AG Becker - Innate Immunity and Risk Factor Analytics
Nils started his involvement in trauma research in 2016. In his MD thesis at the Clinic for Trauma Surgery at the Goethe-University Frankfurt he focused on humoral and cellular mediators of inflammation in multiple-trauma and sepsis in in vivo and patient studies. After graduating in 2019, he started his surgical residency at the Department of Trauma Surgery at the University Clinic RWTH Aachen and continued his experimental and clinical research on trauma-associated risk factors for clinical complications. In December 2023 he joined our lab as clinical scientist in the SFB 1149. His main motivation is to identify clinical risk factors and cellular mediators promoting the development of serious immune-derived complications in surgical patients. He focusses on the innate immune response to trauma and the effect of cell-derived mediators on organ-crosstalk, bone-healing and remote organ damage. Furthermore, he concentrates on the identification of important clinical risk populations. His goal is a translational implementation in patient-orientated treatment algorithms.
Congress Grant Award 22nd European Congress of Trauma and Emergency Surgery (ECTES) 2023
Publikationspreis der DGOU OUMN 02/2023 (“weil Forschung auf vielen Ebenen bereichern kann“)
-Start-Up Funding SFB
-GEROK-Rotation in SFB 1149
-DFG FOR 5417
-Nachwuchsförderprogramm “START” der Medizinischen Fakultät der RWTH Aachen 02/2023
-AO-Nachwuchsförderung 2021
ORCID-ID: orcid.org/0000-0001-7205-2799
Bülow JM, Rinderknecht H, Becker N, Exploring the Bone–Liver Axis: Impact of Acute Ethanol Intoxication on Post-Traumatic Liver Inflammation and Damage Following Femur Fracture. International Journal of Molecular Sciences. 2025; 26(10):4923. doi.org/10.3390/ijms26104923
Becker N, Bülow JM, Franz N, et al. Assessment of early indicators for sepsis development in multiple trauma patients - the Sepsis as Trauma Outcome Prediction (STOP) Score. Shock. Published online May 14, 2025. doi:10.1097/SHK.0000000000002626
Becker, N. et al. (2025). Fallbeispiele: Interprothetische Frakturen. In: Hildebrand, F., Raschke, M.J., Windhagen, H., Wirtz, D.C. (eds) Periimplantäre Frakturen. Springer, Berlin, Heidelberg. doi.org/10.1007/978-3-662-69313-1_16
Steinfeld E, Horst K, (…), Hildebrand F, Becker N. Optimal timing of stabilization and operative technique for extremity fractures in polytrauma patients: a systematic review and meta-analysis. Eur J Trauma Emerg Surg. 2025 Jan 19;51(1):27. doi: 10.1007/s00068-024-02762-x. PMID: 39827327; PMCID: PMC11742870.
Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin e.V.: S3-Leitlinie Intensivmedizin nach Polytrauma (AWMF Registernummer 040-014), Version 1.0 (24.07.2024), Kapitel 3.1.6. Monitoring Extremitäten (N. Becker, K. Horst*), Kapitel 7.1.3. Spezielle Aspekte bei Extremitätenverletzungen im Rahmen des Polytraumas (N. Becker, F. Hildebrand, K. Horst*, J. Dormann#, E. Steinfeld#, K. Dahms#, K. Ansems#), Kapitel 7.2. Relevante Parameter zur Entscheidungsfindung (N. Becker, K. Horst*, F. Hildebrand)
Becker N, Franz N, Eguchi A, et al. Elevated extracellular particle concentration in plasma predicts in-hospital mortality after severe trauma. Front Immunol. 2024;15:1390380. Published 2024 Jun 12. doi:10.3389/fimmu.2024.1390380
Robioneck, M.W., Pishnamaz, M., Becker, N. et al. Development of early complications after treatment of trochanteric fractures with an intramedullary sliding hip screw in a geriatric population. Eur J Trauma Emerg Surg (2023). doi.org/10.1007/s00068-023-02404-8
Chen X, Hao D, Becker N, Müller A, Pishnamaz M, Bollheimer LC, Hildebrand F, Nourbakhsh M. Unsaturated Long-Chain Fatty Acids Activate Resident Macrophages and Stem Cells in a Human Skeletal Muscle Tissue Model. Biology. 2023; 12(8):1111. doi.org/10.3390/biology12081111
Becker N, Hammen A, Bläsius F, Weber CD, Hildebrand F, Horst K. Effect of Injury Patterns on the Development of Complications and Trauma-Induced Mortality in Patients Suffering Multiple Trauma. Journal of Clinical Medicine. 2023; 12(15):5111. doi.org/10.3390/jcm12155111
Becker N. Weil Forschung auf vielen Ebenen bereichern kann. Publikationspreis OUMN 2023. Orthopädie und Unfallchirurgie Mitteilungen und Nachrichten. 02/2023
Hao, D., Becker, N., Mückter, E., Müller, A., Pishnamaz, M., Bollheimer, L.C., Hildebrand, F., Nourbakhsh, M. In Vitro Model of Human Skeletal Muscle Tissue for the Study of Resident Macrophages and Stem Cells. Biology 2022, 11, 936. doi.org/10.3390/biology11060936
Becker, N., Hafner, T., Pishnamaz, M. et al. Patient-specific risk factors for adverse outcomes following geriatric proximal femur fractures. Eur J Trauma Emerg Surg (2022). doi.org/10.1007/s00068-022-01953-8
Becker N, Deilmann A, Kowark P, Hildebrand F, Lichte P. Das komplexe regionale Schmerzsyndrom – eine interdisziplinäre Betrachtung aus der chirurgischen Sprechstunde [Complex regional pain syndrome-An interdisciplinary view from the surgical consultation]. Chirurg. 2021 Nov 8. German. doi: 10.1007/s00104-021-01529-z.
Janicova, A.; Becker, N.; Xu, B.; Simic, M.; Noack, L.; Wagner, N.; Müller, A.J.; Bertrand, J.; Marzi, I.; Relja, B. Severe Traumatic Injury Induces Phenotypic and Functional Changes of Neutrophils and Monocytes. J. Clin. Med. 2021, 10, 4139. doi.org10.3390/ jcm10184139
Becker N, Störmann P, Janicova A, Köhler K, Horst K, Dunay IR, Neunaber C, Marzi I, Vollrath JT, Relja B. Club Cell Protein 16 Attenuates CD16brightCD62dim Immunosuppressive Neutrophils in Damaged Tissue upon Posttraumatic Sepsis-Induced Lung Injury. Journal of Immunology Research (2021) 2021:1–14. doi:10.1155/2021/6647753
Vollrath J, Stoermann P, Becker N, Wutzler S, Hildebrand F, Marzi I, Relja B. Early local neutralization of CC16 in sepsis‑induced ALI following blunt chest trauma leads to delayed mortality without benefitting overall survival. Int J Mol Med (2020) 46:2207–2215. doi:10.3892/ijmm.2020.4767
Greven J, Horst K, Qiao Z, Bläsius FM, Mert Ü, Teuben MPJ, Becker NH, Pfeifer R, Pape H-C, Hildebrand F. Fracture fixation strategy and specific muscle tissue availability of neutrophilic granulocytes following mono- and polytrauma: intramedullary nailing vs. external fixation of femoral fractures. Eur J Med Res (2020) 25:62. doi:10.1186/s40001-020-00461-y
Störmann P, Becker N, Künnemeyer L, Wutzler S, Vollrath JT, Lustenberger T, Hildebrand F, Marzi I, Relja B. Contributing factors in the development of acute lung injury in a murine double hit model. Eur J Trauma Emerg Surg (2019) doi:10.1007/s00068-019-01121-5
Störmann P, Becker N, Vollrath JT, Köhler K, Janicova A, Wutzler S, Hildebrand F, Marzi I, Relja B. Early Local Inhibition of Club Cell Protein 16 Following Chest Trauma Reduces Late Sepsis-Induced Acute Lung Injury. J Clin Med (2019) 8: doi:10.3390/jcm8060896
Janicova A, Becker N, Xu B, Wutzler S, Vollrath JT, Hildebrand F, Ehnert S, Marzi I, Störmann P, Relja B. Endogenous Uteroglobin as Intrinsic Anti-inflammatory Signal Modulates Monocyte and Macrophage Subsets Distribution Upon Sepsis Induced Lung Injury. Front Immunol (2019) 10:2276. doi:10.3389/fimmu.2019.02276
Team
„It always seems impossible until it’s done” - Nelson Mandela
“Curiosity is a prerequisite for knowledge" Jacques-Yves Cousteau
"Nothing in life is to be feared. It is only to be understood. Now is the time to understand more, so that we may fear less" Marie Curie
„Pressure creates diamonds"
"The road to recovery begins with research - and I am grateful to be part of this journey"