mol Syndromol. 2012 Sep;3(3):120-130. doi: 10.1159/000341935. Epub 2012 Aug 23. PMID: 23112754 Free PMC article.

CD57(high) neuroblastoma cells have aggressive attributes ex situ and an undifferentiated phenotype in patients.
Schlitter AM, Dorneburg C, Barth TF, Wahl J, Schulte JH, Brüderlein S, Debatin KM, Beltinger C. PLoS One. 2012;7(8):e42025. doi: 10.1371/journal.pone.0042025. Epub 2012 Aug 10. PMID: 22900004 Free PMC article.

Metastasis of osteosarcoma after 16 years.
Ellegast J, Barth TF, Schulte M, Bielack SS, Schmid M, Mayer-Steinacker R. J Clin Oncol. 2011 Jan 20;29(3):e62-6. doi: 10.1200/JCO.2010.30.8312. Epub 2010 Nov 1. PMID: 21041714 No abstract available.

Pecoma of the lung: a benign tumor with extensive 18F-2-deoxy-D-glucose uptake.
Zarbis N, Barth TF, Blumstein NM, Schelzig H. Interact Cardiovasc Thorac Surg. 2007 Oct;6(5):676-8. doi: 10.1510/icvts.2007.154039. Epub 2007 Jun 7. PMID: 17670735

A 25-year-old woman with a gastric GIST and a PET-positive epicardial tumor.
Kächele V, Pauls S, Mottaghy FM, Blumstein N, Brambs HJ, Barth TF, Hannekum A, Höher M, Jeltsch M, Reske SN, Möller P, Adler G, Seufferlein T. Nat Clin Pract Oncol. 2007 Mar;4(3):197-201. doi: 10.1038/ncponc0743. PMID: 17327860

Early radiation-induced malignant fibrous histiocytoma of the oral cavity.
Wiesmiller K, Barth TF, Gronau S. J Laryngol Otol. 2003 Mar;117(3):224-6. doi: 10.1258/002221503321192584. PMID: 12648384

Mesothelial cells in suspension expose an enriched integrin repertoire capable of capturing soluble fibronectin and laminin.
Barth TF, Rinaldi N, Brüderlein S, Mechtersheimer G, Sträter J, Altevogt P, Möller P. Cell Commun Adhes. 2002 Jan-Feb;9(1):1-14. doi: 10.1080/15419060212184. PMID: 12200961

Loss of laminin and of the laminin receptor integrin subunit alpha 6 in situ correlates with cytokine induced down regulation of alpha 6 on fibroblast-like synoviocytes from rheumatoid arthritis.
Rinaldi N, Barth TF, Weis D, Schwarz-Eywill M, Pezzutto A, Lukoschek M, Brocai D, Brado B. Ann Rheum Dis. 1998 Sep;57(9):559-65. doi: 10.1136/ard.57.9.559. PMID: 9849316 Free PMC article.

Differential expression and functional behaviour of the alpha v and beta 3 integrin subunits in cytokine stimulated fibroblast-like cells derived from synovial tissue of rheumatoid arthritis and osteoarthritis in vitro.
Rinaldi N, Weis D, Brado B, Schwarz-Eywill M, Lukoschek M, Pezzutto A, Keilholz U, Barth TF. Ann Rheum Dis. 1997 Dec;56(12):729-36. doi: 10.1136/ard.56.12.729. PMID: 9496152 Free PMC article.

Pleural mesothelioma mimics the integrin profile of activated, sessile rather than detached mesothelial cells.
Barth TF, Brüderlein S, Rinaldi N, Mechtersheimer G, Möller P. Int J Cancer. 1997 Jul 3;72(1):77-86. doi: 10.1002/(sici)1097-0215(19970703)72:1<77::aid-ijc12>3.0.co;2-7. PMID: 9212227

Increased expression of integrins on fibroblast-like synoviocytes from rheumatoid arthritis in vitro correlates with enhanced binding to extracellular matrix proteins.
Rinaldi N, Schwarz-Eywill M, Weis D, Leppelmann-Jansen P, Lukoschek M, Keilholz U, Barth TF. Ann Rheum Dis. 1997 Jan;56(1):45-51. doi: 10.1136/ard.56.1.45. PMID: 9059141 Free PMC article.

Differential expression of beta 1, beta 3 and beta 4 integrins in sarcomas of the small, round, blue cell category.
Barth T, Möller P, Mechtersheimer G. Virchows Arch. 1995;426(1):19-25. doi: 10.1007/BF00194694. PMID: 7535632

Differential expression of beta 1 integrins in nonneoplastic smooth and striated muscle cells and in tumors derived from these cells.
Mechtersheimer G, Barth T, Quentmeier A, Möller P. Am J Pathol. 1994 Jun;144(6):1172-82. PMID: 7515557 Free PMC article.

Differential expression of beta 1, beta 3, and beta 4 integrin subunits in nonneoplastic neural cells of the peripheral and autonomic nervous system and in tumors derived from these cells.
Mechtersheimer G, Barth T, Quentmeier A, Möller P. Lab Invest. 1994 May;70(5):740-52. PMID: 8196368

Pathologie der Echinokokkose im Menschen.

Mitarbeiter:
Cand. med. Johannes Grimm (Stipendiat des Kolloq. Experimentelle Medizin der medizinischen Fakultät Ulm)
Cand. med. Leonard Schreiber
Cand. med. Franz Ricken

Establishing and evaluation of a polymerase chain reaction for the detection of Echinococcus multilocularis in human tissue.
Grimm J, Krickl J, Beck A, Nell J, Bergmann M, Tappe D, Grüner B, Barth TF, Brehm K. PLoS Negl Trop Dis. 2021 Feb 25;15(2):e0009155. doi: 10.1371/journal.pntd.0009155. eCollection 2021 Feb. PMID: 33630840 Free PMC article.

Emerging human alveolar echinococcosis in Hungary (2003-2018): a retrospective case series analysis from a multi-centre study.
Dezsényi B, Dubóczki Z, Strausz T, Csulak E, Czoma V, Káposztás Z, Fehérvári M, Somorácz Á, Csilek A, Oláh A, Almási K, Patonai A, Görög D, Széll Z, Tolnai Z, Sréter T, Danka J, Auer H, Grüner B, Barth TFE, Casulli A. BMC Infect Dis. 2021 Feb 10;21(1):168. doi: 10.1186/s12879-021-05859-5. PMID: 33568075 Free PMC article.

Immunohistological detection of small particles of Echinococcus multilocularis and Echinococcus granulosus in lymph nodes is associated with enlarged lymph nodes in alveolar and cystic echinococcosis.
Grimm J, Nell J, Hillenbrand A, Henne-Bruns D, Schmidberger J, Kratzer W, Gruener B, Graeter T, Reinehr M, Weber A, Deplazes P, Möller P, Beck A, Barth TFE. PLoS Negl Trop Dis. 2020 Dec 28;14(12):e0008921. doi: 10.1371/journal.pntd.0008921. eCollection 2020 Dec. PMID: 33370302 Free PMC article.

Combining Computed Tomography and Histology Leads to an Evolutionary Concept of Hepatic Alveolar Echinococcosis.
Grimm J, Beck A, Nell J, Schmidberger J, Hillenbrand A, Beer AJ, Dezsényi B, Shi R, Beer M, Kern P, Henne-Bruns D, Kratzer W, Moller P, Barth TF, Gruener B, Graeter T. Pathogens. 2020 Aug 4;9(8):634. doi: 10.3390/pathogens9080634. PMID: 32759781 Free PMC article.

Hepatic alveolar echinococcosis: correlation between computed tomography morphology and inflammatory activity in positron emission tomography.
Graeter T, Eberhardt N, Shi R, Schmidberger J, Beer AJ, Beer M, Henne-Bruns D, Hillenbrand A, Barth TFE, Grimm J, Kratzer W, Gruener B. Sci Rep. 2020 Jul 16;10(1):11808. doi: 10.1038/s41598-020-68624-9. PMID: 32678174 Free PMC article.

Follow-up in hepatic alveolar echinococcosis under benzimidazole therapy using computed tomography.
Graeter T, Shi R, Bao HH, Kratzer W, Barth TFE, Hillenbrand A, Henne-Bruns D, Schmidberger J, Gruener B, Li WX; Echinococcosis Study Group Ulm. Chin Med J (Engl). 2020 Jun 20;133(12):1507-1509. doi: 10.1097/CM9.0000000000000874. PMID: 32568942 Free PMC article. No abstract available.

Echinococcus multilocularis: First European haplotype identified in the United States: An emerging disease?
Polish LB, Pritt B, Barth TFE, Gottstein B, O'Connell EM, Gibson PC. Clin Infect Dis. 2020 Mar 21:ciaa245. doi: 10.1093/cid/ciaa245. Online ahead of print. PMID: 32198510

Pathology of Echinococcosis: A Morphologic and Immunohistochemical Study on 138 Specimens With Focus on the Differential Diagnosis Between Cystic and Alveolar Echinococcosis.
Reinehr M, Micheloud C, Grimm F, Kronenberg PA, Grimm J, Beck A, Nell J, Meyer Zu Schwabedissen C, Furrer E, Müllhaupt B, Barth TFE, Deplazes P, Weber A. Am J Surg Pathol. 2020 Jan;44(1):43-54. doi: 10.1097/PAS.0000000000001374. PMID: 31567204

Simple liver cysts and cystoid lesions in hepatic alveolar echinococcosis: a retrospective cohort study with Hounsfield analysis.
Engler A, Shi R, Beer M, Schmidberger J, Kratzer W, Barth TFE, Grimm J, Hillenbrand A, Henne-Bruns D, Gruener B, Beer AJ, Graeter T. Parasite. 2019;26:54. doi: 10.1051/parasite/2019057. Epub 2019 Aug 30. PMID: 31469072 Free PMC article.

Echinococcus multilocularis.
Casulli A, Barth TFE, Tamarozzi F. Trends Parasitol. 2019 Sep;35(9):738-739. doi: 10.1016/j.pt.2019.05.005. Epub 2019 Jun 7. PMID: 31182385 No abstract available.

Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century.
Baumann S, Shi R, Liu W, Bao H, Schmidberger J, Kratzer W, Li W; interdisciplinary Echinococcosis Working Group Ulm. Infection. 2019 Oct;47(5):703-727. doi: 10.1007/s15010-019-01325-2. Epub 2019 May 30. PMID: 31147846

Health-related quality of life in patients with alveolar echinococcosis: a cross-sectional study.
Schmidberger J, Weimer H, Schlingeloff P, Kratzer W, Grüner B; Echinococcosis Working Group, Ulm. Infection. 2019 Feb;47(1):67-75. doi: 10.1007/s15010-018-1219-0. Epub 2018 Sep 17. PMID: 30225656

Impact of affected lymph nodes on long-term outcome after surgical therapy of alveolar echinococcosis.
Hillenbrand A, Beck A, Kratzer W, Graeter T, Barth TFE, Schmidberger J, Möller P, Henne-Bruns D, Gruener B. Langenbecks Arch Surg. 2018 Aug;403(5):655-662. doi: 10.1007/s00423-018-1687-9. Epub 2018 Jun 16. PMID: 29909530

Human cystic echinococcosis in Hungary (2000-2014): a retrospective case series analysis from a single-center study.
Dezsényi B, Somorácz Á, Danka J, Kucsera I, Barth TFE, Casulli A. Infection. 2018 Aug;46(4):477-486. doi: 10.1007/s15010-018-1146-0. Epub 2018 May 11. PMID: 29752648

Albendazole increases the inflammatory response and the amount of Em2-positive small particles of Echinococcus multilocularis (spems) in human hepatic alveolar echinococcosis lesions.
Ricken FJ, Nell J, Grüner B, Schmidberger J, Kaltenbach T, Kratzer W, Hillenbrand A, Henne-Bruns D, Deplazes P, Moller P, Kern P, Barth TFE. PLoS Negl Trop Dis. 2017 May 25;11(5):e0005636. doi: 10.1371/journal.pntd.0005636. eCollection 2017 May. PMID: 28542546 Free PMC article.

Alveolar echinococcosis in Germany, 1992-2016. An update based on the newly established national AE database.
Schmidberger J, Kratzer W, Stark K, Grüner B; Echinococcosis Working Group. Infection. 2018 Apr;46(2):197-206. doi: 10.1007/s15010-017-1094-0. Epub 2017 Oct 31. PMID: 29090421

Autochthonous human alveolar echinococcosis in a Hungarian patient.
Dezsényi B, Strausz T, Makrai Z, Csomor J, Danka J, Kern P, Rezza G, Barth TF, Casulli A. Infection. 2017 Feb;45(1):107-110. doi: 10.1007/s15010-016-0918-7. Epub 2016 Jun 28. PMID: 27352256

Proposal of a computed tomography classification for hepatic alveolar echinococcosis.
Graeter T, Kratzer W, Oeztuerk S, Haenle MM, Mason RA, Hillenbrand A, Kull T, Barth TF, Kern P, Gruener B. World J Gastroenterol. 2016 Apr 7;22(13):3621-31. doi: 10.3748/wjg.v22.i13.3621. PMID: 27053854 Free PMC article.

Proposal of an ultrasonographic classification for hepatic alveolar echinococcosis: Echinococcosis multilocularis Ulm classification-ultrasound.
Kratzer W, Gruener B, Kaltenbach TE, Ansari-Bitzenberger S, Kern P, Fuchs M, Mason RA, Barth TF, Haenle MM, Hillenbrand A, Oeztuerk S, Graeter T. World J Gastroenterol. 2015 Nov 21;21(43):12392-402. doi: 10.3748/wjg.v21.i43.12392. PMID: 26604646 Free PMC article.

Echinococcus vogeli in immigrant from Suriname to the Netherlands.
Stijnis K, Dijkmans AC, Bart A, Brosens LA, Muntau B, Schoen C, Barth TF, van Gulik T, van Gool T, Grobusch MP, Tappe D. Emerg Infect Dis. 2015 Mar;21(3):528-30. doi: 10.3201/eid2103.141205. PMID: 25695378 Free PMC article. No abstract available.

[Cystic echinococcosis and hepatocellular carcinoma--a coincidence? A case report].
Kübeck M, Stöckl V, Stainer W, Schermaier T, Preisinger J, Schauer W, Hochleitner U, Höbling W, Barth TF, Stadler B, Knoflach P, Kirchgatterer A. Z Gastroenterol. 2014 Jul;52(7):657-62. doi: 10.1055/s-0034-1366528. Epub 2014 Jul 15. PMID: 25026008 German.

Alveolar echinococcosis-spreading disease challenging clinicians: a case report and literature review.
Atanasov G, Benckert C, Thelen A, Tappe D, Frosch M, Teichmann D, Barth TF, Wittekind C, Schubert S, Jonas S. World J Gastroenterol. 2013 Jul 14;19(26):4257-61. doi: 10.3748/wjg.v19.i26.4257. PMID: 23864792 Free PMC article. Review.

Sensitive and specific immunohistochemical diagnosis of human alveolar echinococcosis with the monoclonal antibody Em2G11.
Barth TF, Herrmann TS, Tappe D, Stark L, Grüner B, Buttenschoen K, Hillenbrand A, Juchems M, Henne-Bruns D, Kern P, Seitz HM, Möller P, Rausch RL, Kern P, Deplazes P. PLoS Negl Trop Dis. 2012;6(10):e1877. doi: 10.1371/journal.pntd.0001877. Epub 2012 Oct 25. PMID: 23145198 Free PMC article.

Three-dimensional reconstruction of Echinococcus multilocularis larval growth in human hepatic tissue reveals complex growth patterns.
Tappe D, Zidowitz S, Demmer P, Kern P, Barth TF, Frosch M. Am J Trop Med Hyg. 2010 Jan;82(1):126-7. doi: 10.4269/ajtmh.2010.09-0462. PMID: 20065007 Free PMC article.

Hepatic infestation of Echinococcus multilocularis with extension to regional lymph nodes.
Buttenschoen K, Kern P, Reuter S, Barth TF. Langenbecks Arch Surg. 2009 Jul;394(4):699-704. doi: 10.1007/s00423-009-0481-0. Epub 2009 Apr 17. PMID: 19373487