AG Becker - Innate Immunity and Risk Factor Analytics
Nils started his involvement in trauma research in 2016. In his MD thesis at the Clinic for Trauma Surgery at the Goethe-University Frankfurt he focused on humoral and cellular mediators of inflammation in multiple-trauma and sepsis in in vivo and patient studies. After graduating in 2019, he started his surgical residency at the Department of Trauma Surgery at the University Clinic RWTH Aachen and continued his experimental and clinical research on trauma-associated risk factors for clinical complications. In December 2023 he joined our lab as clinical scientist in the SFB 1149. His main motivation is to identify clinical risk factors and cellular mediators promoting the development of serious immune-derived complications in surgical patients. He focusses on the innate immune response to trauma and the effect of cell-derived mediators on organ-crosstalk, bone-healing and remote organ damage. Furthermore, he concentrates on the identification of important clinical risk populations. His goal is a translational implementation in patient-orientated treatment algorithms.
Congress Grant Award 22nd European Congress of Trauma and Emergency Surgery (ECTES) 2023
Publikationspreis der DGOU OUMN 02/2023 (“weil Forschung auf vielen Ebenen bereichern kann“)
-Start-Up Funding SFB
-GEROK-Rotation in SFB 1149
-DFG FOR 5417
-Nachwuchsförderprogramm “START” der Medizinischen Fakultät der RWTH Aachen 02/2023
-AO-Nachwuchsförderung 2021
ORCID-ID: orcid.org/0000-0001-7205-2799
Steinfeld E, Horst K, Ansems K, et al. Optimal timing of stabilization and operative technique for extremity fractures in polytrauma patients: a systematic review and meta-analysis. Eur J Trauma Emerg Surg. 2025;51(1):27. Published 2025 Jan 19. doi:10.1007/s00068-024-02762-x
Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin e.V.: S3-Leitlinie Intensivmedizin nach Polytrauma (AWMF Registernummer 040-014), Version 1.0 (24.07.2024), Kapitel 3.1.6. Monitoring Extremitäten (N. Becker, K. Horst*), Kapitel 7.1.3.
Spezielle Aspekte bei Extremitätenverletzungen im Rahmen des Polytraumas (N. Becker, F. Hildebrand, K. Horst*, J. Dormann#, E. Steinfeld#, K. Dahms#, K. Ansems#), Kapitel 7.2.
Relevante Parameter zur Entscheidungsfindung (N. Becker, K. Horst*, F. Hildebrand)
Becker N, Franz N, Eguchi A, et al. Elevated extracellular particle concentration in plasma predicts in-hospital mortality after severe trauma. Front Immunol. 2024;15:1390380. Published 2024 Jun 12. doi:10.3389/fimmu.2024.1390380
Robioneck, M.W., Pishnamaz, M., Becker N. et al. Development of early complications after treatment of trochanteric fractures with an intramedullary sliding hip screw in a geriatric population. Eur J Trauma Emerg Surg (2023). doi.org/10.1007/s00068-023-02404-8
Chen X, Hao D, Becker N, Müller A, Pishnamaz M, Bollheimer LC, Hildebrand F, Nourbakhsh M. Unsaturated Long-Chain Fatty Acids Activate Resident Macrophages and Stem Cells in a Human Skeletal Muscle Tissue Model. Biology. 2023; 12(8):1111. doi.org/10.3390/biology12081111
Becker N, Hammen A, Bläsius F, Weber CD, Hildebrand F, Horst K. Effect of Injury Patterns on the Development of Complications and Trauma-Induced Mortality in Patients Suffering Multiple Trauma. Journal of Clinical Medicine. 2023; 12(15):5111. doi.org/10.3390/jcm12155111
Becker N. Weil Forschung auf vielen Ebenen bereichern kann. Publikationspreis OUMN 2023. Orthopädie und Unfallchirurgie Mitteilungen und Nachrichten. 02/2023.
Team
„It always seems impossible until it’s done” - Nelson Mandela
“Curiosity is a prerequisite for knowledge" Jacques-Yves Cousteau
"Nothing in life is to be feared. It is only to be understood. Now is the time to understand more, so that we may fear less" Marie Curie
„Pressure creates diamonds"
"The road to recovery begins with research - and I am grateful to be part of this journey"