Prof. Dr. med. Albert C. Ludolph

Ärztlicher Direktor
Klinik für Neurologie der Universität Ulm, RKU

Telefon: 0731 177-1201
Fax: 0731 177-1202

E-Mail: albert.ludolph@rku.de

 

Personal Data

Name:                                 Albert Christian Ludolph

Citizenship:                         German

Place & Date of Birth:         Bad Pyrmont (Germany), Dezember 12th, 1953

Address:                             Department of Neurology, University of Ulm, Germany,                                                                      Oberer Eselsberg 45, 89081 Ulm

Professional Experience

1979 - 1984               

Resident, Board Neurology and Psychiatry (Department of  Neurology and Psychiatry, University of Münster FRG)(Prof. G. Brune, Prof. R. Tölle)

1984 - 1985

Stipend, Deutsche Forschungsgemeinschaft: Institute of Neurotoxicology, Albert Einstein College of Medicine, Bronx, New York (Prof. P.S. Spencer, Prof. H.H. Schaumburg)

1985 - 1989

Staff, Department of Neurology, University of Münster (Prof. G. Brune)

1987

Habilitation, Faculty of Medicine, University of Münster, C2 Professor of Neurology

1990 - 1992

Staff Scientist, Visiting Assoc. Prof., Center for Research on Occuputational and Environmental Toxicology, Portland (Oregon)

1992

Staff, Department of Epileptology, University of Bonn (Prof. C.E. Elger)

1993 - 1996

C3 Professor of Neurology, Vice Chairman, Department of Neurology, Humboldt University Berlin (Prof. K.-M. Einhäupl)

1996

C4 Professor of Neurology, Chair, Department of Neurology, University of Ulm

2003 -

Chair (elected) Academic Neuroscience Center, University of Ulm

2005 - 2009

Deputy Chair and Chair (elected), European ALS-MND-Group

2007 -

Chair (elected) ALS panel of the EFNS and EAN (since 2014, together with Prof. Vincenzo Silani)

2008 -

Scientific Advisory Board Thierry Latran Foundation

2008 -

Chair, Scientific Council of Deutsche Stiftung Querschnittlähmung (DSQ)

2008 -

Chair Scientific Council Deutsche Gesellschaft für Muskelkranke

2009 -

Scientific Advisory Board Member of the Stifterverband der Schilling-Research-Groups for Translational Neuroscience

2009 -

Chair (elected), World Federation of Neurology, ALS Research Group

2009 -

Reviewer for Neuroscience Board of the German Research Foundation (DFG)

2010 - 2014

Vice Dean of the Medical Faculty of Ulm

2013 -

>Chair (elected), World Federation of Neurology, ALS Research Group

2014 -

Delegate of the German Society of Neurology at the World Federation of Neurology

2015 – 2017

Speaker (elected), Clinical Neurosciences Neurowissenschaftliche Gesellschaft (German Society of Neuroscience)

2017 – 2021

Deputy Chair and Chair elected Neurowissenschaftliche Gesellschaft (German Society of Neuroscience)

2017 –

Chair Scientific Advisory Board Thierry Latran Foundation

2018 - today Speaker, Site Ulm of the DZNE (Deutsches Zentrum für Neurodegenerative Erkrankungen)

Publications

 
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Månberg A, Skene N, Sanders F, Trusohamn M, Remnestål J, Szczepińska A, Aksoylu IS, Lönnerberg P, Ebarasi L, Wouters S, Lehmann M, Olofsson J, von Gohren Antequera I, Domaniku A, De Schaepdryver M, De Vocht J, Poesen K, Uhlén M, Anink J, Mijnsbergen C, Vergunst-Bosch H, Hübers A, Kläppe U, Rodriguez-Vieitez E, Gilthorpe JD, Hedlund E, Harris RA, Aronica E, Van Damme P, Ludolph AC, Veldink J, Ingre C, Nilsson P, Lewandowski SA. Altered perivascular fibroblast activity precedes ALS disease onset. Nat Med. 2021 Apr;27(4):640-646.

 
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Del Tredici K, Ludolph AC, Feldengut S, Jacob C, Reichmann H, Bohl JR, Braak H. Fabry Disease With Concomitant Lewy Body Disease. J Neuropathol Exp Neurol 2020;79(4):378-392
 
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Dorst J, Schuster J, Dreyhaupt J, Witzel S, Weishaupt JH, Kassubek J, Weiland U, Petri S, Meyer T, Grehl T, Hermann A, Jordan B, Grosskreutz J, Zeller D, Boentert M, Schrank B, Prudlo J, Winkler AS, Gorbulev S, Roselli F, Dupuis L, Otto M, Ludolph AC. Effect of high-caloric nutrition on serum neurofilament light chain levels in amyotrophic lateral sclerosis. J Neurol Neurosurg Psych 2020;91(9):1007-1009

 
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Hagenacker T, Wurster CD, Günther R, Schreiber-Katz O, Osmanovic A, Petri S, Weiler M, Ziegler A, Kuttler J, Koch JC, Schneider I, Wunderlich G, Schloss N, Lehmann HC, Cordts I, Deschauer M, Lingor P, Kamm C, Stolte B, Pietruck L, Totzeck A, Kizina K, Mönninghoff C, von Velsen O, Ose C, Reichmann H, Forsting M, Pechmann A, Kirschner J, Ludolph AC, Hermann A, Kleinschnitz C. Nusinersen in adults with 5q spinal muscular atrophy: a non-interventional, multicentre, observational cohort study. Lancet Neurol 2020;19(4):317-325

 
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Ludolph AC, Dorst J, Dreyhaupt J, Weishaupt JH, Kassubek J, Weiland U, Meyer T, Petri S, Hermann A, Emmer A, Grosskreutz J, Grehl T, Zeller D, Boentert M, Schrank B, Prudlo J, Winkler AS, Gorbulev S, Roselli F, Schuster J, Dupuis L; LIPCAL-ALS Study Group. Effect of High-Caloric Nutrition on Survival in Amyotrophic Lateral Sclerosis. Ann Neurol 2020;87(2):206-216

 
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Ludolph AC, Emilian S, Dreyhaupt J, Rosenbohm A, Kraskov A, Lemon RN, Del Tredici K, Braak H. Pattern of paresis in ALS is consistent with the physiology of the corticomotoneuronal projections to different muscle groups. J Neurol Neurosurg Psych 2020;(9):991-998

 
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Lulé DE, Müller HP, Finsel J, Weydt P, Knehr A, Winroth I, Andersen P, Weishaupt J, Uttner I, Kassubek J, Ludolph AC. Deficits in verbal fluency in presymptomatic C9orf72 mutation gene carriers-a developmental disorder. J Neurol Neurosurg Psych 2020;91(11):1195-1200

 
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Miller T, Cudkowicz M, Shaw PJ, Andersen PM, Atassi N, Bucelli RC, Genge A, Glass J, Ladha S, Ludolph AC, Maragakis NJ, McDermott CJ, Pestronk A, Ravits J, Salachas F, Trudell R, Van Damme P, Zinman L, Bennett CF, Lane R, Sandrock A, Runz H, Graham D, Houshyar H, McCampbell A, Nestorov I, Chang I, McNeill M, Fanning L, Fradette S, Ferguson TA. Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS. N Engl J Med 2020;383(2):109-119

 
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Oeckl P, Weydt P, Thal DR, Weishaupt JH, Ludolph AC, Otto M. Proteomics in cerebrospinal fluid and spinal cord suggests UCHL1, MAP2 and GPNMB as biomarkers and underpins importance of transcriptional pathways in amyotrophic lateral sclerosis. Acta Neuropathol 2020;139(1):119-134

 
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Ludolph AC, Schuster J, Dorst J, Dupuis L, Dreyhaupt J, Weishaupt JH, Kassubek J, Weiland U, Petri S, Meyer T, Grosskreutz J, Schrank B, Boentert M, Emmer A, Hermann A, Zeller D, Prudlo J, Winkler AS, Grehl T, Heneka MT, Wollebæk Johannesen S, Göricke B; RAS-ALS Study Group. Safety and efficacy of rasagiline as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomised, double-blind, parallel-group, placebo-controlled, phase 2 trial. Lancet Neurol 2018;17(8):681-688

 
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Lulé DE, Aho-Özhan HEA, Vázquez C, Weiland U, Weishaupt JH, Otto M, Anderl-Straub S, Semler E, Uttner I, Ludolph AC. Story of the ALS-FTD continuum retold: rather two distinct entities. J Neurol Neurosurg Psych 2019;90(5):586-589